Browse Items (87 total)
- Tags: Cultured
PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.
Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X
MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western
Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.
Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1
Interleukin-1beta induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA Chondrocytes.
Tags: *Protein Biosynthesis, 2016, Ansari Mohammad Y, Cells, Chondrocytes/drug effects/metabolism/pathology, Cultured, Cyclooxygenase 2/*genetics, Department of Anatomy & Neurobiology, Dinoprostone/genetics, Fluorescence, Gene Expression Regulation, Haqqi Tariq M, Humans, Immunoprecipitation, In Situ Hybridization, Interleukin-1beta/administration & dosage/*genetics, Messenger/genetics, NEOMED College of Medicine, Nitric Oxide/metabolism, Osteoarthritis/drug therapy/*genetics/pathology, RNA, Scientific reports
Methods and insights from the characterization of osteoprogenitor cells of bats (Mammalia: Chiroptera).
Tags: 2016, Animals, Ball H C, Bone Marrow Cells/cytology, Cell Differentiation/genetics, Cell Proliferation, Cells, Cellular Reprogramming, Chiroptera, Cooper L N, Core Binding Factor Alpha 1 Subunit/genetics/metabolism, Cultured, Department of Anatomy & Neurobiology, Inbred C57BL, Mbimba T, Mice, Moussa F M, NEOMED College of Medicine, Orman R, Osteoblasts/cytology/*metabolism, Osteocalcin/genetics/metabolism, Osteogenesis/*genetics, Real-Time Polymerase Chain Reaction, Safadi F F, Stem cell research, Stem Cells/*cytology/metabolism, Transcription Factors/genetics/metabolism
Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
Tags: 2012, Adapala Ravi K, American journal of physiology. Cell physiology, Animals, Cell Movement/physiology, Cells, Chavez Ronaldo J, Cuadra Rene H, Cultured, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/physiology, Haney Rebecca M, Humans, Inbred C57BL, Janus Kinase 2/*biosynthesis, Knockout, Leptin/*physiology, Male, MAP Kinase Signaling System/*physiology, Mice, Muscle, Myocytes, NEOMED College of Medicine, Raman Priya, Smooth, Smooth Muscle/enzymology/metabolism, Thodeti Charles K, Thrombospondin 1/*biosynthesis, Up-Regulation/*physiology, Vascular/enzymology/*metabolism
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Tags: 2001, Animals, Binding Sites, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/drug effects/*genetics/metabolism, Cricetinae, Cultured, Department of Integrative Medical Sciences, gene, Gene Expression Regulation/drug effects, Genetic, Humans, Hydroxycholesterols, Kimmel R, Liver/physiology, Lovastatin/pharmacology, Luciferases/genetics/metabolism, Mevalonic Acid/metabolism/pharmacology, NEOMED College of Medicine, Nicotinic Acids/pharmacology, Organ Specificity, Polyisoprenyl Phosphates/pharmacology, Rats, Receptors, Response Elements, Retinoic Acid/genetics/metabolism, Retinoid X Receptors, Species Specificity, Steroid/genetics/*metabolism, Stroup D, Tetrahydronaphthalenes/pharmacology, Transcription, Transcription Factors/genetics/metabolism, Transfection
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *Transcription, 2000, Animals, Bile Acids and Salts/*pharmacology, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, DNA-Binding Proteins/*physiology, Genetic, Humans, Kimmel R, NEOMED College of Medicine, Promoter Regions, Receptors, Repressor Proteins/*physiology, Response Elements, Retinoic Acid/genetics, Retinoid X Receptors, Stroup D, The Journal of biological chemistry, Transcription Factors/genetics/*physiology, Tumor Cells, Weinberger C
Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives.
Tags: 2000, Antiviral Agents/*pharmacology, Antiviral research, Callahan M, Craigo J, Cultured, DeLucia A L, Department of Integrative Medical Sciences, Female, Gene Expression Regulation, Genetic/drug effects, HIV Long Terminal Repeat/drug effects, Huang R C, Humans, Lignans/chemistry/pharmacology, Masoprocol/*analogs & derivatives/*pharmacology, NEOMED College of Medicine, Papillomaviridae/*genetics, Promoter Regions, Simian virus 40/genetics, Tumor Cells, Viral/*drug effects
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.
