Browse Items (87 total)
- Tags: Cultured
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1beta stimulated osteoarthritis chondrocytes.
Tags: 2017, Ahmad Imran, Ansari Mohammad Y, Apoptosis/drug effects, Binding Sites, Cells, Chemico-biological interactions, Chondrocytes/cytology/*drug effects/metabolism, Chondroprotective effects, Cultured, Denaturation, Department of Anatomy & Neurobiology, DNA binding, DNA/chemistry/*metabolism, Flavanones/chemistry/metabolism/*pharmacology, Flavonoids/chemistry/pharmacology, Fluorescence Resonance Energy Transfer, Haqqi Tariq M, Humans, Intercalating Agents/chemistry/metabolism/*pharmacology, Interleukin-1beta/*pharmacology, Khan Nazir M, Molecular Docking Simulation, NEOMED College of Medicine, Nucleic Acid Conformation, Osteoarthritis, Osteoarthritis/metabolism/pathology, Protective Agents/chemistry/metabolism/*pharmacology, Reactive Oxygen Species/metabolism, Up-Regulation/drug effects, Wogonin
Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
Tags: 2012, Adapala Ravi K, American journal of physiology. Cell physiology, Animals, Cell Movement/physiology, Cells, Chavez Ronaldo J, Cuadra Rene H, Cultured, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/physiology, Haney Rebecca M, Humans, Inbred C57BL, Janus Kinase 2/*biosynthesis, Knockout, Leptin/*physiology, Male, MAP Kinase Signaling System/*physiology, Mice, Muscle, Myocytes, NEOMED College of Medicine, Raman Priya, Smooth, Smooth Muscle/enzymology/metabolism, Thodeti Charles K, Thrombospondin 1/*biosynthesis, Up-Regulation/*physiology, Vascular/enzymology/*metabolism
Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling.
Tags: 2006, American journal of physiology. Heart and circulatory physiology, Angiotensin II/pharmacology, Animals, Cell Differentiation/*drug effects, Cell Proliferation/drug effects, Cells, Collagen Type I/physiology, Collagen Type III/physiology, Collagen Type VI/*physiology, Coronary Vessels/pathology, Cultured, Department of Integrative Medical Sciences, Doane Kathleen J, Extracellular Matrix/*physiology, Fibroblasts/*cytology, Fibrosis/etiology, Folkesson Hans G, Horne Walter I, Ligation, Male, Maron Michael B, Mase Sharon E, Meszaros J Gary, Myocardial Infarction/physiopathology, Naugle Jennifer E, NEOMED College of Medicine, Olson Erik R, Pilati Charles F, Rats, Sprague-Dawley, Ventricular Remodeling/*physiology, Zhang Xiaojin
Type VI collagen increases cell survival and prevents anti-beta 1 integrin-mediated apoptosis.
Tags: 1998, Animals, Antibodies, Apoptosis/*drug effects/physiology, Cell Nucleus/drug effects/metabolism, Cell Survival/drug effects/physiology, Cells, Chick Embryo, Collagen/*pharmacology, Cornea/drug effects/embryology/ultrastructure, Culture Media/chemistry/pharmacology, Cultured, DNA Fragmentation/drug effects, Doane K J, Experimental cell research, Extracellular Matrix/physiology, Eye/drug effects/embryology/ultrastructure, Fibroblasts/drug effects/metabolism/ultrastructure, Genetic Techniques, Howell S J, Integrins/immunology, Monoclonal/*drug effects/pharmacology
TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.
