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Text
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URL Address
<a href="http://doi.org/10.1111/nyas.13156" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/nyas.13156</a>
Pages
80–86
Issue
1
Volume
1378
Dublin Core
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Title
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Novel approaches to mitigating parathion toxicity: targeting cytochrome
Publisher
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Annals of the New York Academy of Sciences
Date
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2016
2016-08
Subject
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*menadione; *organophosphorus pesticides; *paraoxon; *parathion; *redox cycling; Animals; Cholinesterase Inhibitors/metabolism/*toxicity; Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism; Cytochrome P-450 Enzyme System/metabolism; Drug Delivery Systems/*methods; Humans; Insecticides/metabolism/toxicity; Organophosphate Poisoning/drug therapy/enzymology; Parathion/metabolism/*toxicity; Vitamin K 3/*administration & dosage/metabolism
Creator
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Jan Yi-Hua; Richardson Jason R; Baker Angela A; Mishin Vladimir; Heck Diane E; Laskin Debra L; Laskin Jeffrey D
Description
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Accidental or intentional exposures to parathion, an organophosphorus (OP) pesticide, can cause severe poisoning in humans. Parathion toxicity is dependent on its metabolism by the cytochrome P450 (CYP) system to paraoxon (diethyl
Identifier
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<a href="http://doi.org/10.1111/nyas.13156" target="_blank" rel="noreferrer noopener">10.1111/nyas.13156</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*menadione
*organophosphorus pesticides
*paraoxon
*parathion
*redox cycling
2016
Animals
Annals of the New York Academy of Sciences
Baker Angela A
Cholinesterase Inhibitors/metabolism/*toxicity
Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism
Cytochrome P-450 Enzyme System/metabolism
Department of Pharmaceutical Sciences
Drug Delivery Systems/*methods
Heck Diane E
Humans
Insecticides/metabolism/toxicity
Jan Yi-Hua
Laskin Debra L
Laskin Jeffrey D
Mishin Vladimir
NEOMED College of Pharmacy
Organophosphate Poisoning/drug therapy/enzymology
Parathion/metabolism/*toxicity
Richardson Jason R
Vitamin K 3/*administration & dosage/metabolism