1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90145-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90145-1</a>
Pages
1089–1092
Issue
4
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CGS 10746B is able to attenuate the effects of amphetamine: further evidence for dopaminergic mediation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-08
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*physiology; Discrimination (Psychology)/*drug effects; Antipsychotic Agents/*pharmacology; Thiazepines/*pharmacology; Apomorphine/pharmacology; Cocaine/pharmacology; Alkaloids/pharmacology; Dextroamphetamine/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Conditioning; Operant/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D; Boja J W
Description
An account of the resource
Previous results indicate that agents which either decreases synthesis or block postsynaptic dopamine receptors will attenuate the discriminative stimulus produced by d-amphetamine. CGS 10746B has been reported to decrease dopamine release without changing its metabolism or occupying its receptors. In the present study, rats successfully trained to discriminate intraperitoneally administered (0.8 mg/kg) d-amphetamine in a two-lever, food-motivated operant task were observed to be unable to discriminate amphetamine when pretreated with 30 mg/kg CGS 10746B. This antagonism was shown to be dose-responsive and constitutes a third mechanism, i.e., dopamine release inhibition, that evidences the dopaminergic mediation of amphetamine in the discriminative paradigm. When both cathinone (0.8 mg/kg) and cocaine (10.0 mg/kg) were administered to the amphetamine-trained rats they each were recognized as amphetamine and are, thus, considered to generalize to the amphetamine discriminative stimulus. Coadministration of CGS 10746B and cathinone totally antagonized this generalization, whereas pretreatment with CGS 10746B prior to cocaine significantly reduced cocaine's effects. These results implicate dopamine mechanisms in the discriminative stimulus properties of the psychostimulants amphetamine, cathinone and cocaine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90145-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90145-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Alkaloids/pharmacology
Animals
Antipsychotic Agents/*pharmacology
Apomorphine/pharmacology
Boja J W
Cocaine/pharmacology
Conditioning
Dextroamphetamine/antagonists & inhibitors/*pharmacology
Discrimination (Psychology)/*drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Male
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Thiazepines/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(92)90219-n" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(92)90219-n</a>
Pages
967–973
Issue
6
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Attenuation of drinking sweetened water following calcium channel blockade.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-06
Subject
The topic of the resource
Animals; Calcium Channel Blockers/*pharmacology; Cocaine/pharmacology; Dihydropyridines/pharmacology; Dose-Response Relationship; Drinking Behavior/*drug effects; Drug; Female; Inbred Strains; Injections; Intraventricular; Isradipine; Male; Rats; Reward; Taste/*drug effects
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
Recent reports cite results that both cocaine-induced conditioned place preference and activity stimulation are attenuated by pretreatment with the calcium channel blocker isradipine (ISR) in rats. By blocking voltage-dependent
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(92)90219-n" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(92)90219-n</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Animals
Brain research bulletin
Calcagnetti D J
Calcium Channel Blockers/*pharmacology
Cocaine/pharmacology
Dihydropyridines/pharmacology
Dose-Response Relationship
Drinking Behavior/*drug effects
Drug
Female
Inbred Strains
Injections
Intraventricular
Isradipine
Male
Rats
Reward
Schechter M D
Taste/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02246057" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02246057</a>
Pages
79–84
Issue
1
Volume
119
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.
Publisher
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Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-05
Subject
The topic of the resource
Amphetamine/pharmacology; Animals; Apomorphine/pharmacology; Benzazepines/pharmacology; Cocaine/pharmacology; Discrimination (Psychology); Dopamine Agonists/pharmacology; Dopamine D1/*agonists; Dose-Response Relationship; Drug; Male; Phenanthridines/*pharmacology; Rats; Receptors; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist dihydrexidine (DHX) within 20 sessions using a training dose of 3.0 mg/kg. DHX (0.75-4.5 mg/kg) dose-dependently increased DHX-appropriate responding with an ED50 = 1.44 mg/kg. The selective D1 agonist SKF 38398 (2.0-8.0 mg/kg) dose-responsively generalized with an ED50 = 3.54 mg/kg; significantly less potent than DHX. The selective D1 antagonist SCH 23390 (0.06-0.12 mg/kg) dose-responsively decreased DHX-appropriate discriminative performance. These data would indicate that DHX is a selective D1 agonist that may allow for testing of the selectivity of other putative D1 agonists in this experimental procedure. Administration of non-selective dopaminergically active drugs, including apomorphine, amphetamine and cocaine, were each shown to produce intermediate
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02246057" target="_blank" rel="noreferrer noopener">10.1007/bf02246057</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Amphetamine/pharmacology
Animals
Apomorphine/pharmacology
Benzazepines/pharmacology
Cocaine/pharmacology
Discrimination (Psychology)
Dopamine Agonists/pharmacology
Dopamine D1/*agonists
Dose-Response Relationship
Drug
Male
Phenanthridines/*pharmacology
Psychopharmacology
Rats
Receptors
Schechter M D
Sprague-Dawley