Tags: 13-dienoic Acid/*antagonists & inhibitors/pharmacology, 15-Hydroxy-11 alpha, 2017, 9 alpha-(epoxymethano)prosta-5, Andrei Spencer R, Animals, Bratz Ian N, Cells, Coronary Vessels/*drug effects/metabolism, Cultured, Damron Derek S, Endothelial Cells/drug effects/metabolism, Inbred C57BL, Knockout, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism, Male, Mice, Microvessels/drug effects/metabolism, Nitric Oxide Synthase Type III/metabolism, PloS one, Propofol/*pharmacology, Showalter Loral E, Sinha Sayantani, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*metabolism, TRPA1 Cation Channel, TRPV Cation Channels/genetics/*metabolism, Vasoconstrictor Agents/antagonists & inhibitors/pharmacology, Vasodilation/drug effects/physiology, Vasodilator Agents/*pharmacology
Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Tags: 2015, American journal of physiology. Cell physiology, Aorta/drug effects/metabolism, Cell Proliferation/*drug effects/genetics, Cells, Chavez Ronaldo J, Chromium/*pharmacology, Cultured, Department of Integrative Medical Sciences, Fructosephosphates/metabolism, Ganguly Rituparna, Genetic/drug effects/genetics, Glucose/*metabolism, Glutamine/genetics, Glycosylation/drug effects, Hexosamines/metabolism, Humans, Hyperglycemia/metabolism, Muscle, Myocytes, N-Acetylglucosaminyltransferases/genetics, NEOMED College of Medicine, O-glycosylation, Promoter Regions, Raman Priya, reactive oxygen species, Reactive Oxygen Species/metabolism, Sahu Soumyadip, Signal Transduction/*drug effects/genetics, Smooth, Smooth Muscle/*drug effects/metabolism, Thrombospondin 1/*antagonists & inhibitors/genetics, thrombospondin-1, Transcription, trivalent chromium, vascular smooth muscle cells, Vascular/*drug effects/metabolism
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
Tags: *DNA-Binding Proteins, *Transcription, 2001, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics, Cytoplasmic and Nuclear/physiology, Department of Integrative Medical Sciences, Genetic, Genetic/physiology, Hepatocyte Nuclear Factor 4, Humans, Molecular Sequence Data, NEOMED College of Medicine, Phosphoproteins/*physiology, Promoter Regions, Receptors, Repressor Proteins/*pharmacology, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Transcription Factors/*physiology, Tumor Cells, Zhang M
Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1.
Tags: 2001, Base Sequence, Binding, Binding Sites/genetics, Cell Line, Chiang J Y, Competitive, CpG Islands/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA/genetics, Enzymologic, gene, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics/metabolism, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid/genetics, Protein Binding, Recombinant Fusion Proteins/genetics/metabolism, Regulatory Sequences, Sequence Deletion, Site-Directed, Sp1 Transcription Factor/metabolism/*physiology, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Tumor Cells, Wu Z
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
Thrombospondin-4 mediates TGF-beta-induced angiogenesis.
Tags: 2017, Angiogenesis Inducing Agents/*metabolism, Animals, Cell Movement/drug effects, Cell Proliferation/drug effects, Cells, Chick Embryo, Cultured, Department of Integrative Medical Sciences, Endothelium, Female, Gene Expression Regulation/drug effects, Habib N, Humans, Inbred C57BL, Krukovets I, Male, Mice, Muppala S, Muscle, NEOMED College of Medicine, Neovascularization, Oncogene, Pathologic/drug therapy/metabolism/*pathology, Plow E, Raman P, Signal Transduction/drug effects, Smooth, Stenina-Adognravi O, Thrombospondins/*physiology, Transforming Growth Factor beta/*pharmacology, Vascular/drug effects/metabolism/*pathology, Verbovetsky D, Xiao R, Yendamuri R
The presence of extracellular matrix alters the chondrocyte response to endoplasmic reticulum stress.
Tags: *Stress, 2011, Animals, Apoptosis/drug effects, Articular/cytology, Blotting, Cartilage, Cattle, Cells, Chondrocytes/cytology/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, DNA-Binding Proteins/genetics/metabolism, Dose-Response Relationship, Drug, Endoplasmic Reticulum/*metabolism, Extracellular Matrix/*metabolism, Glucose/pharmacology, Heat-Shock Proteins/genetics/metabolism, Horton Walter E Jr, Journal of cellular biochemistry, McBurney Denise L, NEOMED College of Medicine, Nugent Ashleigh E, Physiological, Proto-Oncogene Proteins c-bcl-2/genetics/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Thapsigargin/pharmacology, Time Factors, Transcription Factors/genetics/metabolism, Tunicamycin/pharmacology, Western
The isolation and characterization of the human cytochrome b5 gene.