Tags: 1994, Animals, Bile Acids and Salts/*pharmacology, Biochemical and biophysical research communications, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Crestani M, Cultured, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Genetic, Genetic/genetics, Humans, Karam W G, Luciferases/biosynthesis/genetics, Messenger/*biosynthesis, NEOMED College of Medicine, Promoter Regions, Rats, Recombinant Fusion Proteins/biosynthesis, RNA, Steroids/*pharmacology, Thyroid Hormones/*pharmacology, Transcription, Transfection
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells
Pertubation of beta1 integrin function using anti-sense or function-blocking antibodies on corneal cells grown on fibronectin and tenascin.
Tags: 2002, Animals, Antisense/*pharmacology, Bhattacharya Raka, Cattle, Cell Adhesion, Cell biology international, Cell Culture Techniques/*methods, Cells, Chick Embryo, Chickens, Complementary/metabolism, Cornea/*cytology, Cultured, DNA, Doane Kathleen J, Dose-Response Relationship, Drug, Fibronectins/*metabolism, Fluorescence, Immunohistochemistry, Integrin beta1/*metabolism/*physiology, Integrins/metabolism, Marchant Jeff, Microscopy, Oligonucleotides, Protein Binding, Retroviridae/genetics, Tenascin/*metabolism
Basic transcription element binding protein (BTEB) transactivates the cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, 1998, Animals, Bile Acids and Salts/genetics, Binding Sites/genetics, Biochemical and biophysical research communications, Carcinoma, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Complementary/analysis, Cultured, Department of Integrative Medical Sciences, DNA, DNA-Binding Proteins/metabolism/*physiology, Electrophoresis, Enzyme Activation/genetics, Foti D, Genetic, Hepatocellular, Humans, Kruppel-Like Transcription Factors, Liver/enzymology, NEOMED College of Medicine, Podophyllin/analogs & derivatives/metabolism, Podophyllotoxin/analogs & derivatives, Polyacrylamide Gel, Promoter Regions, Protein Binding/genetics, Rats, Stroup D, Transcription Factors/metabolism/*physiology, Tumor Cells
Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Tags: 2015, American journal of physiology. Cell physiology, Aorta/drug effects/metabolism, Cell Proliferation/*drug effects/genetics, Cells, Chavez Ronaldo J, Chromium/*pharmacology, Cultured, Department of Integrative Medical Sciences, Fructosephosphates/metabolism, Ganguly Rituparna, Genetic/drug effects/genetics, Glucose/*metabolism, Glutamine/genetics, Glycosylation/drug effects, Hexosamines/metabolism, Humans, Hyperglycemia/metabolism, Muscle, Myocytes, N-Acetylglucosaminyltransferases/genetics, NEOMED College of Medicine, O-glycosylation, Promoter Regions, Raman Priya, reactive oxygen species, Reactive Oxygen Species/metabolism, Sahu Soumyadip, Signal Transduction/*drug effects/genetics, Smooth, Smooth Muscle/*drug effects/metabolism, Thrombospondin 1/*antagonists & inhibitors/genetics, thrombospondin-1, Transcription, trivalent chromium, vascular smooth muscle cells, Vascular/*drug effects/metabolism
Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro.
Tags: *Comovirus, 2016, Aorta/*metabolism, Atherosclerosis/*drug therapy/therapy, Azo Compounds/chemistry, Cell Proliferation, Cells, Chlorides/*chemistry, Chromium Compounds/*chemistry, Cultured, Cytokines/metabolism, Czech Tori, Department of Integrative Medical Sciences, Drug Delivery Systems, Electron, Fluorescence, Ganguly Rituparna, Glucose/chemistry, Humans, Hyperglycemia/*metabolism, Lipids/chemistry, Microscopy, Myer Ashley B, Myocytes, Nanoparticles/chemistry, Nanoscale, NEOMED College of Medicine, NF-kappa B/metabolism, Proliferating Cell Nuclear Antigen/chemistry, Raman Priya, Sahu Soumyadip, Smooth Muscle/*metabolism, Spectrophotometry, Steinmetz Nicole F, Transforming Growth Factor beta/metabolism, Transmission, Ultraviolet, Wen Amy M
Scanning electron microscopy and transmission electron microscopy aspects of synergistic antitumor activity of vitamin C - vitamin K3 combinations against human prostatic carcinoma cells.
