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40
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Text
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Pages
103–112
Issue
1
Volume
23
Dublin Core
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Title
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Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage.
Publisher
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Clinical and experimental rheumatology
Date
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2005
2005-02
Subject
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Humans; Cell Proliferation; Apoptosis/physiology; Gene Expression/physiology; Cartilage; Cartilage Diseases/*physiopathology; Chondrocytes/physiology; Osteoarthritis/*physiopathology; Biological; Models; Articular/*physiopathology
Creator
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Horton W E Jr; Yagi R; Laverty D; Weiner S
Description
An account of the resource
A major area under study in the osteoarthritis (OA) research field is the characterization of specific molecular and biochemical changes that distinguish advanced diseased cartilage from less involved or normal tissue. This information is important to better define the pathogenic mechanisms that are operating during OA progression and to identify disease-specific markers. This review describes recent studies that have addressed changes in chondrocyte gene expression, proliferation, and apoptosis in "experimental" (more advanced OA cartilage) versus "control" (less involved or non-OA cartilage). Included is a comprehensive listing of recently published studies in this area with general findings. The review also includes a discussion of study design and the strengths and weaknesses of the various approaches. In addition, specific strategies to deal with some of the important issues are discussed. One particular model utilizing minimal and advanced OA cartilage obtained from the same patient is described in more detail.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Apoptosis/physiology
Articular/*physiopathology
Biological
Cartilage
Cartilage Diseases/*physiopathology
Cell Proliferation
Chondrocytes/physiology
Clinical and experimental rheumatology
Gene Expression/physiology
Horton W E Jr
Humans
Laverty D
Models
Osteoarthritis/*physiopathology
Weiner S
Yagi R