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Text
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<a href="http://doi.org/10.1155/2020/2597079" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2020/2597079</a>
Pages
2597079
Volume
2020
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July 2020 List
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Cleveland Clinic Akron General Hospital
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Title
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ACTH treatment for management of nephrotic syndrome: A systematic review and reappraisal.
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International Journal of Nephrology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06
Subject
The topic of the resource
DESCRIPTIVE statistics; TREATMENT effectiveness; MEDICAL information storage & retrieval systems; MEDLINE; SYSTEMATIC reviews (Medical research); NEPHROTIC syndrome treatment; ADRENOCORTICOTROPIC hormone; INFORMATION storage & retrieval systems – Medical care
Creator
An entity primarily responsible for making the resource
Chakraborty R; Mehta A; Nair N; Nemer L; Jain R; Joshi H; Raina R
Description
An account of the resource
BACKGROUND: In recent years, the use of adrenocorticotropic hormone (ACTH) therapy for treatment of proteinuria due to nephrotic syndrome (NS) has been heavily explored. ACTH therapy, which comes in the natural (H. P. Acthar Gel) or synthetic (tetracosactide) form, has resulted in remission in patients with immunosuppressive and steroid-resistant NS. However, the exact efficacy of ACTH therapy in the NS etiologies, such as membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), lupus nephritis (LN), IgA nephropathy (IgAN), and membranoproliferative glomerulonephritis (MPGN), has not been determined. OBJECTIVE: This systematic review analyzed the published literature on ACTH therapy in various NS etiologies to determine its efficacy. METHODS: A comprehensive search of MEDLINE, EMBASE, and Cochrane databases was conducted for articles through June 2019. An additional search was performed on clinicaltrials.gov to search for additional trials and cross reference the results of our database search. The literature which studied synthetic or natural ACTH treatment in patients with known etiologies of NS was included. Studies were excluded when they consisted of a single case report or did not analyze the lone effect of ACTH in NS. RESULTS: The initial search yielded a total of 411 papers, and 22 papers were included. In 214 MN patients, there was an overall remission of 40% (85/214) and an overall remission of 43% (42/98) in FSGS patients. In other etiologies, there were overall remissions of 78% (11/14), 31% (5/16), 40% (16/40), and 62% (8/13) in MCD, LN, IgAN, and MPGN patients, respectively. CONCLUSION: ACTH showed benefits in proteinuria reduction across all etiologies of NS. However, more randomized controlled studies with larger population sets and longer follow-ups are imperative to establish causal benefits. New studies into its efficacy in children are also necessary.
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<a href="http://doi.org/10.1155/2020/2597079" target="_blank" rel="noreferrer noopener">10.1155/2020/2597079</a>
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journalArticle
2020
ADRENOCORTICOTROPIC hormone
Chakraborty R
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Descriptive Statistics
INFORMATION storage & retrieval systems – Medical care
International Journal of Nephrology
Jain R
Joshi H
journalArticle
July 2020 List
MEDICAL information storage & retrieval systems
Medline
Mehta A
Nair N
Nemer L
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
NEPHROTIC syndrome treatment
Raina R
SYSTEMATIC reviews (Medical research)
TREATMENT effectiveness
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/jch.13905" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/jch.13905</a>
Pages
1059–1069
Issue
6
Volume
22
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Title
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Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross-sectional pediatric chronic kidney disease cohort from the CKiD study.
Publisher
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Journal of Clinical Hypertension
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06
Subject
The topic of the resource
inflammation; risk; children; blood-pressure; progression; ckd; AASI; chronic kidney disease; pulse pressure; pulse pressure index; aasi; albuminuria; dialysis patients; left-ventricular hypertrophy
Creator
An entity primarily responsible for making the resource
Raina R; Polaconda S; Nair N; Chakraborty R; Sethi S; Krishnappa V; Kapur G; Mhanna M; Kusumi K
Description
An account of the resource
The morbidity and mortality of adult and pediatric chronic kidney disease (CKD) and end-stage renal disease (ESRD) populations are mainly driven by cardiovascular disease (CVD). Improving CVD outcomes focuses on risk assessment of factors including diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular mass index (LVMI), pulse pressure (PP), and pulse pressure index (PPi), which is calculated as PP/SBP. These markers are also proven predictors of CKD progression; however, their role in children has not been established. This study aims to evaluate the relationship between PP, PPi, ambulatory arterial stiffness index (AASI), and proteinuria with kidney function in pediatric CKD patients; it is a retrospective analysis of 620 patients (1-16 years) from the NIDDK Chronic Kidney Disease in Children (CKiD) registry. The authors analyzed data for three separate cohorts: an overall CKD as well as immunological versus non-immunological cause for CKD groups. An inverse relationship was found between SBP, DBP, and PP with iGFR and LVMI in the overall CKD group. Our immunological CKD subgroup showed significantly higher serum creatinine, SBP, DBP, and PP values with significantly lower serum albumin levels compared to the non-immunological group. There were no significant differences with iohexol-based glomerular filtration rate (iGFR), LVMI, PPi, or high-sensitivity C-reactive protein (hs-CRP) between the two groups. A subgroup analysis demonstrated that SBP, DBP, and PP all correlated significantly with LVMI in the immunological CKD patients but not the non-immunological subgroup. Additionally, AASI data in the overall CKD population were significantly correlated with PP, PPi, and DBP. This study is one of the first to correlate noninvasive measurements of vascular compliance including PP, PPi, and AASI with iGFR and LVMI in a pediatric CKD cohort. Improving our understanding of surrogate markers for early CVD is integral to improving the care of pediatric CKD population as these patients have yet to develop the hard end points of ESRD, heart failure, myocardial infarction, or stroke.
