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40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/nu9050436</a>
Issue
5
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.
Publisher
An entity responsible for making the resource available
Nutrients
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
Female; Animals; Anti-Inflammatory Agents/*pharmacology; Rats; Gene Expression Regulation; Signal Transduction; Apoptosis/drug effects; anti-inflammatory effects; Anticarcinogenic Agents/pharmacology; breast tumor; COX-2; Cyclooxygenase 2/genetics/metabolism; DMBA; HSP90; HSP90 Heat-Shock Proteins/genetics/metabolism; I-kappa B Kinase/genetics/metabolism; NF-E2-Related Factor 2/genetics/*metabolism; NF-kappa B/genetics/*metabolism; NF-kappaB; Nrf2; Plant Preparations/*pharmacology; Punica granatum; Punicaceae/*chemistry; Pomegranate; Chemoprevention; Dose-Response Relationship; Drug; Neoplastic; Mammary Neoplasms; 10-Dimethyl-1; 9; Neoplastic/drug effects; Cell Transformation; 2-benzanthracene/toxicity; Experimental/*prevention & control; Animal Studies; Breast Neoplasms; Inflammation Mediators; Physical Education and Training; Neoplasms – Prevention and Control
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bhatia Deepak; Bishayee Anupam
Description
An account of the resource
Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a striking inhibition of dimethylbenz(a)anthracene (DMBA)-initiated rat mammary tumorigenesis via antiproliferative and apoptosis-inducing mechanisms. The objective of the present work is to investigate the anti-inflammatory mechanism of action of PE during DMBA rat mammary carcinogenesis by evaluating the expression of cyclooxygenase-2 (COX-2), heat shock protein 90 (HSP90), nuclear factor-kappaB (NF-kappaB) and nuclear factor erythroid 2p45 (NF-E2)-related factor 2 (Nrf2). Mammary tumor samples were harvested from our previous chemopreventive study in which PE (0.2-5.0 g/kg) was found to reduce mammary tumorigenesis in a dose-dependent manner. The expressions of COX-2, HSP90, NF-kappaB, inhibitory kappaBalpha (IkappaBalpha) and Nrf2 were detected by immunohistochemical techniques. PE decreased the expression of COX-2 and HSP90, prevented the degradation of IkappaBalpha, hindered the translocation of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">10.3390/nu9050436</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/toxicity
2017
9
Animal Studies
Animals
Anti-Inflammatory Agents/*pharmacology
anti-inflammatory effects
Anticarcinogenic Agents/pharmacology
Apoptosis/drug effects
Bhatia Deepak
Bishayee Anupam
Breast Neoplasms
breast tumor
Cell Transformation
Chemoprevention
COX-2
Cyclooxygenase 2/genetics/metabolism
DMBA
Dose-Response Relationship
Drug
Experimental/*prevention & control
Female
Gene Expression Regulation
HSP90
HSP90 Heat-Shock Proteins/genetics/metabolism
I-kappa B Kinase/genetics/metabolism
Inflammation Mediators
Mammary Neoplasms
Mandal Animesh
Neoplasms – Prevention and Control
Neoplastic
Neoplastic/drug effects
NF-E2-Related Factor 2/genetics/*metabolism
NF-kappa B/genetics/*metabolism
NF-kappaB
Nrf2
Nutrients
Physical Education and Training
Plant Preparations/*pharmacology
Pomegranate
Punica granatum
Punicaceae/*chemistry
Rats
Signal Transduction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/srep43789" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/srep43789</a>
Pages
43789–43789
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes.
Publisher
An entity responsible for making the resource available
Scientific reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
Cells; Chemical Fractionation/methods; Chondrocytes/*drug effects/metabolism; Cultured; Cyclooxygenase 2/genetics/metabolism; Flavanones/*pharmacology; Gene Expression Regulation/drug effects; Humans; Interleukin-1beta/pharmacology; Interleukin-6/genetics/metabolism; Osteoarthritis/pathology; Plant Extracts/*pharmacology; Plant Roots/*chemistry; Protective Agents/pharmacology; Reactive Oxygen Species/metabolism; Scutellaria baicalensis/*chemistry; Transcription Factor AP-1/genetics/*metabolism
Creator
An entity primarily responsible for making the resource
Khan Nazir M; Haseeb Abdul; Ansari Mohammad Y; Haqqi Tariq M
Description
An account of the resource
Osteoarthritis (OA) is a common joint disorder with varying degrees of inflammation and sustained oxidative stress. The root extract of Scutellaria baicalensis (SBE) has been used for the treatment of inflammatory and other diseases. Here, we performed activity-guided HPLC-fractionation of SBE, identified the active ingredient(s) and investigated its chondroprotective potential. We found that the Wogonin containing fraction-4 (F4) was the most potent fraction based on its ability to inhibit ROS production and the suppression of catabolic markers including IL-6, COX-2, iNOS, MMP-3, MMP-9,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/srep43789" target="_blank" rel="noreferrer noopener">10.1038/srep43789</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Ansari Mohammad Y
Cells
Chemical Fractionation/methods
Chondrocytes/*drug effects/metabolism
Cultured
Cyclooxygenase 2/genetics/metabolism
Department of Anatomy & Neurobiology
Flavanones/*pharmacology
Gene Expression Regulation/drug effects
Haqqi Tariq M
Haseeb Abdul
Humans
Interleukin-1beta/pharmacology
Interleukin-6/genetics/metabolism
Khan Nazir M
NEOMED College of Medicine
Osteoarthritis/pathology
Plant Extracts/*pharmacology
Plant Roots/*chemistry
Protective Agents/pharmacology
Reactive Oxygen Species/metabolism
Scientific reports
Scutellaria baicalensis/*chemistry
Transcription Factor AP-1/genetics/*metabolism