1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.ntt.2018.05.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2018.05.004</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 66-71 Volume 68 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters Publisher An entity responsible for making the resource available Neurotoxicology and Teratology Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-07 Subject The topic of the resource C. elegans; Toxicology; Neurosciences & Neurology; parkinsons-disease; exposure; degeneration; costa-rica; pregnant-women; antidepressant; caenorhabditis-elegans; infants environmental-health; leads; Mancozeb; Mancozeb; Manzate; Mn/Zn ethylene-bis-dithiocarbamate; Neurotransmitter transporters; Neurotransmitters Creator An entity primarily responsible for making the resource Montgomery K; Corona C; Frye R; Barnett R; Bailey A; Fitsanakis V A Description An account of the resource Mancozeb (MZ), an organic-metal fungicide used predominantly on vegetables and fruits, has been linked to neurodegeneration and behavioral disruptions in a variety of organisms, including humans. Both gamma-aminobutyric acid and dopamine neurons appear to be more vulnerable to MZ exposure than other neuronal populations. Based on these observations, we hypothesized that MZ may be differentially transported into these cells through their presynaptic neurotransmitter transporters. To test this, we pretreated Caenorhabditis elegans with transporter antagonists followed by exposure to various concentrations of MZ. Potential neuroprotection was monitored via green fluorescence associated with various neuron populations in transgenic worm strains. Neurodegeneration associated with subacute MZ treatment (30 min) was not altered by transporter antagonist pretreatment. On the other hand, pretreatment with a dopamine transporter antagonist (GBR12909) appeared to protect dopaminergic neurons from chronic (24 h) MZ treatment. These results are consistent with other reports that dopamine transporter levels or activity may modulate toxicity for neurotoxicants. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.ntt.2018.05.004" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2018.05.004</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 2018 antidepressant Bailey A Barnett R C. elegans caenorhabditis-elegans Corona C costa-rica degeneration Department of Pharmaceutical Sciences exposure Fitsanakis V A Frye R infants environmental-health Journal Article or Conference Abstract Publication leads Mancozeb Manzate Mn/Zn ethylene-bis-dithiocarbamate Montgomery K NEOMED College of Pharmacy Neurosciences & Neurology Neurotoxicology and teratology Neurotransmitter transporters NEUROTRANSMITTERS parkinsons-disease pregnant-women Toxicology