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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/0929867023368674" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/0929867023368674</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2271-2285
Issue
24
Volume
9
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Potential therapeutic application of the association of vitamins C and K-3 in cancer treatment
Publisher
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Current Medicinal Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
oxidative stress; cancer; Biochemistry & Molecular Biology; Pharmacology & Pharmacy; apoptosis; cell-death; growth-invitro; synergistic antitumor-activity; ascorbic-acid; carcinoma-cells; autoschizis; induced apoptosis; ascorbate (vitamin C); caloric restriction; cycle arrest; menadione (vitamin K-3); programmed; tumor-specific expression
Creator
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Calderon P B; Cadrobbi J; Marques C; Hong-Ngoc N; Jamison J M; Gilloteaux J; Summers J L; Taper H S
Description
An account of the resource
The decision of stressed cells to die or to survive is made by integrating signals at different levels through multiple check points. However, initiation and continued progression toward cell death by apoptosis in cancer cells may be blocked by mutation of the tumor suppressor p53 or overexpression of members of the bcl-2 family of proteins. The existence of such mechanisms indicates that cancer cells lose the controls regulating their cell cycle. Therefore, the activation of their programmed cell death appears as a major therapeutic target. Oxidative stress can stimulate growth, trigger apoptosis, or cause necrosis depending upon the dose and the exposure time of the oxidizing agent. A large body of evidence supports the idea that oxidative stress induced by redox cycling of vitamins C and K-3 in association surpasses cancer cellular defense systems and results in cell death. The molecular mechanisms underlying such a process are, however, still unknown. Indeed, several types of cell death may be produced, namely autoschizis, apoptosis and necrosis. Combined vitamin C and K-3 administration in vitro and in vivo produced tumor growth inhibition and increased the life-span of tumor-bearing mice. CK3-treatment selectively potentiated tumor chemotherapy, produced sensitization of tumors resistant to some drugs, potentiated cancer radiotherapy and caused inhibition of the development of cancer metastases without inducing toxicity in the host. We propose the association of vitamins C and K-3 as an adjuvant cancer therapy which may be introduced into human cancer therapy without any change in the classical anticancer protocols, and without any supplementary risk for patients.
Identifier
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<a href="http://doi.org/10.2174/0929867023368674" target="_blank" rel="noreferrer noopener">10.2174/0929867023368674</a>
Format
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Journal Article or Conference Abstract Publication
2002
Apoptosis
ascorbate (vitamin C)
ascorbic-acid
autoschizis
Biochemistry & Molecular Biology
Cadrobbi J
Calderon P B
caloric restriction
Cancer
carcinoma-cells
cell-death
Current medicinal chemistry
cycle arrest
Gilloteaux J
growth-invitro
Hong-Ngoc N
induced apoptosis
Jamison J M
Journal Article or Conference Abstract Publication
Marques C
menadione (vitamin K-3)
Oxidative Stress
Pharmacology & Pharmacy
programmed
Summers J L
synergistic antitumor-activity
Taper H S
tumor-specific expression
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/09298673113209990112" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/09298673113209990112</a>
Pages
1662–1672
Issue
13
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Rationally designed multi-targeted agents against neurodegenerative diseases.
Publisher
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Current medicinal chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-07
Subject
The topic of the resource
Humans; Animals; Drug Discovery/*methods; Signal Transduction/drug effects; Amyloid beta-Peptides/antagonists & inhibitors; Calcium Channel Blockers/chemistry/pharmacology; Cholinesterase Inhibitors/chemistry/pharmacology; Molecular Targeted Therapy/methods; Monoamine Oxidase Inhibitors/chemistry/pharmacology; Neurodegenerative Diseases/*drug therapy/metabolism; Receptors; N-Methyl-D-Aspartate/antagonists & inhibitors
Creator
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Geldenhuys W J; Van der Schyf C J
Description
An account of the resource
Neurodegenerative diseases are complex disorders with several pathoetiological pathways leading to cell death. Rationally designed multi-targeted agents, or "multi-targeted designed drugs" (MTDD) show significant promise in preclinical studies as neuroprotective and disease-modifying agents. In this review, we highlight the use of chemical scaffolds that lend themselves exquisitely to the development of MTDDs in neurodegeneration. Notably, synthetic polycyclic cage compounds have served as scaffolds for novel voltage-gated calcium channel blockers, NMDA receptor antagonists, and sigma-receptor ligands - attractive targets in neurodegeneration. In an entirely different approach, compounds containing the thiazolidinedione moiety (referred to as glitazones) alter mitochondrial function through the mitochondrial protein mitoNEET, an attractive new drug target for the treatment of neurodegenerative diseases. The design strategy for yet another agent, ladostigil, employed the amalgamation of active chemical moieties of the AChE inhibitor rivastigmine, and the monoamine oxidase-B (MAO-B) inhibitor rasagiline, leading to a single compound that targets both enzymes simultaneously. Natural products have also served as design templates for several MTDD design studies. In particular, the stilbene scaffold has become popular in particular due to the neuroprotective effects of the non-flavonoid natural product resveratrol. Recently, stilbene scaffold-based compounds were developed to reduce - through chelation with metal ions that interact with beta-amyloid - both metal-induced beta-amyloid protein aggregation, and ROS generated from this aggregate. Other subtle modifications of the stilbene motif led to the creation of reversible, non-competitive MAO inhibitors. Finally, compounds derived from the xanthine scaffold afford neuroprotection in Parkinson's disease through mechanisms that include dual adenosine A2A receptor antagonism and MAO-B inhibition.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/09298673113209990112" target="_blank" rel="noreferrer noopener">10.2174/09298673113209990112</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Amyloid beta-Peptides/antagonists & inhibitors
Animals
Calcium Channel Blockers/chemistry/pharmacology
Cholinesterase Inhibitors/chemistry/pharmacology
Current medicinal chemistry
Drug Discovery/*methods
Geldenhuys W J
Humans
Molecular Targeted Therapy/methods
Monoamine Oxidase Inhibitors/chemistry/pharmacology
N-Methyl-D-Aspartate/antagonists & inhibitors
Neurodegenerative Diseases/*drug therapy/metabolism
Receptors
Signal Transduction/drug effects
Van der Schyf C J