1
40
9
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.juro.2012.09.096" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.juro.2012.09.096</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1588-1594
Issue
4
Volume
189
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Title
A name given to the resource
Impact Of Parturition On Chemokine Homing Factor Expression In The Vaginal Distention Model Of Stress Urinary Incontinence
Publisher
An entity responsible for making the resource available
Journal of Urology
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
animal-model; cells; cytokines; deficiency; delivery; female; obstetric; pregnancy; rats; simulated childbirth injuries; urethra; urogenital organs; Urology & Nephrology; vagina; women; wounds and injuries
Creator
An entity primarily responsible for making the resource
Lenis A T; Kuang M; Woo L L; Hijaz A; Penn M S; Butler R S; Rackley R; Damaser M S; Wood H M
Description
An account of the resource
Purpose: Human childbirth simulated by vaginal distention is known to increase the expression of chemokines and receptors involved in stem cell homing and tissue repair. We hypothesized that pregnancy and parturition in rats contributes to the expression of chemokines and receptors after vaginal distention. Materials and Methods: We used 72 age matched female Lewis rats, including virgin rats with and without vaginal distention, and delivered rats with and without vaginal distention. Each rat was sacrificed immediately, or 3 or 7 days after vaginal distention and/or parturition, and the urethra was harvested. Relative expression of chemokines and receptors was determined by real-time polymerase chain reaction. Mixed models were used with the Bonferroni correction for multiple comparisons. Results: Vaginal distention up-regulated urethral expression of CCL7 immediately after injury in virgin and postpartum rats. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor were up-regulated only in virgin rats immediately after vaginal distention. CD191 expression was immediately up-regulated in postpartum rats without vaginal distention compared to virgin rats without vaginal distention. CD195 was up-regulated in virgin rats 3 days after vaginal distention compared to virgin rats without vaginal distention. CD193 and CXCR4 showed delayed up-regulation in virgin rats 7 days after vaginal distention. CXCL12 was up-regulated in virgin rats 3 days after vaginal distention compared to immediately after vaginal distention. Interleukin-8 and CD192 showed no differential expression. Conclusions: Vaginal distention results in up-regulation of the chemokines and receptors expressed during tissue injury, which may facilitate the spontaneous functional recovery previously noted. Pregnancy and delivery up-regulated CD191 and attenuated the expression of hypoxia inducible factor-1 alpha and vascular endothelial growth factor in the setting of vaginal distention, likely by decreasing hypoxia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.juro.2012.09.096" target="_blank" rel="noreferrer noopener">10.1016/j.juro.2012.09.096</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
animal-model
Butler R S
Cells
Cytokines
Damaser M S
deficiency
Delivery
Female
Hijaz A
Journal Article or Conference Abstract Publication
Journal of Urology
Kuang M
Lenis A T
Obstetric
Penn M S
Pregnancy
Rackley R
Rats
simulated childbirth injuries
urethra
urogenital organs
Urology & Nephrology
vagina
Women
Woo L L
Wood H M
wounds and injuries
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/14767058.2013.811484" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/14767058.2013.811484</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1816-1819
Issue
18
Volume
26
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Title
A name given to the resource
The Use Of The Cervilenz Device To Aid In The Diagnosis Of Premature Labor
Publisher
An entity responsible for making the resource available
Journal of Maternal-Fetal & Neonatal Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-12
Subject
The topic of the resource
birth; Cervical length; Cervical length; cervilenz; delivery; epidemiology; fetal fibronectin; intact membranes; Obstetrics & Gynecology; prediction; premature labor; preterm uterine contractions; sonography; transvaginal ultrasonographic measurement
Creator
An entity primarily responsible for making the resource
Lavin J P; Guy M; Gil K; Crane S
Description
An account of the resource
Objective: A short cervix measured by transvaginal ultrasound has been correlated with increased risk for preterm delivery (PTD). Many patients presenting with a complaint of possible premature labor (PL); may not have access to cervical length (CL) screening by ultrasound. Cervilenz is an FDA cleared disposable device for obtaining vaginal CL measurements. This study was conducted to correlate Cervilenz measurements of CL with the occurrence of PTD. Methods: Women presenting with regular uterine contractions at gestational age (GA) >= 22 and <34 weeks with intact membranes and cervical dilation <3 cm were recruited. A speculum examination was performed and Cervilenz measurement of CL was obtained. Patients were treated with tocolytics and/or corticosteroids based upon the attending physician's judgment. The occurrences of PTD as a result of PL or premature rupture of membranes within 7 days, <32 weeks, <34 weeks and <37 weeks, were determined. Patients who were delivered preterm for other maternal or fetal indications were excluded. Negative predictive value (NPV) was calculated. Results: Of the 220 women recruited, 20 were subsequently excluded from analysis because they required PTD for unrelated indications. The mean GA at enrollment was 29.8 +/- 2.8 (SD) weeks. One (0.5%), 2 (1.0%), 4 (2.0%) and 29 (14.5%) women delivered at <= 7 days from enrollment, <= 32 weeks, <= 34 weeks, and <= 37 weeks, inclusively. Seventy-seven (38.5%), 39 (19.5%) and 19 (9.5%) women had Cervilenz measurement of <= 30, <= 25 and <= 20 mm, respectively. The NPV for a Cervilenz measurement of >20 mm for delivery at, <= 32, <= 34 and <= 37 weeks were 99.2%, 98.3% and 86.7%, respectively. Conclusion: Cervilenz measurement >20mm appears to have high NPV for PTD prior to 34 weeks.