Browse Items · NEOMED Bibliography Database

Characterization of ex vivo-generated bovine and human cartilage by immunohistochemical, biochemical, and magnetic resonance imaging analyses.

Osteoarthritis (OA) is a prevalent age-associated disease involving altered chondrocyte homeostasis and cartilage degeneration. The avascular nature of cartilage and the altered chondrocyte phenotype characteristic of OA severely limit the capacity…

Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.

Bcl-2 is an anti-apoptotic protein that has recently been shown to regulate other cellular functions. We previously reported that Bcl-2 regulates chondrocyte matrix gene expression, independent of its anti-apoptotic function. Here, we further…

Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko

Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis.

The endoplasmic reticulum is the site of synthesis and folding of secretory proteins and is sensitive to changes in the internal and external environment of the cell. Both physiological and pathological conditions may perturb the function of the…

A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.

BAG-1 (Bcl-2 associated athanogene-1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. In vivo, BAG-1 is expressed in growth plate and articular cartilage, and the expression of BAG-1 is…

Murine metapodophalangeal sesamoid bones: morphology and potential means of mineralization underlying function.

Normal murine metapodophalangeal sesamoid bones, closely associated with tendons, were examined in terms of their structure and mineralization with reference to their potential function following crystal deposition. This study utilized radiography,…

Browse Items (5 total)

Characterization of ex vivo-generated bovine and human cartilage by immunohistochemical, biochemical, and magnetic resonance imaging analyses.

Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.

Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis.

A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.

Murine metapodophalangeal sesamoid bones: morphology and potential means of mineralization underlying function.