1
40
39
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0003-2697(85)90552-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0003-2697(85)90552-4</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
361-365
Issue
2
Volume
146
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A MICROPREPARATION OF FLUORESCEIN CONJUGATES OF IMMUNOGLOBULIN-G AND FAB FROM SERUM
Publisher
An entity responsible for making the resource available
Analytical Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1985
1985
Subject
The topic of the resource
Chemistry; Biochemistry & Molecular Biology
Creator
An entity primarily responsible for making the resource
Mohanty J G; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0003-2697(85)90552-4" target="_blank" rel="noreferrer noopener">10.1016/0003-2697(85)90552-4</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1985
Analytical biochemistry
Biochemistry & Molecular Biology
Chemistry
Journal Article or Conference Abstract Publication
Mohanty J G
Rosenthal K S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1039/c4ra12878h" target="_blank" rel="noreferrer noopener">http://doi.org/10.1039/c4ra12878h</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
28019-28022
Issue
35
Volume
5
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Title
A name given to the resource
A naturally derived dextran-peptide vector for microRNA antagomir delivery
Publisher
An entity responsible for making the resource available
Rsc Advances
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015
Subject
The topic of the resource
cells; Chemistry; gene delivery; human cancers; in-vitro; mechanism; RNA interference; therapy; vivo
Creator
An entity primarily responsible for making the resource
Tang Q; Lei X; Cao B; Sun B B; Zhang Y Q; Cheng G
Description
An account of the resource
Single stranded microRNAs and their antagomirs are unstable and polyanionic, which impedes efficient cellular uptake and reduces half-life. Therefore, effective delivery systems with low toxicity for microRNAs are urgently needed for the success of microRNA-based therapy. Here, a dextran-peptide hybrid, Dex10-R5H5(40%), was developed as a carrier to deliver microRNAs. Dex10-R5H5(40%) loaded with antagomir-149 could reduce the level of endogenous microRNA-149 by 76% and it is more effective than the commercially available transfection reagent, RNAiMAX, which leads to 67% reduction. Additionally, Dex10-R5H5(40%) exhibited no cytotoxicity to HepG2 cells. These results indicate that the dextran-peptide hybrid may be a promising delivery system for the safe and efficient microRNA-based therapy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1039/c4ra12878h" target="_blank" rel="noreferrer noopener">10.1039/c4ra12878h</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2015
Cao B
Cells
Chemistry
Cheng G
gene delivery
human cancers
in-vitro
Journal Article
Lei X
mechanism
RNA Interference
Rsc Advances
Sun B B
Tang Q
therapy
vivo
Zhang Y Q
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
U410-U410
Volume
219
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Dublin Core
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Title
A name given to the resource
Amphiphilic Gels With Controlled-mesh Dimensions For Insulin Delivery
Publisher
An entity responsible for making the resource available
Abstracts of Papers of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-03
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Kennedy J P; Fenyvesi G; Na S; Keszler B; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
Abstracts of Papers of the American Chemical Society
Chemistry
Fenyvesi G
Journal Article or Conference Abstract Publication
Kennedy J P
Keszler B
Na S
Rosenthal K S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
11-20
Issue
1
Volume
70
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Title
A name given to the resource
Anomalous Phase Transition In Dipalmitoylphosphatidylethanolamine/palmitoylphosphatidylcholine/water System
Publisher
An entity responsible for making the resource available
Biophysical Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-01
Subject
The topic of the resource
bilayer; Biochemistry & Molecular Biology; Biophysics; Chemistry; compressibility; DSC; lysolecithin; lysophosphatidylcholine; membrane; NMR; permeability; phase transition; phosphatidylcholine vesicles; phosphatidylethanolamine; phospholipid; phospholipid-vesicles; translocation; volumetric
Creator
An entity primarily responsible for making the resource
La Rosa C; Grasso D; Checchetti A; Golemme A; Chidichimo G; Westerman P
Description
An account of the resource
An anomalous phase transition with a marked rise in specific heat, the isobaric thermal expansion coefficient, and the compressibility coefficient at 62.5 degrees C for an equimolar mixture of 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) and 1-palmitoyl-sn-glycero-3-phosphocholine (PLPC), in water (34 wt.%) has been shown by differential scanning calorimetry, scanning dilatometry and isothermal compressibility measurements. This transition occurs 15 degrees C above a first-order transition observed in the same system, P-31 and H-2 nuclear magnetic resonance results are consistent with the occurrence of 'defects' in the bilayer in the temperature range between the first and the anomalous phase transitions, It is proposed that conically, PLPC molecules prefer regions with high curvature in the defective bilayer, while DPPE molecules are mostly confined to the flat regions of the bilayers. (C) 1998 Elsevier Science B.V.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
bilayer
Biochemistry & Molecular Biology
Biophysical Chemistry
Biophysics
Checchetti A
Chemistry
Chidichimo G
compressibility
DSC
Golemme A
Grasso D
Journal Article or Conference Abstract Publication
La Rosa C
lysolecithin
lysophosphatidylcholine
membrane
nmr
Permeability
phase transition
phosphatidylcholine vesicles
phosphatidylethanolamine
phospholipid
phospholipid-vesicles
Translocation
volumetric
Westerman P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf01978800" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf01978800</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
746-749
Issue
6
Volume
11
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anti-inflammatory Properties Of Copper Implants In The Rat Paw Edema - A Preliminary-study
Publisher
An entity responsible for making the resource available
Agents and Actions
Date
A point or period of time associated with an event in the lifecycle of the resource
1981
1981
Subject
The topic of the resource
Chemistry; Pharmacology & Pharmacy
Creator
An entity primarily responsible for making the resource
Dollwet H H A; Schmidt S P; Seeman R E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf01978800" target="_blank" rel="noreferrer noopener">10.1007/bf01978800</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1981
Agents and Actions
Chemistry
Department of Pharmaceutical Sciences
Dollwet H H A
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Pharmacology & Pharmacy
Schmidt S P
Seeman R E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2010.04.098" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2010.04.098</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3208-3210
Issue
11
Volume
20
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter
Publisher
An entity responsible for making the resource available
Bioorganic & Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
12-diyl-bis-3-picolinium dibromide; analogs; Bis-quaternary ammonium salts; Blood-brain barrier; Chemistry; Choline transporter; evoked dopamine release; extracellular dopamine; hyperactivity; mediated transport; n; n'-dodecane-1; nicotinic-receptor antagonist; nucleus-accumbens; Pharmacology & Pharmacy; rat; tobacco dependence; vector
Creator
An entity primarily responsible for making the resource
Zheng G R; Zhang Z F; Lockman P R; Geldenhuys W J; Allen D D; Dwoskin L P; Crooks P A
Description
An account of the resource
A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained from this study suggest that incorporating a linear, conformationally restricted linker into the molecule improves affinity for the BBB-ChT. (C) 2010 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2010.04.098" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2010.04.098</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
12-diyl-bis-3-picolinium dibromide
2010
Allen D D
analogs
Bioorganic & medicinal chemistry letters
Bis-quaternary ammonium salts
Blood-brain barrier
Chemistry
Choline transporter
Crooks P A
Dwoskin L P
evoked dopamine release
extracellular dopamine
Geldenhuys W J
hyperactivity
Journal Article
Lockman P R
mediated transport
n
n'-dodecane-1
nicotinic-receptor antagonist
nucleus-accumbens
Pharmacology & Pharmacy
rat
tobacco dependence
vector
Zhang Z F
Zheng G R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2008.08.099" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2008.08.099</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
5622-5625
Issue
20
Volume
18
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Dublin Core
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Title
A name given to the resource
bis-pyridinium cyclophanes: Novel ligands with high affinity for the blood-brain barrier choline transporter
Publisher
An entity responsible for making the resource available
Bioorganic & Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
