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Text
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<a href="http://doi.org/10.1007/s40123-019-00217-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s40123-019-00217-w</a>
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Pages
589-598
Issue
4
Volume
8
ISSN
2193-8245
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Title
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Atropine 0.01% Eye Drops for Myopia Control in American Children: A Multiethnic Sample Across Three US Sites
Publisher
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Ophthalmology And Therapy
Date
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2019
2019-12
Subject
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Atropine; Childhood myopia; Eye drops; Myopia; Refractive error; Side effects
Creator
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Larkin G Luke; Tahir Alifiya; Epley K David; Beauchamp Cynthia L; Tong John T; Clark Robert A
Description
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INTRODUCTION: Topical atropine eye drops at low concentrations have been shown to slow myopia progression in East Asian studies. This study explored the effect of atropine 0.01% eye drops on controlling myopia progression in a multiethnic cohort of children in the USA. METHODS: A multicenter retrospective case-control study (n = 198) quantified the effect of adding nightly atropine 0.01% eye drops to treatment as usual on the progression of childhood (ages 6-15 years) myopia. Cases included all children treated with atropine for at least 1 year. Controls were matched to cases on both age (± 6 months) and baseline spherical equivalent refraction (SER) (± 0.50 diopters, D) at treatment initiation. The primary endpoint was the average SER myopia progression after 1, 1.5, and 2 years of therapy. A secondary outcome was the percentage of subjects with a clinically significant worsening of myopia, defined as a greater than - 0.75 D SER increase in myopia. RESULTS: The average baseline SERs for the atropine (n = 100) and control (n = 98) groups were similar (- 3.1 ± 1.9 D and - 2.8 ± 1.6 D, respectively) (p = 0.23). The average SER increase from baseline was significantly less for the atropine group than the control group at year 1 (- 0.2 ± 0.8 D compared with - 0.6 ± 0.4 D, p < 0.001) and at year 2 (- 0.3 ± 1.1 D compared with - 1.2 ± 0.7 D, p < 0.001). Secondary analysis at year 2 revealed that 80% of the control group vs. 37% of the atropine group experienced clinically significant worsening myopia of at least - 0.75 D (p < 0.001). There were no major safety issues reported in either group. CONCLUSION: Similar to results reported in Asia, atropine 0.01% eye drops significantly reduced myopia progression in a cohort of US children over 2 years of treatment. FUNDING: Nevakar, Inc. Plain language summary available for this article.
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<a href="http://doi.org/10.1007/s40123-019-00217-w" target="_blank" rel="noreferrer noopener">10.1007/s40123-019-00217-w</a>
PMID: 31602553
Format
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Journal Article
2019
Atropine
Beauchamp Cynthia L
Childhood myopia
Clark Robert A
Department of Emergency Medicine
Epley K David
Eye drops
Journal Article
Larkin G Luke
Myopia
NEOMED College of Medicine
November 2019 Update
Ophthalmology And Therapy
Refractive error
Side effects
Summa Health System Akron City Hospital
Tahir Alifiya
Tong John T