1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(95)02275-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(95)02275-9</a>
Pages
491–494
Issue
2
Volume
54
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-06
Subject
The topic of the resource
Animals; Cocaine/*analogs & derivatives/pharmacology; Convulsants/*pharmacology; Dopamine Uptake Inhibitors/*pharmacology; Drug Interactions; Epilepsy; Female; Inbred Strains; Kindling; Male; Mice; Neurologic/*drug effects; Seizures/*chemically induced; Status Epilepticus/chemically induced; Tonic-Clonic/chemically induced
Creator
An entity primarily responsible for making the resource
Meehan S M; Schechter M D
Description
An account of the resource
Sensitization and cross-sensitization to the seizurogenic effects of cocaine and cocaethylene were examined in the HS strain of mice. Animals were administered IP injections of either 48 mg/kg cocaine or 32 mg/kg cocaethylene once per day for 4 days. On the fifth day, mice were injected with either the same drug that was administered on days 1-4 or the alternative psychostimulant and the occurrence of seizure activity was recorded. Repeated cocaine administration resulted in the induction of tonic-clonic seizures and status epilepticus in 90% of the animals tested with cocaine on the fifth day. A similar increase in seizure prevalence, noted as a kindling effect, was observed in cocaethylene-treated animals tested with cocaethylene in that 90% of the mice exhibited status epilepticus on the last test day. Significant cross-sensitization was observed only in the group that received cocaethylene following repeated cocaine exposure. However, data obtained from animals injected with cocaine following cocaethylene treatment also were suggestive of cross-sensitization effects. Results are discussed in terms of the potential mechanistic differences between cocaine and its ethanol-derived product, as well as its relevance to cocaine use/abuse.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(95)02275-9" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(95)02275-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Cocaine/*analogs & derivatives/pharmacology
Convulsants/*pharmacology
Dopamine Uptake Inhibitors/*pharmacology
Drug Interactions
Epilepsy
Female
Inbred Strains
Kindling
Male
Meehan S M
Mice
Neurologic/*drug effects
Pharmacology, biochemistry, and behavior
Schechter M D
Seizures/*chemically induced
Status Epilepticus/chemically induced
Tonic-Clonic/chemically induced
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(95)00053-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(95)00053-y</a>
Pages
549–552
Issue
2
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cocaethylene produces conditioned place preference in rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-07
Subject
The topic of the resource
Animals; Avoidance Learning/drug effects; Cocaine/*analogs & derivatives/pharmacology; Conditioning; Discrimination (Psychology)/drug effects; Male; Motor Activity/*drug effects; Operant/*drug effects; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place preference apparatus as determined on a baseline test day. Subsequently, these rats spent a greater amount of time in that cocaethylene-paired nonpreferred side when later tested in a drug-free state. In contrast, rats conditioned with the same dose of cocaethylene and confined in their preferred side, as well as other rats treated with saline on both sides, did not show a significant shift in their preference or aversion. Results are discussed in light of the rewarding activity of cocaethylene, a compound formed in humans who concurrently use cocaine and ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(95)00053-y" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(95)00053-y</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Avoidance Learning/drug effects
Cocaine/*analogs & derivatives/pharmacology
Conditioning
Discrimination (Psychology)/drug effects
Male
Motor Activity/*drug effects
Operant/*drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Sprague-Dawley