Tags: 1995, Antineoplastic Agents/*pharmacology, Ascorbic Acid/*pharmacology, Carcinoma/*drug therapy/pathology, Cell Membrane/drug effects/ultrastructure, Coloring Agents, Combination, Cultured, Cytoskeleton/drug effects/ultrastructure, Drug Synergism, Drug Therapy, Electron, Giammar D, Gilloteaux J, Humans, Jamison J M, Male, Microscopy, Mitochondria/drug effects/ultrastructure, Prostatic Neoplasms/*drug therapy/pathology, Scanning, Scanning microscopy, Summers J L, Tetrazolium Salts, Thiazoles, Tumor Cells, Venugopal M, Vitamin K/*pharmacology
Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Tags: *Airway Remodeling, *fibronectin, *myofibroblasts, *PAI-1, *PI3K, *TGF-beta1, 2017, Adult, Al-Azzam Nosayba, Animals, Asthma/etiology/genetics/*metabolism/pathology, Cells, Cultured, Department of Integrative Medical Sciences, Dermatophagoides farinae/immunology, Duah Ernest, Extracellular Matrix/*metabolism/pathology, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Fibroblasts/metabolism, Fibronectins/*metabolism, Gombedza Farai, Hexter Madison, Humans, Inbred C57BL, Kondeti Vinay, Koppes Stephanie, Male, Mice, NEOMED College of Medicine, Paruchuri Sailaja, Patil Prachi, Phillips Daniel, Phosphatidylinositol 3-Kinases/metabolism, Plasminogen Activator Inhibitor 1/metabolism, Thodeti Charles K, Transforming Growth Factor beta/metabolism, TRPV Cation Channels/genetics/*metabolism
Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.
Tags: *Intracellular Signaling Peptides and Proteins, 2001, Amyloid beta-Peptides/*biosynthesis/metabolism, Apoptosis Regulatory Proteins, Apoptosis/*physiology, Carrier Proteins/genetics/*physiology, Caspases/*metabolism, Chang X, Cultured, Du H, Enzyme Activation, Guo Q, Humans, Kinetics, Leucine Zippers, Neuroblastoma, Peptide Fragments/*biosynthesis/metabolism, Recombinant Proteins/metabolism, The Journal of biological chemistry, Time Factors, Transfection, Tumor Cells, Xie J
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: 2009, Base Sequence, Calcitriol/drug effects/genetics/*physiology, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cultured, Department of Integrative Medical Sciences, DNA Primers, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Gene Knockdown Techniques, Genetic/*physiology, Han Shuxin, Hepatocytes/*drug effects/enzymology, Humans, Immunoprecipitation, Lithocholic Acid/pharmacology, Messenger/genetics, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, RNA, Small Interfering, Transcription, Tumor, Two-Hybrid System Techniques
Tags: *Carbon Dioxide, *Helium, *Neoplasm Transplantation, *Nitrous Oxide, *Peritoneal Cavity, *Pneumoperitoneum, 2002, Adenocarcinoma/pathology, American journal of obstetrics and gynecology, Animals, Artificial, Cultured, Haller Nairmeen Awad, Holda Sheri, Hopkins Michael P, Inbred F344, Injections, Intraperitoneal, Peritoneal Neoplasms/pathology, Rats, Tumor Cells, von Gruenigen Vivian
Tags: 1998, Animals, Antibodies, Apoptosis/*drug effects/physiology, Cell Nucleus/drug effects/metabolism, Cell Survival/drug effects/physiology, Cells, Chick Embryo, Collagen/*pharmacology, Cornea/drug effects/embryology/ultrastructure, Culture Media/chemistry/pharmacology, Cultured, DNA Fragmentation/drug effects, Doane K J, Experimental cell research, Extracellular Matrix/physiology, Eye/drug effects/embryology/ultrastructure, Fibroblasts/drug effects/metabolism/ultrastructure, Genetic Techniques, Howell S J, Integrins/immunology, Monoclonal/*drug effects/pharmacology
Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.
Tags: 1998, alpha-Macroglobulins/administration & dosage/*pharmacology, Animals, Cells, Choline O-Acetyltransferase/*antagonists & inhibitors, Corpus Striatum/drug effects/*enzymology/metabolism, Cultured, Dluzen D E, Dopamine Antagonists/*pharmacology, Dopamine/analysis/*metabolism, Enzyme Activation/drug effects, Hu Y Q, Injections, Intraventricular, Journal of neuroscience research, Koo P H, Liebl D J, Male, Neurons/drug effects/*enzymology/metabolism, Rats, Serotonin/pharmacology, Sprague-Dawley, Stereotaxic Techniques
Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells.
