Browse Items · NEOMED Bibliography Database

CGS 10746B is able to attenuate the effects of amphetamine: further evidence for dopaminergic mediation.

Previous results indicate that agents which either decreases synthesis or block postsynaptic dopamine receptors will attenuate the discriminative stimulus produced by d-amphetamine. CGS 10746B has been reported to decrease dopamine release without…

Tags: 1988, Alkaloids/pharmacology, Animals, Antipsychotic Agents/*pharmacology, Apomorphine/pharmacology, Boja J W, Cocaine/pharmacology, Conditioning, Dextroamphetamine/antagonists & inhibitors/*pharmacology, Discrimination (Psychology)/*drug effects, Dopamine/*physiology, Dose-Response Relationship, Drug, Male, Operant/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/*pharmacology

Cocaethylene produces conditioned place preference in rats.

The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place…

Tags: 1995, Animals, Avoidance Learning/drug effects, Cocaine/*analogs & derivatives/pharmacology, Conditioning, Discrimination (Psychology)/drug effects, Male, Motor Activity/*drug effects, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley

Cocaine discrimination is attenuated by isradipine and CGS 10746B.

The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were…

Deficits in shock-induced freezing and naltrexone enhancement of freezing in fawn hooded rats.

When a rat is returned to a context associated with mild electric foot shock (1 mA/0.75 s), the environmental cues elicit a species-specific defensive behavior termed freezing. Genetically divergent strains of rats given identical shock conditioning…

Tags: *Fear, 1994, Animals, Brain research bulletin, Calcagnetti D J, Classical/*drug effects, Conditioning, Electroshock, Female, Inbred Strains, Naltrexone/*pharmacology, Rats, Schechter M D

Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.

Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place…

Tags: 1992, Animals, Avoidance Learning/*drug effects, Conditioning, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Krimmer E C, Motor Activity/drug effects, Operant/drug effects, Psychopharmacology, Rats, Schechter M D, Sleep/drug effects, Species Specificity

Discriminative characteristics of high and low cocaine administration: effect of other psychostimulants.

Two groups of N/Nih male rats were trained to discriminate saline vehicle from either 2.0 mg/kg (n = 10) or 10.0 mg/kg (n = 10) cocaine in a food-motivated, two-lever operant paradigm. The rats trained at the low-dose cocaine took a significantly…

Discriminative stimulus properties of isradipine: effect of other calcium channel blockers.

This study constitutes the first report of a calcium channel blocker used as a drug capable of controlling differential responding in a drug-discrimination paradigm. Male Sprague-Dawley rats were trained to discriminate between intraperitoneally…

Tags: 1995, Animals, Calcium Channel Blockers/*pharmacology, Conditioning, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Generalization, Isradipine/*pharmacology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley, Stimulus/*drug effects

Effect of learned behavior upon conditioned place preference to cathinone.

The purpose of this study was to examine whether first training rats to discriminate the stimulus cues produced by an indirect dopamine agonist, cathinone, would influence a subsequent test of preference. The conditioned place preference (CPP)…

Tags: 1991, Alkaloids/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Conditioning, Cues, Discrimination (Psychology)/drug effects, Discrimination Learning/drug effects, Dopamine/drug effects, Dopamine/physiology, Inbred Strains, Learning/*physiology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Thiazepines/pharmacology

Effect of MDMA neurotoxicity upon its conditioned place preference and discrimination.

Experiments were conducted to investigate the functional consequences of a neurotoxic regimen of MDMA administration upon two behaviors, conditioned place preference and drug discrimination. Rats were trained to discriminate 1.5 mg/kg MDMA from its…

Effect of repeated administrations upon cathinone discrimination and conditioned place preference.

1. Eight male rats were trained to discriminate the interoceptive cues produced by 0.8 mg/kg l-cathinone in a two-lever, food-motivated operant task and they were, subsequently, tested for preference to cathinone in a conditioned place preference…

Tags: 1991, Alkaloids/*pharmacology, Animals, Conditioning, Department of Anatomy & Neurobiology, Discrimination (Psychology)/*drug effects, Drug Tolerance/physiology, General pharmacology, Inbred Strains, Male, McBurney D, NEOMED College of Medicine, Operant/*drug effects, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure.

It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This…

Tags: 1993, Animals, Brain research bulletin, Calcagnetti D J, Classical, Cocaine/*pharmacology, Conditioning, Extinction, Habituation, Inbred Strains, Male, Operant/*drug effects, Psychological/*drug effects, Psychophysiologic/drug effects, Rats, Reward, Schechter M D

Functional consequences of fenfluramine neurotoxicity.

Male Sprague-Dawley rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-motivated (fixed-ratio 10 schedule) two-lever operant task. Once trained, doses of 0.5,…

Tags: 1990, Animals, Conditioning, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Fenfluramine/*toxicity, Inbred Strains, Male, Nervous System Diseases/*chemically induced/psychology, Operant/drug effects, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D

Isradipine produces neither a conditioned place preference nor aversion.

Isradipine (ISR) has been reported to block cocaine-induced conditioned place preference. Using this procedure, the pairing of this L-type calcium blocker, at doses of 2.5, 5.0 and 10 mg/kg, with a preferred (cue-distinct) environment was…

Tags: 1994, Animals, Calcagnetti D J, Cocaine/*pharmacology, Conditioning, Isradipine/administration & dosage/*pharmacology, Life sciences, Male, Operant/*drug effects, Rats, Schechter M D, Sprague-Dawley

Lack of generalization of nisoxetine with amphetamine in the rat.

Rats were trained to discriminate between the stimulus properties of intraperitoneally administered d-amphetamine (0.8 mg/kg) and its vehicle in a two-lever, food-motivated operant task. Once trained, doses of the norepinephrine reuptake inhibiting…

Tags: *Discrimination (Psychology), 1988, Animals, Boja J W, Conditioning, Dextroamphetamine/*pharmacology, Dose-Response Relationship, Drug, Fluoxetine/*analogs & derivatives/pharmacology, Inbred Strains, Male, Norepinephrine/antagonists & inhibitors, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Reference Values, Schechter M D

Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine.

This study investigated the ability of bilateral excitotoxic lesions of the basolateral amygdala (BLA) to disrupt cocaine self-administration, responding during extinction sessions, and stimulus cued recovery of extinguished responding in rats. BLA…

LSD produces conditioned place preference in male but not female fawn hooded rats.

Male and female Fawn Hooded rats were examined for conditioned place preference (CPP) or aversion (CPA) to lysergic acid diethylamide (LSD). Using a biased design, experimental animals were trained with LSD (0.2 mg/kg, I.P.) administered in…

Tags: *Cues, *Sex Characteristics, 1998, Analysis of Variance, Animals, Choice Behavior/*drug effects, Conditioning, Female, Humans, Inbred Strains, Lysergic Acid Diethylamide/*pharmacology, Male, Meehan S M, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion…

Nicotine place preference using the biased method of conditioning.

1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three…

Tags: 1994, Animals, Calcagnetti D J, Conditioning, Cues, Injections, Male, Motor Activity/drug effects, Nicotine/*pharmacology, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Subcutaneous

Olanzapine attenuates the reinforcing effects of cocaine.

The possibility that the atypical neuroleptic olanzapine can antagonize the ability of cocaine to produce both conditioned place preference and self-administration in rats was investigated. Pre-treatment with olanzapine (3.0, 4.5 mg/kg, but not 1.5…

Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference.

The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p…

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

Reducing the time needed to conduct conditioned place preference testing.

The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the…

Tags: 1992, Alkaloids/pharmacology, Animals, Calcagnetti D J, Choice Behavior/*drug effects, Conditioning, Experimental/instrumentation/methods, Inbred Strains, Male, Motor Activity/drug effects, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Psychology, Psychotropic Drugs/pharmacology, Rats, Schechter M D

Scopolamine-physostigmine combination does not substitute for nicotine.

1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be…

Temporal parameters of cathinone, amphetamine and cocaine.

Rats were trained to discriminate intraperitoneally administered 0.8 mg/kg

Tags: 1989, Alkaloids/*pharmacology, Amphetamines/*pharmacology, Animals, Cocaine/*pharmacology, Conditioning, Discrimination (Psychology)/*drug effects, Inbred Strains, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Task Performance and Analysis, Time Factors

The effect of rubrospinal tractotomy on a conditioned limb response in the cat.

Five cats were trained to perform a forelimb conditioned response to a paired tone CS/shock UCS. Rubrospinal tract section ipsilateral to the trained limb was carried out following criterion CR performance. Lesion sites were identified histologically…

Tags: 1999, Animal/physiology, Animals, Behavior, Behavioural brain research, Cats, Conditioning, Forelimb/innervation/*physiology, Functional Laterality/physiology, Neural Pathways/anatomy & histology/physiology, Operant/*physiology, Red Nucleus/anatomy & histology/*physiology, Spinal Cord/anatomy & histology/*physiology, Stereotaxic Techniques, Voneida T J

The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue.

The drug discrimination paradigm was used to evaluate the contribution of dopamine or serotonin receptors in the mediation of the stimulus properties of ethanol. Briefly, rats were trained to discriminate between ethanol (600 mg/kg, IP) and water…

Tags: 1988, Animals, Conditioning, Cues, Discrimination (Psychology)/*physiology, Dopamine/drug effects/*physiology, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Male, Operant/physiology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/drug effects/*physiology, Signs S A

Browse Items (26 total)