12-diyl-bis-3-picolinium dibromide; acetylcholine receptor; ammonium-salts; blood-brain barrier choline transporter; carrier-mediated transport; Chemistry; drug delivery; evoked dopamine release; extracellular dopamine; hyperactivity; inhibition; n; n-alkylnicotinium analogs; n'-dodecane-1; nicotinic; nicotinic receptor antagonists; Pharmacology & Pharmacy; quaternary; quaternary ammonium
Creator
An entity primarily responsible for making the resource
Zhang Z F; Lockman P R; Mittapalli R K; Allen D D; Dwoskin L P; Crooks P A
Description
An account of the resource
A series of bis-pyridinium cyclophane analogs designed as conformationally restricted bis-quaternary ammonium compounds were evaluated for their affinity for the blood-brain barrier (BBB) choline transporter. All the cyclophanes investigated exhibited high affinity compared to choline. Of these compounds, N, N'-(1,10-decanediyl)3,3'-(1,9-decadiyn-1,10-diyl)-bis-pyridinium diiodide (5c) and N, N'-(1,9-nonanediyl) 3,3'-(1,9-decadiyn-1,10-diyl)-bis-pyridinium dibromide (5b) exhibited highest affinity with K(i) values of 0.8 mu M and 1.4 mu M, respectively, and constitute some of the most potent BBB choline transporter ligands reported. (C) 2008 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2008.08.099" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2008.08.099</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
12-diyl-bis-3-picolinium dibromide
2008
acetylcholine receptor
Allen D D
ammonium-salts
Bioorganic & medicinal chemistry letters
blood-brain barrier choline transporter
carrier-mediated transport
Chemistry
Crooks P A
Drug delivery
Dwoskin L P
evoked dopamine release
extracellular dopamine
hyperactivity
inhibition
Journal Article
Lockman P R
Mittapalli R K
n
n-alkylnicotinium analogs
n'-dodecane-1
nicotinic
nicotinic receptor antagonists
Pharmacology & Pharmacy
quaternary
quaternary ammonium
Zhang Z F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1039/b505706j" target="_blank" rel="noreferrer noopener">http://doi.org/10.1039/b505706j</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1495-1503
Issue
16
Volume
16
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Dublin Core
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Title
A name given to the resource
Collagen As A Scaffold For Biomimetic Mineralization Of Vertebrate Tissues
Publisher
An entity responsible for making the resource available
Journal of Materials Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006
Subject
The topic of the resource
3 dimensions; bone; Chemistry; elastic energy-storage; electron-microscopic tomography; fibril structure; i collagen; Materials Science; matrix; mechanical-properties; molecular packing; organic; turkey tendons
Creator
An entity primarily responsible for making the resource
Landis W J; Silver F H; Freeman J W
Description
An account of the resource
Collagen is a well known protein component that has the capacity to mineralize in a variety of vertebrate tissues. In its mineralized form, collagen potentially can be utilized as a biomimetic material for a variety of applications, including, for example, the augmentation and repair of damaged, congenitally defective, diseased or otherwise impaired calcified tissues such as bone and cartilage. In order to effect an optimal response in this regard, the manner in which collagen becomes mineralized is critically important to understand. This paper provides details concerning collagen-mineral interaction and its implications with respect to designing biomimetic mineralizing collagen that will be functionally competent in its biological, chemical, and biomechanical properties.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1039/b505706j" target="_blank" rel="noreferrer noopener">10.1039/b505706j</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2006
3 dimensions
Bone
Chemistry
Department of Family & Community Medicine
elastic energy-storage
electron-microscopic tomography
fibril structure
Freeman J W
i collagen
Journal Article or Conference Abstract Publication
Journal of Materials Chemistry
Landis W J
Materials Science
matrix
mechanical-properties
molecular packing
NEOMED College of Medicine
organic
Silver F H
turkey tendons
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/ac00258a031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/ac00258a031</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1115-1117
Issue
7
Volume
55
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Title
A name given to the resource
CRITICAL MICELLE CONCENTRATION DETERMINATION OF NON-IONIC DETERGENTS WITH COOMASSIE BRILLIANT BLUE G-250
Publisher
An entity responsible for making the resource available
Analytical Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1983
1983
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Rosenthal K S; Koussaie F
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/ac00258a031" target="_blank" rel="noreferrer noopener">10.1021/ac00258a031</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1983
Analytical Chemistry
Chemistry
Journal Article
Koussaie F
Rosenthal K S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-4347(00)81427-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-4347(00)81427-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
29-35
Issue
1
Volume
230
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
DETERMINATION OF METHYLPREDNISOLONE IN CENTRAL NERVOUS-TISSUE AND PLASMA USING NORMAL-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
Publisher
An entity responsible for making the resource available
Journal of Chromatography
Date
A point or period of time associated with an event in the lifecycle of the resource
1982
1982
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
McGinley P A; Braughler J M; Hall E D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0378-4347(00)81427-9" target="_blank" rel="noreferrer noopener">10.1016/s0378-4347(00)81427-9</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1982
Braughler J M
Chemistry
Hall E D
Journal Article or Conference Abstract Publication
Journal of Chromatography
McGinley P A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/la500905z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/la500905z</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
5202-5208
Issue
18
Volume
30
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Title
A name given to the resource
Dextran-Peptide Hybrid for Efficient Gene Delivery
Publisher
An entity responsible for making the resource available
Langmuir
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-05
Subject
The topic of the resource
cationic lipids; cells; Chemistry; cytotoxicity; drug delivery; in-vitro; Materials Science; nanoparticles; nonviral vector; plasmid dna; polyethylenimine; therapy
Creator
An entity primarily responsible for making the resource
Tang Q; Cao B; Lei X; Sun B B; Zhang Y Q; Cheng G
Description
An account of the resource
Gene therapy has drawn significant interest in the past two decades since it provides a promising strategy to treat both genetic disorders and acquired diseases. However, the transfer of gene therapy to clinical applications is troubled with many difficulties, since many current systems are of toxicity, low transfection efficiency and low biodegradability. To address these challenges, we developed a dextran-peptide hybrid system as a safe and efficient vector for gene therapy and investigated the structure-function-cytotoxicity relationship of this dextran-peptide hybrid system. Dextrans (Dex10, Dex20, and Dex70) with different molecular weights (10, 20 and 70 kDa) were conjugated with a cationic peptide, R5H5, at various degrees of substitution. Gene expression and cytotoxicity mediated by this delivery system were evaluated against SKOV-3 human ovarian carcinoma cells and compared to 25 kDa branched poly(ethylenimine) (PEI). The results showed that Dex10-R5H5 and Dex20-R5H5 hybrids derived from low molecular weight dextrans induced higher gene expression and lower cytotoxicity than Dex70-R5H5 hybrid from higher molecular weight dextran. The best performance on gene expression was achieved by Dex10-R5H5 at 40% substitution of R5H5, which induced greater gene expression than PEI at a low N/P ratio of S. Dex10-R5H5/DNA complexes at 40% substitution of R5H5 also showed much higher cell viability (93%) than PEI/DNA (66%) at the same N/P ratio. These results indicate that the Dex-R5H5 hybrid with the low molecular weight of dextran and the high degree of substitution of R5H5 is a very promising material for safe and efficient gene therapy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/la500905z" target="_blank" rel="noreferrer noopener">10.1021/la500905z</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2014
Cao B
Cationic lipids
Cells
Chemistry
Cheng G
cytotoxicity
Drug delivery
in-vitro
Journal Article
Langmuir
Lei X
Materials Science
Nanoparticles
nonviral vector
plasmid dna
polyethylenimine
Sun B B
Tang Q
therapy
Zhang Y Q
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.aca.2013.03.053" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.aca.2013.03.053</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
41-49
Volume
779
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differences In Infrared Spectroscopic Data Of Connective Tissues In Transflectance And Transmittance Modes
Publisher
An entity responsible for making the resource available
Analytica Chimica Acta
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
BaF2 window; bone; cartilage; Chemistry; collagen orientation; consequences; Fourier transform infrared imaging spectroscopy; Low-e; proteoglycan; scattering; slide; Transflectance; Transmittance; variance
Creator
An entity primarily responsible for making the resource
Hanifi A; McGoverin C; Ou Y T; Safadi F; Spencer R G; Pleshko N