Tags: *Fibrin Tissue Adhesive, *Osteogenesis, 2000, Animals, Bone and Bones/chemistry/cytology/diagnostic imaging, Cattle, Cells, Cultured, Experimental, Gerstenfeld L C, Gotoh Y, Implants, Injections, Isogai N, Landis W J, Mice, Mori R, Non-programmatic, Nude, Osteopontin, Periosteum/*cytology, Plastic and reconstructive surgery, Radiography, Sialoglycoproteins/analysis, Upton J, Vacanti J P
Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.
Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya
Cell cycle arrest and autoschizis in a human bladder carcinoma cell line following Vitamin C and Vitamin K3 treatment.
Tags: 2004, Antioxidants/*pharmacology, Ascorbic Acid/*pharmacology, Biochemical pharmacology, Calcium/metabolism, Cell Cycle/*drug effects, Cultured, DNA, Flow Cytometry, Gilloteaux Jacques, Humans, Hydrogen Peroxide/metabolism, Jamison James M, Male, Nassiri M Reza, Neal Deborah R, Neoplasm/drug effects, Sulfhydryl Compounds/metabolism, Summers Jack L, Tumor Cells, Urinary Bladder Neoplasms/pathology, Venugopal Meenakshi, Vitamin K 3/*pharmacology
Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes.
Tags: 2018, Adult, Aged, Animal Studies, Animals, Apolipoprotein A-I/blood/*metabolism, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Bena James, Biochemical Phenomena, Case Control Studies, Case-Control Studies, Cells, Comparative Studies, Cultured, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Dyslipidemias/complications/diet therapy/*metabolism, Evaluation Research, Female, Funding Source, Glycosylation, Golizeh Makan, HDL – Metabolism, HDL/*metabolism, Human, Humans, Hyperglycemia – Complications, Hyperglycemia – Diet Therapy, Hyperglycemia – Metabolism, Hyperglycemia/complications/diet therapy/*metabolism, Hyperlipidemia – Complications, Hyperlipidemia – Diet Therapy, Hyperlipidemia – Metabolism, Ilchenko Serguei, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Lipoproteins, Male, Mice, Middle Age, Middle Aged, Multicenter Studies, NEOMED College of Pharmacy, Osme Abdullah, Previs Stephen F, Protein Stability, Smith Jonathan D, The Journal of clinical endocrinology and metabolism, Type 2 – Complications, Type 2 – Diet Therapy, Type 2 – Metabolism, Type 2/complications/*diet therapy/metabolism, Validation Studies, Wang Shuhui
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1beta stimulated osteoarthritis chondrocytes.
Tags: 2017, Ahmad Imran, Ansari Mohammad Y, Apoptosis/drug effects, Binding Sites, Cells, Chemico-biological interactions, Chondrocytes/cytology/*drug effects/metabolism, Chondroprotective effects, Cultured, Denaturation, Department of Anatomy & Neurobiology, DNA binding, DNA/chemistry/*metabolism, Flavanones/chemistry/metabolism/*pharmacology, Flavonoids/chemistry/pharmacology, Fluorescence Resonance Energy Transfer, Haqqi Tariq M, Humans, Intercalating Agents/chemistry/metabolism/*pharmacology, Interleukin-1beta/*pharmacology, Khan Nazir M, Molecular Docking Simulation, NEOMED College of Medicine, Nucleic Acid Conformation, Osteoarthritis, Osteoarthritis/metabolism/pathology, Protective Agents/chemistry/metabolism/*pharmacology, Reactive Oxygen Species/metabolism, Up-Regulation/drug effects, Wogonin
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.
Tags: *Apoptosis, *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, 2018, 70-kDa/metabolism, 90-kDa/metabolism, Ahmad Imran, Carboxylic Ester Hydrolases/metabolism, Caspases/metabolism, Cells, Chondrocytes/*physiology, Cultured, ets-Domain Protein Elk-1/metabolism, Free radical biology & medicine, Haqqi Tariq M, Humans, Interleukin-1beta/immunology, Khan Nazir M, MAP Kinase Signaling System, NF-E2-Related Factor 2/genetics/*metabolism, Osteoarthritis/*metabolism, Oxidative Stress, Ribosomal Protein S6 Kinases, Up-Regulation
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes.
