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Text
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<a href="http://doi.org/10.1007/s00455-020-10100-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-020-10100-7</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of Superior Laryngeal Nerve Lesion on Kinematics of Swallowing and Airway Protection in an Infant Pig Model.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03
Subject
The topic of the resource
Deglutition; Deglutition disorders; Kinematics; Biomechanics; Animal model; Airway; Superior laryngeal nerve; Neural control; Swallow
Creator
An entity primarily responsible for making the resource
Lammers Andrew R; Abid Saja; Ding Peng; German Rebecca Z
Description
An account of the resource
The superior laryngeal nerve provides detailed sensory information from the mucosal surfaces of laryngeal structures superior to the vocal folds, including the valleculae. Injury to this nerve results in airway penetration and aspiration. Furthermore, such injuries might have an impact on the function of multiple structures involved in intraoral transport and swallowing due to connections within the brainstem. We sought to determine the effects of a surgical lesion of the superior laryngeal nerve on kinematics of the tongue, hyoid, and epiglottis during swallowing. We implanted radio-opaque markers into five infant pigs under anesthesia. Then we fed milk mixed with contrast agent to the pigs while they were recorded via video fluoroscopy, before and after a surgery to transect the superior laryngeal nerve. We digitized and rated airway protection in 177 swallows. We found that in most animals, swallow duration was shorter after nerve lesion. The hyoid also traveled a shorter distance after lesion. Frequently, individuals reacted differently to the same nerve lesion. We suggest that these differences are due to individual differences in neurological connections. When comparing hyoid kinematics between swallows with successful or failed airway protection, we found more consistency among individuals. This indicates that protecting the airway requires specific sets of kinematic events to occur, regardless of the neurological differences among individuals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-020-10100-7" target="_blank" rel="noreferrer noopener">10.1007/s00455-020-10100-7</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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Journal Article
2020
Abid Saja
Airway
Animal model
biomechanics
Deglutition
Deglutition disorders
Department of Anatomy & Neurobiology
Ding Peng
Dysphagia
German Rebecca Z
Kinematics
Lammers Andrew R
NEOMED College of Medicine
Neural control
Superior laryngeal nerve
Swallow
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2018/6537072" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2018/6537072</a>
Pages
6537072–6537072
Volume
2018
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.
Publisher
An entity responsible for making the resource available
Parkinson's disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Animal Studies; Deglutition – Drug Effects; Deglutition Disorders; Eating – Drug Effects; Feeding Methods; Isoflavones – Administration and Dosage; Isoflavones – Pharmacodynamics; Mastication; Oropharynx – Pathology; Parkinson Disease; Phenotype; Rats
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Gross Andrew; German Rebecca Z; Richardson Jason R
Description
An account of the resource
Swallowing disorders in Parkinson's disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson's disease. Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg). The higher dose had a much more severe parkinsonian phenotype than the low dose. Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing. Dose-dependent effects were evident. These preliminary results indicate that future research in toxicological models of Parkinson's disease should incorporate the study of oropharyngeal dysfunction. A better understanding of nongenetic models of Parkinson's disease in feeding may open new avenues for research into the neurological and behavioral bases for swallowing dysfunction in Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2018/6537072" target="_blank" rel="noreferrer noopener">10.1155/2018/6537072</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animal Studies
Deglutition – Drug Effects
Deglutition disorders
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Eating – Drug Effects
Feeding Methods
German Rebecca Z
Gould François D H
Gross Andrew
Isoflavones – Administration and Dosage
Isoflavones – Pharmacodynamics
Mastication
NEOMED College of Medicine
NEOMED College of Pharmacy
Oropharynx – Pathology
Parkinson Disease
Parkinson's disease
Phenotype
Rats
Richardson Jason R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-018-9881-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-018-9881-z</a>
Pages
627–635
Issue
5
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
*Animal model; *Deglutition; *Development; *Infant; *Recurrent laryngeal nerve; *Respiration; *Sensorimotor; Animal; Animal Population Groups; Animals; Biological; Deglutition – Physiology; Deglutition Disorders; Deglutition/*physiology; Disease Models; Humans; Laryngeal Nerves – Injuries; Laryngeal Nerves – Physiology; Larynx – Physiology; Larynx/*physiology; Models; Newborn; Questionnaires; Recurrent Laryngeal Nerve Injuries/*complications; Recurrent Laryngeal Nerve/physiology; Respiration; Swine
Creator
An entity primarily responsible for making the resource
Ballester Ashley; Gould Francois; Bond Laura; Stricklen Bethany; Ohlemacher Jocelyn; Gross Andrew; DeLozier Katherine R; Buddington Randall; Buddington Karyl; Danos Nicole; German Rebecca
Description
An account of the resource