Description
An account of the resource
Fourier transform infrared imaging spectroscopy (FT-IRIS) has been used extensively to characterize the composition and orientation of macromolecules in thin tissue sections. Earlier and current studies of normal and polarized FT-IRIS data have primarily used tissues sectioned onto infrared transmissive substrates, such as salt windows. Recently, the use of low-emissivity ("low-e") substrates has become of great interest because of their low cost and favorable infrared optical properties. However, data are collected in transflectance mode when using low-e slides and in transmittance mode using salt windows. In the current study we investigated the comparability of these two modes for assessment of the composition of connective tissues. FT-IRIS data were obtained in transflectance and transmittance modes from serial sections of cartilage, bone and tendon, and from a standard polymer, polymethylmethacrylate. Both non-polarized and polarized FTIR data differed in absorbance, and in some cases peak position, between transflectance and transmittance modes. However, the FT-IRIS analysis of the collagen fibril orientation in cartilage resulted in the expected zonal arrangement of fibrils in both transmittance and transflectance. We conclude that numerical comparison of FT-IRIS-derived parameters of tissue composition should account for substrate type and data collection mode, while analysis of overall tissue architecture may be more invariant between modes. (c) 2013 Elsevier B.V. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/j.aca.2013.03.053" target="_blank" rel="noreferrer noopener">10.1016/j.aca.2013.03.053</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Analytica Chimica Acta
BaF2 window
Bone
Cartilage
Chemistry
collagen orientation
consequences
Fourier transform infrared imaging spectroscopy
Hanifi A
Journal Article or Conference Abstract Publication
Low-e
McGoverin C
Ou Y T
Pleshko N
proteoglycan
Safadi F
Scattering
slide
Spencer R G
Transflectance
Transmittance
variance
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/bm3003336" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/bm3003336</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1625-1631
Issue
5
Volume
13
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
ECM Production of Primary Human and Bovine Chondrocytes in Hybrid PEG Hydrogels Containing Type I Collagen and Hyaluronic Acid
Publisher
An entity responsible for making the resource available
Biomacromolecules
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-05
Subject
The topic of the resource
osteoarthritis; Chemistry; Biochemistry & Molecular Biology; prevalence; stem-cells; matrix; arthritis; articular-cartilage; knee; networks; Polymer Science; chondral defects; microfracture
Creator
An entity primarily responsible for making the resource
Callahan L A S; Ganios A M; McBurney D L; Dilisio M F; Weiner S D; Horton W E; Becker M L
Description
An account of the resource
The development of advanced materials that facilitate hyaline cartilage formation and regeneration in aging populations is imperative. Critical to the success of this endeavor is the optimization of ECM production from clinically relevant cells. However, much of the current literature focuses on the investigation of primary bovine chondrocytes from young calves, which differ significantly than osteoarthritic cells from human sources. This study examines the levels of extracellular matrix (ECM) production using various levels of type I collagen and hyaluronic acid in poly(ethylene glycol) dimethacrylate (PEGDM) hydrogels in total knee arthroplasties, compared with the results from bovine chondrocytes. The addition of type 1 collagen in both the presence and absence of low levels of hyaluronic acid increased ECM production and/or retention in scaffolds containing either bovine or human chondrocytes. These findings are supported consistently with colorimetric quantification, whole mount extracellular matrix staining for both cell types, and histological staining for glycoaminoglycans and collagen of human chondrocyte containing samples. While exhibiting similar trends, the relative ECM productions levels for the primary human chondrocytes are significantly less than the bovine chondrocytes which reinforces the need for additional optimization.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bm3003336" target="_blank" rel="noreferrer noopener">10.1021/bm3003336</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Arthritis
articular-cartilage
Becker M L
Biochemistry & Molecular Biology
Biomacromolecules
Callahan L A S
Chemistry
chondral defects
Dilisio M F
Ganios A M
Horton W E
Journal Article or Conference Abstract Publication
Knee
matrix
McBurney D L
microfracture
networks
Osteoarthritis
Polymer Science
Prevalence
stem-cells
Weiner S D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
245
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Effects of drying methods of bacterial cellulose membrane on differentiation and proliferation of induced pluripotent stem cells
Publisher
An entity responsible for making the resource available
Abstracts of Papers of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Taokaew S; Phisalaphong M; Yin L Y; Newby B M Z
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
Abstracts of Papers of the American Chemical Society
Chemistry
Journal Article
Newby B M Z
Phisalaphong M
Taokaew S
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jnn.2017.13449</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4867-4881
Issue
7
Volume
17
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Dublin Core
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Title
A name given to the resource
Engineering Alkoxyphenacyl-Polycarbonate Nanoparticles for Potential Application in Near-Infrared Light-Modulated Drug Delivery via Photon Up-Conversion Process
Publisher
An entity responsible for making the resource available
Journal of Nanoscience and Nanotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-07
Subject
The topic of the resource
800 nm; alkoxylphenacyl-based polycarbonates; biocompatibility; Chemistry; Doxorubicin; Drug Release; luminescence; Materials Science; mesoporous-silica; nanocrystals; Nanotechnology; Near-Infrared Light; photodynamic therapy; Physics; release; Science & Technology - Other Topics; Stimuli-Responsive; upconverting nanoparticles; uv
Creator
An entity primarily responsible for making the resource
Wehrung D; Chamsaz E A; Andrews J H; Joy A; Oyewumi M O
Description
An account of the resource
Photoresponsive delivery systems that are activated by high energy photo-triggers have been accorded much attention because of the capability to achieve reliable photoreactions at short irradiation times. However, the application of a high energy photo-trigger (UV light) is not clinically viable. Meanwhile, the process of photon-upconversion is an effective strategy to generate a high energy photo-trigger (in-situ) through exposure to clinically relevant near-infrared (NIR) light. In this regard, we synthesized photon upconverting nanocrystals (UCNCs) that were subsequently loaded into photoresponsive nanoparticles (NPs) that were prepared using alkoxyphenacyl-based polycarbonate homopolymer (UCNC-APP-NPs). UCNC loading affected resultant NP size, size distribution, colloidal stability but not the zeta potential. The efficiency of NIR-modulated drug delivery was impacted by the heterogenetic nature of the resultant UCNC-APP-NPs which was plausibly formed through a combination of UCNC entrapment within the polymeric NP matrix and nucleation of polymer coating on the surface of the UCNCs. The biocompatibility of UCNC-APP-NPs was demonstrated through cytotoxicity, macrophage activation, and red blood cell lysis assays. Studies in tumor-bearing (nu/nu) athymic mice showed a negligible distribution of UCNC-APP-NPs to reticuloendothelial tissues. Further, distribution of UCNC-APP-NPs to various tissues was in the order (highest to lowest): Lungs> Tumor > Kidneys > Liver > Spleen> Brain > Blood > Heart. In all, the work highlighted some important factors that may influence the effectiveness, reproducibility and biocompatibility of drug delivery systems that operate on the process of photon-upconversion.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">10.1166/jnn.2017.13449</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
800 nm
alkoxylphenacyl-based polycarbonates
Andrews J H
Biocompatibility
Chamsaz E A
Chemistry
Department of Pharmaceutical Sciences
Doxorubicin
Drug Release
Journal Article
Journal of nanoscience and nanotechnology
Joy A
luminescence
Materials Science
mesoporous-silica
nanocrystals
Nanotechnology
Near-Infrared Light
NEOMED College of Pharmacy
Oyewumi M O
photodynamic therapy
Physics
release
Science & Technology - Other Topics
Stimuli-responsive
upconverting nanoparticles
uv
Wehrung D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
245
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Fabricating injectable cell/polymer bundles for deep wound repair
Publisher
An entity responsible for making the resource available
Abstracts of Papers of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Newby B M Z; Yin L Y; Chilian W; Song H
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
Abstracts of Papers of the American Chemical Society
Chemistry
Chilian W
Journal Article
Newby B M Z
Song H
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ejpb.2014.07.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejpb.2014.07.011</a>
Pages
962–972
Issue
3
Volume
88
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates.
