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Text
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Pages
519–533
Issue
4
Volume
25
Dublin Core
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Title
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Epithelial surface changes and induction of gallstones in the male Syrian hamster gallbladder as a result of a two-month sex steroid treatment.
Publisher
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Journal of submicroscopic cytology and pathology
Date
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1993
1993-10
Subject
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Male; Animals; Body Weight/drug effects; Reference Values; Cricetinae; Mesocricetus; Estradiol/*toxicity; Medroxyprogesterone/*toxicity; Cell Membrane/pathology/ultrastructure; Cholelithiasis/chemically induced/*pathology; Cytoplasmic Granules/ultrastructure; Epithelium/pathology/ultrastructure; Gallbladder/drug effects/*pathology/ultrastructure; Vacuoles/ultrastructure; Microscopy; Electron; Scanning
Creator
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Gilloteaux J; Kosek E; Kelly T R
Description
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Transmission (TEM) and scanning (SEM) electron microscopic observations were correlated to characterize morphologic changes induced in the gallbladder of male Syrian hamsters following a two-month estradiol (E) and estradiol + medroxyprogesterone (E + MP) treatment. Compared to control (C), E-treated surface epithelial cells show pleomorphism, cytoplasmic vacuolizations, apical granules, excrescences and decapitations, and small gallstone-like deposits. Following both E + MP treatment, a large accumulation of apical granules containing acidic mucoid products, abundant intraluminal deposits and numerous fields of observation suggest that cell debris and mucous condensation could participate in the formation of the large intraluminal gallstone-like deposits detected as a result of this treatment. In control gallbladders these events were never observed. MP added to E also increases liver and gallbladder weight as well as blood lipid levels. These findings complement and confirm other previous data obtained following short steroid treatment in male, ovariectomized and intact female hamsters. In addition, these results support our hypothesis that gallstone nucleation and growth originate from multiple factors, hormonal disturbance, modulation of liver lipid metabolism, production of cell debris and mucus, can be responsible for the initial gallstone nucleation.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Body Weight/drug effects
Cell Membrane/pathology/ultrastructure
Cholelithiasis/chemically induced/*pathology
Cricetinae
Cytoplasmic Granules/ultrastructure
Electron
Epithelium/pathology/ultrastructure
Estradiol/*toxicity
Gallbladder/drug effects/*pathology/ultrastructure
Gilloteaux J
Journal of submicroscopic cytology and pathology
Kelly T R
Kosek E
Male
Medroxyprogesterone/*toxicity
Mesocricetus
Microscopy
Reference Values
Scanning
Vacuoles/ultrastructure