1
40
6
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Text
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<a href="http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41581-020-0267-8</a>
ISSN
1759-507X 1759-5061
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.
Publisher
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Nature reviews. Nephrology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04-08
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Bedoyan Jirair K; Lichter-Konecki Uta; Jouvet Philippe; Picca Stefano; Mew Nicholas Ah; Machado Marcel C; Chakraborty Ronith; Vemuganti Meghana; Grewal Manpreet K; Bunchman Timothy; Sethi Sidharth Kumar; Krishnappa Vinod; McCulloch Mignon; Alhasan Khalid; Bagga Arvind; Basu Rajit K; Schaefer Franz; Filler Guido; Warady Bradley A
Description
An account of the resource
Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial. This expert Consensus Statement presents recommendations for the management of hyperammonaemia requiring KRT in paediatric populations. Additional studies are required to strengthen these recommendations.
Identifier
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<a href="http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">10.1038/s41581-020-0267-8</a>
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journalArticle
2020
Alhasan Khalid
Bagga Arvind
Basu Rajit K
Bedoyan Jirair K
Bunchman Timothy
Chakraborty Ronith
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Filler Guido
Grewal Manpreet K
journalArticle
Jouvet Philippe
June 2020 Update II
Krishnappa Vinod
Lichter-Konecki Uta
Machado Marcel C
McCulloch Mignon
Mew Nicholas Ah
Nature reviews. Nephrology
NEOMED College of Medicine
Picca Stefano
Raina Rupesh
Schaefer Franz
Sethi Sidharth Kumar
Vemuganti Meghana
Warady Bradley A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.14740/cr955" target="_blank" rel="noreferrer noopener">http://doi.org/10.14740/cr955</a>
Pages
76-88
Issue
2
Volume
11
ISSN
1923-2829 1923-2829
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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An Update on the Pathophysiology and Treatment of Cardiorenal Syndrome.
Publisher
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Cardiology research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
cardiac resynchronization therapy; Cardiorenal syndrome; cardiovascular events; Chronic kidney disease; Chronic kidney disease; decompensated heart-failure; Heart failure; impact; left-ventricular dysfunction; preserved ejection fraction; risk; vasopressin; worsening renal-function
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Nair Nikhil; Chakraborty Ronith; Nemer Lena; Dasgupta Rahul; Varian Kenneth
Description
An account of the resource
Cardiorenal syndrome (CRS) encompasses various disorders of the heart and kidneys; dysfunction of one organ leads to acute or chronic dysfunction of the other. It incorporates the intersection of heart-kidney interactions across several mediums, hemodynamically, through the alterations in neurohormonal markers, and increased venous and renal pressure, all of which are hallmarks of its clinical phenotypes. This article explores the epidemiology, pathology, classification and treatment of each type of CRS.
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<a href="http://doi.org/10.14740/cr955" target="_blank" rel="noreferrer noopener">10.14740/cr955</a>
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journalArticle
2020
cardiac resynchronization therapy
Cardiology research
Cardiorenal syndrome
cardiovascular events
Chakraborty Ronith
Chronic kidney disease
Cleveland Clinic Akron General Hospital
Dasgupta Rahul
decompensated heart-failure
Department of Internal Medicine
Heart failure
impact
Journal Article
journalArticle
June 2020 Update I
left-ventricular dysfunction
Nair Nikhil
Nemer Lena
NEOMED College of Medicine
preserved ejection fraction
Raina Rupesh
Risk
Varian Kenneth
vasopressin
worsening renal-function
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Text
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URL Address
<a href="http://doi.org/10.1007/s12098-019-03150-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s12098-019-03150-9</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Renal Replacement Therapy in Pediatric Acute Kidney Injury.
Publisher
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Indian journal of pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-01
Subject
The topic of the resource
Acute kidney injury; Dialysis; Pediatric; Renal replacement therapy
Creator
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Sethi Sidharth Kumar; Chakraborty Ronith; Joshi Hirva; Raina Rupesh
Description
An account of the resource
Acute kidney injury (AKI) is common in critically ill children and affects nearly
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s12098-019-03150-9" target="_blank" rel="noreferrer noopener">10.1007/s12098-019-03150-9</a>
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Journal Article
2020
Acute kidney injury
Chakraborty Ronith
Dialysis
Indian journal of pediatrics
Joshi Hirva
NEOMED College of Medicine Student
NEOMED Student Publications
Pediatric
Raina Rupesh
renal replacement therapy
Sethi Sidharth Kumar
-
Text
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URL Address
<a href="http://doi.org/10.1159/000504623" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000504623</a>
Pages
22-34
Issue
1
Volume
6
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Graduate Studies; NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
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Title
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The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.
Publisher
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Kidney diseases (Basel, Switzerland)
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-01
Subject
The topic of the resource
Focal segmental glomerulosclerosis; Diabetic nephropathy; Endothelin; Endothelin antagonists; Hypertensive nephropathy
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Chauvin Abigail; Chakraborty Ronith; Nair Nikhil; Shah Haikoo; Krishnappa Vinod; Kusumi Kirsten
Description
An account of the resource
Background: Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling pathways tied to regulation of aldosterone, catecholamines, and angiotensin. In the kidney, ET-1 is critical to maintaining renal perfusion and controls glomerular arteriole tone and hemodynamics. It is hypothesized that
Identifier
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<a href="http://doi.org/10.1159/000504623" target="_blank" rel="noreferrer noopener">10.1159/000504623</a>
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Journal Article
2020
Chakraborty Ronith
Chauvin Abigail
Diabetic nephropathy
Endothelin
Endothelin antagonists
Focal segmental glomerulosclerosis
Hypertensive nephropathy
Kidney diseases (Basel
Kidney diseases (Basel, Switzerland)
Krishnappa Vinod
Kusumi Kirsten
Nair Nikhil
NEOMED College of Graduate Studies Student
NEOMED College of Medicine Student
NEOMED Student Publications
Raina Rupesh
Shah Haikoo
Switzerland)
-
Text
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URL Address
<a href="http://doi.org/10.1159/000506277" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000506277</a>
Pages
1-11
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Graduate Studies
NEOMED Department
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Extracorporeal Therapies in the Treatment of Focal Segmental Glomerulosclerosis.
