1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3181/00379727-193-43030" target="_blank" rel="noreferrer noopener">http://doi.org/10.3181/00379727-193-43030</a>
Pages
225–231
Issue
3
Volume
193
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Excessive sympathetic nervous system activity decreases myocardial contractility.
Publisher
An entity responsible for making the resource available
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-03
Subject
The topic of the resource
Female; Male; Animals; Rabbits; Epinephrine/blood; Norepinephrine/blood; Cisterna Magna; Hemodynamics/drug effects; Sympathetic Nervous System/drug effects/*physiology; Citrates/administration & dosage/pharmacology; Citric Acid; Extravascular Lung Water/drug effects; Heart Ventricles/drug effects/ultrastructure; Myocardial Contraction/*physiology; Ventricular Function; Veratrine/administration & dosage/pharmacology
Creator
An entity primarily responsible for making the resource
Pilati C F; Clark R S; Gilloteaux J; Bosso F J; Holcomb P; Maron M B
Description
An account of the resource
The objective of this study was to determine whether myocardial contractility is depressed by intense activation of the sympathetic nervous system. A massive sympathetic discharge was produced by injecting veratrine or sodium citrate into the cisterna magna of anesthetized rabbits (n = 10). Two and one-half hr later, the hearts were isolated and their left ventricular (LV) performance evaluated and compared with the LV performance of hearts isolated from control animals (n = 10). LV performance was evaluated from steady-state peak isovolumic systolic and end-diastolic pressures that were generated at various end-diastolic volumes (LV function curves). The relationship between peak LV systolic pressure (or the average peak developed LV wall stress) and LV end-diastolic volume was rotated downward (P less than 0.01) in the hearts removed from rabbits treated with veratrine or citrate. The LV end-diastolic pressure or LV end-diastolic wall stress of these hearts was not different from control at any end-diastolic volume. The diminished ability of the experimental hearts to develop systolic pressure or wall stress suggests that intense sympathetic activation depressed contractility. Severely damaged myofibers, located largely in the subendocardium, were found in these hearts. Furthermore, the depressed contractility was not related to pulmonary edema since only 2 of 10 rabbits developed edema.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3181/00379727-193-43030" target="_blank" rel="noreferrer noopener">10.3181/00379727-193-43030</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Animals
Bosso F J
Cisterna Magna
Citrates/administration & dosage/pharmacology
Citric Acid
Clark R S
Epinephrine/blood
Extravascular Lung Water/drug effects
Female
Gilloteaux J
Heart Ventricles/drug effects/ultrastructure
Hemodynamics/drug effects
Holcomb P
Male
Maron M B
Myocardial Contraction/*physiology
Norepinephrine/blood
Pilati C F
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Rabbits
Sympathetic Nervous System/drug effects/*physiology
Ventricular Function
Veratrine/administration & dosage/pharmacology