1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1186/s12929-015-0133-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s12929-015-0133-3</a> Pages 30–30 Volume 22 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. Publisher An entity responsible for making the resource available Journal of biomedical science Date A point or period of time associated with an event in the lifecycle of the resource 2015 2015-05 Subject The topic of the resource Animals; Bile Acids and Salts/metabolism; Cytoplasmic and Nuclear/biosynthesis/*genetics/metabolism; Diabetes Mellitus/*drug therapy/genetics/metabolism; Gene Expression Regulation/drug effects; Glucose/metabolism; Hepatocytes/drug effects; Humans; Insulin Resistance/genetics; Insulin/*metabolism; Leptin/deficiency/genetics; Lipid Metabolism/drug effects; Messenger/genetics; Mice; Obese; PPAR gamma/*biosynthesis/genetics; Receptors; RNA; Thiazolidinediones/*administration & dosage Creator An entity primarily responsible for making the resource Tseng Hsiu-Ting; Park Young Joo; Lee Yoon-Kwang; Moore David D Description An account of the resource BACKGROUND: Small heterodimer partner (SHP, NR0B2) is involved in diverse metabolic pathways, including hepatic bile acid, lipid and glucose homeostasis, and has been implicated in effects on the peroxisome proliferator-activated receptor gamma (PPARgamma), a master regulator of adipogenesis and the receptor for antidiabetic drugs thiazolidinediones (TZDs). In this study, we aim to investigate the role of SHP in TZD response by comparing TZD-treated leptin-deficient (ob/ob) and leptin-, SHP-deficient (ob/ob;Shp(-/-)) double mutant mice. RESULTS: Both ob/ob and double mutant ob/ob;Shp(-/-) mice developed hyperglycemia, insulin resistance, and hyperlipidemia, but hepatic fat accumulation was decreased in the double mutant ob/ob;Shp(-/-) mice. PPARgamma2 mRNA levels were markedly lower in ob/ob;Shp(-/-) liver and decreased to a lesser extent in adipose tissue. The TZD troglitazone did not reduce glucose or circulating triglyceride levels in ob/ob;Shp(-/-) mice. Expression of the adipocytokines, such as adiponectin and resistin, was not stimulated by troglitazone treatment. Expression of hepatic lipogenic genes was also reduced in ob/ob;Shp(-/-) mice. Moreover, overexpression of SHP by adenovirus infection increased PPARgamma2 mRNA levels in mouse primary hepatocytes. CONCLUSIONS: Our results suggest that SHP is required for both antidiabetic and hypolipidemic effects of TZDs in ob/ob mice through regulation of PPARgamma expression. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1186/s12929-015-0133-3" target="_blank" rel="noreferrer noopener">10.1186/s12929-015-0133-3</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2015 Animals Bile Acids and Salts/metabolism Cytoplasmic and Nuclear/biosynthesis/*genetics/metabolism Department of Integrative Medical Sciences Diabetes Mellitus/*drug therapy/genetics/metabolism Gene Expression Regulation/drug effects Glucose/metabolism Hepatocytes/drug effects Humans Insulin Resistance/genetics Insulin/*metabolism Journal of biomedical science Lee Yoon-Kwang Leptin/deficiency/genetics Lipid Metabolism/drug effects Messenger/genetics Mice Moore David D NEOMED College of Medicine Obese Park Young Joo PPAR gamma/*biosynthesis/genetics Receptors RNA Thiazolidinediones/*administration & dosage Tseng Hsiu-Ting