Browse Items (75 total)
- Tags: Chiang John Y L
Bile acids as metabolic regulators.
Tags: 2015, Bile Acids and Salts/*metabolism, Biological Transport, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Current opinion in gastroenterology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Energy Metabolism, Homeostasis, Humans, Inflammation/*metabolism, Intestine, Li Tiangang, Liver/*metabolism/pathology, NEOMED College of Medicine, Obesity/*metabolism, Receptors, Signal Transduction, Small/*metabolism/pathology, Type 2/*metabolism
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
Tags: *Gene Expression Regulation, *Transcriptional Activation, 2006, Adolescent, Adult, Animals, Chiang John Y L, Child, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzymologic, Female, Forkhead Box Protein O1, Forkhead Transcription Factors/*physiology, Hepatocytes/*enzymology, Humans, Insulin/metabolism/*physiology, Kong Xiaoying, Li Tiangang, Male, Middle Aged, NEOMED College of Medicine, Owsley Erika, Preschool, Rats, Sterol Regulatory Element Binding Protein 1/*physiology, Strom Stephen, The Journal of biological chemistry, Transcription Factors/*physiology
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
Tags: *Gene Expression Regulation, 2006, Aged, Amino Acid Motifs, Bile Acids and Salts/metabolism, Cell Line, Cell Nucleus/metabolism, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*chemistry/*genetics, Cultured/metabolism, Department of Integrative Medical Sciences, Enzymologic, Female, Genes, Genetic, Gluconeogenesis, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/metabolism/*physiology, Hepatocytes/metabolism, Homeodomain Proteins/metabolism/*physiology, Humans, Immunoprecipitation, Li Tiangang, Liver/metabolism, Luciferases/metabolism, Male, Messenger/metabolism, Middle Aged, NEOMED College of Medicine, Phosphoenolpyruvate Carboxykinase (ATP)/metabolism, Plasmids/metabolism, Protein Structure, Reporter, Response Elements, Reverse Transcriptase Polymerase Chain Reaction, RNA, Small Interfering/metabolism, Song Kwang-Hoon, Tertiary, The Journal of biological chemistry, Time Factors, Transcription, Transcriptional Activation, Transfection, Tumor Suppressor Proteins, Two-Hybrid System Techniques
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
Tags: *bile acid, *bile acid metabolism, *FXR, *Gene Expression Regulation, *GLP-1, *Lipid Metabolism, *liver metabolism, *Non-alcoholic Fatty Liver Disease, *Obesity, *TGR5, *type 2 diabetes, 2017, Animals, Bile Acids and Salts/*biosynthesis/genetics, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Dietary Fats, G-Protein-Coupled/genetics/*metabolism, Glucagon-Like Peptide 1/genetics/metabolism, Glucose/metabolism, Gonzalez Frank, Knockout, Krausz Kristopher W, Lipid Metabolism, Liu Hailiang, Liver/*metabolism, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism/pathology, Pathak Preeti, Receptors, The Journal of biological chemistry, Xie Cen
Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis.
Tags: 2013, Animals, Bile Acids and Salts/*biosynthesis, Chiang John Y L, Cholesterol, Cholesterol/*biosynthesis/genetics, Circadian Rhythm/*physiology, Department of Integrative Medical Sciences, Diabetes, Diabetes Mellitus, Enzyme Induction/physiology, Fasting/*metabolism, Fatty Liver/drug therapy/genetics/metabolism/pathology, Group F, Hep G2 Cells, Humans, Li Tiangang, Lipid Metabolism, Member 1/genetics/*metabolism, Mice, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease, Nuclear Receptor Subfamily 1, Nuclear Receptors, Obesity, Pathak Preeti, Phosphorylation/physiology, Protein Kinases/genetics/metabolism, Response Elements/physiology, Steroid 12-alpha-Hydroxylase/*biosynthesis/genetics, The Journal of biological chemistry, Type 2/drug therapy/genetics/metabolism/pathology
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Tags: *Gene Expression Regulation, 2012, Animals, Bile Acids and Salts/*biosynthesis, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Dietary Fats/administration & dosage/adverse effects, Enzymologic, Epigenesis, Erickson Sandra K, Experimental/genetics/*metabolism, Fasting/metabolism, Francl Jessica M, Genetic/genetics, Glucose/*metabolism/pharmacology, Insulin/*metabolism, Klaassen Curtis D, Li Tiangang, Mice, NEOMED College of Medicine, Obesity/etiology/genetics/*metabolism, Ochoa Adrian, Postprandial Period/genetics, Receptors, Sweetening Agents/pharmacology, The Journal of biological chemistry, Transgenic, Zhang Youcai
A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.