The timing of the occurrence of a swallow in a respiratory cycle is critical for safe swallowing, and changes with infant development. Infants with damage to the recurrent laryngeal nerve, which receives sensory information from the larynx and supplies the intrinsic muscles of the larynx, experience a significant incidence of dysphagia. Using our validated infant pig model, we determined the interaction between this nerve damage and the coordination between respiration and swallowing during postnatal development. We recorded 23 infant pigs at two ages (neonatal and older, pre-weaning) feeding on milk with barium using simultaneous high-speed videofluoroscopy and measurements of thoracic movement. With a complete linear model, we tested for changes with maturation, and whether these changes are the same in control and lesioned individuals. We found (1) the timing of swallowing and respiration coordination changes with maturation; (2) no overall effect of RLN lesion on the timing of coordination, but (3) a greater magnitude of maturational change occurs with RLN injury. We also determined that animals with no surgical intervention did not differ from animals that had surgery for marker placement and a sham procedure for nerve lesion. The coordination between respiration and swallowing changes in normal, intact individuals to provide increased airway protection prior to weaning. Further, in animals with an RLN lesion, the maturation process has a larger effect. Finally, these results suggest a high level of brainstem sensorimotor interactions with respect to these two functions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-018-9881-z" target="_blank" rel="noreferrer noopener">10.1007/s00455-018-9881-z</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Animal model
*Deglutition
*Development
*Infant
*Recurrent laryngeal nerve
*Respiration
*Sensorimotor
2018
Animal
Animal Population Groups
Animals
Ballester Ashley
Biological
Bond Laura
Buddington Karyl
Buddington Randall
Danos Nicole
Deglutition – Physiology
Deglutition disorders
Deglutition/*physiology
DeLozier Katherine R
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
German Rebecca
Gould Francois
Gross Andrew
Humans
Laryngeal Nerves – Injuries
Laryngeal Nerves – Physiology
Larynx – Physiology
Larynx/*physiology
Models
NEOMED College of Medicine
Newborn
Ohlemacher Jocelyn
Questionnaires
Recurrent Laryngeal Nerve Injuries/*complications
Recurrent Laryngeal Nerve/physiology
Respiration
Stricklen Bethany
Swine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-015-9648-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-015-9648-8</a>
Pages
714–722
Issue
6
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-12
Subject
The topic of the resource
Animal; Animals; Aspiration; Biological; Deglutition; Deglutition – Physiology; Deglutition disorders; Deglutition Disorders – Etiology; Deglutition Disorders – Physiopathology; Deglutition Disorders/*etiology/physiopathology; Deglutition/*physiology; Disease Models; Esophagus; Esophagus – Physiopathology; Esophagus/*physiopathology; Human; Infant; Laryngeal Nerves – Injuries; Laryngeal Nerves – Physiopathology; Models; Oropharynx – Physiopathology; Oropharynx/*physiopathology; Recurrent laryngeal nerve; Recurrent Laryngeal Nerve Injuries/*complications/physiopathology; Recurrent Laryngeal Nerve/*physiopathology; Swine
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Lammers Andrew R; Ohlemacher Jocelyn; Ballester Ashley; Fraley Luke; Gross Andrew; German Rebecca Z
Description
An account of the resource
Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN unilaterally in an infant mammalian animal model to characterize the degree and variability of dysphagia in a controlled experimental setting. We tested the hypotheses that (1) both airway protection and esophageal function would be compromised by lesion, (2) given our design, variability between multiple post-lesion trials would be minimal, and (3) variability among individuals would be minimal. Individuals' swallowing performance was assessed pre- and post-lesion using high speed VFSS. Aspiration was assessed using the Infant Mammalian Penetration-Aspiration Scale (IMPAS). Esophageal function was assessed using two measures devised for this study. Our results indicate that RLN lesion leads to increased frequency of aspiration, and increased esophageal dysfunction, with significant variation in these basic patterns at all levels. On average, aspiration worsened with time post-lesion. Within a single feeding sequence, the distribution of unsafe swallows varied. Individuals changed post-lesion either by increasing average IMPAS score, or by increasing variation in IMPAS score. Unilateral RLN transection resulted in dysphagia with both compromised airway protection and esophageal function. Despite consistent, experimentally controlled injury, significant variation in response to lesion remained. Aspiration following RLN lesion was due to more than unilateral vocal fold paralysis. We suggest that neurological variation underlies this pattern.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-015-9648-8" target="_blank" rel="noreferrer noopener">10.1007/s00455-015-9648-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Animal
Animals
Aspiration
Ballester Ashley
Biological
Deglutition
Deglutition – Physiology
Deglutition disorders
Deglutition Disorders – Etiology
Deglutition Disorders – Physiopathology
Deglutition Disorders/*etiology/physiopathology
Deglutition/*physiology
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
Esophagus
Esophagus – Physiopathology
Esophagus/*physiopathology
Fraley Luke
German Rebecca Z
Gould François D H
Gross Andrew
Human
Infant
Lammers Andrew R
Laryngeal Nerves – Injuries
Laryngeal Nerves – Physiopathology
Models
NEOMED College of Medicine
Ohlemacher Jocelyn
Oropharynx – Physiopathology
Oropharynx/*physiopathology
Recurrent laryngeal nerve
Recurrent Laryngeal Nerve Injuries/*complications/physiopathology
Recurrent Laryngeal Nerve/*physiopathology
Swine