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Text
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URL Address
<a href="http://doi.org/10.1179/joc.2000.12.4.314" target="_blank" rel="noreferrer noopener">http://doi.org/10.1179/joc.2000.12.4.314</a>
Pages
314–325
Issue
4
Volume
12
Dublin Core
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Title
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Gemifloxacin versus amoxicillin/clavulanate in the treatment of acute exacerbations of chronic bronchitis. The 070 Clinical Study group.
Publisher
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Journal of chemotherapy (Florence, Italy)
Date
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2000
2000-08
Subject
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*Fluoroquinolones; 80 and over; Acute-Phase Reaction; Adult; Aged; Amoxicillin/pharmacology/therapeutic use; Anti-Infective Agents/adverse effects/pharmacology/*therapeutic use; Bronchitis/*drug therapy; Chronic Disease; Clavulanic Acid/pharmacology/therapeutic use; Combination/pharmacology/*therapeutic use; Double-Blind Method; Drug Therapy; Female; Gemifloxacin; Haemophilus influenzae/drug effects; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Moraxella (Branhamella) catarrhalis/drug effects; Multicenter Studies as Topic; Naphthyridines/adverse effects/pharmacology/*therapeutic use; Streptococcus pneumoniae/drug effects; Treatment Outcome
Creator
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File T; Schlemmer B; Garau J; Lode H; Lynch S; Young C
Description
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Six hundred patients were evaluated in this randomized, double-blind, double-dummy, multicenter, parallel-group study comparing the efficacy and safety of gemifloxacin (320 mg once-daily for 5 days) and amoxicillin/clavulanate (500/125 mg three-times daily for 7 days) for the treatment of acute exacerbations of chronic bronchitis (AECB). Of note, more than 90% of study participants had stage 2 disease at study entry. The two drugs were found to be equally effective, with clinical success rates of 93.6% for gemifloxacin and 93.2% on amoxicillin/clavulanate (95% CI -3.9 to 4.6). Bacteriological success rates favored gemifloxacin (90.9% compared with 79.5% for amoxicillin/clavulanate; 95% CI -3.3 to 26.0); however, this difference was not statistically significant. Gemifloxacin and amoxicillin/clavulanate were both well tolerated. In summary, gemifloxacin was found to be well tolerated and effective for the treatment of AECB, suggesting it is well suited for empirical treatment of this common respiratory condition in the current clinical environment.
Identifier
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<a href="http://doi.org/10.1179/joc.2000.12.4.314" target="_blank" rel="noreferrer noopener">10.1179/joc.2000.12.4.314</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fluoroquinolones
2000
80 and over
Acute-Phase Reaction
Adult
Aged
Amoxicillin/pharmacology/therapeutic use
Anti-Infective Agents/adverse effects/pharmacology/*therapeutic use
Bronchitis/*drug therapy
Chronic Disease
Clavulanic Acid/pharmacology/therapeutic use
Combination/pharmacology/*therapeutic use
Department of Internal Medicine
Double-Blind Method
Drug Therapy
Female
File T
Garau J
Gemifloxacin
Haemophilus influenzae/drug effects
Humans
Journal of chemotherapy (Florence, Italy)
Lode H
Lynch S
Male
Microbial Sensitivity Tests
Middle Aged
Moraxella (Branhamella) catarrhalis/drug effects
Multicenter Studies as Topic
Naphthyridines/adverse effects/pharmacology/*therapeutic use
NEOMED College of Medicine
Schlemmer B
Streptococcus pneumoniae/drug effects
Treatment Outcome
Young C