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<a href="http://doi.org/10.1111/jch.13905" target="_blank" rel="noreferrer noopener">10.1111/jch.13905</a>
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journalArticle
2020
AASI
albuminuria
blood-pressure
Chakraborty R
Children
Chronic kidney disease
ckd
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Dialysis Patients
Inflammation
Journal of Clinical Hypertension
journalArticle
July 2020 List
Kapur G
Krishnappa V
Kusumi K
left-ventricular hypertrophy
Mhanna M
Nair N
NEOMED College of Medicine
Polaconda S
progression
pulse pressure
pulse pressure index
Raina R
Risk
Sethi S
-
Text
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URL Address
<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Pages
625
Issue
4
Volume
77
ISSN
0272-6386
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April 2021 List
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Department of Internal Medicine
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Akron Children's Hospital
Cleveland Clinic Akron General Hospital
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Title
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Acute kidney injury in COVID-19 pediatric patients: Analysis of the virtual pediatric systems data
Publisher
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American Journal Of Kidney Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-04
Creator
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Mawby I; Chakraborty R; Pandya A; Mahajan S;Rupesh R
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2021
American Journal of Kidney Diseases
April 2021 List
Chakraborty R
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
journalArticle
Mahajan S
Mawby I
NEOMED College of Medicine
NEOMED Student Publications
Pandya A
Rupesh R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.15586/jkcvhl.2020.131" target="_blank" rel="noreferrer noopener">http://doi.org/10.15586/jkcvhl.2020.131</a>
Pages
5-19
Issue
3
Volume
7
ISSN
2203-5826
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Title
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Renal manifestations of tuberous sclerosis complex.
Publisher
An entity responsible for making the resource available
Journal Of Kidney Cancer And VHL
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-08-27
Subject
The topic of the resource
angiomyolipoma; autosomal polycystic kidney disease; renal cystic disease; tuberous sclerosis; Von Hippel–Lindau disease
Creator
An entity primarily responsible for making the resource
Nair N;Chakraborty R;Mahajan Z;Sharma A;Sethi SK;Raina R
Description
An account of the resource
Tuberous sclerosis complex (TSC) is a genetic condition caused by a mutation in either the TSC1 or TSC2 gene. Disruption of either of these genes leads to impaired production of hamartin or tuberin proteins, leading to the manifestation of skin lesions, tumors, and seizures. TSC can manifest in multiple organ systems with the cutaneous and renal systems being the most commonly affected. These manifestations can secondarily lead to the development of hypertension, chronic kidney disease, and neurocognitive declines. The renal pathologies most commonly seen in TSC are angiomyolipoma, renal cysts, and less commonly, oncocytomas. In this review, we highlight the current understanding on the renal manifestations of TSC along with current diagnosis and treatment guidelines. (Copyright: Nair N et al.)
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<a href="http://doi.org/10.15586/jkcvhl.2020.131" target="_blank" rel="noreferrer noopener">10.15586/jkcvhl.2020.131</a>
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journalArticle
2020
angiomyolipoma
autosomal polycystic kidney disease
Chakraborty R
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Journal of kidney cancer and VHL
journalArticle
Mahajan Z
Nair N
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
NEOMED Student Publications
Raina R
renal cystic disease
September 2020 List
Sethi SK
Sharma A
tuberous sclerosis
Von Hippel–Lindau disease
-
Text
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<a href="http://doi.org/10.1111/1744-9987.13584" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/1744-9987.13584</a>
ISSN
1744-9987
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Title
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Changing the terminology from kidney replacement therapy to kidney support therapy.
