Browse Items · NEOMED Bibliography Database

Opioids: a review.

Recent discoveries in opioid pharmacology help explain the enormous variability in clinical responses to these powerful analgesics. Although there is only one m opioid receptor gene, splice variants of that gene's expression result in a panoply of…

Tags: 2003, Analgesics, Animals, Chevlen Eric, Clinical Trials as Topic, Current pain and headache reports, Department of Internal Medicine, Drug Tolerance, Humans, mu/drug effects/genetics/physiology, NEOMED College of Medicine, Opioid, Opioid/*drug effects/genetics/physiology, Opioid/adverse effects/*therapeutic use, Pain/*drug therapy/physiopathology, Receptors, Trans-Activators/genetics

Recent advances in clinical use of opioids.

Opioid therapy for pain is the subject of numerous randomized clinical trials. Opioids are being developed for delivery by a wide variety of mechanisms. New opioids are becoming available for clinical use. This review surveys recent developments in…

Tags: 2004, Analgesics, Chevlen Eric, Clinical Trials as Topic, Current pain and headache reports, Department of Internal Medicine, Humans, NEOMED College of Medicine, Opioid/administration & dosage/pharmacology/*therapeutic use, Pain/*drug therapy

Does empiric therapy for atypical pathogens improve outcomes for patients with CAP?

The present controversy regarding the need to cover atypical pathogens in the empiric therapy of community-acquired pneumonia is related to several issues, including the relevance of terminology, imprecise diagnostic methods, and perceived…

Tags: 2013, Anti-Bacterial Agents/*therapeutic use, Antibiotic Prophylaxis, Antibiotics – Therapeutic Use, Clinical Trials, Clinical Trials as Topic, Community-Acquired Infections – Drug Therapy, Community-Acquired Infections – Microbiology, Community-Acquired Infections/drug therapy/microbiology, Department of Internal Medicine, File Thomas M Jr, Humans, Infectious disease clinics of North America, Marrie Thomas J, NEOMED College of Medicine, Pneumonia – Drug Therapy, Pneumonia – Microbiology, Pneumonia/*drug therapy/microbiology

The emergence of designed multiple ligands for neurodegenerative disorders.

The incidence of neurodegenerative diseases has seen a constant increase in the global population, and is likely to be the result of extended life expectancy brought about by better health care. Despite this increase in the incidence of…

Tags: *Drug Design, *Ligands, 2011, Amyloid beta-Peptides/metabolism, Antiparkinson Agents/therapeutic use, Carroll Richard T, Clinical Trials as Topic, Geldenhuys Werner J, Humans, Molecular Structure, Neurodegenerative Diseases/*drug therapy, Neuroprotective Agents/*therapeutic use, Progress in neurobiology, Van der Schyf Cornelis J, Youdim Moussa B H

Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.

Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as…

Tags: 2016, aerodigestive and gastrointestinal tract, Animal, Animal Studies, Animals, Anthocyanins/analysis/pharmacology, Anticarcinogenic Agents/*analysis/pharmacology, Antineoplastic Agents – Analysis, Antineoplastic Agents – Pharmacodynamics, Benzopyrans – Analysis, Benzopyrans – Pharmacodynamics, Berry, Biological, Bishayee Anupam, Cancer, Chemoprevention, Clinical Trials, Clinical Trials as Topic, Critical reviews in food science and nutrition, Digestion – Drug Effects, Digestion/drug effects, Disease Models, Do Chau, Ellagic Acid/analysis/pharmacology, Fruit, Fruit/*chemistry, Gastrointestinal Neoplasms – Prevention and Control, Gastrointestinal Neoplasms/*prevention & control, Haskell Yennie, Human, Humans, Models, Mohandas Nima, Phytochemicals – Analysis, Phytochemicals – Pharmacodynamics, Phytochemicals/analysis/pharmacology, Plant Extracts – Analysis, Plant Extracts – Pharmacodynamics, Plant Extracts/*analysis/pharmacology, Polyphenols – Analysis, Polyphenols – Pharmacodynamics, Polyphenols/analysis/pharmacology, Sethi Gautam, Siveen Kodappully Sivaraman, Stoner Gary D, Treatment

Recommendations for treatment of hospital-acquired and ventilator-associated pneumonia: review of recent international guidelines.

