1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/srep35610" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/srep35610</a>
Pages
35610–35610
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis.
Publisher
An entity responsible for making the resource available
Scientific reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-10
Subject
The topic of the resource
Alcoholic/*immunology; Animals; Cell Proliferation; Cells; Collagen/genetics/metabolism; Common/*pathology; Cultured; Female; Gene Expression Profiling; Gene Expression Regulation; Hepatic Duct; Hepatitis; Hepatocytes/*metabolism/pathology; Humans; Inbred BALB C; Keratins; Knockout; Lipopolysaccharides/metabolism; Male; Mice; Middle Aged; Signal Transduction; Toll-Like Receptor 4/genetics/*metabolism; Type I/genetics/*metabolism
Creator
An entity primarily responsible for making the resource
Odena Gemma; Chen Jiegen; Lozano Juan Jose; Altamirano Jose; Rodrigo-Torres Daniel; Affo Silvia; Morales-Ibanez Oriol; Matsushita Hiroshi; Zou Jian; Dumitru Raluca; Caballeria Juan; Gines Pere; Arroyo Vicente; You Min; Rautou Pierre-Emmanuel; Valla Dominique; Crews Fulton; Seki Ekihiro; Sancho-Bru Pau; Bataller Ramon
Description
An account of the resource
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease for which there are no effective therapies. Patients with AH show impaired hepatocyte proliferation, expansion of inefficient ductular cells and high lipopolysaccharide (LPS) levels. It is unknown whether LPS mediates ductular cell expansion. We performed transcriptome studies and identified keratin 23 (KRT23) as a new ductular cell marker. KRT23 expression correlated with mortality and LPS serum levels. LPS-TLR4 pathway role in ductular cell expansion was assessed in human and mouse progenitor cells, liver slices and liver injured TLR4 KO mice. In AH patients, ductular cell expansion correlated with portal hypertension and collagen expression. Functional studies in ductular cells showed that KRT23 regulates collagen expression. These results support a role for LPS-TLR4 pathway in promoting ductular reaction in AH. Maneuvers aimed at decreasing LPS serum levels in AH patients could have beneficial effects by preventing ductular reaction development.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/srep35610" target="_blank" rel="noreferrer noopener">10.1038/srep35610</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Affo Silvia
Alcoholic/*immunology
Altamirano Jose
Animals
Arroyo Vicente
Bataller Ramon
Caballeria Juan
Cell Proliferation
Cells
Chen Jiegen
Collagen/genetics/metabolism
Common/*pathology
Crews Fulton
Cultured
Department of Pharmaceutical Sciences
Dumitru Raluca
Female
Gene Expression Profiling
Gene Expression Regulation
Gines Pere
Hepatic Duct
Hepatitis
Hepatocytes/*metabolism/pathology
Humans
Inbred BALB C
Keratins
Knockout
Lipopolysaccharides/metabolism
Lozano Juan Jose
Male
Matsushita Hiroshi
Mice
Middle Aged
Morales-Ibanez Oriol
NEOMED College of Pharmacy
Odena Gemma
Rautou Pierre-Emmanuel
Rodrigo-Torres Daniel
Sancho-Bru Pau
Scientific reports
Seki Ekihiro
Signal Transduction
Toll-Like Receptor 4/genetics/*metabolism
Type I/genetics/*metabolism
Valla Dominique
You Min
Zou Jian