Publisher
An entity responsible for making the resource available
Therapeutic Apheresis And Dialysis
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-18
Subject
The topic of the resource
dialysis; acute kidney injury; extracorporeal organ support; kidney replacement therapy; kidney support therapy
Creator
An entity primarily responsible for making the resource
Raina R;Joshi H;Chakraborty R
Description
An account of the resource
Kidney replacement therapy(KRT) is a common supportive treatment for renal dysfunction, especially acute kidney injury. However, critically ill or immunosuppressed patients with renal dysfunction often have dysfunction in other organs as well. To improve patient outcomes, clinicians began to initiate kidney replacement therapy in situations where non-renal conditions may lead to AKI, such as septic shock, hematopoietic stem cell transplantation, veno-occlusive renal disease, cardiopulmonary bypass, chemotherapy, tumor lysis syndrome, hyperammonemia, and various others. In this review, we discuss the use of various modes of kidney replacement therapy in treating renal and non-renal complications to illustrate why kidney support therapy is a more appropriate terminology than renal replacement therapy. This article is protected by copyright. All rights reserved. (This article is protected by copyright. All rights reserved.)
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<a href="http://doi.org/10.1111/1744-9987.13584" target="_blank" rel="noreferrer noopener">10.1111/1744-9987.13584</a>
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journalArticle
2020
Acute kidney injury
Chakraborty R
Department of Internal Medicine
Dialysis
extracorporeal organ support
Joshi H
journalArticle
kidney replacement therapy
kidney support therapy
NEOMED College of Medicine
Raina R
September 2020 List
Therapeutic Apheresis And Dialysis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/hdi.12868" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/hdi.12868</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1542-4758 1492-7535
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October 2020 List
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Department of Internal Medicine
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Title
A name given to the resource
Challenges of long-term vascular access in pediatric hemodialysis: Recommendations for practitioners.
Publisher
An entity responsible for making the resource available
Hemodialysis International.
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-18
Subject
The topic of the resource
Pediatrics; hemodialysis; vascular access; central venous catheter; arteriovenous grafts
Creator
An entity primarily responsible for making the resource
Raina R;Joshi H;Chakraborty R;Sethi SK
Description
An account of the resource
Kidney transplantation is the preferred treatment of end-stage renal disease in children. However, time to transplant varies, making a well-functioning long-term vascular access essential for performing hemodialysis efficiently and without disruption until a kidney becomes available. However, establishing long-term vascular access in pediatric patients can present distinct challenges due to this population's unique characteristics, such as smaller body size and lower-diameter blood vessels. There are three main pediatric long-term vascular access options, which include central venous catheters (CVC), arteriovenous fistula (AVF), and arteriovenous graft (AVG). CVC are currently the most widely used modality, although various studies and guidelines recommend AVF or AVG as the preferred option. Although AVF should be used whenever possible, it is crucial that clinicians consider factors such as patient size, physical exam findings, comorbidities, predicted duration of treatment to decide on the most optimal long-term vascular access modality. This article reviews the three long-term vascular access methods in children and the benefits and complications of each.
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<a href="http://doi.org/10.1111/hdi.12868" target="_blank" rel="noreferrer noopener">10.1111/hdi.12868</a>
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journalArticle
2020
arteriovenous grafts
central venous catheter
Chakraborty R
Department of Internal Medicine
Hemodialysis
Hemodialysis International.
Joshi H
journalArticle
NEOMED College of Medicine
NEOMED Student Publications
October 2020 List
Pediatrics
Raina R
Sethi SK
vascular access
-
Text
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URL Address
<a href="http://doi.org/10.3389/fped.2020.588911" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fped.2020.588911</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
588911
Volume
8
ISSN
2296-2360 2296-2360
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Title
A name given to the resource
Hypertensive crisis in pediatric patients: An overview.
Publisher
An entity responsible for making the resource available
Frontiers in Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
1905-07
Subject
The topic of the resource
management; acute severe hypertension; hypertensive crisis; hypertensive emergency; hypertensive urgency
Creator
An entity primarily responsible for making the resource
Raina R;Mahajan Z;Sharma A;Chakraborty R;Mahajan S;Sethi SK;Kapur G;Kaelber D
Description
An account of the resource
Hypertensive crisis can be a source of morbidity and mortality in the pediatric population. While the epidemiology has been difficult to pinpoint, it is well-known that secondary causes of pediatric hypertension contribute to a greater incidence of hypertensive crisis in pediatrics. Hypertensive crisis may manifest with non-specific symptoms as well as distinct and acute symptoms in the presence of end-organ damage. Hypertensive emergency, the form of hypertensive crisis with end-organ damage, may present with more severe symptoms and lead to permanent organ damage. Thus, it is crucial to evaluate any pediatric patient suspected of hypertensive emergency with a thorough workup while acutely treating the elevated blood pressure in a gradual manner. Management of hypertensive crisis is chosen based on the presence of end-organ damage and can range from fast-acting intravenous medication to oral medication for less severe cases. Treatment of such demands a careful balance between decreasing blood pressure in a gradual manner while preventing damage end-organ damage. In special situations, protocols have been established for treatment of hypertensive crisis, such as in the presence of endocrinologic neoplasms, monogenic causes of hypertension, renal diseases, and cardiac disease. With the advent of telehealth, clinicians are further able to extend their reach of care to emergency settings and aid emergency medical service (EMS) providers in real time. In addition, further updates on the evolving topic of hypertension in the pediatric population and novel drug development continues to improve outcomes and efficiency in diagnosis and management of hypertension and consequent hypertensive crisis.