Publisher
An entity responsible for making the resource available
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-11
Subject
The topic of the resource
Animals; Biocompatibility; Cardiotoxicity; Cell Line; Chemistry; Dose-Response Relationship; Doxorubicin; Drug; Drug Delivery Systems/*methods; Heart/drug effects; Humans; Inbred BALB C; Mice; Nanotechnology; Pharmaceutical; Photic Stimulation/*methods; Photoresponsive; Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity; Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity; Polymer chain scission; Stimuli-responsive; Tumor
Creator
An entity primarily responsible for making the resource
Wehrung Daniel; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O
Description
An account of the resource
Recently, we reported the synthesis and biocompatibility of alkoxylphenacyl-based polycarbonates (APP); a promising new class of polymers that undergo photo-induced chain scission. In the current study, nanoparticles (NPs) were prepared from the APP polymer (APP-NPs) and loaded with doxorubicin (DOX) (DOX-APP-NPs) in order to identify and evaluate formulation and photoirradiation parameters that influence photoresponsive efficacy. Stable and spherical APP-NPs were prepared with diameters between 70-80nm depending on APP concentration (10-40mg/mL). There was a direct relationship between APP concentration and resultant particle size. Drug release studies indicated that exposure to the photo-trigger was capable of altering the rate and extent of DOX released. Photoresponsive DOX release was markedly influenced by the frequency of photoirradiation while the effect of APP concentration was most likely propagated through NP size. DOX released by photoactivation retained its efficacy as assessed by cytotoxicity studies in human lung adenocarcinoma (A549) cells. Studies in BALB/c mice indicated that DOX-APP-NPs induce less cardiotoxicity than DOX alone and that DOX-APP-NPs are not susceptible to dose dumping after photoirradiation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejpb.2014.07.011" target="_blank" rel="noreferrer noopener">10.1016/j.ejpb.2014.07.011</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Biocompatibility
Cardiotoxicity
Cell Line
Chamsaz Elaheh A
Chemistry
Department of Pharmaceutical Sciences
Dose-Response Relationship
Doxorubicin
Drug
Drug Delivery Systems/*methods
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Heart/drug effects
Humans
Inbred BALB C
Joy Abraham
Mice
Nanotechnology
NEOMED College of Pharmacy
Oyewumi Moses O
Pharmaceutical
Photic Stimulation/*methods
Photoresponsive
Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity
Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity
Polymer chain scission
Stimuli-responsive
Tumor
Wehrung Daniel
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/bm200157b" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/bm200157b</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1795-1799
Issue
5
Volume
12
Search for Full-text
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Title
A name given to the resource
Highly Hydrophobic Electrospun Fiber Mats From Polyisobutylene-based Thermoplastic Elastomers
Publisher
An entity responsible for making the resource available
Biomacromolecules
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-05
Subject
The topic of the resource
arborescent; architecture; Biochemistry & Molecular Biology; block-copolymers; Chemistry; coatings; drug-eluting stent; nanofibers; Polymer Science; surfaces
Creator
An entity primarily responsible for making the resource
Lim G T; Puskas J E; Reneker D H; Jakli A; Horton W E
Description
An account of the resource
This paper is the first report of electrospinning neat polyisobutylene-based thermoplastic elastomers. Two generations of these materials are investigated: a linear poly(styrene-b-isobutylene-b-styrene) (LSIBS) triblock copolymer and a dendritic poly(isobutylene-b-p-methylstyrene) (DIB-MS), also a candidate for biomedical applications. Cross-polarized optical microscopy shows birefringence, indicating orientation in the electrospun fibers, which undergo large elongation and shear during electrospinning. In contrast to the circular cross section of LSIBS fibers, DIB-MS yields dumbbell-shaped fiber cross sections for the combination of processing conditions, molecular weight, and architecture. Hydrophobic surfaces with a water contact angle as high as 146 +/- 30 degrees were obtained with DIB-MS that had the noncircular fiber cross section and a hierarchical arrangement of nano- to micrometer-sized fibers in the mat. These highly water repellent fiber mats were found to serve as an excellent scaffold for bovine chondrocytes to produce cartilage tissue.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bm200157b" target="_blank" rel="noreferrer noopener">10.1021/bm200157b</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
arborescent
architecture
Biochemistry & Molecular Biology
Biomacromolecules
block-copolymers
Chemistry
coatings
drug-eluting stent
Horton W E
Jakli A
Journal Article or Conference Abstract Publication
Lim G T
nanofibers
Polymer Science
Puskas J E
Reneker D H
surfaces
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/01483919008049244" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/01483919008049244</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1215-1236
Issue
6
Volume
13
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
HPLC DETERMINATION OF HEPATIC CHOLESTEROL 7-ALPHA-HYDROXYLASE ACTIVITY USING IMMOBILIZED CHOLESTEROL OXIDASE AND CHEMILUMINESCENCE DETECTION
Publisher
An entity responsible for making the resource available
Journal of Liquid Chromatography
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990
Subject
The topic of the resource
Chemistry; Biochemistry & Molecular Biology
Creator
An entity primarily responsible for making the resource
Mike J H; Vernell R J; Hutterer F
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/01483919008049244" target="_blank" rel="noreferrer noopener">10.1080/01483919008049244</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Biochemistry & Molecular Biology
Chemistry
Hutterer F
Journal Article or Conference Abstract Publication
Journal of Liquid Chromatography
Mike J H
Vernell R J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.foodhyd.2012.02.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.foodhyd.2012.02.006</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
234-245
Issue
1
Volume
29
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Title
A name given to the resource
Interrelations among physical characteristics, sensory perception and oral processing of protein-based soft-solid structures
Publisher
An entity responsible for making the resource available
Food Hydrocolloids
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-10
Subject
The topic of the resource
Fracture; Chemistry; Food Science & Technology; feeding-behavior; human mastication; chewing patterns; electromyography; periodontal mechanoreceptors; Physiology; Microstructure; Sensory perception; Texture; food texture; breakdown; elevator muscle-activity; Mixed gels; Oral processing
Creator
An entity primarily responsible for making the resource
Cakir E; Vinyard C J; Essick G; Daubert C R; Drake M; Foegeding E A
Description
An account of the resource
Oral processing is essential in breaking down the physicochemical structure of the food and thus important to the sensory perception of food in the mouth. To have an understanding of protein-based, soft-solid texture perception, a multidisciplinary approach was applied that combined studies of food microstructure with mechanical properties, sensory evaluation, and oral physiology. Model foods were developed by combining ion-induced micro-phase separation and protein-polysaccharide phase separation and inversion. Activities of masseter, anterior temporalis and anterior digastric muscles during oral processing were recorded by electromyography (EMG), while jaw movement amplitudes, durations, and velocities were simultaneously collected by a three-dimensional jaw tracking system (JT-3D). Changes in the microstructure of mixed gels significantly altered the characteristics of the chewing sequence, including the muscle activities, number of chews, chewing duration and chewing frequency. Mechanical attributes related to structural breakdown and sensory perception of firmness were highly correlated with the amount of muscle activity required to transform the initial structure into a bolus ready for swallowing. Chewing frequency was linked to mechanical properties such as recoverable energy, fracture strain and water holding capacity of the gels. Increased adhesiveness and moisture release also resulted in slower chewing frequency. Evaluation of oral processing parameters at various stages (i.e., first cycle, first 5 cycles, and last 3 cycles) was found to be a useful method to investigate the dynamic nature of sensory perception at first bite, during chewing and after swallowing. The study showed that muscle activity and jaw movement can be used to understand the links between physical properties of foods and sensory texture. (C) 2012 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.foodhyd.2012.02.006" target="_blank" rel="noreferrer noopener">10.1016/j.foodhyd.2012.02.006</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