Publisher
An entity responsible for making the resource available
Blood purification
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-02
Subject
The topic of the resource
Focal segmental glomerulosclerosis; Low-density lipoprotein apheresis; Extracorporeal therapy; Immunoadsorption; Plasma exchange
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Wang Joseph; Sharma Aditya; Chakraborty Ronith
Description
An account of the resource
Focal segmental glomerulosclerosis (FSGS) is one of the most frequent and severe glomerular kidney disease with frequent progression to end-stage renal disease and a high rate of recurrence in renal transplantations. Due to intolerance or resistance to the current immunomodulatory treatments, the management of FSGS is a therapeutic challenge. Over the last few years, development in extracorporeal therapies has shown potential beneficial outcomes in drug-resistant and recurrent FSGS patients. Thus, this study reviews the current literature on the use of extracorporeal therapies, such as plasma exchange therapy, immunoadsorption, and low-density lipoprotein apheresis, for the treatment of FSGS in the pediatric population.
Identifier
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<a href="http://doi.org/10.1159/000506277" target="_blank" rel="noreferrer noopener">10.1159/000506277</a>
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Journal Article
2020
Blood purification
Chakraborty Ronith
Extracorporeal therapy
Focal segmental glomerulosclerosis
Immunoadsorption
Low-density lipoprotein apheresis
NEOMED College of Graduate Studies
NEOMED College of Graduate Studies Student
Plasma exchange
Raina Rupesh
Sharma Aditya
Wang Joseph
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fped.2019.00454</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
454
Volume
7
ISSN
2296-2360
Search for Full-text
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fped.2019.00454</a>
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Update Year & Number
January 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Affiliated Hospital
Cleveland Clinic Akron General
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dextran-Sulfate Plasma Adsorption Lipoprotein Apheresis in Drug Resistant Primary Focal Segmental Glomerulosclerosis Patients: Results From a Prospective, Multicenter, Single-Arm Intervention Study
Publisher
An entity responsible for making the resource available
Frontiers in Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
1905-07
Subject
The topic of the resource
focal segmental glomerulosclerosis; lipoprotein apheresis; liposorber; nephrotic syndrome; proteinuria
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Krishnappa Vinod; Sanchez-Kazi Cheryl; Quiroga Alejandro; Twombley Katherine E; Mathias Robert; Lo Megan; Chakraborty Ronith; Mahesh Shefali; Steinke Julia; Bunchman Timothy; Zaritsky Joshua
Description
An account of the resource
Background: Focal segmental glomerulosclerosis (FSGS) causes end stage renal disease (ESRD) in significant proportion of patients worldwide. Primary FSGS carries poor prognosis and management of FSGS patients, refractory to standard treatments or resistant to steroids, remains a major challenge. Lipoprotein apheresis is a therapeutic approach for drug resistant primary FSGS and post-renal transplant primary FSGS recurrence. Objectives: To examine the safety and probable benefit at 1, 3, 6, 12, and 24-months following completion of apheresis treatment using Liposorber® LA-15 system in patients with nephrotic syndrome (NS), due to refractory primary FSGS or primary FSGS associated NS, in post renal transplant children. Material and Methods: Prospective, multicenter, single-arm intervention study using Liposorber® LA-15 system. Patients ≤21 years old with drug resistant or drug intolerant NS secondary to primary FSGS with glomerular filtration rate (GFR) ≥60 ml/min/1.73 m2 or post renal transplant patients ≤21 years old with primary FSGS associated NS were included in the study. Each patient had 12 dextran-sulfate plasma adsorption lipoprotein apheresis sessions over a period of 9 weeks. All patients were followed up at 1, 3, 6, 12, and 24-months following completion of treatment. Results: Of 17 patients enrolled, six were excluded from the outcome analysis (protocol deviations). Of the remaining 11 patients, all but one have completed apheresis treatments. Three patients were lost to follow-up immediately after completion of apheresis and excluded from outcome analysis. At one-month follow-up, 1 of 7 patients (14.3%) attained partial remission of NS while 2 of 4 subjects (50%) and 2 of 3 subjects (66.7%) had partial/complete remission at 3- and 6-months follow-up, respectively. One of two patients followed up for 12 months had complete remission and one patient had partial remission of NS after 24 months. Improved or stable eGFR was noted in all patients over the follow-up period. Conclusion: The results of our multicenter study showed improvement in the response rates to steroid or immunosuppressive therapy and induced complete or partial remission of proteinuria in some of the patients with drug resistant primary FSGS. The main limitation of our study is the small number of subjects and high dropout rate.
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<a href="http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">10.3389/fped.2019.00454</a>
PMID: 31850285 PMCID: PMC6902874
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Bunchman Timothy
Chakraborty Ronith
Focal segmental glomerulosclerosis
Frontiers in pediatrics
January 2020 Update
Journal Article
Krishnappa Vinod
Lipoprotein apheresis
liposorber
Lo Megan
Mahesh Shefali
Mathias Robert
NEOMED College of Graduate Studies Student
NEOMED Student Publications
Nephrotic syndrome
Proteinuria
Quiroga Alejandro
Raina Rupesh
Sanchez-Kazi Cheryl
Steinke Julia
Twombley Katherine E
Zaritsky Joshua