Recently published guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia are reviewed for recommendations regarding diagnosis and antimicrobial therapy to assess the implications for development of future…

Tags: *Practice Guidelines as Topic, 2010, Anti-Bacterial Agents/*therapeutic use, Bacteria/drug effects/isolation & purification, Bacterial/diagnosis/*drug therapy, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Cross Infection/diagnosis/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Hospitals, Humans, Microbial Sensitivity Tests, NEOMED College of Medicine, Pneumonia, Time Factors, Ventilator-Associated/diagnosis/*drug therapy

Summary of ceftaroline fosamil clinical trial studies and clinical safety.

In October 2010, the new cephalosporin, ceftaroline fosamil, was approved by the US Food and Drug Administration for therapy of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSIs). The active…

Tags: 2012, Anti-Bacterial Agents/adverse effects/*therapeutic use, Bacterial/drug therapy, Cephalosporins/adverse effects/*therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumonia, Staphylococcal Skin Infections/drug therapy, Stein Gary E, Wilcox Mark H

Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials.

Resveratrol (3,4',5-trihydroxy-trans-stilbene) is a dietary polyphenol derived from grapes, berries, peanuts, and other plant sources. During the last decade, resveratrol has been shown to possess a fascinating spectrum of pharmacologic properties.…

Tags: 2009, Animals, Antineoplastic Agents/*therapeutic use, Bishayee Anupam, Cancer prevention research (Philadelphia, Pa.), Clinical Trials as Topic, Humans, Neoplasms/*prevention & control, Resveratrol, Stilbenes/*therapeutic use

Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.

INTRODUCTION: Neurodegenerative diseases have had devastating effects on patients' quality of life. These complex diseases have several pathways that are affected to initiate cell death. Current therapies, designed to address only a single target,…

Tags: *Drug Design, 2013, Central Nervous System Diseases/*drug therapy, Clinical Trials as Topic, Expert opinion on drug discovery, Geldenhuys Werner J, Humans, Neurodegenerative Diseases/*drug therapy, Neuroprotective Agents/*chemistry/therapeutic use, Van der Schyf Cornelis J

Anticholinergic therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia.

Lower urinary tract symptoms (LUTS) are commonly associated with benign prostatic hyperplasia (BPH). The LUTS-BPH complex consists of both voiding and storage symptoms that may overlap with overactive bladder symptoms. Drug therapy for men with LUTS…

Tags: 2008, Adrenergic alpha-1 Receptor Antagonists, Cholestenone 5 alpha-Reductase/antagonists & inhibitors, Cholinergic Antagonists/*therapeutic use, Clinical Trials as Topic, Department of Internal Medicine, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Frazee Lawrence A, Gallegos Patrick J, Humans, Male, NEOMED College of Medicine, NEOMED College of Pharmacy, Pharmacotherapy, Prostatic Hyperplasia/complications/*drug therapy/therapy, Quality of Life, Urination Disorders/*drug therapy/etiology/therapy

International guidelines for the treatment of community-acquired pneumonia in adults: the role of macrolides.

The significance of community-acquired pneumonia (CAP) has led to the publication of guidelines from numerous international organisations. Because the macrolide class of antimicrobials is active against most of the key pathogens associated with CAP,…

Role of serotonin in Alzheimer's disease: a new therapeutic target?

Mounting evidence accumulated over the past few years indicates that the neurotransmitter serotonin plays a significant role in cognition. As a drug target, serotonin receptors have received notable attention due in particular to the role of several…

Tags: 2011, Alzheimer Disease/*drug therapy/*metabolism, Alzheimer's Disease – Drug Therapy, Alzheimer's Disease – Metabolism, Animals, Cell Surface – Metabolism, Clinical Trials, Clinical Trials as Topic, CNS drugs, Drug Evaluation, Geldenhuys Werner J, Humans, Preclinical, Receptors, Serotonin – Pharmacodynamics, Serotonin – Therapeutic Use, Serotonin/*metabolism, Serotonin/*pharmacology/*therapeutic use, Van der Schyf Cornelis J

Present state and future prospects: a review of cooperative groups' adjuvant and neoadjuvant trials in breast cancer.

