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Text
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URL Address
<a href="http://doi.org/10.1002/jcb.21328" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcb.21328</a>
Pages
786–800
Issue
3
Volume
102
Dublin Core
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Title
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A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.
Publisher
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Journal of cellular biochemistry
Date
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2007
2007-10
Subject
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*Gene Expression Regulation; Animals; Apoptosis; Biological; Cell Proliferation; Chondrocytes/*metabolism/pathology; Collagen Type II/metabolism; DNA-Binding Proteins/*metabolism/physiology; Endoplasmic Reticulum/metabolism; Models; Phenotype; Rats; RNA Interference; Subcellular Fractions/metabolism; Time Factors; Transcription Factors/*metabolism/physiology; Transfection
Creator
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Yang Ling; McBurney Denise; Tang Shou-Ching; Carlson Sara G; Horton Walter E Jr
Description
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BAG-1 (Bcl-2 associated athanogene-1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. In vivo, BAG-1 is expressed in growth plate and articular cartilage, and the expression of BAG-1 is decreased with aging. Chondrocytes respond to endoplasmic reticulum (ER) stress with decreased expression of extracellular matrix proteins, and prolonged ER stress leads to chondrocyte apoptosis. Here we demonstrate for the first time that BAG-1 is involved in ER stress-induced apoptosis in chondrocytes. Induction of ER stress through multiple mechanisms all resulted in downregulation of BAG-1 expression. In addition, direct suppression of BAG-1 expression resulted in chondrocyte growth arrest and apoptosis, while stable overexpression of BAG-1 delayed the onset of ER stress-mediated apoptosis. In addition to regulating apoptosis, we also observed decreased expression of collagen type II in BAG-1 deficient chondrocytes. In contrast, overexpression of BAG-1 resulted in increased expression of collagen type II. Moreover, under ER stress conditions, the reduced expression of collagen type II was delayed in chondrocytes overexpressing BAG-1. These results suggest a novel role for BAG-1 in supporting viability and matrix expression of chondrocytes.
Identifier
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<a href="http://doi.org/10.1002/jcb.21328" target="_blank" rel="noreferrer noopener">10.1002/jcb.21328</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Expression Regulation
2007
Animals
Apoptosis
Biological
Carlson Sara G
Cell Proliferation
Chondrocytes/*metabolism/pathology
Collagen Type II/metabolism
Department of Anatomy & Neurobiology
DNA-Binding Proteins/*metabolism/physiology
Endoplasmic Reticulum/metabolism
Horton Walter E Jr
Journal of cellular biochemistry
McBurney Denise
Models
NEOMED College of Medicine
Phenotype
Rats
RNA Interference
Subcellular Fractions/metabolism
Tang Shou-Ching
Time Factors
Transcription Factors/*metabolism/physiology
Transfection
Yang Ling