Tags: 2017, Ansari Mohammad Y, Cells, Chemical Fractionation/methods, Chondrocytes/*drug effects/metabolism, Cultured, Cyclooxygenase 2/genetics/metabolism, Department of Anatomy & Neurobiology, Flavanones/*pharmacology, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Humans, Interleukin-1beta/pharmacology, Interleukin-6/genetics/metabolism, Khan Nazir M, NEOMED College of Medicine, Osteoarthritis/pathology, Plant Extracts/*pharmacology, Plant Roots/*chemistry, Protective Agents/pharmacology, Reactive Oxygen Species/metabolism, Scientific reports, Scutellaria baicalensis/*chemistry, Transcription Factor AP-1/genetics/*metabolism
Tags: 2004, Aging/*metabolism, Animals, Articular/cytology/*metabolism, Carrier Proteins/genetics/*metabolism, Cartilage, Cell Division/physiology, Cells, Chondrocytes/cytology/*metabolism, Cultured, Department of Anatomy & Neurobiology, DNA-Binding Proteins, Gene Expression Regulation, Growth Plate/*metabolism, Horton Walter E Jr, Inbred C57BL, Kinkel Mary D, McBurney Denise, Mice, NEOMED College of Medicine, Nugent Ashleigh, Proto-Oncogene Proteins c-bcl-2/*metabolism, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, Tissue Distribution, Transcription Factors, Yagi Rieko
Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells.
Tags: 1996, Biochemical and biophysical research communications, Cell Line, Cinnamates/*pharmacology, Cultured, G2 Phase/*drug effects, Humans, Jamison J M, Koch J A, Lymphocytes/cytology/*drug effects, Mitosis/*drug effects, Monocytes/cytology/drug effects, Rosenthal K S, Summers J L, Transformed, Tumor Cells
Inhibition of nerve growth factor-stimulated neurite outgrowth by methylamine-modified alpha 2-macroglobulin.
Tags: 1992, alpha-Macroglobulins/metabolism/*pharmacology, Animals, Cells, Chick Embryo, Cultured, Drug Interactions, Female, Ganglia, Humans, Journal of neuroscience research, Koo P H, Liebl D J, Male, Methylamines/*pharmacology, Mice, Nerve Growth Factors/antagonists & inhibitors/metabolism/*pharmacology, Neurites/drug effects/*physiology/ultrastructure, Neurons/cytology/physiology, Placenta, Pregnancy, Spinal/physiology, Submandibular Gland
Tags: 1993, Antiviral Agents/*pharmacology, Carmine/*analogs & derivatives/pharmacokinetics/pharmacology, Cell biology international, Cell Nucleolus/metabolism, Cells, Chromatin/metabolism, Cultured, Doxorubicin/pharmacology, Drug Combinations, Drug Synergism, Fluorescence, Gilloteaux J, Humans, Interferon-beta/biosynthesis/physiology, Jamison J M, Krabill K, Microscopy, Phase-Contrast, Poly A-U/*pharmacokinetics/*pharmacology, Summers J L, Vesicular stomatitis Indiana virus/drug effects/growth & development, Viral Plaque Assay
Enhanced antiviral activity and altered subcellular distribution of magnesium/poly r(A-U) combinations.
Tags: 1992, Antiviral Agents/*pharmacology, Cell biology international reports, Cells, Chromatin/drug effects, Cultured, Ethidium/*pharmacology, Gilloteaux J, Humans, Jamison J M, Krabill K, Magnesium/metabolism/*pharmacology, Nucleolus Organizer Region/*drug effects, Poly A-U/*pharmacology, Summers J L, Vesicular stomatitis Indiana virus/drug effects
Tags: *RNA Interference, 2008, Animals, Biological Transport/drug effects, Cells, Cultured, Cystic Fibrosis Transmembrane Conductance Regulator/*genetics/*metabolism, Epithelial Sodium Channels/genetics/metabolism, Female, Folkesson Hans G, Gene Expression Regulation/drug effects, Koshy Shyny, Li Tianbo, Lung/cytology/drug effects/*metabolism, Messenger/metabolism, Newborn, Pregnancy, Rats, Respiratory Mucosa/cytology/drug effects/metabolism, Respiratory research, RNA, Small Interfering/*pharmacology, Sprague-Dawley, Water/*metabolism
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao