Browse Items (75 total)
- Tags: Chiang John Y L
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells
Bile acid metabolism and signaling.
Tags: 2013, Animals, Bile Acids and Salts/*metabolism/therapeutic use, Biliary Tract Diseases/metabolism, Chiang John Y L, Cholesterol/metabolism, Comprehensive Physiology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Enterohepatic Circulation/physiology, Feedback, G-Protein-Coupled/metabolism, Homeostasis/physiology, Humans, Inflammation/metabolism, Liver/metabolism, NEOMED College of Medicine, Physiological/physiology, Receptors, Signal Transduction/*physiology
Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet.
Bile acid metabolism and signaling in liver disease and therapy.
Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.
Tags: 2003, American journal of physiology. Gastrointestinal and liver physiology, Animals, Bile Acids and Salts/biosynthesis/genetics/*physiology, Bile/*physiology, Cardiovascular Diseases/genetics/physiopathology, Chiang John Y L, Cholesterol/physiology, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback/physiology, Gene Expression Regulation/physiology, Humans, Liver Diseases/genetics/physiopathology, Liver/*physiology, NEOMED College of Medicine, Receptors
Bile acids: regulation of synthesis.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology
Bile acid regulation of gene expression: roles of nuclear hormone receptors.
Recent advances in understanding bile acid homeostasis.
Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Chiang John Y L, Department of Integrative Medical Sciences, Expert opinion on drug metabolism & toxicology, Gene Expression Regulation, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 4/genetics/*metabolism, Humans, Lipid Metabolism, Liver/metabolism, Mutation, NEOMED College of Medicine, Pharmaceutical Preparations/*metabolism, Signal Transduction/physiology
Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.
Tags: *Lipid Metabolism, 2005, Animals, Chiang John Y L, Chronic Disease, Current opinion in investigational drugs (London, England : 2000), Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/metabolism, Dyslipidemias/drug therapy/metabolism, Heart Diseases/*drug therapy/metabolism, Humans, Hypoglycemic Agents/therapeutic use, Hypolipidemic Agents/therapeutic use, Liver Diseases/*drug therapy/metabolism, Metabolic Diseases/*drug therapy/metabolism, NEOMED College of Medicine, Receptors
Bile Acid Metabolism in Liver Pathobiology.
Bile Acids as Metabolic Regulators and Nutrient Sensors
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.
Tags: 2020, alcoholic and nonalcoholic fatty, American journal of physiology. Gastrointestinal and liver physiology, Bile acid metabolism, bile acid therapies, Chiang John Y L, Department of Integrative Medical Sciences, Farnesoid X receptor, Ferrell Jessica M, Liver Diseases, NEOMED College of Graduate Studies, NEOMED College of Medicine, Takeda G protein-coupled receptor 5
Bile Acid Biology, Pathophysiology, and Therapeutics.
Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation.
Tags: *Signal Transduction, 2017, Animals, Bile Acids and Salts/biosynthesis/metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Digestive diseases (Basel, Switzerland), Donepudi Ajay, Ferrell Jessica, G-Protein-Coupled/*metabolism, Humans, Intestinal Mucosa/*metabolism, Liu Hailiang, Liver/metabolism, NEOMED College of Medicine, Pathak Preeti, Receptors
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction
Deficiency of cholesterol 7alpha-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice.
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Circadian rhythms in liver metabolism and disease.
Tags: 2015, Acta pharmaceutica Sinica. B, ARC, arcuate nucleus, BMAL1, brain and muscle ARNT-like 1, CAR, Chiang John Y L, cholesterol 7alpha-hydroxylase, circadian locomotor output cycles kaput, Circadian Rhythm, CLOCK, constitutive androstane receptor, CRY, cryptochrome, CYP7A1, CYPs, cytochrome P450 enzymes, D-site binding protein, DBP, Department of Integrative Medical Sciences, E-box, emergency medical technician, EMT, enhance box, FAA, familial advanced sleep-phase syndrome, farnesoid-X receptor, FASPS, FEO, Ferrell Jessica M, food anticipatory activity, food entrainable oscillator, forkhead box O3, FOXO3, FXR, G protein-coupled bile acid receptor, glucose transporter 2, GLUT2, HDAC3, hepatic leukemia factor, Hip, histone deacetylase 3, HLF, hypoxia inducing protein, LDL, Liver, liver receptor homolog 1, Low-density lipoprotein, LRH1, Metabolic syndrome, NAD+, NEOMED College of Medicine, nicotinamide adenine dinucleotide, PER, period, retinohypothalamic tract, retinoid-related orphan receptor alpha, RHT, ROR-response element, RORalpha, RORE, SCN, SHP, SIRT1, sirtuin 1, small heterodimer partner, suprachiasmatic nucleus, TEF, TGR5, thyrotroph embryonic factor, transcriptional translational feedback loop, TTFL, Type 2 diabetes
Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
Tags: 2019, Bile Acids and Salts, Chiang John Y L, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, Diabetes & Metabolism Journal, Ferrell Jessica M, G-protein-coupled, Gastrointestinal Microbiome, June 2019 Update, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease, Receptors
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.