In patients with operable breast cancer, adjuvant hormonal therapy and adjuvant chemotherapy result in significant and long-term reductions in the rates of disease recurrence and death. These reductions are evident in both patients with node-negative…

Tags: 2001, Adjuvant, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use, Breast Neoplasms/*drug therapy/surgery, Chemotherapy, Clinical breast cancer, Clinical Trials as Topic, Decision Making, Diphosphonates/therapeutic use, Female, Hormonal/*therapeutic use, Humans, Mamounas E P, Neoadjuvant Therapy, Ovary/drug effects/physiology, Prognosis, Tamoxifen/administration & dosage, Taxoids/therapeutic use

[Clinical impact of appropriate use of antibiotic in hospital according to CARAT criteria].

In response to the overuse and misuse of antibiotics, leading to increasing bacterial resistance and the decreasing development of new antibiotics, the Council for Appropriate and Rational Antibiotic Therapy (an independent, interdisciplinary panel…

Bromocriptine therapy in cocaine withdrawal.

Twenty-four cocaine addicts who experienced withdrawal symptoms were studied for six weeks in a double-blind design. Half of the group received daily treatment with bromocriptine and the other half with placebo. Significant relief with bromocriptine…

Tags: *Cocaine, 1987, Adult, Baumgartel P, Bromocriptine/*therapeutic use, Clinical Trials as Topic, DiMarzio L R, Double-Blind Method, Giannini A J, Humans, Journal of clinical pharmacology, Male, Psychiatric Status Rating Scales, Random Allocation, Substance Withdrawal Syndrome/*drug therapy/psychology

Clonidine in the treatment of premenstrual syndrome: a subgroup study.

The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels.…

Tags: 1988, Adult, beta-Endorphin/blood, Clinical Trials as Topic, Clonidine/*therapeutic use, Double-Blind Method, Female, Giannini A J, Humans, Loiselle R H, Placebos, Premenstrual Syndrome/blood/*drug therapy/psychology, Psychiatric Status Rating Scales, Sarachene J, Sullivan B, The Journal of clinical psychiatry

American Urological Association Annual Meeting–AUA 2004. 8-13 May 2004, San Francisco, CA, USA.

Significant areas of new drug development discussed at this year's American Urological Association (AUA) meeting included: antioxidants, immunosuppressants, anti-androgens, kinase inhibitors, immunotherapeutic agents and antitumor vaccines. The…

Tags: 2004, Antineoplastic Agents/pharmacology/*therapeutic use, Clinical Trials as Topic, Humans, IDrugs : the investigational drugs journal, Jamison James, Kidney Neoplasms/*drug therapy, Male, Prostatic Neoplasms/*drug therapy, Urinary Bladder Neoplasms/*drug therapy

Incorporating the Oncotype DX breast cancer assay into community practice: an expert Q&A and case study sampling.

Advances in breast cancer research have confirmed that this malignancy is not a single disease, but rather a collection of genetically distinct diseases with different treatment requirements. In recent years, several studies have confirmed the…

Predicting locoregional recurrence after neoadjuvant chemotherapy in patients with breast cancer.

Tags: *Neoplasm Recurrence, 2013, Breast Neoplasms/*diagnosis/drug therapy/therapy, Clinical advances in hematology & oncology : H&O, Clinical Trials as Topic, Female, Humans, Local, Mamounas Terry P, Neoadjuvant Therapy, Prognosis, Research Design, Risk, Treatment Outcome

Antipsychotic effects of verapamil in schizophrenia.

The antipsychotic effects of verapamil were tested in a double-blind, placebo-controlled, randomized study in 18 patients who met Research Diagnostic Criteria for acute schizophrenia. The antipsychotic effect of verapamil as measured by the…

Tags: 1987, Adult, Clinical Trials as Topic, Double-Blind Method, Female, Haloperidol/therapeutic use, Humans, Male, Middle Aged, Price W A, Random Allocation, Schizophrenia/*drug therapy, The Hillside journal of clinical psychiatry, Verapamil/*therapeutic use

Browse Items (20 total)