breakdown
Cakir E
Chemistry
chewing patterns
Daubert C R
Drake M
Electromyography
elevator muscle-activity
Essick G
feeding-behavior
Foegeding E A
Food Hydrocolloids
Food Science & Technology
food texture
Fracture
human mastication
Journal Article or Conference Abstract Publication
microstructure
Mixed gels
Oral processing
periodontal mechanoreceptors
Physiology
Sensory perception
texture
Vinyard C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0021-9797(89)90052-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0021-9797(89)90052-0</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
487-491
Issue
2
Volume
127
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
KINETICS OF THE MAIN PHASE-TRANSITION IN LIPID BILAYER-MEMBRANES CONTAINING NORMAL-ALKANOLS - A TIME-RESOLVED X-RAY-DIFFRACTION STUDY
Publisher
An entity responsible for making the resource available
Journal of Colloid and Interface Science
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-02
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Phonphok N; Westerman P W; Lis L J; Quinn P J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0021-9797(89)90052-0" target="_blank" rel="noreferrer noopener">10.1016/0021-9797(89)90052-0</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1989
Chemistry
Journal Article
Journal of Colloid and Interface Science
Lis L J
Phonphok N
Quinn P J
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/15421400590957288" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/15421400590957288</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
587-598
Volume
434
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lyotropic chromonic liquid crystals for biological sensing applications
Publisher
An entity responsible for making the resource available
Molecular Crystals and Liquid Crystals
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005
Subject
The topic of the resource
biosensor; cells; Chemistry; chromonics; Crystallography; ligand-receptor binding; liquid crystal; Materials Science
Creator
An entity primarily responsible for making the resource
Shiyanovskii S V; Lavrentovich O D; Schneider T; Ishikawa T; Smalyukh I I; Woolverton C J; Niehaus G D; Doane K J
Description
An account of the resource
We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle's size. The effect allows us to propose a real-time microbial sensor based on a lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the uniformly aligned LCLC. Upon antibody-antigen binding, the growing immune complexes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/15421400590957288" target="_blank" rel="noreferrer noopener">10.1080/15421400590957288</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
biosensor
Cells
Chemistry
chromonics
Crystallography
Doane K J
Ishikawa T
Journal Article
Lavrentovich O D
ligand-receptor binding
liquid crystal
Materials Science
Molecular Crystals and Liquid Crystals
Niehaus G D
Schneider T
Shiyanovskii S V
Smalyukh I I
Woolverton C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
882-882
Volume
233
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MEDI 231-Discovery and SAR studies of thienopyridones: A class of small molecule AMPK activators
Publisher
An entity responsible for making the resource available
Abstracts of Papers of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-03
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Bezuidenhout L M; Liebenberg W; Malan S F; Van der Schyfl C J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
Abstracts of Papers of the American Chemical Society
Bezuidenhout L M
Chemistry
Journal Article or Conference Abstract Publication
Liebenberg W
Malan S F
Van der Schyfl C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
865-865
Volume
233
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Medi 401-glut-4 Translocation Facilitating Activity Of Flavonoids From Cephalotaxus Sinensis On Mice Adipocytes
Publisher
An entity responsible for making the resource available
Abstracts of Papers of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-03
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Geldenhuys W J; Bezuidenhout L M; Malan S F; Van der Schyf C J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
Abstracts of Papers of the American Chemical Society
Bezuidenhout L M
Chemistry
Geldenhuys W J
Malan S F
Van der Schyf C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/bm0100615" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/bm0100615</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
750-756
Issue
3
Volume
2
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Molecular basis for elastic energy storage in mineralized tendon
Publisher
An entity responsible for making the resource available
Biomacromolecules
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001
Subject
The topic of the resource
Biochemistry & Molecular Biology; bone; Chemistry; collagen fibrils; dentin phosphophoryn; electron-microscopic tomography; in-vivo; matrix; Polymer Science; proteoglycan
Creator
An entity primarily responsible for making the resource
Silver F H; Freeman J W; Horvath I; Landis W J
Description
An account of the resource
Animals store elastic energy in leg and foot tendons during locomotion. In the turkey, much of the locomotive force generated by the gastrocnemius muscle is stored as elastic energy during tendon deformation. Little energy storage occurs within the muscle. During growth of some avians, including the turkey, leg tendons mineralize in the portions distal to the attached muscle and show increased tensile strength and modulus as a result. The put-pose of this study is to test the hypothesis that the degree of elastic energy storage in mineralizing turkey tendon is directly related to the tendon mineral content. To test this hypothesis, the stress-strain behavior of tendons was separated into elastic and viscous components. Both the elastic spring constant and the elastic energy stored, calculated up to a strain of 20%, were found to be proportional to tendon mineral content. It is concluded that mineralization is an efficient means for increasing the amount of elastic energy storage that is required for increased load-bearing ability needed for locomotion of adult birds. Examination of molecular models of the hole region, where mineralization is initiated within the collagen fibril, leads to the hypothesis that elastic energy is stored in the tendon by direct stretching of the flexible regions. Flexible regions within the collagen molecule fall within the positively stained bands of the collagen D period. It is proposed that mineralization increases the stored elastic energy by preventing flexible regions within the positively stained bands from stretching. These observations suggest that mineralization be-ins in the hole region due to the large number of charged amino acid residues found in the d and e bands.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bm0100615" target="_blank" rel="noreferrer noopener">10.1021/bm0100615</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
Biochemistry & Molecular Biology
Biomacromolecules
Bone
Chemistry
collagen fibrils
dentin phosphophoryn
Department of Family & Community Medicine
electron-microscopic tomography
Freeman J W
Horvath I
in-vivo
Journal Article
Landis W J
matrix
NEOMED College of Medicine
Polymer Science
proteoglycan
Silver F H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/ml200196p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/ml200196p</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
39-42
Issue
1
Volume
3
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Title
A name given to the resource
Molecular Insights Into Human Monoamine Oxidase B Inhibition By The Glitazone Antidiabetes Drugs
Publisher
An entity responsible for making the resource available
Acs Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Antidiabetes drug; Chemistry; drug design; gamma agonist pioglitazone; high-level expression; lsd1; monoamine oxidase; mouse model; neurodegeneration; neuroprotection; parkinsons-disease; parkinsons-disease; Pharmacology & Pharmacy; pichia-pastoris; pioglitazone; rosiglitazone
Creator
An entity primarily responsible for making the resource
Binda C; Aldeco M; Geldenhuys W J; Tortorici M; Mattevi A; Edmondson D E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/ml200196p" target="_blank" rel="noreferrer noopener">10.1021/ml200196p</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Acs Medicinal Chemistry Letters
Aldeco M
Antidiabetes drug
Binda C
Chemistry
Drug Design
Edmondson D E
gamma agonist pioglitazone
Geldenhuys W J
high-level expression
lsd1
Mattevi A
monoamine oxidase
Mouse model
Neurodegeneration