Tags: 1995, Animals, Base Sequence, Biochemical and biophysical research communications, Cattle, Cell Line, Cloning, Cosmids, Cultured, Cytochromes b5/biosynthesis/*genetics, DNA Primers, DNA/genetics/isolation & purification, Gene Library, Genetic, Giordano S J, Hominidae/*genetics, Humans, Introns, Li X R, Luciferases/biosynthesis, Messenger/analysis/biosynthesis, Molecular, Molecular Sequence Data, Polymerase Chain Reaction, Promoter Regions, Rabbits, RNA, Steggles A W, Transfection, Tumor Cells, Yoo M
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.
Tags: *Neuroinflammation, *Parkinson's disease, 1-Methyl-4-phenyl-1, 2, 2018, 3, 6-tetrahydropyridine/pharmacology, Analysis of Variance, Animals, Anti-Inflammatory Agents/*therapeutic use, Astrocyte, Astrocytes/*drug effects, Boyle Alexa M, Budge Kevin M, Case-Control Studies, CD44, Cells, Chemical, Cultured, Cytokines/genetics/metabolism, Databases, Female, Glial Fibrillary Acidic Protein/metabolism, GPNMB, Humans, Hyaluronan Receptors/*metabolism, Inflammation/*drug therapy/etiology, Journal of neuroinflammation, Male, Membrane Glycoproteins/*therapeutic use, Messenger/metabolism, Mice, Neal Matthew L, Neurotoxins/toxicity, Nitric Oxide/metabolism, Parkinson Disease/complications/*pathology, Reactive Oxygen Species/metabolism, Richardson Jason R, RNA, Safadi Fayez F, Signal Transduction/drug effects
The effect of various insufflation gases on tumor implantation in an animal model.
Tags: *Carbon Dioxide, *Helium, *Neoplasm Transplantation, *Nitrous Oxide, *Peritoneal Cavity, *Pneumoperitoneum, 2002, Adenocarcinoma/pathology, American journal of obstetrics and gynecology, Animals, Artificial, Cultured, Haller Nairmeen Awad, Holda Sheri, Hopkins Michael P, Inbred F344, Injections, Intraperitoneal, Peritoneal Neoplasms/pathology, Rats, Tumor Cells, von Gruenigen Vivian
Synergistic antitumour activity of vitamins C and K3 against human prostate carcinoma cell lines.
Tags: 1996, Adenosine Triphosphate/biosynthesis, Antineoplastic Agents/*pharmacology/toxicity, Antineoplastic Combined Chemotherapy Protocols/pharmacology, Ascorbic Acid/*pharmacology/toxicity, Carcinoma/*metabolism, Catalase/pharmacology, Cell biology international, Cultured, Department of Anatomy & Neurobiology, DNA, Gilloteaux J, Hoke J, Humans, Hydrogen Peroxide/metabolism, Jamison J M, Koch J A, Lipid Peroxidation, Male, NEOMED College of Medicine, Neoplasm Proteins/biosynthesis, Neoplasm/biosynthesis, Prostatic Neoplasms/*metabolism, Sowick C, Sulfhydryl Compounds/analysis, Summers J L, Summers M, Tumor Cells, Venugopal M, Vitamin K/*pharmacology/toxicity
Subcellular localization and antiviral activity of carminic acid/poly r(A-U) combinations.
Tags: 1993, Antiviral Agents/*pharmacology, Carmine/*analogs & derivatives/pharmacokinetics/pharmacology, Cell biology international, Cell Nucleolus/metabolism, Cells, Chromatin/metabolism, Cultured, Doxorubicin/pharmacology, Drug Combinations, Drug Synergism, Fluorescence, Gilloteaux J, Humans, Interferon-beta/biosynthesis/physiology, Jamison J M, Krabill K, Microscopy, Phase-Contrast, Poly A-U/*pharmacokinetics/*pharmacology, Summers J L, Vesicular stomatitis Indiana virus/drug effects/growth & development, Viral Plaque Assay
Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potential.
