Browse Items · NEOMED Bibliography Database

BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.

A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known…

Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction

Increased mitochondrial prooxidant activity mediates up-regulation of Complex I

In response to oxidative stress, mitochondrial Complex I is reversibly

Mitochondrial complex I in the post-ischemic heart: reperfusion-mediated oxidative injury and protein cysteine sulfonation.

A serious consequence of ischemia-reperfusion injury (I/R) is oxidative damage leading to mitochondrial dysfunction. Such I/R-induced mitochondrial dysfunction is observed as impaired state 3 respiration and overproduction of O2(-). The cascading ROS…

Tags: 2018, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Family & Community Medicine, Department of Integrative Medical Sciences, Journal of molecular and cellular cardiology, Kang Patrick T, Lin Paul, Mitochondrial dysfunction, Myocardial ischemia and reperfusion, NEOMED College of Medicine, Protein cysteine sulfonation, Protein Structure, Zhang Liwen, Zweier Jay L

Simplified method for concentration of mitochondrial membrane protein complexes

Extracting and concentrating mitochondrial protein complexes from gel strips after blue native PAGE (BN-PAGE) can be daunting tasks using the traditional methods, such as electroelution, passive diffusion and centrifugal concentration. We present a…

Tags: 2010, Angelos M G, Biochemistry & Molecular Biology, blue, Blue native PAGE, Chemistry, Chen Y R, Complex I, Electrophoresis, Electrophoretic concentration, Journal Article, Mitochondria, native electrophoresis, oxidative-phosphorylation, polyacrylamide-gels, sds-page, Yeh S T

Mitochondrial redox regulation and myocardial ischemia-reperfusion injury

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cellular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by complexes I…

Tags: 2022, Complex I, Complex III, ischemia and reperfusion, oxidative posttranslational modification, proton motive force

Browse Items (5 total)

BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.

Increased mitochondrial prooxidant activity mediates up-regulation of Complex I

Mitochondrial complex I in the post-ischemic heart: reperfusion-mediated oxidative injury and protein cysteine sulfonation.

Simplified method for concentration of mitochondrial membrane protein complexes

Mitochondrial redox regulation and myocardial ischemia-reperfusion injury