Neuroprotection
parkinsons-disease
Pharmacology & Pharmacy
pichia-pastoris
pioglitazone
Rosiglitazone
Tortorici M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/ml200196p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/ml200196p</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
39-42
Issue
1
Volume
3
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Molecular Insights Into Human Monoamine Oxidase B Inhibition By The Glitazone Antidiabetes Drugs
Publisher
An entity responsible for making the resource available
Acs Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Antidiabetes drug; Chemistry; drug design; gamma agonist pioglitazone; high-level expression; lsd1; monoamine oxidase; mouse model; neurodegeneration; neuroprotection; parkinsons-disease; parkinsons-disease; Pharmacology & Pharmacy; pichia-pastoris; pioglitazone; rosiglitazone
Creator
An entity primarily responsible for making the resource
Binda C; Aldeco M; Geldenhuys W J; Tortorici M; Mattevi A; Edmondson D E
Description
An account of the resource
The widely employed antidiabetic drug pioglitazone (Actos) is shown to be a specific and reversible inhibitor of human monoamine oxidase B (MAO B). The crystal structure of the enzyme-inhibitor complex shows that the R-enantiomer is bound with the thiazolidinedione ring near the flavin. The molecule occupies both substrate and entrance cavities of the active site, establishing noncovalent interactions with the surrounding amino acids. These binding properties differentiate pioglitazone from the clinically used MAO inhibitors, which act through covalent inhibition mechanisms and do not exhibit a high degree of MAO A versus B selectivity. Rosiglitazone (Avandia) and troglitazone, other members of the glitazone class, are less selective in that they are weaker inhibitors of both MAO A and MAO B. These results suggest that pioglitazone may have utility as a "repurposed" neuroprotectant drug in retarding the progression of disease in Parkinson's patients. They also provide new insights for the development of reversible isoenzyme-specific MAO inhibitors.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/ml200196p" target="_blank" rel="noreferrer noopener">10.1021/ml200196p</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Acs Medicinal Chemistry Letters
Aldeco M
Antidiabetes drug
Binda C
Chemistry
Drug Design
Edmondson D E
gamma agonist pioglitazone
Geldenhuys W J
high-level expression
Journal Article or Conference Abstract Publication
lsd1
Mattevi A
monoamine oxidase
Mouse model
Neurodegeneration
Neuroprotection
parkinsons-disease
Pharmacology & Pharmacy
pichia-pastoris
pioglitazone
Rosiglitazone
Tortorici M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1039/c0sc00544d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1039/c0sc00544d</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
642-648
Issue
4
Volume
2
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
N-Aryl-substituted 3-(beta-D-glucopyranosyloxy)-2-methyl-4(1H)-pyridinones as agents for Alzheimer's therapy
Publisher
An entity responsible for making the resource available
Chemical Science
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011
Subject
The topic of the resource
4(1h)-pyridinone; biological evaluation; Blood-brain barrier; Chemistry; copper; Crystal structure; derivatives; disease; iron chelators; physicochemical properties; targeting a-beta; transgenic mice
Creator
An entity primarily responsible for making the resource
Scott L E; Telpoukhovskaia M; Rodriguez-Rodriguez C; Merkel M; Bowen M L; Page B D G; Green D E; Storr T; Thomas F; Allen D D; Lockman P R; Patrick B O; Adam M J; Orvig C
Description
An account of the resource
Molecules designed to sequester, redistribute and/or remove metal ions are attractive therapeutic agents in neurodegenerative diseases such as Alzheimer's disease. The multifactorial nature of the condition and the generally poor target specificity associated with metal ion-binding therapy has led to the development of multifunctional 3-hydroxy-4-(1H)-pyridinone pro-ligands. The excellent qualities of the basic 3-hydroxy-4-pyridinone framework as a low toxicity metal chelator and an antioxidant, as well as its antibacterial and analgesic properties among other functions, inspired us to functionalize it with a framework derived from thioflavin-T, the well-known traditional dye used as a marker to detect amyloid deposits in tissue sections. Thus 2-methyl-3-hydroxy-1-(4-dimethylaminophenyl)-4(1H)-pyridinone(HL1), 2-methyl-3-hydroxy-1-(4-methylaminophenyl)-4(1H)-pyridinone (HL2), 1-(4-aminophenyl)-3-hydroxy-2-methyl-4(1H)-pyridinone (HL3), 1-(6-benzothiazolyl)-3-hydroxy-2-methyl-4(1H)-pyridinone (HL4), 1-(2-benzothiazolyl)-3-hydroxy-2-methyl-4(1H)-pyridinone (HL5) and 2-methyl-3-hydroxy-1-[4-(4-bromophenyl)-2-thiazolyl]-4(1H)-pyridinone (HL6) were obtained. Glycosylation, as well as incorporation of structures mimicking those of known amyloid imaging agents, may target drug action to the site of interest, the metal-overloaded amyloid plaques in the Alzheimer's brain. The pro-ligands were assessed for their antioxidant activity, cytotoxicity and ability to interfere with metal ion-induced amyloid peptide aggregation to screen promising lead compounds. Finally, in a brain uptake study with a radiolabeled glucoconjugate pyridinone, 3-(beta-Dglucopyranosyloxy)-1-[4-(4-[I-125] iodophenyl)-2-thiazolyl]-2-methyl-4(1H)-pyridinone ([I-125]-GL(7)) was shown to cross the blood-brain barrier using an in situ rat brain perfusion technique.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1039/c0sc00544d" target="_blank" rel="noreferrer noopener">10.1039/c0sc00544d</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2011
4(1h)-pyridinone
Adam M J
Allen D D
biological evaluation
Blood-brain barrier
Bowen M L
Chemical science
Chemistry
copper
Crystal structure
derivatives
Disease
Green D E
iron chelators
Journal Article
Lockman P R
Merkel M
Orvig C
Page B D G
Patrick B O
physicochemical properties
Rodriguez-Rodriguez C
Scott L E
Storr T
targeting a-beta
Telpoukhovskaia M
Thomas F
Transgenic mice
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2009.12.079" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2009.12.079</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
870-877
Issue
3
Volume
20
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Predictive Screening Model For Potential Vector-mediated Transport Of Cationic Substrates At The Blood-brain Barrier Choline Transporter
Publisher
An entity responsible for making the resource available
Bioorganic & Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-02
Subject
The topic of the resource
12-diyl-bis-3-picolinium dibromide; analogs; Carrier-mediated transport; central-nervous-system; Chemistry; Drug bioavailability; Drug screening; evoked dopamine; extracellular dopamine; high-affinity choline; molecular-field analysis; n; n'-dodecane-1; Nicotinic receptor antagonists; Nicotinic receptor antagonists; perfusion technique; Pharmacology & Pharmacy; Quaternary ammonium; quaternary ammonium analogs; rat; release; Smoking cessation; striatal synaptosomes
Creator
An entity primarily responsible for making the resource
Geldenhuys W J; Manda V K; Mittapalli R K; Van der Schyf C J; Crooks P A; Dwoskin L P; Allen D D; Lockman P R
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2009.12.079" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2009.12.079</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
12-diyl-bis-3-picolinium dibromide
2010
Allen D D
analogs
Bioorganic & medicinal chemistry letters
carrier-mediated transport
central-nervous-system
Chemistry
Crooks P A
Drug bioavailability
Drug screening
Dwoskin L P
evoked dopamine
extracellular dopamine
Geldenhuys W J
high-affinity choline
Lockman P R
Manda V K
Mittapalli R K
molecular-field analysis
n
n'-dodecane-1
nicotinic receptor antagonists
perfusion technique
Pharmacology & Pharmacy
quaternary ammonium
quaternary ammonium analogs
rat
release
Smoking Cessation
striatal synaptosomes
Van der Schyf C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
244
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rapid and sensitive LC-MS method for the quantification of a neuroprotective thiazolidinedione ligand, NL-1, in mouse serum
Publisher
An entity responsible for making the resource available
Abstracts of Papers of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Pedada K K; Zhou X; Jogiraju H; Carroll R T; Geldenhuys W J; Anderson D J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
Abstracts of Papers of the American Chemical Society
Anderson D J
Carroll R T
Chemistry
Department of Internal Medicine
Geldenhuys W J
Jogiraju H
Journal Article
NEOMED College of Medicine
Pedada K K
Zhou X
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/ed084p979" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/ed084p979</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
979-982
Issue
6
Volume
84
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Receptor Surface Models In The Classroom: Introducing Molecular Modeling To Students In A 3-d World
