1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1167/iovs.15-17885" target="_blank" rel="noreferrer noopener">http://doi.org/10.1167/iovs.15-17885</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
8215-8227
Issue
13
Volume
56
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Decreased Energy Capacity And Increased Autophagic Activity In Optic Nerve Axons With Defective Anterograde Transport
Publisher
An entity responsible for making the resource available
Investigative Ophthalmology & Visual Science
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-12
Subject
The topic of the resource
anterograde transport; autophagy; cholera; cholera-toxin; degeneration; dying back process; endoplasmic-reticulum; glaucoma; microscopy; Mitochondria; mitophagy; mouse model; Ophthalmology; optic neuropathy; stress; toxin-B
Creator
An entity primarily responsible for making the resource
Kleesattel D; Crish S D; Inman D M
Description
An account of the resource
PURPOSE. Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally differentiated cells like neurons manage cytoskeletal and organelle turnover. How autophagy relates to associated neurodegenerative pathologies remain unclear. We examined autophagy in optic neuropathy by investigating cytoskeletal degradation, mitochondria, and autophagic vesicles in the DBA2/J mouse model of glaucoma exhibiting differing levels of axon transport functionality. METHODS. DBA/2J and DBA/2J(wt-gpnmb) control mice 11 to 14 months of age were injected with cholera toxin-B (CTB) to assay anterograde axonal transport. Axonal mitochondria and autophagic vesicles were analyzed with respect to transport integrity in proximal and distal optic nerve using serial block face scanning electron microscopy (3D EM). RESULTS. Several indices varied significantly between the DBA/2J and DBA/2Jwt-gpnmb mice, including mitochondrial volume, average number of autophagic vesicles per axon, and mitochondrial cristae. However, there were no differences in mitochondrial cristae for axons with functional versus dysfunctional CTB transport, suggesting that mitochondrial dysfunction precedes overt transport blockade. Anterograde transport failure was accompanied by a dissociation of the relationship between mitochondrial and axon volumes. Autophagic vesicle profiles were significantly increased in optic nerve with transport deficit, consistent with greater autophagic activity. Mitochondria within autophagosomes, indicative of mitophagy, were observed in both proximal and distal axons. CONCLUSIONS. Loss of anterograde transport in DBA/2J optic nerve is concomitant with diminished mitochondrial volume, increased cytoskeletal breakdown and autophagic activity, and accumulation of autophagic profiles, including signs of mitophagy, in proximal optic nerve. Axons with transport deficit are metabolically underserved, though not necessarily from mitophagy.
Identifier
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<a href="http://doi.org/10.1167/iovs.15-17885" target="_blank" rel="noreferrer noopener">10.1167/iovs.15-17885</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2015
anterograde transport
Autophagy
Cholera
cholera-toxin
Crish S D
degeneration
Department of Pharmaceutical Sciences
dying back process
endoplasmic-reticulum
Glaucoma
Inman D M
Investigative ophthalmology & visual science
Journal Article or Conference Abstract Publication
Kleesattel D
Microscopy
Mitochondria
mitophagy
Mouse model
NEOMED College of Pharmacy
Ophthalmology
optic neuropathy
Stress
toxin-B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11908-011-0225-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11908-011-0225-5</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
47-52
Issue
1
Volume
14
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Gastrointestinal Infections in the Setting of Natural Disasters
Publisher
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Current Infectious Disease Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-02
Subject
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Cholera; Earthquakes; Floods; Gastrointestinal illness; Hepatitis A; Hepatitis E; Hurricanes; Infectious Diseases; Norovirus; Tsunamis; Typhoid fever; vaccines
Creator
An entity primarily responsible for making the resource
Watkins R R
Description
An account of the resource
Gastrointestinal illness following natural disasters is a common occurrence and often results from the disruption of potable water supplies. The risk for outbreaks of gastrointestinal illness is higher in developing countries because of fewer available resources and poorer infrastructure. But industrialized countries are not immune from this problem, as demonstrated by an outbreak of gastroenteritis from norovirus that followed in the wake of Hurricane Katrina in 2005. Rates of gastrointestinal illness following natural disasters are influenced by the endemicity of specific pathogens in the affected region before the disaster, the type of disaster itself, the availability of health care resources, and the response by public health personnel after the disaster. Ensuring the uninterrupted supply of safe drinking water following a natural disaster, like adding chlorine, is the most important strategy to prevent outbreaks of gastrointestinal illness.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11908-011-0225-5" target="_blank" rel="noreferrer noopener">10.1007/s11908-011-0225-5</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
Cholera
Current infectious disease reports
Department of Internal Medicine
Earthquakes
Floods
Gastrointestinal illness
Hepatitis A
Hepatitis E
Hurricanes
Infectious Diseases
Journal Article
NEOMED College of Medicine
Norovirus
Tsunamis
Typhoid fever
Vaccines
Watkins R R