1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A46-A46
Issue
4
Volume
13
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen effects in the peripheral nervous system. Estrogen receptors in autonomic and sensory nerves that innervate the female reproductive system
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
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Papka R; Williams S J; Collins J
Identifier
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n/a
Format
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Journal Article
1999
Biochemistry & Molecular Biology
Cell Biology
Collins J
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Papka R
Topics
Williams S J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.peptides.2003.07.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.peptides.2003.07.009</a>
Pages
1163–1174
Issue
8
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord.
Publisher
An entity responsible for making the resource available
Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-08
Subject
The topic of the resource
Animals; Calcitonin Gene-Related Peptide/analysis/biosynthesis/*genetics; Cervix Uteri/*physiology; Estrogens/*physiology; Female; Ganglia; Immunohistochemistry; In Situ Hybridization; Messenger/metabolism; Pregnancy; Radioimmunoassay; Rats; RNA; Spinal Cord/*physiology; Spinal/*physiology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Mowa C N; Usip S; Collins J; Storey-Workley M; Hargreaves K M; Papka R E
Description
An account of the resource
Before parturition the uterine cervix undergoes a ripening process ("softens" and dilates) to allow passage of the fetus at term. The exact mechanism(s) responsible for cervical ripening are unknown, though a role for peptidergic sensory neurons is emerging. Previous work demonstrated that administration of substance P (SP) to ovariectomized rats caused events associated with cervical ripening, that production of SP in cervix-related dorsal root ganglion (DRG) is estrogen responsive, and that release of SP from neurons terminating in the cervix and spinal cord peaks prior to parturition. The present study was designed to test the hypothesis that calcitonin gene-related peptide (CGRP), a neuropeptide co-stored with SP in many sensory neurons, undergoes changes with pregnancy and hormonal environment. Immunohistochemistry, in situ hybridization, reverse transcriptase-polymerase chain reaction (RT-PCR) and radioimmunoassay (RIA) were used to investigate CGRP in L6-S1 DRG, spinal cord and cervix during pregnancy and the role of estrogen in CGRP synthesis. CGRP-immunoreactive primary sensory neurons expressed estrogen receptors (ER-alpha and ER-beta). In the cervix, CGRP concentrations decreased, but in the L6-S1 DRG and the spinal cord segments, CGRP levels increased, with peak effects observed at day 20 of gestation. CGRP mRNA synthesis increased in DRG over pregnancy. Sensory neurons of ovariectomized rats treated with estrogen showed increased CGRP mRNA synthesis in a dose-related manner, an effect blocked by the ER antagonist ICI 182 780. From these results, we postulate that synthesis of CGRP in L6-S1 DRG and utilization in the cervix increase over pregnancy and this synthesis is the under influence of the estrogen-ER system. Collectively, these data are consistent with the hypothesis that CGRP plays a role in cervical ripening and, consequently in the birth process.
Identifier
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<a href="http://doi.org/10.1016/j.peptides.2003.07.009" target="_blank" rel="noreferrer noopener">10.1016/j.peptides.2003.07.009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Animals
Calcitonin Gene-Related Peptide/analysis/biosynthesis/*genetics
Cervix Uteri/*physiology
Collins J
Department of Anatomy & Neurobiology
Estrogens/*physiology
Female
Ganglia
Hargreaves K M
Immunohistochemistry
In Situ Hybridization
Messenger/metabolism
Mowa C N
NEOMED College of Medicine
Papka R E
Peptides
Pregnancy
Radioimmunoassay
Rats
RNA
Spinal Cord/*physiology
Spinal/*physiology
Sprague-Dawley
Storey-Workley M
Usip S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s004419900071" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s004419900071</a>
Pages
63–74
Issue
1
Volume
298
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Calretinin-immunoreactive nerves in the uterus, pelvic autonomic ganglia, lumbosacral dorsal root ganglia and lumbosacral spinal cord.
