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Text
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URL Address
<a href="http://doi.org/10.1002/hep4.1341" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep4.1341</a>
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Pages
763-775
Issue
6
Volume
3
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Title
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Lipocalin‐2 Protects Against Diet‐Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes.
Publisher
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Hepatology Communications
Date
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2019
2019-06
Subject
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FATTY liver; LIPOCALIN; LIVER disease treatment
Creator
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Xu Yanyong; Zhu Yingdong; Jadhav Kavita; Li Yuanyuan; Sun Huihui; Yin Liya; Kasumov Takhar; Chen Xiaoli; Zhang Yanqiao
Description
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Hepatocytes are the major source of hepatic lipocalin‐2 (LCN2), which is up‐regulated in response to inflammation, injury, or metabolic stress. So far, the role of hepatocyte‐derived LCN2 in the development of nonalcoholic fatty liver disease (NAFLD) remains unknown. Herein we show that overexpression of human LCN2 in hepatocytes protects against high fat/high cholesterol/high fructose (HFCF) diet–induced liver steatosis and nonalcoholic steatohepatitis by promoting lipolysis and fatty acid oxidation (FAO) and inhibiting de novo lipogenesis (DNL), lipid peroxidation, and apoptosis. LCN2 fails to reduce triglyceride accumulation in hepatocytes lacking sterol regulatory element‐binding protein 1. In contrast, Lcn2−/− mice have defective lipolysis, increased lipid peroxidation and apoptosis, and exacerbated NAFLD after being fed an HFCF diet. In primary hepatocytes, Lcn2 deficiency stimulates de novo lipogenesis but inhibits FAO. Conclusion: The current study indicates that hepatocyte LCN2 protects against diet‐induced NAFLD by regulating lipolysis, FAO, DNL, lipid peroxidation, and apoptosis. Targeting hepatocyte LCN2 may be useful for treatment of NAFLD. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.1002/hep4.1341" target="_blank" rel="noreferrer noopener">10.1002/hep4.1341</a>
2019
Chen Xiaoli
Department of Integrative Medical Sciences
Fatty Liver
Hepatology communications
Jadhav Kavita
Kasumov Takhar
Li Yuanyuan
LIPOCALIN
LIVER disease treatment
NEOMED College of Medicine
September 2019 Update
Sun Huihui
Xu Yanyong
Yin Liya
Zhang Yanqiao
Zhu Yingdong