Tags: *Genetic Variation, 2003, Animals, Cercopithecus aethiops, Cultured, Encephalitis, Genetic, Herpes Simplex/*physiopathology/virology, Herpesvirus 1, Human/*classification/genetics/*pathogenicity, Inbred BALB C, Journal of virology, Male, Mao Hanwen, Mice, Recombination, Rosenthal Ken S, Transfection, Tumor Cells, Vero Cells, Viral Envelope Proteins/metabolism, Viral Plaque Assay, Viral Proteins/*chemistry/*genetics/metabolism
Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.
Tags: 1993, Afferent/drug effects/ultrastructure, alpha-Macroglobulins/metabolism/*pharmacology, Animals, Bovine/pharmacology, Cell Survival/drug effects, Cells, Chick Embryo, Cultured, Frontal Lobe/*cytology/embryology, Ganglia, Humans, Journal of neuroscience research, Koo P H, Liebl D J, Nerve Growth Factors/*antagonists & inhibitors/pharmacology, Neurites/drug effects/ultrastructure, Neurons, Neurons/*drug effects/ultrastructure, Protein Binding, Rats, Serotonin/metabolism/*pharmacology, Serum Albumin, Spinal/*cytology/embryology
Scanning electron microscopy and transmission electron microscopy aspects of synergistic antitumor activity of vitamin C - vitamin K3 combinations against human prostatic carcinoma cells.
Tags: 1995, Antineoplastic Agents/*pharmacology, Ascorbic Acid/*pharmacology, Carcinoma/*drug therapy/pathology, Cell Membrane/drug effects/ultrastructure, Coloring Agents, Combination, Cultured, Cytoskeleton/drug effects/ultrastructure, Drug Synergism, Drug Therapy, Electron, Giammar D, Gilloteaux J, Humans, Jamison J M, Male, Microscopy, Mitochondria/drug effects/ultrastructure, Prostatic Neoplasms/*drug therapy/pathology, Scanning, Scanning microscopy, Summers J L, Tetrazolium Salts, Thiazoles, Tumor Cells, Venugopal M, Vitamin K/*pharmacology
RNA interference for CFTR attenuates lung fluid absorption at birth in rats.
Tags: *RNA Interference, 2008, Animals, Biological Transport/drug effects, Cells, Cultured, Cystic Fibrosis Transmembrane Conductance Regulator/*genetics/*metabolism, Epithelial Sodium Channels/genetics/metabolism, Female, Folkesson Hans G, Gene Expression Regulation/drug effects, Koshy Shyny, Li Tianbo, Lung/cytology/drug effects/*metabolism, Messenger/metabolism, Newborn, Pregnancy, Rats, Respiratory Mucosa/cytology/drug effects/metabolism, Respiratory research, RNA, Small Interfering/*pharmacology, Sprague-Dawley, Water/*metabolism
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells
Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells.
Tags: 2000, Alitretinoin, Antineoplastic Agents/*pharmacology, Biochemical and biophysical research communications, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 4, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Hardwick J P, Humans, Hydroxylation, Leukotriene B4/metabolism, Molecular Sequence Data, NEOMED College of Medicine, Tretinoin/*pharmacology, Tumor Cells, Up-Regulation, Zhang X
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Tags: 2001, Animals, Binding Sites, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/drug effects/*genetics/metabolism, Cricetinae, Cultured, Department of Integrative Medical Sciences, gene, Gene Expression Regulation/drug effects, Genetic, Humans, Hydroxycholesterols, Kimmel R, Liver/physiology, Lovastatin/pharmacology, Luciferases/genetics/metabolism, Mevalonic Acid/metabolism/pharmacology, NEOMED College of Medicine, Nicotinic Acids/pharmacology, Organ Specificity, Polyisoprenyl Phosphates/pharmacology, Rats, Receptors, Response Elements, Retinoic Acid/genetics/metabolism, Retinoid X Receptors, Species Specificity, Steroid/genetics/*metabolism, Stroup D, Tetrahydronaphthalenes/pharmacology, Transcription, Transcription Factors/genetics/metabolism, Transfection
Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.
