1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00227.2014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00227.2014</a>
Pages
683–704
Issue
3
Volume
112
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-08
Subject
The topic of the resource
Action Potentials/physiology; Animals; Antigens/metabolism; auditory midbrain; Calcium/metabolism; env/metabolism; Experimental/physiopathology; Gene Products; Hearing Loss/physiopathology; Inferior Colliculi/physiopathology/virology; inferior colliculus; Leukemia; Leukemia Virus; Membrane Potentials/physiology; Mice; Microglia/physiology/virology; Murine/*physiology; Neural Pathways/physiopathology; Neurodegenerative Diseases/*physiopathology; Neuroglia/physiology/virology; Neurons/*physiology/virology; Patch-Clamp Techniques; postinhibitory rebound neurons; Proteoglycans/metabolism; Retroviridae Infections/*physiopathology/virology; retrovirus; Tissue Culture Techniques; Tumor Virus Infections/*physiopathology/virology; Voltage-Sensitive Dye Imaging; voltage-sensitive dyes
Creator
An entity primarily responsible for making the resource
Li Ying; Davey Robert A; Sivaramakrishnan Shobhana; Lynch William P
Description
An account of the resource
Certain retroviruses induce progressive spongiform motor neuron disease with features resembling prion diseases and amyotrophic lateral sclerosis. With the neurovirulent murine leukemia virus (MLV) FrCasE, Env protein expression within glia leads to postsynaptic vacuolation, cellular effacement, and neuronal loss in the absence of neuroinflammation. To understand the physiological changes associated with MLV-induced spongiosis, and its neuronal specificity, we employed patch-clamp recordings and voltage-sensitive dye imaging in brain slices of the mouse inferior colliculus (IC), a midbrain nucleus that undergoes extensive spongiosis. IC neurons characterized by postinhibitory rebound firing (PIR) were selectively affected in FrCasE-infected mice. Coincident with Env expression in microglia and in glia characterized by NG2 proteoglycan expression (NG2 cells), rebound neurons (RNs) lost PIR, became hyperexcitable, and were reduced in number. PIR loss and hyperexcitability were reversed by raising internal calcium buffer concentrations in RNs. PIR-initiated rhythmic circuits were disrupted, and spontaneous synchronized bursting and prolonged depolarizations were widespread. Other IC neuron cell types and circuits within the same degenerative environment were unaffected. Antagonists of NMDA and/or AMPA receptors reduced burst firing in the IC but did not affect prolonged depolarizations. Antagonists of L-type calcium channels abolished both bursts and slow depolarizations. IC infection by the nonneurovirulent isogenic virus Friend 57E (Fr57E), whose Env protein is structurally similar to FrCasE, showed no RN hyperactivity or cell loss; however, PIR latency increased. These findings suggest that spongiform neurodegeneration arises from the unique excitability of RNs, their local regulation by glia, and the disruption of this relationship by glial expression of abnormal protein.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00227.2014" target="_blank" rel="noreferrer noopener">10.1152/jn.00227.2014</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Action Potentials/physiology
Animals
Antigens/metabolism
auditory midbrain
Calcium/metabolism
Davey Robert A
Department of Integrative Medical Sciences
env/metabolism
Experimental/physiopathology
Gene Products
Hearing Loss/physiopathology
Inferior Colliculi/physiopathology/virology
inferior colliculus
Journal of neurophysiology
Leukemia
Leukemia Virus
Li Ying
Lynch William P
Membrane Potentials/physiology
Mice
Microglia/physiology/virology
Murine/*physiology
NEOMED College of Medicine
Neural Pathways/physiopathology
Neurodegenerative Diseases/*physiopathology
Neuroglia/physiology/virology
Neurons/*physiology/virology
Patch-Clamp Techniques
postinhibitory rebound neurons
Proteoglycans/metabolism
Retroviridae Infections/*physiopathology/virology
retrovirus
Sivaramakrishnan Shobhana
Tissue Culture Techniques
Tumor Virus Infections/*physiopathology/virology
Voltage-Sensitive Dye Imaging
voltage-sensitive dyes