Publisher
An entity responsible for making the resource available
Cell and tissue research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-10
Subject
The topic of the resource
Animals; Autonomic/*metabolism; Calbindin 2; Capsaicin/pharmacology; Female; Ganglia; Immunohistochemistry; Lumbosacral Region; Nerve Fibers/drug effects/metabolism; Pelvis; Rats; S100 Calcium Binding Protein G/*metabolism; Spinal Cord/*metabolism; Spinal/*metabolism; Sprague-Dawley; Uterus/*innervation
Creator
An entity primarily responsible for making the resource
Papka R E; Collins J; Copelin T; Wilson K
Description
An account of the resource
Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin and the source(s) of calretinin-synthesizing nerves in the rat (are they sensory, efferent, or both?). Calretinin-immunoreactive nerves were present in the uterine horns and cervix where they were associated with arteries, uterine smooth muscle, glands, and the epithelium. Calretinin-immunoreactive terminals were apposed to neurons in the paracervical ganglia; in addition, some postganglionic neurons in this ganglion were calretinin positive. Calretinin perikarya were present in the lumbosacral dorsal root ganglia, no-dose ganglia, and lumbosacral spinal cord. Retrograde axonal tracing, utilizing Fluorogold injected into the uterus or paracervical parasympathetic ganglia, revealed calretinin-positive/Fluorogold-labeled neurons in the dorsal root and nodose ganglia. Also, capsaicin treatment substantially reduced the calretinin-positive fibers in the uterus and pelvic ganglia, thus indicating the sensory nature of these fibers. The presence of calretinin immunoreactivity identifies a subset of nerves that are involved in innervation of the pelvic viscera and have origins from lumbosacral dorsal root ganglia and vagal nodose ganglia. Though the exact function of calretinin in these nerves is not currently known, calretinin is likely to play a role in calcium regulation and their function.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s004419900071" target="_blank" rel="noreferrer noopener">10.1007/s004419900071</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animals
Autonomic/*metabolism
Calbindin 2
Capsaicin/pharmacology
Cell and tissue research
Collins J
Copelin T
Female
Ganglia
Immunohistochemistry
Lumbosacral Region
Nerve Fibers/drug effects/metabolism
Papka R E
Pelvis
Rats
S100 Calcium Binding Protein G/*metabolism
Spinal Cord/*metabolism
Spinal/*metabolism
Sprague-Dawley
Uterus/*innervation
Wilson K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s004410051290" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s004410051290</a>
Pages
293–305
Issue
2
Volume
296
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors.
Publisher
An entity responsible for making the resource available
Cell and tissue research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-05
Subject
The topic of the resource
Acetylcholinesterase/*analysis; Animals; Autonomic/*cytology/physiology/ultrastructure; Autoradiography; Axonal Transport; Axons/physiology/*ultrastructure; Cervix Uteri/*innervation; Choline O-Acetyltransferase/*analysis; Female; Ganglia; Muscarinic/analysis/*metabolism; Quinuclidinyl Benzilate/pharmacokinetics; Rats; Receptors; Spinal Cord/cytology/metabolism; Sprague-Dawley; Tritium; Uterus/*innervation
Creator
An entity primarily responsible for making the resource
Papka R E; Traurig H H; Schemann M; Collins J; Copelin T; Wilson K
Description
An account of the resource
Acetylcholine (ACh) stimulates contraction of the uterus and dilates the uterine arterial supply. Uterine cholinergic nerves arise from the paracervical ganglia and were, in the past, characterized based on acetylcholinesterase (AChE) histochemistry. However, the histochemical reaction for acetylcholinesterase provides only indirect evidence of acetylcholine location and is a nonspecific marker for cholinergic nerves. The present study: (1) reevaluated cholinergic neurons of the paracervical ganglia, (2) examined the cholinergic innervation of the uterus by using retrograde axonal tracing and antibodies against molecules specific to cholinergic neurons, choline acetyltransferase and the vesicular acetylcholine transporter, and (3) examined muscarinic receptors in the paracervical ganglia using autoradiography and a radiolabeled agonist. Most ganglionic neurons were choline acetyltransferase- and vesicular acetylcholine transporter-immunoreactive and were apposed by choline acetyltransferase/vesicular acetylcholine transporter-immunoreactive terminals. Retrograde tracing showed that some cholinergic neurons projected axons to the uterus. These nerves formed moderately dense plexuses in the myometrium, cervical smooth muscle and microarterial system of the uterine horns and cervix. Finally, the paracervical ganglia contain muscarinic receptors. These results clearly reveal the cholinergic innervation of the uterus and cervix, a source of these nerves, and demonstrate the muscarinic receptor content of the paracervical ganglia. Cholinergic nerves could play significant roles in the control of uterine myometrium and vasculature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s004410051290" target="_blank" rel="noreferrer noopener">10.1007/s004410051290</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Acetylcholinesterase/*analysis
Animals
Autonomic/*cytology/physiology/ultrastructure
Autoradiography
Axonal Transport
Axons/physiology/*ultrastructure
Cell and tissue research
Cervix Uteri/*innervation
Choline O-Acetyltransferase/*analysis
Collins J
Copelin T
Female
Ganglia
Muscarinic/analysis/*metabolism
Papka R E
Quinuclidinyl Benzilate/pharmacokinetics
Rats
Receptors
Schemann M
Spinal Cord/cytology/metabolism
Sprague-Dawley
Traurig H H
Tritium
Uterus/*innervation
Wilson K