Tags: 2007, Bile Acids and Salts/metabolism, Carcinoma, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology, Gastroenterology, Genetic/drug effects/*physiology, Hepatocellular/*metabolism/pathology, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/drug effects/*metabolism/pathology, Humans, Hydroxamic Acids/pharmacology, Li Tiangang, Liver Neoplasms/*metabolism/pathology, Messenger/metabolism, NEOMED College of Medicine, RNA, Signal Transduction/physiology, Smad3 Protein/metabolism, Transcription, Transforming Growth Factor beta1/*metabolism, Tumor
Orphan nuclear receptor oestrogen-related receptor gamma (ERRgamma) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.
Tags: 2015, Animals, bile acid, Bile Acids and Salts/metabolism, Cannabinoid, cannabinoid receptors, CB1/agonists/genetics/*metabolism, Cells, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, cholesterol 7alpha-hydroxylase (CYP7A1), Cultured, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Drug Inverse Agonism, Estrogen/genetics/*metabolism, Ethanol/pharmacology, Gene Expression, Genetic, Glycerides/pharmacology, GSK5182, HEK293 Cells, Hepatocytes/metabolism, Humans, Inbred C57BL, Jeong Won-Il, Kim Don-Kyu, Kim Seong Heon, Knockout, Lee Chul-Ho, Lee In-Kyu, Lee Ji-Min, Liver/*metabolism, Mice, NEOMED College of Medicine, oestrogen-related receptor gamma (ERRgamma), orphan nuclear receptor, Park Seung Bum, Promoter Regions, Rats, Receptor, Receptors, small heterodimer partner (SHP), Sprague-Dawley, The Biochemical journal, Transcription, Zhang Yaochen
Bile acid metabolism and signaling in liver disease and therapy.
Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a
Tags: 2017, 4EBP-1, ACAT, acyl-CoA:cholesterol acyltransferase, CE, Cellular and molecular gastroenterology and hepatology, Chavan Hemantkumar, Chiang John Y L, chloroquine, Cholesterol, cholesterol 7alpha-hydroxylase, cholesterol ester, Cholestyramine, ChTM, CQ, CYP7A1, Department of Integrative Medical Sciences, diet-induced obesity, Ding Wen-Xing, Ding Yifeng, DIO, endoplasmic reticulum, ER, eukaryotic translation initiation factor 4E-binding protein 1, Fatty Liver, FC, free cholesterol, glycogen synthase kinase 3beta, GSK3beta, HMG-CoA reductase, HMGCR, Krishnamurthy Partha, LC3, LDLR, Li Jibiao, Li Tiangang, LMP, low-density lipoprotein receptor, lysosome membrane permeabilization, Matye David, messenger RNA, microtubule-associated protein 1A/1B-light chain 3, mRNA, mTOR, NEOMED College of Medicine, Ni Hong-Min, Nuclear Receptor, phosphatidylinositol, PI, plasma membrane, PM, S6, SREBP, sterol response element binding protein, the nutrient sensing mechanistic target of rapamycin, tibosomal protein S6, Wang Yifeng
Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.
Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein.