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/14767058.2013.811484" target="_blank" rel="noreferrer noopener">10.3109/14767058.2013.811484</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
birth
Cervical length
cervilenz
Crane S
Delivery
Epidemiology
fetal fibronectin
Gil K
Guy M
intact membranes
Journal Article or Conference Abstract Publication
Journal of Maternal-Fetal & Neonatal Medicine
Lavin J P
Obstetrics & Gynecology
prediction
premature labor
preterm uterine contractions
sonography
transvaginal ultrasonographic measurement
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0142-9612(03)00189-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0142-9612(03)00189-3</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3493-3503
Issue
20
Volume
24
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synthesis, Permeability And Biocompatibility Of Tricomponent Membranes Containing Polyethylene Glycol, Polydimethylsiloxane And Polypentamethylcyclopentasiloxane Domains
Publisher
An entity responsible for making the resource available
Biomaterials
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-09
Subject
The topic of the resource
biocompatibility; compatibility; delivery; Engineering; hydrogels; insulin diffusion; Materials Science; membrane; molecular weight cut-off; networks; oxygen diffusion; star; surface-properties; water
Creator
An entity primarily responsible for making the resource
Kurian P; Kasibhatla B; Daum J; Burns C A; Moosa M; Rosenthal K S; Kennedy J P
Description
An account of the resource
The synthesis of "smart" tricomponent amphiphilic membranes containing poly(ethylene glycol) (PEG), polydimethylsiloxane (PDMS) and polypentamethylcyclopentasiloxane (PD(5)) domains is described. Contact angle hysteresis indicates that in air, the surfaces of such PEG/PD(5)/PDMS membranes are enriched by the hydrophobic components, PDMS and PD(5), while in water, the surfaces are rich in the hydrophilic PEG. The oxygen permeability of a series of membranes with varying M(c,hydrophilic) (M(n,PEG) = 4600, 10,000 and 20,000 g/mol) and varying PEG/PD(5)/PDMS compositions was studied. Oxygen permeability increased with the amount of PDMS in the membrane. The molecular weight cut-off (MWCO) ranges and permeability coefficients of insulin through a series of PEG/PD(5)/PDMS(=29/14/57) membranes with varying M(c,hydrophilic) were determined. Insulin permeability is directly related to Mc,hydrophilic of the membrane. MWCO studies show that the membranes are semipermeable to, i.e., allow the transport of smaller proteins such as insulin (M(n) = 5733 g/mol, R(s) = 1.34 nm) and cytochrome c (M(n) = 12,400 g/mol, R(s) = 1.63 nm), but are barriers to larger proteins such as albumin (M(n) = 66,000 g/mol, R(s) = 3.62 nm). Implantation of representative membranes in rats showed them to be biocompatible. According to these studies, PEG/PD(5)/PDMS membranes may be suitable for biological applications, e.g., immunoisolation of cells. (C) 2003 Elsevier Science Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0142-9612(03)00189-3" target="_blank" rel="noreferrer noopener">10.1016/s0142-9612(03)00189-3</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2003
Biocompatibility
Biomaterials
Burns C A
compatibility
Daum J
Delivery
Engineering
hydrogels
insulin diffusion
Journal Article or Conference Abstract Publication
Kasibhatla B
Kennedy J P
Kurian P
Materials Science
membrane
molecular weight cut-off
Moosa M
networks
oxygen diffusion
Rosenthal K S
star
surface-properties
Water
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/cbir.1993.1042" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/cbir.1993.1042</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1091-1105
Issue
12
Volume
17
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect Of Ethidium On The Morphology, Antiviral Activity And Subcellular-distribution Of Poly R(a-u)
Publisher
An entity responsible for making the resource available
Cell Biology International
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-12
Subject
The topic of the resource
agents; binding; Cell Biology; complex; delivery; dna; double-stranded-rna; human interferon; induction; inhibition; microscopy
Creator
An entity primarily responsible for making the resource
Jamison J M; Gilloteaux J J; Adrian M; Summers J L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/cbir.1993.1042" target="_blank" rel="noreferrer noopener">10.1006/cbir.1993.1042</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
Adrian M
agents
Binding
Cell Biology
Cell biology international
complex
Delivery
DNA
double-stranded-rna
Gilloteaux J J
human interferon
induction
inhibition
Jamison J M
Journal Article or Conference Abstract Publication
Microscopy
