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Text
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URL Address
<a href="http://doi.org/10.1016/s0196-9781(03)00120-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0196-9781(03)00120-7</a>
Pages
761–771
Issue
5
Volume
24
Dublin Core
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Title
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Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.
Publisher
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Peptides
Date
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2003
2003-05
Subject
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Afferent/metabolism; Animals; Cervix Uteri/cytology/*metabolism; Down-Regulation; Estradiol/*analogs & derivatives/pharmacology; Estrogen/antagonists & inhibitors; Estrogens/*pharmacology; Female; Fulvestrant; Ganglia; Immunohistochemistry; In Situ Hybridization; Messenger/genetics/metabolism; Neurons; Postpartum Period; Pregnancy/*metabolism; Radioimmunoassay; Rats; Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spinal Cord/cytology/*metabolism; Spinal/cytology/*metabolism; Sprague-Dawley; Substance P/*biosynthesis/genetics/metabolism; Up-Regulation
Creator
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Mowa C N; Usip S; Storey-Workley M; Amann R; Papka R
Description
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Prior to parturition the non-pliable uterine cervix undergoes a ripening process ("softens" and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence for a role for sensory neurons and their contained neuropeptides is emerging. Moreover, an apparent increase in neuropeptide immunoreactive nerves occurs in the cervix during pregnancy, maternal serum estrogen levels rise at term and uterine cervix-related L6-S1 dorsal root ganglia (DRG) sensory neurons express estrogen receptor (ER) and neuropeptides. Thus, we sought to test the hypothesis that the neuropeptide substance P (SP) changes biosynthesis and release over pregnancy, that estrogen, acting via the ER pathway, increases synthesis of SP in DRG, and that SP is utilized in cervical ripening at late pregnancy. Using immunohistochemistry, in situ hybridization, reverse transcriptase-polymerase chain reaction (RT-PCR) and radioimmunoassay (RIA), we investigated coexpression of ER-alpha/beta and SP; differential expression of
Identifier
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<a href="http://doi.org/10.1016/s0196-9781(03)00120-7" target="_blank" rel="noreferrer noopener">10.1016/s0196-9781(03)00120-7</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Afferent/metabolism
Amann R
Animals
Cervix Uteri/cytology/*metabolism
Department of Anatomy & Neurobiology
Down-Regulation
Estradiol/*analogs & derivatives/pharmacology
Estrogen/antagonists & inhibitors
Estrogens/*pharmacology
Female
Fulvestrant
Ganglia
Immunohistochemistry
In Situ Hybridization
Messenger/genetics/metabolism
Mowa C N
NEOMED College of Medicine
Neurons
Papka R
Peptides
Postpartum Period
Pregnancy/*metabolism
Radioimmunoassay
Rats
Receptors
Reverse Transcriptase Polymerase Chain Reaction
RNA
Spinal Cord/cytology/*metabolism
Spinal/cytology/*metabolism
Sprague-Dawley
Storey-Workley M
Substance P/*biosynthesis/genetics/metabolism
Up-Regulation
Usip S