Publisher
An entity responsible for making the resource available
Journal of Chemical Education
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-06
Subject
The topic of the resource
binding; blood-brain-barrier; Chemistry; choline transporter; Education & Educational Research; identification
Creator
An entity primarily responsible for making the resource
Geldenhuys W J; Hayes M; Van der Schyf C J; Allen D D; Malan S F
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/ed084p979" target="_blank" rel="noreferrer noopener">10.1021/ed084p979</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
Allen D D
Binding
blood-brain-barrier
Chemistry
Choline transporter
Education & Educational Research
Geldenhuys W J
Hayes M
identification
Journal of Chemical Education
Malan S F
Van der Schyf C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/elps.201000019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/elps.201000019</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1934-1936
Issue
12
Volume
31
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Simplified method for concentration of mitochondrial membrane protein complexes
Publisher
An entity responsible for making the resource available
Electrophoresis
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
Biochemistry & Molecular Biology; blue; Blue native PAGE; Chemistry; Complex I; Electrophoretic concentration; Mitochondria; native electrophoresis; oxidative-phosphorylation; polyacrylamide-gels; sds-page
Creator
An entity primarily responsible for making the resource
Yeh S T; Angelos M G; Chen Y R
Description
An account of the resource
Extracting and concentrating mitochondrial protein complexes from gel strips after blue native PAGE (BN-PAGE) can be daunting tasks using the traditional methods, such as electroelution, passive diffusion and centrifugal concentration. We present a simplified gel electrophoresis method to concentrate mitochondrial protein complexes with excellent recovery rate. Mitochondrial complex I present in a long gel strip from BN-PAGE can be easily concentrated into a 0.8 cm gel strip when a second BN-PAGE is performed with a Y-shaped gel and the addition of 0.01% n-dodecyl beta-D-maltoside and 0.001% SDS in the cathode buffer. Once completed, the concentrated protein complex in the gel strip is ready for SDS-PAGE or proteomic studies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/elps.201000019" target="_blank" rel="noreferrer noopener">10.1002/elps.201000019</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2010
Angelos M G
Biochemistry & Molecular Biology
blue
Blue native PAGE
Chemistry
Chen Y R
Complex I
Electrophoresis
Electrophoretic concentration
Journal Article
Mitochondria
native electrophoresis
oxidative-phosphorylation
polyacrylamide-gels
sds-page
Yeh S T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0003-2697(89)90581-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0003-2697(89)90581-2</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
212-216
Issue
2
Volume
182
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Simultaneous Measurement Of Cholesterol 7-alpha-hydroxylase Activity By Reverse-phase High-performance Liquid-chromatography Using Both Endogenous And Exogenous 4-c-14 Cholesterol As Substrate
Publisher
An entity responsible for making the resource available
Analytical Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-11
Subject
The topic of the resource
Biochemistry & Molecular Biology; Chemistry
Creator
An entity primarily responsible for making the resource
Hylemon P B; Studer E J; Pandak W M; Heuman D M; Vlahcevic Z R; Chiang J Y L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0003-2697(89)90581-2" target="_blank" rel="noreferrer noopener">10.1016/0003-2697(89)90581-2</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1989
Analytical biochemistry
Biochemistry & Molecular Biology
Chemistry
Chiang J Y L
Heuman D M
Hylemon P B
Journal Article or Conference Abstract Publication
Pandak W M
Studer E J
Vlahcevic Z R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
281-286
Issue
3
Volume
42
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synthesis of 3 beta-(4- I-125 Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ( I-125 RTI-229)
Publisher
An entity responsible for making the resource available
Journal of Labelled Compounds & Radiopharmaceuticals
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-03
Subject
The topic of the resource
acid isopropyl ester; analogs; Biochemistry & Molecular Biology; brain; Chemistry; chloramine-T; cocaine; dopamine transporter; high-affinity; iodine-125 labelling; iododestannylation; ligand; nonhuman primates; Pharmacology & Pharmacy; radioiodination; RTI-229
Creator
An entity primarily responsible for making the resource
Zhong D S; Kotian P; Wyrick C D; Seltzman H H; Kepler J A; Boja J W; Kuhar M J; Carroll F I
Description
An account of the resource
A WIN 35,055-2 analog, 3 beta-(4-iodophenyl)tropane-2 beta-pyrrolidine carboxamide (RTI-229), has been radiolabelled with iodine-125 by radioiododestannylation of the corresponding trimethyltin derivative using carrier-free sodium iodide-125 as the isotope source. Purification by reversed-phase HPLC gives [I-125]RTI-229 in good yield (89.4%) with high radiochemical purity (>99%) and high specific activity (2125 mCi/mu mol, 78.6 GBq/mu mol, based on the specific activity of the (NaI)-I-125 used).
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1999
acid isopropyl ester
analogs
Biochemistry & Molecular Biology
Boja J W
Brain
Carroll F I
Chemistry
chloramine-T
Cocaine
Dopamine transporter
high-affinity
iodine-125 labelling
iododestannylation
Journal Article
Journal of Labelled Compounds & Radiopharmaceuticals
Kepler J A
Kotian P
Kuhar M J
ligand
nonhuman primates
Pharmacology & Pharmacy
radioiodination
RTI-229
Seltzman H H
Wyrick C D
Zhong D S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.foodhyd.2011.04.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.foodhyd.2011.04.011</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
33-43
Issue
1
Volume
26
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Dublin Core
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Title
A name given to the resource
The effect of microstructure on the sensory perception and textural characteristics of whey protein/kappa-carrageenan mixed gels
Publisher
An entity responsible for making the resource available
Food Hydrocolloids
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Fracture; Chemistry; mechanism; quality; Food Science & Technology; Fracture; mechanical-properties; cheddar cheese; Microstructure; Mixed gels; Sensory perception; Texture
Creator
An entity primarily responsible for making the resource
Cakir E; Daubert C R; Drake M A; Vinyard C J; Essick G; Foegeding E A
Description
An account of the resource
The objective of the study was to understand how physical and structural properties of food translate into sensory perception. A range of gels with different structures were developed by combined mechanisms of ion-induced micro-phase separation of whey proteins, whey protein/k-carrageenan phase separation and network inversion. Descriptive sensory analysis was used to assess textural attributes of gels during the oral processing phases of first compression by tongue, first bite, mastication, and post swallow. Large deformation properties and fracture behavior of the gels were determined by uniaxial compression and single-edge notched bend tests. Mechanical properties at varying stages of deformation (before, during and after fracture) and sensory properties at different stages of oral processing (first compression, first bite and after 5-8 chews) followed similar trends based on the change in microstructure. Recoverable energies of gels were in agreement with springiness and compressibility evaluated at first compression in the mouth before biting. Young's modulus together with fracture properties, including critical energy release rate and fracture toughness, varied among different microstructures along with firmness. After the fracture point, the speed of macroscopic breakdown determined the fracture type of the gels, which was related to the degree of fracturability at the first bite. Overall, five out of six microstructures were discriminated in sensory texture properties. It was demonstrated that defined physical and sensorial properties of soft-solid foods can be generated by modifying the gel microstructure through colloidal interactions. (C) 2011 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.foodhyd.2011.04.011" target="_blank" rel="noreferrer noopener">10.1016/j.foodhyd.2011.04.011</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Cakir E
cheddar cheese
Chemistry
Daubert C R
Drake M A
Essick G
Foegeding E A
Food Hydrocolloids
Food Science & Technology
Fracture
Journal Article or Conference Abstract Publication
mechanical-properties
mechanism
microstructure
Mixed gels
quality
Sensory perception
texture
