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40
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Text
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URL Address
<a href="http://doi.org/10.2174/138920112798868548" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/138920112798868548</a>
Pages
117–124
Issue
1
Volume
13
Dublin Core
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Title
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Natural products of dietary origin as lead compounds in virtual screening and drug design.
Publisher
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Current pharmaceutical biotechnology
Date
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2012
2012-01
Subject
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Humans; Animals; Diet; Resveratrol; *Drug Design; *Biological Products/pharmacology; Caffeine/pharmacology; Curcumin/pharmacology; Genistein/pharmacology; Stilbenes/pharmacology
Creator
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Geldenhuys Werner J; Bishayee Anupam; Darvesh Altaf S; Carroll Richard T
Description
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Natural products have been found to be useful in the treatment of several diseases across the ages. In this article, we review the use of natural products, obtained from dietary sources, as lead compounds in developing novel therapeutic agents. These compounds have shown tremendous promise in the prevention and as well as treatment of a variety of chronic ailments. In addition, to being patentable and biocompatible, these compounds are a rich source of novel scaffolds to invigorate the pipelines of the pharmaceutical industry. In this communication, we also focus on studies which show how natural products have proved useful as lead compounds in virtual screening and structure-based drug design programs. Natural dietary constituents, such as resveratrol, curcumin and caffeine as well as other compounds, are discussed to illustrate this approach.
Identifier
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<a href="http://doi.org/10.2174/138920112798868548" target="_blank" rel="noreferrer noopener">10.2174/138920112798868548</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Biological Products/pharmacology
*Drug Design
2012
Animals
Bishayee Anupam
Caffeine/pharmacology
Carroll Richard T
Curcumin/pharmacology
Current pharmaceutical biotechnology
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diet
Geldenhuys Werner J
Genistein/pharmacology
Humans
NEOMED College of Pharmacy
Resveratrol
Stilbenes/pharmacology