Tags: *Intracellular Signaling Peptides and Proteins, 2001, Amyloid beta-Peptides/*biosynthesis/metabolism, Apoptosis Regulatory Proteins, Apoptosis/*physiology, Carrier Proteins/genetics/*physiology, Caspases/*metabolism, Chang X, Cultured, Du H, Enzyme Activation, Guo Q, Humans, Kinetics, Leucine Zippers, Neuroblastoma, Peptide Fragments/*biosynthesis/metabolism, Recombinant Proteins/metabolism, The Journal of biological chemistry, Time Factors, Transfection, Tumor Cells, Xie J
PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.
Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X
Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.
Tags: 2002, Angiotensin II/*metabolism, Animals, Arachidonic Acid/metabolism, Arachidonic Acids/pharmacology, Archives of biochemistry and biophysics, Blotting, Cells, Chromones/pharmacology, Cultured, Enzyme Inhibitors/pharmacology, Flavonoids/pharmacology, Freeman Ernest J, Group IV Phospholipases A2, Male, Mitogen-Activated Protein Kinases/metabolism, Morpholines/pharmacology, Muscle, Phosphatidylinositol 3-Kinases/*physiology, Phospholipases A/*metabolism, Phospholipases A2, Phosphorylation, Rats, Silfani Tonous N, Smooth, Sprague-Dawley, Vascular/drug effects/*growth & development, Western
Pertubation of beta1 integrin function using anti-sense or function-blocking antibodies on corneal cells grown on fibronectin and tenascin.
Tags: 2002, Animals, Antisense/*pharmacology, Bhattacharya Raka, Cattle, Cell Adhesion, Cell biology international, Cell Culture Techniques/*methods, Cells, Chick Embryo, Chickens, Complementary/metabolism, Cornea/*cytology, Cultured, DNA, Doane Kathleen J, Dose-Response Relationship, Drug, Fibronectins/*metabolism, Fluorescence, Immunohistochemistry, Integrin beta1/*metabolism/*physiology, Integrins/metabolism, Marchant Jeff, Microscopy, Oligonucleotides, Protein Binding, Retroviridae/genetics, Tenascin/*metabolism
Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling.
Tags: *MAP Kinase Signaling System, *Signal Transduction, 2016, Abdelmagid Samir M, Animals, Cell Differentiation, Cells, Cultured, Department of Anatomy & Neurobiology, Experimental & molecular medicine, Eye Proteins/*metabolism, Geldenhuys Werner J, Hyaluronan Receptors/*metabolism, Inbred C57BL, Jaber Fatima A, Male, Mbimba Thomas S, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, Osteoclasts/*cytology/metabolism, RANK Ligand/metabolism, Recombinant Proteins/metabolism, Safadi Fayez F, Sondag Gregory R, Yu Bing
Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells.
Tags: *Cell Movement, *Cell Proliferation, 2016, Animals, Apoptosis, Biomarkers, Carcinoma, Cell Adhesion, Cultured, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Female, GPNMB, Humans, integrin, Lung cancer, Lung Neoplasms/metabolism/*pathology, Manickavasagam Dharani, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, NEOMED College of Pharmacy, Neoplasm Invasiveness, Non-Small-Cell Lung/metabolism/*pathology, Novak Kimberly, NSCLC, Nude, Oncotarget, Oyewumi Moses O, Paulic Nikola, Protein Domains, Safadi Fayez F, Sondag Gregory R, Tumor Cells, Tumor/*metabolism, Wehrung Daniel, Xenograft Model Antitumor Assays
Orphan nuclear receptor oestrogen-related receptor gamma (ERRgamma) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.