Summers J L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.105.5.1504" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.105.5.1504</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1504-1510
Issue
5
Volume
105
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Dublin Core
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Title
A name given to the resource
Prostacyclin In Septic Shock
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-05
Subject
The topic of the resource
critically; delivery; failure; General & Internal Medicine; ill patients; increases oxygen-consumption; infusion; lactate; norepinephrine therapy; Respiratory System; respiratory-distress syndrome; sepsis; tissue oxygenation
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Meierhellmann A; Bredle D L
Description
An account of the resource
Objective: Investigation of the hypothesis that the infusion of 10 ng/kg/min prostacyclin (epoprostenol) (PGI(2)) improves O-2 uptake in patients with hyperdynamic septic shock. Design: Prospective, single cohort design. Setting: ICU, university hospital. Patients: Fifteen postoperative patients with septic shock. Interventions: Infusion of 10 ng/kg/min of PGI(2) for 60 min. Measurements: Complete hemodynamic profile with O-2 transport-related variables (simultaneous measurements of Vo(2) from the respiratory gases and by cardiovascular Fick) and blood lactate levels before start of the PGI(2)-infusion and 60 min thereafter. Main results: Oxygen delivery increased significantly (14 percent) from its already high value, 750+/-238 to 852+/-214 ml/min/m(2). The O-2 extraction ratio remained unchanged. When Vo(2) was measured from the respiratory gases, it was unchanged. When Vo(2) was measured by cardiovascular Fick, it increased slightly (p<0.05). Conclusions: We conclude that in this O-2 challenge test with PGI(2) in patients with septic shock, an increase in O-2 delivery was not matched by an increase in Vo(2). We believe that the adequate conventional support of these patients may have prevented the PGI(2) from revealing a ''covert'' O-2 debt. The PGI(2) test did not predict mortality by O-2 supply dependency. The small increase in Vo(2) as calculated indirectly suggests a degree of mathematical coupling of O-2 delivery and uptake.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.105.5.1504" target="_blank" rel="noreferrer noopener">10.1378/chest.105.5.1504</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
Bredle D L
Chest
critically
Delivery
failure
General & Internal Medicine
Hannemann L
ill patients
increases oxygen-consumption
infusion
Journal Article or Conference Abstract Publication
lactate
Meierhellmann A
norepinephrine therapy
Reinhart K
Respiratory System
respiratory-distress syndrome
sepsis
tissue oxygenation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00024382-199602000-00008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00024382-199602000-00008</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
130-134
Issue
2
Volume
5
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hypertonic Saline In Stabilized Hyperdynamic Sepsis
Publisher
An entity responsible for making the resource available
Shock
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
& Cardiology; cardiac-output; Cardiovascular System; delivery; dogs; fluid resuscitation; General & Internal Medicine; Hematology; hyperosmotic nacl; osmolality; oxygen consumption; respiratory-distress syndrome; septic shock; severe hemorrhagic-shock; Surgery
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Korell R; Spies C; Bredle D L
Description
An account of the resource
Hypertonic saline with or without colloidal solution has been successfully used for treating hemorrhagic shock in animal experiments and clinical studies. Due to its various effects at systemic, organ, and microcirculatory levels, the substance appears to be a promising candidate for improving tissue oxygenation in sepsis. We therefore investigated the hypothesis that infusion of hypertonic saline would further improve O-2 delivery, O-2 extraction, and O-2 uptake in hyperdynamic septic shock patients already stabilized by adequate volume and catecholamine infusion. Twenty-one patients received 2-4 mL/kg body weight of hypertonic saline in hydroxyethyl starch within 15 min. This hypertonic saline infusion caused a rapid significant increase in O-2 delivery by 14% but only a marginal increase in O-2 consumption (7% by cardiovascular Fick [p < .05], 4% by respiratory gases [n.s.]). Hypertonic saline increased the already elevated cardiac output by 24%. The pulmonary capillary wedge pressure increased from 14 +/- 3 to 23 +/- 3 mmHg and pulmonary shunt fraction increased 15%, but arterial PO2 did not fall. Except for the increase in pulmonary capillary wedge pressure, none of the cardiovascular changes lasted longer than 60 min. Plasma sodium levels increased from 138 +/- 25 to 163 +/- 38 mmol/L and normalized within 24 h. In these hyperdynamic septic patients, hypertonic saline infusion produced a transient increase in circulation, but no evidence of a substantial increase in O-2 consumption. Either there was no significant O-2 debt due to the already elevated O-2 delivery levels at baseline (700 mL/min/m(2)) or the global O-2 measurements we used were not able to detect discrete regional hypoxia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00024382-199602000-00008" target="_blank" rel="noreferrer noopener">10.1097/00024382-199602000-00008</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
& Cardiology
1996
Bredle D L
