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Tags: Choline O-Acetyltransferase/*antagonists & inhibitors/biosynthesis/metabolism

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Par-4 induces cholinergic hypoactivity by suppressing ChAT protein synthesis and inhibiting NGF-inducibility of ChAT activity.

Profound reductions in choline acetyl-transferase (ChAT) activity are reliable markers for cholinergic hypoactivity associated with cognitive function deficit in Alzheimer's disease (AD). Par-4 (prostate apoptosis response-4) is a novel mediator of…

Tags: *Intracellular Signaling Peptides and Proteins, 2000, Amyloid beta-Peptides/pharmacology, Animals, Apoptosis Regulatory Proteins, Brain research, Carrier Proteins/genetics/*physiology, Choline O-Acetyltransferase/*antagonists & inhibitors/biosynthesis/metabolism, Du H, Enzyme Induction/drug effects, Gene Expression/physiology, Guo Q, Leucine Zippers/genetics, Nerve Growth Factor/*pharmacology, Osmolar Concentration, PC12 Cells, Peptide Fragments/pharmacology, Rats, Xie J

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