1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11916-003-0005-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11916-003-0005-5</a>
Pages
15–23
Issue
1
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Opioids: a review.
Publisher
An entity responsible for making the resource available
Current pain and headache reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-02
Subject
The topic of the resource
Analgesics; Animals; Clinical Trials as Topic; Drug Tolerance; Humans; mu/drug effects/genetics/physiology; Opioid; Opioid/*drug effects/genetics/physiology; Opioid/adverse effects/*therapeutic use; Pain/*drug therapy/physiopathology; Receptors; Trans-Activators/genetics
Creator
An entity primarily responsible for making the resource
Chevlen Eric
Description
An account of the resource
Recent discoveries in opioid pharmacology help explain the enormous variability in clinical responses to these powerful analgesics. Although there is only one m opioid receptor gene, splice variants of that gene's expression result in a panoply of different functioning receptors. Other sources of variable response include polymorphisms in the m opioid receptor regulatory region, and pharmacokinetic differences because of cytochrome P-450 mono-oxygenase heterogeneity. Analgesic tolerance is likely the key phenomenon limiting the benefit of opioids. A plethora of intracellular pathways affects this. Among them are the N-methyl-D-aspartate receptor, protein kinase C gamma activity, nitric oxide synthase, and GM1 ganglioside content of the neuronal membrane. Clinical studies undercut the routine use of meperidine in most settings. Other studies have shown better ways to diminish opioid side effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11916-003-0005-5" target="_blank" rel="noreferrer noopener">10.1007/s11916-003-0005-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Analgesics
Animals
Chevlen Eric
Clinical Trials as Topic
Current pain and headache reports
Department of Internal Medicine
Drug Tolerance
Humans
mu/drug effects/genetics/physiology
NEOMED College of Medicine
Opioid
Opioid/*drug effects/genetics/physiology
Opioid/adverse effects/*therapeutic use
Pain/*drug therapy/physiopathology
Receptors
Trans-Activators/genetics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11916-004-0053-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11916-004-0053-5</a>
Pages
205–211
Issue
3
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Recent advances in clinical use of opioids.
Publisher
An entity responsible for making the resource available
Current pain and headache reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-06
Subject
The topic of the resource
Analgesics; Clinical Trials as Topic; Humans; Opioid/administration & dosage/pharmacology/*therapeutic use; Pain/*drug therapy
Creator
An entity primarily responsible for making the resource
Chevlen Eric
Description
An account of the resource
Opioid therapy for pain is the subject of numerous randomized clinical trials. Opioids are being developed for delivery by a wide variety of mechanisms. New opioids are becoming available for clinical use. This review surveys recent developments in these clinical trials and provides an overview of what may be expected in the near future for opioid management of pain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11916-004-0053-5" target="_blank" rel="noreferrer noopener">10.1007/s11916-004-0053-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Analgesics
Chevlen Eric
Clinical Trials as Topic
Current pain and headache reports
Department of Internal Medicine
Humans
NEOMED College of Medicine
Opioid/administration & dosage/pharmacology/*therapeutic use
Pain/*drug therapy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
3–17; quiz 18
Issue
6
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
From mechanisms to management: translating the neuropathic pain consensus recommendations into clinical practice.
Publisher
An entity responsible for making the resource available
Journal of the American Academy of Nurse Practitioners
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-06
Subject
The topic of the resource
Adult; Female; Humans; Middle Aged; Aged; Chronic Disease; Inflammation; Risk Factors; Evidence-Based Medicine; Practice Guidelines as Topic; Patient Selection; Acute Disease; Analgesics/therapeutic use; Patient Education as Topic; *Pain/diagnosis/etiology/physiopathology; Anticonvulsants/therapeutic use; Nervous System Diseases/*complications; Nurse Practitioners; Pain Management; Anesthetics; Drug Therapy; Combination; Antidepressive Agents; Local/therapeutic use; Tricyclic/therapeutic use
Creator
An entity primarily responsible for making the resource
Chevlen Eric; Davis Pamela Stitzlein; Rhiner Michelle
Description
An account of the resource
Chronic neuropathic pain poses a treatment challenge, and is associated with significant psychologic distress, physical disability, and impaired functioning, which impact the activities of daily living. Efforts to provide relief are often inadequate and/or require polypharmacy. This has spurred interest among researchers and clinicians alike to develop early, intensive treatments that target the molecular and cellular mechanisms involved in pain transduction, transmission, and modulation, or ideally, that prevent neuropathic pain from occurring in the first place. Currently, researchers are attempting to capitalize on our understanding of neuropathic pain pathophysiology to develop drugs that interrupt distinct activities involved in its perpetuation. In this regard, several potential agents (eg, NMDA and AMPA/kainate antagonists) are in phase 2 and 3 clinical trials. In the interim, evolving data and evidence-based neuropathic treatment recommendations provide guidance for selecting first- and second-line medications that alone or in combination offer acceptable neuropathic pain control and allow clinicians to bridge the gap between current knowledge and its application in the clinical setting. Hopefully, as basic and clinical science progresses, further treatment advances and management tools will be found to improve the care of patients who live with neuropathic pain.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Pain/diagnosis/etiology/physiopathology
2005
Acute Disease
Adult
Aged
Analgesics/therapeutic use
Anesthetics
Anticonvulsants/therapeutic use
Antidepressive Agents
Chevlen Eric
Chronic Disease
Combination
Davis Pamela Stitzlein
Department of Internal Medicine
Drug Therapy
Evidence-Based Medicine
Female
Humans
Inflammation
Journal of the American Academy of Nurse Practitioners
Local/therapeutic use
Middle Aged
NEOMED College of Medicine
Nervous System Diseases/*complications
Nurse Practitioners
Pain Management
Patient Education as Topic
Patient Selection
Practice Guidelines as Topic
Rhiner Michelle
Risk Factors
Tricyclic/therapeutic use