1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1113/jphysiol.1995.sp020771" target="_blank" rel="noreferrer noopener">http://doi.org/10.1113/jphysiol.1995.sp020771</a>
Pages
817–825
Volume
485 ( Pt 3)
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Local modulation of adrenergic responses in the hindlimb vasculature of the intact conscious rat.
Publisher
An entity responsible for making the resource available
The Journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-06
Subject
The topic of the resource
Adrenergic Agonists/*pharmacology; Animals; Arginine/analogs & derivatives/pharmacology; Cyclooxygenase Inhibitors/pharmacology; Female; Hemodynamics/*drug effects/physiology; Hindlimb/*blood supply/drug effects/metabolism; Indomethacin/pharmacology; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase/antagonists & inhibitors; Rats; Sprague-Dawley
Creator
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DiCarlo S E; Patil R D; Collins H L; Chen C Y
Description
An account of the resource
1. Local modulation of adrenergic responses was examined in the hindlimb vasculature of chronically instrumented intact conscious rats. Sprague-Dawley rats (n = 22) were instrumented with a Doppler flow probe around the right common iliac artery, a polyethylene catheter inserted just distal to the flow probe and a left carotid arterial catheter. 2. The effects of various concentrations of the alpha 1-adrenergic receptor agonist phenylephrine (0.005-0.075 microgram kg-1), the alpha 2-adrenergic receptor agonist clonidine (0.1-0.7 microgram kg-1), and the endogenous adrenergic receptor agonist adrenaline (0.02-0.08 microgram kg-1), were investigated under control conditions, and in the presence of the nitric oxide (NO) synthase inhibitor N omega-nitro-L-arginine methyl ester hydrochoride (L-NAME) (NO-X, 0.2 mg kg-1) and the cyclo-oxygenase inhibitor indomethacin (CO-X, 10 mg kg-1). Results were presented as dose-response curves. 3. Heart rate and arterial pressure were not altered by any of the agents because all were locally injected into the hindlimb vasculature and the selected doses were lower than those which elicited systemic responses. 4. Maximal vasoconstrictor responses to phenylephrine were enhanced in the presence of NO-X (50 +/- 6%) and
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1113/jphysiol.1995.sp020771" target="_blank" rel="noreferrer noopener">10.1113/jphysiol.1995.sp020771</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Adrenergic Agonists/*pharmacology
Animals
Arginine/analogs & derivatives/pharmacology
Chen C Y
Collins H L
Cyclooxygenase Inhibitors/pharmacology
DiCarlo S E
Female
Hemodynamics/*drug effects/physiology
Hindlimb/*blood supply/drug effects/metabolism
Indomethacin/pharmacology
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase/antagonists & inhibitors
Patil R D
Rats
Sprague-Dawley
The Journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00099.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00099.2002</a>
Pages
H2062–2073
Issue
5
Volume
283
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.
Publisher
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American journal of physiology. Heart and circulatory physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-11
Subject
The topic of the resource
*Sex Characteristics; Animals; Aorta/drug effects/physiology; Bridged Bicyclo Compounds; Cyclooxygenase Inhibitors/pharmacology; Endothelium; Enzyme Inhibitors/pharmacology; Estrogens/*physiology; Fatty Acids; Female; Heterocyclic; Hydrazines/pharmacology; Imidazoles/pharmacology; Indomethacin/pharmacology; Male; Ovariectomy; Phenylephrine/pharmacology; Progesterone/*physiology; Prostaglandins/*metabolism; Rats; Sprague-Dawley; Thromboxanes/metabolism; Unsaturated; Vascular/*metabolism; Vasoconstriction/drug effects/*physiology; Vasoconstrictor Agents/pharmacology; Vasopressins/pharmacology
Creator
An entity primarily responsible for making the resource
Fulton Clifford T; Stallone John N
Description
An account of the resource
The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile response of control (Cont) aortas to VP was markedly higher in females (3,885 +/- 332 mg/mg ring wt) than in males (810 +/- 148 mg). Indomethacin (Indo; 10 microM) attenuated maximal response to VP in females (3,043 +/- 277 mg) but not in males. SQ-29,548 (SQ; 1 microM) attenuated maximal response to VP in females (3,042 +/- 290 mg) to a similar extent as Indo. Dazoxiben (Daz; 10 microM) alone had no effect, but Daz + SQ attenuated maximal contractile response to VP to a similar extent as SQ alone. Removal of the endothelium in female aortas attenuated contractile responses to VP in Cont aortas. OVX attenuated maximal contractile response to VP in Cont aortas (2,093 +/- 329 mg) and abolished the attenuating effects of Indo. Indo, SQ, and Daz exerted identical effects on contractile responses of male, female, and OVX female aortas to PE. These findings establish the following in the rat aorta: 1) CP, probably thromboxane and/or endoperoxide, is responsible for approximately
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00099.2002" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00099.2002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2002
American journal of physiology. Heart and circulatory physiology
Animals
Aorta/drug effects/physiology
Bridged Bicyclo Compounds
Cyclooxygenase Inhibitors/pharmacology
Endothelium
Enzyme Inhibitors/pharmacology
Estrogens/*physiology
Fatty Acids
Female
Fulton Clifford T
Heterocyclic
Hydrazines/pharmacology
Imidazoles/pharmacology
Indomethacin/pharmacology
Male
Ovariectomy
Phenylephrine/pharmacology
Progesterone/*physiology
Prostaglandins/*metabolism
Rats
Sprague-Dawley
Stallone John N
Thromboxanes/metabolism
Unsaturated
Vascular/*metabolism
Vasoconstriction/drug effects/*physiology
Vasoconstrictor Agents/pharmacology
Vasopressins/pharmacology