cardiac-output
Cardiovascular System
Delivery
Dogs
fluid resuscitation
General & Internal Medicine
Hannemann L
Hematology
hyperosmotic nacl
Journal Article or Conference Abstract Publication
Korell R
osmolality
Oxygen Consumption
Reinhart K
respiratory-distress syndrome
Septic shock
severe hemorrhagic-shock
Shock
Spies C
Surgery
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1365-2753.2009.01264.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1365-2753.2009.01264.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1118-1124
Issue
6
Volume
15
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Patient Computer Use To Prompt Doctor Adherence To Diabetes Management Guidelines
Publisher
An entity responsible for making the resource available
Journal of Evaluation in Clinical Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-12
Subject
The topic of the resource
complications; computer; delivery; diabetes; General & Internal; Health Care Sciences & Services; intervention; involvement; knowledge; management guidelines; Medical Informatics; Medicine; mellitus; patient; performance; preventive services; primary care; quality; risk; standards
Creator
An entity primarily responsible for making the resource
Haller N A; Gil K M; Gardner W G; Whittier F C
Description
An account of the resource
Rationale, Aims and Objectives Doctor compliance with diabetic care guidelines is low and may be improved with system-wide changes that include patient involvement. The objective of this study was to determine if patients in an internal medicine teaching clinic would use a touch-screen computer to receive personalized information regarding their need for diabetes care. Outcomes included determining if this intervention would improve resident doctor compliance with diabetic guidelines. Methods In this prospective study a computer was available for patients to use independently in one clinic, while another computer was placed in a second clinic with nursing support. Patients responding they were diabetic to the first screen received screens covering HbA1c, blood pressure, cholesterol, foot, eye examinations and compliance with having labs drawn. Non-diabetic patients received three general health screens. A response-based report was printed for patients to share with their doctor. Chart reviews were conducted to assess diabetic health care delivery. Results The computer was used voluntarily by 20.6% of patients in the primary clinic and by 100% of patients in the nurse-assisted clinic. A total of 104 patients from both clinics responded they were diabetic; over 50% did not know what HbA1c meant and a minority responded their HbA1c, blood pressure and cholesterol were at good levels. Significantly more HbA1c tests conducted within 6 months were documented in patients' charts. Discussion Patients used the computer effectively without direction in the primary clinic. In this initial study, implementation of the computer program increased the number of HbA1c tests ordered. Future studies incorporating refinements may increase both usage and efficacy of this intervention.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1365-2753.2009.01264.x" target="_blank" rel="noreferrer noopener">10.1111/j.1365-2753.2009.01264.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
complications
computer
Delivery
Department of Internal Medicine
Diabetes
Gardner W G
General & Internal
Gil K M
Haller N A
Health Care Sciences & Services
Intervention
involvement
Journal Article or Conference Abstract Publication
Journal of evaluation in clinical practice
Knowledge
management guidelines
Medical Informatics
Medicine
mellitus
NEOMED College of Medicine
Patient
Performance
preventive services
primary care
quality
Risk
standards
Whittier F C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2217/rme.13.38" target="_blank" rel="noreferrer noopener">http://doi.org/10.2217/rme.13.38</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
381-384
Issue
4
Volume
8
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The importance of understanding the molecular mechanism of stem cell-induced cardiac tissue repair
Publisher
An entity responsible for making the resource available
Regenerative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-07
Subject
The topic of the resource
acute myocardial-infarction; acute myocardial-infarction; Cell Biology; chemokines; chronic heart-failure; chronic heart-failure; delivery; endogenous stem cell repair; Engineering; factor-i; ischemic cardiomyopathy; left-ventricular function; marrow; mononuclear-cells; progenitor cells; randomized-trial; sdf-1cxcr4 axis; stem-cells
Creator
An entity primarily responsible for making the resource
Penn M S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2217/rme.13.38" target="_blank" rel="noreferrer noopener">10.2217/rme.13.38</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
acute myocardial-infarction
Cell Biology
chemokines
chronic heart-failure
Delivery
endogenous stem cell repair
Engineering
factor-i
ischemic cardiomyopathy
Journal Article
left-ventricular function
marrow
mononuclear-cells
Penn M S
progenitor cells
randomized-trial
Regenerative Medicine
sdf-1cxcr4 axis
stem-cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/SPV.0000000000000394" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/SPV.0000000000000394</a>
Pages
449–456
Issue
6
Volume
23
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of Pregnancy and Delivery on Cytokine Expression in a Mouse Model of Pelvic Organ Prolapse.