Tags: 2015, Animals, bile acid, Bile Acids and Salts/metabolism, Cannabinoid, cannabinoid receptors, CB1/agonists/genetics/*metabolism, Cells, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, cholesterol 7alpha-hydroxylase (CYP7A1), Cultured, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Drug Inverse Agonism, Estrogen/genetics/*metabolism, Ethanol/pharmacology, Gene Expression, Genetic, Glycerides/pharmacology, GSK5182, HEK293 Cells, Hepatocytes/metabolism, Humans, Inbred C57BL, Jeong Won-Il, Kim Don-Kyu, Kim Seong Heon, Knockout, Lee Chul-Ho, Lee In-Kyu, Lee Ji-Min, Liver/*metabolism, Mice, NEOMED College of Medicine, oestrogen-related receptor gamma (ERRgamma), orphan nuclear receptor, Park Seung Bum, Promoter Regions, Rats, Receptor, Receptors, small heterodimer partner (SHP), Sprague-Dawley, The Biochemical journal, Transcription, Zhang Yaochen
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.
Tags: *Collateral Circulation/drug effects, *Coronary Circulation/drug effects, *MAP Kinase Signaling System/drug effects, 2007, Acetophenones/pharmacology, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Blood Flow Velocity, Cells, Chilian William M, Coronary Vessels/surgery, Cultured, Department of Integrative Medical Sciences, Disease Models, Ditiocarb/pharmacology, Endothelial Cells/drug effects/enzymology/*metabolism, Enzyme Inhibitors/pharmacology, Humans, Imidazoles/pharmacology, Inbred WKY, Kolz Christopher, Ligation, Male, Myocardial Reperfusion Injury/enzymology/metabolism/*physiopathology, NADPH Oxidases/antagonists & inhibitors/metabolism, NEOMED College of Medicine, Neovascularization, Onium Compounds/pharmacology, Oxygenases/antagonists & inhibitors/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Physiologic, Potter Barry, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reed Ryan, Rocic Petra, Superoxide Dismutase/antagonists & inhibitors/metabolism, Vascular Endothelial Growth Factor A/metabolism
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.
Tags: *Apoptosis, *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, 2018, 70-kDa/metabolism, 90-kDa/metabolism, Ahmad Imran, Carboxylic Ester Hydrolases/metabolism, Caspases/metabolism, Cells, Chondrocytes/*physiology, Cultured, ets-Domain Protein Elk-1/metabolism, Free radical biology & medicine, Haqqi Tariq M, Humans, Interleukin-1beta/immunology, Khan Nazir M, MAP Kinase Signaling System, NF-E2-Related Factor 2/genetics/*metabolism, Osteoarthritis/*metabolism, Oxidative Stress, Ribosomal Protein S6 Kinases, Up-Regulation
Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis.
Tags: 2005, Animals, Annexin A5/metabolism, Anti-Bacterial Agents/metabolism, Apoptosis/*physiology, Biomarkers, Carlson Sara G, Caspase 12, Caspases/metabolism, CCAAT-Enhancer-Binding Proteins/metabolism, Cell Differentiation/*physiology, Cells, Chondrocytes/cytology/*physiology, Collagen Type II/metabolism, Cultured, Department of Anatomy & Neurobiology, DNA Fragmentation, Endoplasmic Reticulum/*metabolism, Extracellular Matrix/metabolism, Gene Expression Regulation, Glucose/metabolism, Horton Walter E Jr, McBurney Denise, NEOMED College of Medicine, Proliferating Cell Nuclear Antigen/metabolism, Rats, Signal Transduction/*physiology, Thapsigargin/metabolism, The Journal of biological chemistry, Transcription Factor CHOP, Transcription Factors/metabolism, Tunicamycin/metabolism, Yang Ling
Monoamine-activated alpha 2-macroglobulin inhibits choline acetyltransferase of embryonic basal forebrain neurons and reversal of the inhibition by NGF and BDNF but not NT-3.
