1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.heares.2010.12.019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2010.12.019</a> Pages 85–95 Issue 1 Volume 279 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex. Publisher An entity responsible for making the resource available Hearing research Date A point or period of time associated with an event in the lifecycle of the resource 2011 2011-09 Subject The topic of the resource Acetylcholine/metabolism; Animals; Auditory Cortex/pathology; Auditory Pathways; Axons/physiology; Cholinergic Agents/*metabolism; Cholinergic Fibers/*metabolism; Cochlear Nucleus/*physiology; Cognition Disorders; Guinea Pigs; Humans; Neurotransmitter Agents/metabolism; Prosencephalon/pathology; Rats; Tegmentum Mesencephali/metabolism/*physiology Creator An entity primarily responsible for making the resource Schofield Brett R; Motts Susan D; Mellott Jeffrey G Description An account of the resource Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea receives cholinergic innervation from the superior olivary complex. Much of the remainder of the auditory pathways receives innervation from the pedunculopontine and laterodorsal tegmental nuclei, two nuclei referred to collectively as the pontomesencephalic tegmentum (PMT). The PMT provides the major source of ACh to the auditory thalamus and the midbrain, and is a substantial source (in addition to the superior olivary complex) of ACh in the cochlear nucleus. Individual cholinergic cells in the PMT often have axon branches that innervate multiple auditory nuclei, including nuclei on both sides of the brain as well as nuclei at multiple levels of the auditory system. The auditory cortex has direct axonal projections to the PMT cells, including cholinergic cells that project to the inferior colliculus or cochlear nucleus. The divergent projections of PMT cholinergic cells suggest widespread effects on the auditory pathways. These effects are likely to include plasticity as well as novelty detection, sensory gating, reward behavior, arousal and attention. Descending projections from the forebrain, including the auditory cortex, are likely to provide a high level of cognitive input to these cholinergic effects. Dysfunction associated with the cholinergic system may play a role in disorders such as tinnitus and schizophrenia. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.heares.2010.12.019" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2010.12.019</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2011 Acetylcholine/metabolism Animals Auditory Cortex/pathology Auditory Pathways Axons/physiology Cholinergic Agents/*metabolism Cholinergic Fibers/*metabolism Cochlear Nucleus/*physiology Cognition Disorders Department of Anatomy & Neurobiology Guinea Pigs Hearing research Humans Mellott Jeffrey G Motts Susan D NEOMED College of Medicine Neurotransmitter Agents/metabolism Prosencephalon/pathology Rats Schofield Brett R Tegmentum Mesencephali/metabolism/*physiology