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<a href="http://doi.org/10.3389/fped.2020.588911" target="_blank" rel="noreferrer noopener">10.3389/fped.2020.588911</a>
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journalArticle
2020
acute severe hypertension
Chakraborty R
Department of Internal Medicine
Frontiers in pediatrics
hypertensive crisis
hypertensive emergency
hypertensive urgency
journalArticle
Kaelber D
Kapur G
Mahajan S
Mahajan Z
Management
NEOMED College of Medicine
October 2020 List
Raina R
Sethi SK
Sharma A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.xkme.2021.01.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.xkme.2021.01.007</a>
ISSN
2590-0595
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April 2021 List
NEOMED College
NEOMED College of Medicine
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Department of Internal Medicine
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Title
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Telemedicine for pediatric nephrology: Perspectives on COVID-19, future practices, and workflow changes.
Publisher
An entity responsible for making the resource available
Kidney Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-03-28
Creator
An entity primarily responsible for making the resource
Rupesh R; Nair N; Sharma A; Chakraborty R; Rush S
Description
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While the use of telemedicine in rural areas has increased steadily over the years, its use was rapidly implemented during the onset of the COVID-19 crisis. Due to this rapid implementation, there is a lack of standardized workflows to assess and treat for various nephrotic conditions, symptoms, treatment modalities and transition processes in the pediatric population. In order to provide a foundation/suggestion for future standardized workflows, the authors of this paper have developed standardized workflows via the Delphi method. These workflows were informed based on results from cross sectional surveys directed to patients and providers. The majority of patients and providers were satisfied, 87% and 71% respectively, with their telemedicine visits. Common issues that were raised with the use of telemedicine included difficulty in procuring physical laboratory results and a lack of personal warmth during telemedicine visits. The workflows created based on these suggestions will both enhance safety in treating patients and allow for the best possible care.
Identifier
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<a href="http://doi.org/10.1016/j.xkme.2021.01.007" target="_blank" rel="noreferrer noopener">10.1016/j.xkme.2021.01.007</a>
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journalArticle
2021
April 2021 List
Chakraborty R
Department of Internal Medicine
journalArticle
Kidney Medicine
Nair N
NEOMED College of Medicine
Rupesh R
Rush S
Sharma A
-
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<a href="http://doi.org/10.23876/j.krcp.20.053" target="_blank" rel="noreferrer noopener">http://doi.org/10.23876/j.krcp.20.053</a>
ISSN
2211-9132
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.23876/j.krcp.20.053" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.23876/j.krcp.20.053</a>
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
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Title
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Development of acute kidney injury following pediatric cardiac surgery.
Publisher
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Kidney Research and Clinical Practice
Date
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2020
2020-08-10
Subject
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Pediatrics; Acute kidney injury; Nephrology; Thoracic surgery
Creator
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Sharma A; Chakraborty R; Sharma K; Sethi SK; Raina R
Description
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Acute kidney injury (AKI) in the pediatric population is a relatively common phenomenon. Specifically, AKI has been found in increasing numbers within the pediatric population following cardiac surgery, with up to 43% of pediatric patients developing AKI post-cardiac surgery. However, recent advances have allowed for the identification of risk factors. These can be divided into preoperative, intraoperative, and postoperative factors. Although the majority of pediatric patients developing AKI after cardiac surgery completely recover, this condition is associated with worse outcomes. These include fluid overload and increased mortality and result in longer hospital and intensive care unit stays. Detecting the presence of AKI has advanced; use of relatively novel biomarkers, including neutrophil gelatinase associated lipocalin, has shown promise in detecting more subtle changes in kidney function when compared to conventional methods. While a single, superior treatment has not been elucidated yet, novel functions of medications, including fenoldopam, theophylline and aminophylline, have been shown to have better outcomes for these patients. With the recent advances in identification of risk factors, outcomes, diagnosis, and management, the medical community can further explain the complexities of AKI in the pediatric population post-cardiac surgery.
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<a href="http://doi.org/10.23876/j.krcp.20.053" target="_blank" rel="noreferrer noopener">10.23876/j.krcp.20.053</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Acute kidney injury
August 2020 List
Chakraborty R
journalArticle
Kidney Research and Clinical Practice
NEOMED College of Medicine Student
NEOMED Student Publications
Nephrology
Pediatrics
Raina R
Sethi SK
Sharma A
Sharma K
Thoracic surgery