Tags: 2019, BILE acids, Bile Acids and Salts, Chiang John Y L, cholesterol 7-alpha-hydroxylase, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, Diabetes & Metabolism Journal, Endocrinology & Metabolism, Farnesoid X receptor, farnesoid-x-receptor, Fatty Liver, fatty liver-disease, Ferrell Jessica M, G protein coupled receptors, G-protein-coupled, Gastrointestinal Microbiome, growth-factor 19, gut microbiota, hepatic steatosis, improves insulin sensitivity, Liver disease, Metabolic, NEOMED College of Medicine, Non-alcoholic fatty, Non-alcoholic Fatty Liver Disease, nuclear, Receptor, Receptors, September 2019 Update, serum fgf21 levels, Syndrome
Deficiency of both farnesoid X receptor and Takeda G protein-coupled receptor 5 exacerbated liver fibrosis in mice.
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: 2009, Base Sequence, Calcitriol/drug effects/genetics/*physiology, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cultured, Department of Integrative Medical Sciences, DNA Primers, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Gene Knockdown Techniques, Genetic/*physiology, Han Shuxin, Hepatocytes/*drug effects/enzymology, Humans, Immunoprecipitation, Lithocholic Acid/pharmacology, Messenger/genetics, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, RNA, Small Interfering, Transcription, Tumor, Two-Hybrid System Techniques
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Tags: 2010, Calcitriol/*metabolism, Calcitriol/pharmacology, Cell Membrane/drug effects/metabolism, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzyme Activation/drug effects, Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors, Genetic/genetics, Han Shuxin, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*drug effects/enzymology/*metabolism, Humans, Intracellular Space/drug effects/metabolism, Li Tiangang, Ligands, Lithocholic Acid/*pharmacology, Mitogen-Activated Protein Kinase Kinases/metabolism, Molecular endocrinology (Baltimore, Md.), NEOMED College of Medicine, Phosphorylation/drug effects, Phosphotyrosine/metabolism, Promoter Regions, Protein Kinase Inhibitors/pharmacology, Protein Transport/drug effects, Proto-Oncogene Proteins c-raf/metabolism, Receptors, Retinoid X Receptor alpha/metabolism, Signal Transduction/*drug effects, src-Family Kinases/metabolism, Steroid Hydroxylases/genetics/metabolism, Strom Stephen, Vitamin D3 24-Hydroxylase
Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Cell Line, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Chromosome Mapping, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Inhibitors/pharmacology, Gene Expression Regulation/*drug effects, Genetic/drug effects, Genetic/physiology, Hepatocyte Nuclear Factor 4, Hepatocytes/metabolism, Humans, Interleukin-1/*pharmacology, Jahan Asmeen, MAP Kinase Signaling System/drug effects/physiology, Messenger/antagonists & inhibitors, Mitogen-Activated Protein Kinase 8/metabolism, Mitogen-Activated Protein Kinases/antagonists & inhibitors, NEOMED College of Medicine, Phosphoproteins/genetics/metabolism, Phosphorylation, Promoter Regions, Response Elements/genetics, RNA, Steroid 12-alpha-Hydroxylase/antagonists & inhibitors/*genetics, Transcription, Transcription Factors/genetics/metabolism
Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.
Tags: 2013, Alcohol-Induced Injury, Alcoholic Liver Disease, Alcoholic/genetics/*metabolism/prevention & control, Animals, Cannabinoid, CB1/*physiology, Chiang John Y L, Choi Hueng-Sik, Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP2E1/genetics/*metabolism, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology/therapeutic use, Enzymologic/drug effects/physiology, Estrogen/deficiency/genetics/*physiology, Ethanol/pharmacology, Gene Expression Profiling/methods, Gene Expression Regulation, Gene Regulation, Genetic/physiology, Gut, Inbred C57BL, Jang Hyun-Hee, Jeong Won-Il, Kim Don-Kyu, Kim Jung Ran, Kim Yong-Hoon, Knockout, Koh Minseob, Koo Seung-Hoi, Lee Chul-Ho, Liver, Liver Diseases, Liver Metabolism, Liver/metabolism, Male, Mice, NEOMED College of Medicine, Oxidation-Reduction, Oxidative Stress/physiology, Park Jinyoung, Park Seung Bum, Park Tae-Sik, Receptor, Receptors, Signal Transduction/drug effects/physiology, Tamoxifen/analogs & derivatives/pharmacology/therapeutic use, Transcription, Yun Chul-Ho
All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.
Tags: 2014, Animals, Axe David, Basic Helix-Loop-Helix Transcription Factors/genetics, Blood Glucose/analysis, Chiang John Y L, Cook Aaron, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Fatty Liver/*drug therapy/metabolism, Gene Expression Regulation, Genetic, Hardwick James P, Hepatology (Baltimore, Md.), Inbred C57BL, Kim Chun-Ki, Kim Seong-Chul, Lee Mikang, Lee Yoon-Kwang, Li Tiangang, Lipid Metabolism, Liver/metabolism, Male, Mice, Moore David D, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease, PPAR gamma/*genetics, Receptors, Repressor Proteins/genetics, Retinoic Acid Receptor alpha, Retinoic Acid/physiology, Smallwood Nicole, Transcription, Tretinoin/pharmacology/*therapeutic use
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao