The role of TRPV4 channels in ocular function and pathologies.
Glaucoma; TRPV4; Angiogenesis; Retina; Calcium channel; Cornea; Diabetic retinopathy; Lens; Osmolarity
Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. TRPV4 is widely expressed throughout the body, and plays an important role in normal physiological function, as well as different pathologies, however, its role in the eye is not well known. In the eye, TRPV4 is expressed in various tissues, such as the retina, corneal epithelium, ciliary body, and the lens. In this review, we provide an overview on TRPV4 structure, activation, mutations, and summarize the current knowledge of TRPV4 function and signaling mechanisms in various locations throughout the eye, as well as its role in ocular diseases, such as glaucoma and diabetic retinopathy. Based on the available data, we highlight the therapeutic potential of TRPV4 as well as the shortcomings of current research. Finally, we provide future perspectives on the implications of targeting TRPV4 to treat various ocular pathologies. (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Guarino BD;Paruchuri S;Thodeti CK
Experimental Eye Research
2020
2020-09-29
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.1016/j.exer.2020.108257" target="_blank" rel="noreferrer noopener">10.1016/j.exer.2020.108257</a>
Copper Deposition In A Variant Of Multiple Myeloma: Pathologic Changes In The Cornea And The Lens Capsule
central defect; copper deposition; deposition; Descemet membrane; descemets membrane; hypercupremia; immunoglobulin; leukomas; monoclonal gammopathy; multiple myeloma; ocular; Ophthalmology; true exfoliation; wilsons-disease
Edward D P; Patil A J; Sugar J; Parikh M
Cornea
2011
2011-03
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/ICO.0b013e3181ee67fd" target="_blank" rel="noreferrer noopener">10.1097/ICO.0b013e3181ee67fd</a>