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Text
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URL Address
<a href="http://doi.org/10.1152/ajpheart.1991.260.2.H453" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1991.260.2.H453</a>
Pages
H453–458
Issue
2
Volume
260
Dublin Core
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Title
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Sexual dimorphism in vasopressin-induced contraction of rat aorta.
Publisher
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The American journal of physiology
Date
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1991
1991-02
Subject
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*Sex Characteristics; *Vasoconstriction; Animals; Aorta/*drug effects; Arginine Vasopressin/*pharmacology; Dose-Response Relationship; Drug; Female; Male; Osmolar Concentration; Phenylephrine/pharmacology; Rats
Creator
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Stallone J N; Crofton J T; Share L
Description
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Previously, we reported that, in the rat, pressor responsiveness to vasopressin (VP) is higher in males than in females during most phases of the estrous cycle. To explore the role of the vasculature in this phenomenon, we examined vascular reactivity to VP in thoracic aortas of male rats and female rats during each phase of the estrous cycle. Aortic rings were prepared from age-matched male and female Sprague-Dawley rats and mounted for isometric tension recording. Maximal response of female aortas to VP (4,246 +/- 163 mg/mg ring dry wt) was more than twice (P less than 0.001) that of male aortas (1,877 +/- 215 mg/mg ring wt). Sensitivity of female aortas to VP was substantially higher (P less than 0.001) than that of male aortas (EC50: 10.9 +/- 0.7 vs. 19.0 +/- 1.6 nM, respectively). Maximal rate of tension development (dT/dtmax) during contraction with VP was nearly twofold higher (P less than 0.01) in female aortas (536 +/- 23 mg/min) than in male aortas (300 +/- 19 mg/min). Maximal response, sensitivity, and dT/dtmax of female aortas did not vary significantly during the estrous cycle. Maximal response of female aortas to phenylephrine (PE; 1,251 +/- 93 mg/mg ring wt) was half that (P less than 0.001) of male aortas (2,546 +/- 194 mg/mg ring wt); sensitivity to PE did not differ significantly (EC50: 0.33 +/- 0.02 vs. 0.38 +/- 0.06 microM, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
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<a href="http://doi.org/10.1152/ajpheart.1991.260.2.H453" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1991.260.2.H453</a>
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*Sex Characteristics
*Vasoconstriction
1991
Animals
Aorta/*drug effects
Arginine Vasopressin/*pharmacology
Crofton J T
Dose-Response Relationship
Drug
Female
Male
Osmolar Concentration
Phenylephrine/pharmacology
Rats
Share L
Stallone J N
The American journal of physiology