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Text
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URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90831-d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90831-d</a>
Pages
101–104
Issue
1
Volume
124
Dublin Core
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Title
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Evidence for mu opiate receptors on inhibitory terminals in area CA1 of rat hippocampus.
Publisher
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Neuroscience letters
Date
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1991
1991-03
Subject
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Animals; Rats; Action Potentials/drug effects; Quinoxalines/pharmacology; Bicuculline/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Ion Channel Gating/drug effects; Barium/pharmacology; Dendrites/chemistry; Enkephalins/metabolism/pharmacology; Hippocampus/*chemistry/ultrastructure; Naloxone/pharmacology; Nerve Endings/chemistry; Potassium Channels/drug effects; Receptors; Enkephalin; Opioid; Ala(2)-MePhe(4)-Gly(5)-; GABA-A/drug effects/physiology; mu; Opioid/*analysis
Creator
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Lambert N A; Harrison N L; Teyler T J
Description
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The mechanism of disinhibition produced by opioid peptides was studied using intracellular recording in area CA1 of rat hippocampal slices. The mu-selective opioid peptide [D-Ala2,N-Me-Phe4,Gly-ol5]-enkephalin (DAGO) reversibly depressed directly-activated, monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV) in a naloxone-sensitive manner. Depression of monosynaptic inhibitory postsynaptic potentials (IPSPs) by DAGO was not prevented by 1-2 mM Ba2+. DAGO reversibly depressed monosynaptic IPSPs when applied locally close to the recording site, but was ineffective when applied close to the stimulating site in stratum radiatum. These results suggest that DAGO disinhibits pyramidal neurons in area CA1 of the rat hippocampus by activating mu opiate receptors located on the terminals of inhibitory neurons, and by a Ba(2+)-insensitive mechanism.
Identifier
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<a href="http://doi.org/10.1016/0304-3940(91)90831-d" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90831-d</a>
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1991
2-Amino-5-phosphonovalerate/pharmacology
Action Potentials/drug effects
Ala(2)-MePhe(4)-Gly(5)-
Animals
Barium/pharmacology
Bicuculline/pharmacology
Dendrites/chemistry
Enkephalin
Enkephalins/metabolism/pharmacology
GABA-A/drug effects/physiology
Harrison N L
Hippocampus/*chemistry/ultrastructure
Ion Channel Gating/drug effects
Lambert N A
mu
Naloxone/pharmacology
Nerve Endings/chemistry
Neuroscience letters
Opioid
Opioid/*analysis
Potassium Channels/drug effects
Quinoxalines/pharmacology
Rats
Receptors
Teyler T J