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Text
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URL Address
<a href="http://doi.org/10.1016/j.bcp.2013.08.015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2013.08.015</a>
Pages
1517–1524
Issue
11
Volume
86
Dublin Core
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Title
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Bile acid receptors in non-alcoholic fatty liver disease.
Publisher
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Biochemical pharmacology
Date
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2013
2013-12
Subject
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Animals; Bile Acids and Salts/*metabolism; Cholesterol; Cytoplasmic and Nuclear/agonists/*metabolism; Fatty Liver/drug therapy/immunology/*metabolism; FXR; G-Protein-Coupled/agonists/*metabolism; Glucose/metabolism; Humans; Inflammation; Lipid Metabolism/drug effects; Lipid Regulating Agents/chemistry/pharmacology/therapeutic use; Molecular Structure; Non-alcoholic Fatty Liver Disease; Receptors; TGR5; Triglyceride; Triglycerides/metabolism
Creator
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Li Yuanyuan; Jadhav Kavita; Zhang Yanqiao
Description
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Accumulating data have shown that bile acids are important cell signaling molecules, which may activate several signaling pathways to regulate biological processes. Bile acids are endogenous ligands for the farnesoid X receptor (FXR) and TGR5, a G-protein coupled receptor. Gain- and loss-of-function studies have demonstrated that both FXR and TGR5 play important roles in regulating lipid and carbohydrate metabolism and inflammatory responses. Importantly, activation of FXR or TGR5 lowers hepatic triglyceride levels and inhibits inflammation. Such properties of FXR or TGR5 have indicated that these two bile acid receptors are ideal targets for treatment of non-alcoholic fatty liver disease, one of the major health concerns worldwide. In this article, we will focus on recent advances on the role of both FXR and TGR5 in regulating hepatic triglyceride metabolism and inflammatory responses under normal and disease conditions.
Identifier
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<a href="http://doi.org/10.1016/j.bcp.2013.08.015" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2013.08.015</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Animals
Bile Acids and Salts/*metabolism
Biochemical pharmacology
Cholesterol
Cytoplasmic and Nuclear/agonists/*metabolism
Fatty Liver/drug therapy/immunology/*metabolism
FXR
G-Protein-Coupled/agonists/*metabolism
Glucose/metabolism
Humans
Inflammation
Jadhav Kavita
Li Yuanyuan
Lipid Metabolism/drug effects
Lipid Regulating Agents/chemistry/pharmacology/therapeutic use
Molecular Structure
Non-alcoholic Fatty Liver Disease
Receptors
TGR5
Triglyceride
Triglycerides/metabolism
Zhang Yanqiao