Tags: 1994, alpha-Macroglobulins/antagonists & inhibitors/*pharmacology, Animals, Biogenic Monoamines/*pharmacology, Brain-Derived Neurotrophic Factor, Cells, Choline O-Acetyltransferase/*antagonists & inhibitors, Cultured, Humans, Journal of neuroscience research, Koo P H, Liebl D J, Nerve Growth Factors/*pharmacology, Nerve Tissue Proteins/pharmacology, Neurons/drug effects/*metabolism, Neurotrophin 3, Prosencephalon/*cytology, Rats
Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling.
Tags: 2013, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Body Weight/physiology, Cells, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Collateral Circulation, Coronary Circulation, Coronary Vessels/cytology/*enzymology, Cultured, Department of Integrative Medical Sciences, Disease Models, Dyck Jason R B, Endothelial Cells/cytology/*enzymology, Enrick Molly, Hardwick James P, Humans, Inbred WKY, Ischemia/metabolism/pathology, Kolz Christopher, Mitochondria, Mitochondria/drug effects/*metabolism, Myocardium/enzymology/pathology, NEOMED College of Medicine, Oxidative Stress/*physiology, Pung Yuh Fen, Rats, reactive oxygen species, Rotenone/pharmacology, Sam Wai Johnn, Signal Transduction/*physiology, Stevanov Kelly, Thakker Prashanth, TOR Serine-Threonine Kinases/metabolism, Uncoupling Agents/pharmacology, Yin Liya
MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1beta-stimulated human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Arthritis & rheumatology (Hoboken, N.J.), Articular/drug effects/*metabolism, Cartilage, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, Enzyme-Linked Immunosorbent Assay, Funding Source, Gene Knockdown Techniques, Haqqi Tariq M, Haseeb Abdul, Hip/*genetics/metabolism, Human, Humans, Immunoblotting – Utilization, Immunoprecipitation, Interleukin-1beta/pharmacology, Interleukin-6/*genetics/metabolism, Interleukins – Physiology, Makki Mohammad S, Messenger/drug effects/*metabolism, MicroRNAs/drug effects/*genetics/metabolism, Middle Aged, NEOMED College of Medicine, Ohio, Osteoarthritis, Osteoarthritis – Complications, Osteoarthritis – Physiopathology, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleases/drug effects/*genetics/metabolism, RNA, T-Tests, Transcription Factors/drug effects/*genetics/metabolism
MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western
Methods and insights from the characterization of osteoprogenitor cells of bats (Mammalia: Chiroptera).
Tags: 2016, Animals, Ball H C, Bone Marrow Cells/cytology, Cell Differentiation/genetics, Cell Proliferation, Cells, Cellular Reprogramming, Chiroptera, Cooper L N, Core Binding Factor Alpha 1 Subunit/genetics/metabolism, Cultured, Department of Anatomy & Neurobiology, Inbred C57BL, Mbimba T, Mice, Moussa F M, NEOMED College of Medicine, Orman R, Osteoblasts/cytology/*metabolism, Osteocalcin/genetics/metabolism, Osteogenesis/*genetics, Real-Time Polymerase Chain Reaction, Safadi F F, Stem cell research, Stem Cells/*cytology/metabolism, Transcription Factors/genetics/metabolism
Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Tags: *Airway Remodeling, *fibronectin, *myofibroblasts, *PAI-1, *PI3K, *TGF-beta1, 2017, Adult, Al-Azzam Nosayba, Animals, Asthma/etiology/genetics/*metabolism/pathology, Cells, Cultured, Department of Integrative Medical Sciences, Dermatophagoides farinae/immunology, Duah Ernest, Extracellular Matrix/*metabolism/pathology, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Fibroblasts/metabolism, Fibronectins/*metabolism, Gombedza Farai, Hexter Madison, Humans, Inbred C57BL, Kondeti Vinay, Koppes Stephanie, Male, Mice, NEOMED College of Medicine, Paruchuri Sailaja, Patil Prachi, Phillips Daniel, Phosphatidylinositol 3-Kinases/metabolism, Plasminogen Activator Inhibitor 1/metabolism, Thodeti Charles K, Transforming Growth Factor beta/metabolism, TRPV Cation Channels/genetics/*metabolism