Vinyard C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/ja00278a009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/ja00278a009</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
5426-5433
Issue
18
Volume
108
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
THE ORDERING OF BENZYL ALCOHOL AND ITS INFLUENCE ON PHOSPHOLIPID ORDER IN BILAYER-MEMBRANES
Publisher
An entity responsible for making the resource available
Journal of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
1986-09
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Pope J M; Dubro D; Doane J W; Westerman P W
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/ja00278a009" target="_blank" rel="noreferrer noopener">10.1021/ja00278a009</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1986
Chemistry
Doane J W
Dubro D
Journal Article
Journal of the American Chemical Society
Pope J M
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/bm9900139" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/bm9900139</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
180-185
Issue
2
Volume
1
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of mineral in the storage of elastic energy in turkey tendons
Publisher
An entity responsible for making the resource available
Biomacromolecules
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000
Subject
The topic of the resource
age; Biochemistry & Molecular Biology; Chemistry; collagen; crosslinks; mechanical properties; Polymer Science; tissue
Creator
An entity primarily responsible for making the resource
Silver F H; Christiansen D; Snowhill P B; Chen Y; Landis W J
Description
An account of the resource
Mammals elastically store energy in leg and foot tendons during locomotion. In the turkey, much of the force generated by the gastrocnemius muscle is stored as elastic energy during tendon deformation and not within the muscle. During growth, avian tendons mineralize in the portions distal to the muscle and show increased tensile strength and modulus as a result. The purpose of this study was to evaluate the viscoelastic behavior of turkey tendons and self-assembled collagen fiber models to determine the molecular basis for tendon deformation. The stress-strain behavior of tendons and self-assembled collagen fibers was broken into elastic and viscous components. The elastic component was found to be to a first approximation independent of source of the collagen and to depend only on the extent of cross-linking. In the absence of cross-links the elastic component of the stress was found to be negligible for self-assembled type I collagen fibers. In the presence of cross-links the behavior approached that found for mineralized turkey tendons. The elastic constant for turkey tendon was shown to be between 5 and 7.75 GPa while it was about 6.43 Gpa for self-assembled collagen fibers aged for 6 months at 22 degreesC. The viscous component for mineralized turkey tendons was about the same as that of self-assembled collagen fibers aged for 6 months, a result suggesting that addition of mineral does not alter the viscous properties of tendon. It is concluded that elastic energy storage in tendons involves direct stretching of the collagen triple-helix, nonhelical ends, and cross-links between the molecules and is unaffected by mineralization. Furthermore, it is hypothesized that mineralization of turkey tendons is an efficient means of preserving elastic energy storage while providing for increased load-bearing ability required for locomotion of adult birds.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bm9900139" target="_blank" rel="noreferrer noopener">10.1021/bm9900139</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2000
Age
Biochemistry & Molecular Biology
Biomacromolecules
Chemistry
Chen Y
Christiansen D
Collagen
crosslinks
Journal Article
Landis W J
mechanical properties
Polymer Science
Silver F H
Snowhill P B
tissue
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.molstruc.2013.04.030" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.molstruc.2013.04.030</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
86-94
Volume
1045
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Dublin Core
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Title
A name given to the resource
Triquinane scaffolds: Shape and geometry as a function of saturation and bridgehead groups
Publisher
An entity responsible for making the resource available
Journal of Molecular Structure
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-08
Subject
The topic of the resource
amines; blocker; Chemistry; Crystal structure; derivatives; L-type calcium channel blockers; olefin metathesis; Pentacycloundecane; Polycyclic cage; system; Triquinane
Creator
An entity primarily responsible for making the resource
Young L M; Zeller M; Geldenhuys W J; Malan S F; Van der Schyf C J
Description
An account of the resource
Polycyclic hydrocarbon compounds, also known as "cage compounds", are of interest in drug discovery due to their versatility as scaffolds. Derivatives of both pentacycloundecane-dione and triquinane-dione have been the focus of numerous investigations as multifunctional neuroprotective drugs where these compounds were used as novel drug scaffolds with the ability to cross the blood brain barrier. Here we present the synthesis, characterization and single crystal X-ray analysis for two triquinane synthons; tricyclo[6.3.0.0(2.6)]undecane-4,9-diene-3,11-dione (compound 5 crystallizes in the monoclinic system, unit cell parameters are: a=6.5876 (12) angstrom, b=10.4204 (19) angstrom, c=12.074 (2) angstrom; V=825.4 (3) angstrom(3) and Z=4) and tricyclo[6.3.0.0(2.6)]undecane-3,11-dione (compound 6 crystallizes in monoclinic system, unit cell parameters are: a=7.5992 (7) angstrom, b=10.7294 (10)angstrom, c=10.8664 (10) angstrom; V=884.04 (14) angstrom(3) and Z=4); as well as a triquinane derivative, N-(3-methoxybenzyl)-3,11-azatricyclo[6.3.0.0(2.6)]undecane (compound 11 crystallizes in triclinic system, unit cell parameters are: a = 7.6714 (7) angstrom, b=9.0100 (9) angstrom, c=11.2539 (11) angstrom; V=745.78 (12) angstrom(3) and Z=2). The size and geometrical conformation of the triquinane scaffolds were compared to tetra and pentacycloundecanes, revealing that tricyclo[6.3.0.0(2.6)]-undecane-3,11-dione experiences strain relief resulting in greater flexibility, a more asymmetric molecular shape and larger surface area. However, with the introduction of the aza-bridge in N-(3-methoxybenzyl)-3,11-azatricyclo[6.3.0.0(2.6)]undecane, much of the flexibility and asymmetry is lost again. We also discuss the rearrangement mechanism for the observed retro cycloaddition and reversion, and utilized density functional theory calculations to discuss the photocyclization mechanism of this unique [2 + 2] Diels-Alder system. (C) 2013 Elsevier B.V. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.molstruc.2013.04.030" target="_blank" rel="noreferrer noopener">10.1016/j.molstruc.2013.04.030</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
amines
blocker
Chemistry
Crystal structure
derivatives
Geldenhuys W J
Journal Article
Journal of Molecular Structure
L-type calcium channel blockers
Malan S F
olefin metathesis
Pentacycloundecane
Polycyclic cage
system
Triquinane
Van der Schyf C J
Young L M
Zeller M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/ja904670x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/ja904670x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
15078-+
Issue
42
Volume
131
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Vitamin B-12 and Redox Homeostasis: Cob(II)alamin Reacts with Superoxide at Rates Approaching Superoxide Dismutase (SOD)
Publisher
An entity responsible for making the resource available
Journal of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-10
Subject
The topic of the resource
binding; chaperone; Chemistry; cobalamin; free-radicals; mechanism; nitric-oxide; oxidation; state
Creator
An entity primarily responsible for making the resource
Suarez-Moreira E; Yun J; Birch C S; Williams J H H; McCaddon A; Brascht N E
Description
An account of the resource
We report a kinetic study of the reaction between superoxide and an important intracellular form of vitamin B-12, cob(II)alamin. Superoxide is implicated in the pathophysiology of many inflammatory diseases, whereas vitamin B,2 derivatives are often beneficial in their treatment. We found that cob(II)alamin reacts with superoxide at rates approaching those of superoxide dismutase itself, suggesting a probable mechanism by which vitamin B-12. protects against chronic inflammation and modulates redox homeostasis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/ja904670x" target="_blank" rel="noreferrer noopener">10.1021/ja904670x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2009
Binding
Birch C S
Brascht N E
chaperone
Chemistry
cobalamin
free-radicals
Journal Article
Journal of the American Chemical Society
McCaddon A
mechanism
nitric-oxide
oxidation
state
Suarez-Moreira E
Williams J H H
Yun J