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<a href="http://doi.org/10.1159/000497447" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000497447</a>
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1-16
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Title
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Role of Lipoprotein Apheresis in Cardiovascular Disease Risk Reduction.
Publisher
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Blood purification
Date
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2019
2019-02
Subject
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Cardiovascular disease; *Atherosclerosis; Lipoprotein apheresis; Lipoprotein(a); Low-density lipoprotein; Peripheral vascular disease
Creator
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Raina Rupesh; Young Claire; Krishnappa Vinod; Chanchlani Rahul
Description
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BACKGROUND AND AIM: Elevated low-density lipoprotein cholesterol and/or lipoprotein(a) are established risk factors for cardiovascular disease (CVD). Management of hypercholesterolemia consists of drug therapies, including statins and proprotein convertase subtilisin/kexin type 9 inhibitors. In patients with familial hypercholesterolemia (FH), lipoprotein apheresis (LA) is utilized to control lipid levels. However, LA is not currently a standard therapy for non-FH. This review summarizes the literature regarding LA therapy in CVD prevention. METHODS: PubMed/MEDLINE databases were searched using the keywords "LA" and "CVD". Citations were individually reviewed for relevance. RESULTS: The efficacy of LA was clearly demonstrated, largely based on evidence from observational studies. In patients who are unresponsive to traditional lipid-lowering medications, LA effectively reduced serum lipoprotein levels and adverse cardiovascular events. CONCLUSION: It was concluded that LA is a safe and effective technique that could be considered in the management of hypercholesterolemia and future risk. Randomized control trials would further support a role for LA as a therapeutic option.
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<a href="http://doi.org/10.1159/000497447" target="_blank" rel="noreferrer noopener">10.1159/000497447</a>
*Atherosclerosis
2019
Blood purification
CARDIOVASCULAR DISEASE
Chanchlani Rahul
Department of Internal Medicine
Krishnappa Vinod
Lipoprotein apheresis
Lipoprotein(a)
Low-density lipoprotein
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
Peripheral vascular disease
Raina Rupesh
Young Claire