Tags: *Transcription Factors, 2004, Base Sequence, Biochemical and biophysical research communications, CCAAT-Enhancer-Binding Proteins/*metabolism, Chiang John Y L, Cytochrome P-450 Enzyme System/*genetics/physiology, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Enzyme Repression, Genetic, Humans, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Norlin Maria, Promoter Regions, Response Elements, Sp1 Transcription Factor/antagonists & inhibitors, Steroid Hydroxylases/*genetics/physiology, Sterol Regulatory Element Binding Protein 1, Sterols/metabolism, Transcription
Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
Tags: 2015, Animals, Bile acid metabolism, Bile Acids and Salts/genetics/*metabolism, Biochimica et biophysica acta, Cheng Jie, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, CYP7A1, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism, Diet, farnesoid X receptor (FXR), Female, Ferrell Jessica M, Glucose/genetics/metabolism, Gonzalez Frank J, High-Fat/methods, Homeostasis, Inbred C57BL, Insulin Resistance, Intestinal Mucosa/metabolism, Jiang Changtao, Krausz Kristopher W, Li Tiangang, Lipid Metabolism/*physiology, lipidomics, Liver/metabolism, Male, Metabolome/*genetics, Metabolomics/methods, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism, Qi Yunpeng, Rats, Signal Transduction, tauro-beta-muricholic acid, Taurocholic Acid/analogs & derivatives/genetics/metabolism, Transgenic
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Tags: 2009, Adenoviridae/genetics, Animals, Bile Acids and Salts/biosynthesis, Biochimica et biophysica acta, Cell Line, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*antagonists & inhibitors/genetics/metabolism, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage/*pharmacology, Down-Regulation/drug effects, Enzymologic/drug effects, Feeding Behavior/*drug effects, Forkhead Box Protein O1, Forkhead Transcription Factors/genetics/*metabolism, Gene Expression Regulation, Gene Knockdown Techniques, Gene Transfer Techniques, Hepatocytes/drug effects/*enzymology, Humans, Inbred C57BL, Insulin Resistance, Insulin/metabolism, Lee Yoon-Kwang, Li Tiangang, Ma Huiyan, Male, Messenger/genetics/metabolism, Mice, Moore David D, NEOMED College of Medicine, Park Young Joo, RNA, RNA Interference/drug effects, Strom Stephen, Tumor
Circadian rhythms in liver metabolism and disease.
Tags: 2015, Acta pharmaceutica Sinica. B, ARC, arcuate nucleus, BMAL1, brain and muscle ARNT-like 1, CAR, Chiang John Y L, cholesterol 7alpha-hydroxylase, circadian locomotor output cycles kaput, Circadian Rhythm, CLOCK, constitutive androstane receptor, CRY, cryptochrome, CYP7A1, CYPs, cytochrome P450 enzymes, D-site binding protein, DBP, Department of Integrative Medical Sciences, E-box, emergency medical technician, EMT, enhance box, FAA, familial advanced sleep-phase syndrome, farnesoid-X receptor, FASPS, FEO, Ferrell Jessica M, food anticipatory activity, food entrainable oscillator, forkhead box O3, FOXO3, FXR, G protein-coupled bile acid receptor, glucose transporter 2, GLUT2, HDAC3, hepatic leukemia factor, Hip, histone deacetylase 3, HLF, hypoxia inducing protein, LDL, Liver, liver receptor homolog 1, Low-density lipoprotein, LRH1, Metabolic syndrome, NAD+, NEOMED College of Medicine, nicotinamide adenine dinucleotide, PER, period, retinohypothalamic tract, retinoid-related orphan receptor alpha, RHT, ROR-response element, RORalpha, RORE, SCN, SHP, SIRT1, sirtuin 1, small heterodimer partner, suprachiasmatic nucleus, TEF, TGR5, thyrotroph embryonic factor, transcriptional translational feedback loop, TTFL, Type 2 diabetes
Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet.
Deficiency of cholesterol 7alpha-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice.
Deficiency of both farnesoid X receptor and Takeda G protein-coupled receptor 5 exacerbated liver fibrosis in mice.
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction
All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.
Tags: 2014, Animals, Axe David, Basic Helix-Loop-Helix Transcription Factors/genetics, Blood Glucose/analysis, Chiang John Y L, Cook Aaron, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Fatty Liver/*drug therapy/metabolism, Gene Expression Regulation, Genetic, Hardwick James P, Hepatology (Baltimore, Md.), Inbred C57BL, Kim Chun-Ki, Kim Seong-Chul, Lee Mikang, Lee Yoon-Kwang, Li Tiangang, Lipid Metabolism, Liver/metabolism, Male, Mice, Moore David D, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease, PPAR gamma/*genetics, Receptors, Repressor Proteins/genetics, Retinoic Acid Receptor alpha, Retinoic Acid/physiology, Smallwood Nicole, Transcription, Tretinoin/pharmacology/*therapeutic use
Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice.
