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Text
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<a href="http://doi.org/10.1016/j.jstrokecerebrovasdis.2015.12.029" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jstrokecerebrovasdis.2015.12.029</a>
Pages
883–893
Issue
4
Volume
25
Dublin Core
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Title
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Parathyroid Hormone and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study.
Publisher
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Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Date
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2016
2016-04
Subject
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*Magnetic Resonance Imaging; Brain; Brain Diseases; Brain Diseases – Complications; brain MRI; Brain/*diagnostic imaging; cerebrovascular disease; Cerebrovascular Disorders; Cerebrovascular Disorders – Blood; Cerebrovascular Disorders/*blood/*diagnostic imaging; Cohort Studies; Computer Assisted; Computer-Assisted; Cross Sectional Studies; Cross-Sectional Studies; Female; Funding Source; Human; Humans; Image Processing; Leukoencephalopathies/complications/diagnostic imaging; Magnetic Resonance Imaging; Male; Middle Age; Middle Aged; Parathyroid hormone; Parathyroid Hormone/*blood; Parathyroid Hormones – Blood; Prospective Studies; subclinical brain infarcts; white matter hyperintensities
Creator
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Korada Sai Krishna C; Zhao Di; Gottesman Rebecca F; Guallar Eliseo; Lutsey Pamela L; Alonso Alvaro; Sharrett A Richey; Post Wendy S; Reis Jared P; Mosley Thomas H; Michos Erin D
Description
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BACKGROUND: Elevated parathyroid hormone (PTH) levels have been associated with cardiovascular disease risk factors and events. We hypothesized that elevated PTH levels would also be associated with subclinical cerebrovascular disease. We examined the relationship between elevated PTH level and white matter hyperintensities (WMHs) and subclinical infarcts measured on brain magnetic resonance imaging (MRI). METHODS: PTH was measured at baseline (1993-1994) among participants free of prior clinical stroke who underwent a brain MRI at baseline (n = 1703) and a second brain MRI 10 years later (n = 948). PTH levels of 65 pg/mL or higher were considered elevated (n = 204). Participants who did not return for a follow-up MRI had, at baseline, higher PTH and a greater prevalence of cardiovascular risk factors (P \textless .05 for all); therefore, multiple imputation was used. The cross-sectional and prospective associations of PTH levels with WMH and MRI-defined infarcts (and their progression) were investigated using multivariable regression models. RESULTS: At baseline, the participants had a mean age of 62 years and were 60% female and 49% black. Cross-sectionally, after adjusting for demographic and lifestyle factors, elevated PTH level was associated with higher WMH score (beta = .19, 95% confidence interval [CI] .04-.35) and increased odds of prevalent infarcts (odds ratio 1.56, 95% CI 1.02-2.36). Results were attenuated after adjustment for potential mediators of this association (i.e., hypertension). No prospective associations were found between PTH and incident infarcts or change in estimated WMH volume, although estimates were imprecise. CONCLUSIONS: Although associated cross-sectionally, we did not confirm any association between elevated PTH level and progression of cerebrovascular changes on brain MRIs obtained 10 years apart. The relationship of PTH with subclinical brain disease warrants further study.
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<a href="http://doi.org/10.1016/j.jstrokecerebrovasdis.2015.12.029" target="_blank" rel="noreferrer noopener">10.1016/j.jstrokecerebrovasdis.2015.12.029</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Magnetic Resonance Imaging
2016
Alonso Alvaro
Brain
Brain Diseases
Brain Diseases – Complications
brain MRI
Brain/*diagnostic imaging
cerebrovascular disease
Cerebrovascular Disorders
Cerebrovascular Disorders – Blood
Cerebrovascular Disorders/*blood/*diagnostic imaging
Cohort Studies
Computer Assisted
Computer-Assisted
Cross Sectional Studies
Cross-Sectional Studies
Female
Funding Source
Gottesman Rebecca F
Guallar Eliseo
Human
Humans
Image Processing
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Korada Sai Krishna C
Leukoencephalopathies/complications/diagnostic imaging
Lutsey Pamela L
Magnetic Resonance Imaging
Male
Michos Erin D
Middle Age
Middle Aged
Mosley Thomas H
Parathyroid hormone
Parathyroid Hormone/*blood
Parathyroid Hormones – Blood
Post Wendy S
Prospective Studies
Reis Jared P
Sharrett A Richey
subclinical brain infarcts
white matter hyperintensities
Zhao Di