1
40
1
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Text
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URL Address
<a href="http://doi.org/10.1007/s11908-011-0224-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11908-011-0224-6</a>
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Pages
33-40
Issue
1
Volume
14
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Dublin Core
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Title
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Update On Cytomegalovirus Infections Of The Gastrointestinal System In Solid Organ Transplant Recipients
Publisher
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Current Infectious Disease Reports
Date
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2012
2012-02
Subject
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CMV; Cytomegalovirus; Gastrointestinal infection; Infectious Diseases; Solid organ transplant
Creator
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Lemonovich T L; Watkins R R
Description
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Cytomegalovirus (CMV) infection of the gastrointestinal tract is the most common manifestation of tissue-invasive CMV disease, and is a significant cause of morbidity and mortality in the solid organ transplantation (SOT) recipient. In addition to the direct effects of the infection, its indirect effects on allograft function, risk for other opportunistic infections, and mortality are significant in this population. The most common clinical syndromes are esophagitis, colitis, and hepatitis; however, infection can occur anywhere in the gastrointestinal tract. Diagnosis is usually by histopathology or viral culture of tissue specimens; molecular assays also often have a role. Antivirals are the cornerstone of therapy for gastrointestinal tract CMV disease and complications such as recurrent infection and antiviral resistance are not uncommon. Prevention with antiviral prophylaxis or preemptive therapy is important. This review summarizes recent data regarding the clinical manifestations, diagnosis, treatment, and prevention of gastrointestinal tract CMV infection in the SOT population.
Identifier
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<a href="http://doi.org/10.1007/s11908-011-0224-6" target="_blank" rel="noreferrer noopener">10.1007/s11908-011-0224-6</a>
Format
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Journal Article or Conference Abstract Publication
2012
CMV
Current infectious disease reports
Cytomegalovirus
Department of Internal Medicine
Gastrointestinal infection
Infectious Diseases
Journal Article or Conference Abstract Publication
Lemonovich T L
NEOMED College of Medicine
Solid organ transplant
Watkins R R