Publisher
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Female pelvic medicine & reconstructive surgery
Date
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2017
2017-12
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Amino Acid Oxidoreductases/*genetics/metabolism; Animal; Animals; Chemokine CCL7/genetics/metabolism; Chemokine CXCL12/genetics/metabolism; Delivery; Female; Humans; Knockout; Mice; Models; Obstetric/*adverse effects/methods; Pelvic Organ Prolapse/*genetics/metabolism/pathology; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Urethra/metabolism; Urinary Bladder/metabolism; Vagina/metabolism
Creator
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Couri Bruna M; Lenis Andrew T; Borazjani Ali; Balog Brian M; Kuang Mei; Butler Robert S; Penn Marc S; Damaser Margot S
Description
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OBJECTIVES: The aim of this study was to determine the effect of pregnancy and delivery mode on cytokine expression in the pelvic organs and serum of lysyl oxidase like-1 knockout (LOXL1 KO) mice, which develop pelvic organ prolapse after delivery. METHODS: Bladder, urethra, vagina, rectum, and blood were harvested from female LOXL1 KO mice during pregnancy, after vaginal or cesarean delivery, and from sham cesarean and unmanipulated controls. Pelvic organs and blood were also harvested from pregnant and vaginally delivered wild-type (WT) mice and from unmanipulated female virgin WT controls. Specimens were assessed using quantitative real-time reverse transcription polymerase chain reaction and/or enzyme-linked immunosorbent assay. RESULTS: Both CXCL12 and CCL7 mRNA were significantly up-regulated in the vagina, urethra, bladder, and rectum of pregnant LOXL1 KO mice compared with pregnant WT mice, suggesting systemic dysregulation of both of these cytokines in LOXL1 KO mice as a response to pregnancy.The differences in cytokine expression between LOXL1 KO and WT mice in pregnancy persisted after vaginal delivery. CCL7 gene expression increases faster and to a greater extent in LOXL1 KO mice, translating to longer lasting increases in CCL7 in serum of LOXL1 KO mice after vaginal delivery, compared with pregnant mice. CONCLUSIONS: Lysyl oxidase like-1 KO mice have an increased cytokine response to pregnancy perhaps because they are less able to reform and re-cross-link stretched elastin to accommodate pups, and this resultant tissue stretches during pregnancy. The up-regulation of CCL7 after delivery could provide an indicator of level of childbirth injury, to which the urethra and vagina seem to be particularly vulnerable.
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<a href="http://doi.org/10.1097/SPV.0000000000000394" target="_blank" rel="noreferrer noopener">10.1097/SPV.0000000000000394</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Amino Acid Oxidoreductases/*genetics/metabolism
Animal
Animals
Balog Brian M
Borazjani Ali
Butler Robert S
Chemokine CCL7/genetics/metabolism
Chemokine CXCL12/genetics/metabolism
Couri Bruna M
Damaser Margot S
Delivery
Female
Female pelvic medicine & reconstructive surgery
Humans
Knockout
Kuang Mei
Lenis Andrew T
Mice
Models
Obstetric/*adverse effects/methods
Pelvic Organ Prolapse/*genetics/metabolism/pathology
Penn Marc S
Pregnancy
Reverse Transcriptase Polymerase Chain Reaction
Urethra/metabolism
Urinary Bladder/metabolism
Vagina/metabolism