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Tags: Chemical Biology & Drug Design

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Fragment based screening and hit-based substructure search: Rapid discovery of 8-hydroxyquinoline-7-carboxylic acid as a low-cytotoxic, nanomolar metallo β-lactamase inhibitor.

Metallo-β-lactamases (MBLs) are zinc containing carbapenemases that inactivate a broad range of β-lactam antibiotics. There is a lack of β-lactamase inhibitors for restoring existing β-lactam antibiotics arsenals against common bacterial …

Tags: 2021, Bergstrom A, Chemical Biology & Drug Design, Crowder MW, Department of Pharmaceutical Sciences, Jennings IR, journalArticle, June 2021 List, Muthyala R, NEOMED College of Medicine, Nguyen ME, Sham YY, Shin WS

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