Tags: 2013, Acetyl Coenzyme A/metabolism, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Francl Jessica M, Hepatology (Baltimore, Md.), Homeostasis/*physiology, Knockout, Li Tiangang, Lipid Metabolism/physiology, Liver/metabolism, Male, Messenger/metabolism, Mice, MicroRNAs/*metabolism, Models, NEOMED College of Medicine, RNA, Signal Transduction/*physiology, Sterol Regulatory Element Binding Protein 2/*metabolism, Transgenic
Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Tags: 2011, Animals, ATP Binding Cassette Transporter, ATP-Binding Cassette Transporters/metabolism, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cholesterol/*metabolism, Cytoplasmic and Nuclear/agonists, Department of Integrative Medical Sciences, Ellis Ewa, Guo Grace, Hepatocytes/drug effects, Hepatology (Baltimore, Md.), Homeostasis, Humans, Isoxazoles/pharmacology, Knockout, Kong Bo, Li Tiangang, Lipoproteins/metabolism, Liver/*metabolism, Matozel Michelle, Member 5, Member 8, Mice, NEOMED College of Medicine, Nilsson Lisa-Mari, Receptors, Subfamily G
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
Tags: *Insulin Resistance, 2010, Animals, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage, Hepatology (Baltimore, Md.), Homeostasis, Hsu Peter, Li Tiangang, Lipid Metabolism, Lipoproteins, Liver/*metabolism, Matozel Michelle, Mice, NEOMED College of Medicine, Novak Colleen M, Obesity/*metabolism, Owsley Erika, Transgenic, VLDL/metabolism
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Tags: 2009, Butadienes/pharmacology, Carcinoma, Cell Line, Chenodeoxycholic Acid/*pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cytoplasmic and Nuclear/metabolism/physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Fibroblast Growth Factor, Fibroblast Growth Factors/drug effects/*physiology, Gene Expression/drug effects, Hepatocellular/metabolism, Hepatocytes/metabolism, Hepatology (Baltimore, Md.), Humans, Isoxazoles/pharmacology, Li Tiangang, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, NEOMED College of Medicine, Nitriles/pharmacology, Owsley Erika, Receptor, Receptors, Signal Transduction/drug effects, Song Kwang-Hoon, Strom Stephen, Transcription Factors/metabolism, Tumor, Type 4/antagonists & inhibitors
Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.
Tags: 2007, Bile Acids and Salts/*biosynthesis, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cultured, Department of Integrative Medical Sciences, Ellis Ewa, Hepatocyte Growth Factor/*metabolism, Hepatocytes/*metabolism, Hepatology (Baltimore, Md.), Humans, NEOMED College of Medicine, Signal Transduction, Song Kwang-Hoon, Strom Stephen
Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.
Tags: 2006, Bile Acids and Salts/*metabolism, Cells, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cultured, Cytokines/*metabolism, Department of Integrative Medical Sciences, Gene Expression Regulation, Genetic, Hepatocytes/*cytology/drug effects, Hepatology (Baltimore, Md.), Humans, Immunoblotting, In Vitro Techniques, Interleukin-1/pharmacology, Jahan Asmeen, Li Tiangang, Messenger/analysis, NEOMED College of Medicine, Probability, Proto-Oncogene Proteins c-jun/*metabolism, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sensitivity and Specificity, Signal Transduction/genetics, Transcription
Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
Tags: *Gluconeogenesis, 2006, 8-Bromo Cyclic Adenosine Monophosphate/*pharmacology, Adolescent, Bile Acids and Salts/*biosynthesis, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Chromatin/metabolism, Cultured, Cyclic AMP-Dependent Protein Kinases/physiology, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Female, Gene Expression Regulation, Genetic/drug effects, Glucagon/*pharmacology, Hepatocyte Nuclear Factor 4/genetics/metabolism, Hepatocytes/*enzymology, Hepatology (Baltimore, Md.), Humans, Male, Messenger/analysis, Middle Aged, NEOMED College of Medicine, Organ Specificity, Phosphorylation, RNA, Song Kwang-Hoon, Transcription
Bile acid metabolism and signaling.
Tags: 2013, Animals, Bile Acids and Salts/*metabolism/therapeutic use, Biliary Tract Diseases/metabolism, Chiang John Y L, Cholesterol/metabolism, Comprehensive Physiology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Enterohepatic Circulation/physiology, Feedback, G-Protein-Coupled/metabolism, Homeostasis/physiology, Humans, Inflammation/metabolism, Liver/metabolism, NEOMED College of Medicine, Physiological/physiology, Receptors, Signal Transduction/*physiology