Browse Items · NEOMED Bibliography Database

Animal Models of Tinnitus: A Review.

Animal models have significantly contributed to understanding the pathophysiology of chronic subjective tinnitus. They are useful because they control etiology, which in humans is heterogeneous; employ random group assignment; and often use methods…

Tags: 2020, Acoustic startle reflex, Animal models, Brozoski Thomas J, Department of Anatomy & Neurobiology, Galazyuk Alexander, journalArticle, June 2020 Update II, NEOMED College of Medicine, Operant behavioral methods, Otolaryngologic clinics of North America, Psychophysics, Tinnitus

Ankle morphology of the earliest Cetaceans and its implications for the phylogenetic relations among ungulates.

Recent molecular studies are inconsistent with ungulate phylogenetic trees that are based on morphological traits. These inconsistencies especially relate to the position of cetaceans and perissodactyls. Evaluation of the close phylogenetic ties…

Tags: *Phylogeny, 1999, Animals, Cetacea/*anatomy & histology/classification, Department of Anatomy & Neurobiology, Hindlimb/anatomy & histology, Joints/*anatomy & histology, Madar S I, NEOMED College of Medicine, Ruminants/*anatomy & histology/classification, Systematic biology, Thewissen J G

Anterograde Tract Tracing for Assaying Axonopathy and Transport Deficits in Glaucoma.

Whether to stage degeneration or investigate early pathology in glaucoma, examination of axonal structure and function is essential. There are a wide variety of methods available to investigators using animal models of glaucoma, with varying…

Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma.

Axonal transport deficits have been reported as an early pathology in several neurodegenerative disorders, including glaucoma. However, the progression and mechanisms of these deficits are poorly understood. Previous work suggests that anterograde…

Anthracobunids from the middle eocene of India and pakistan are stem perissodactyls.

Anthracobunidae is an Eocene family of large mammals from south Asia that is commonly considered to be part of the radiation that gave rise to elephants (proboscideans) and sea cows (sirenians). We describe a new collection of anthracobunid fossils…

Tags: *Fossils, 2014, Animals, Bajpai Sunil, Clementz Mark, Cooper Lisa Noelle, Department of Anatomy & Neurobiology, Dugong, Elephants, Hussain S Taseer, India, Madar Sandra I, NEOMED College of Medicine, Pakistan, PloS one, Seiffert Erik R, Thewissen J G M

Aquatic adaptation and the evolution of smell and taste in whales.

INTRODUCTION: While olfaction is one of the most important senses in most terrestrial mammals, it is absent in modern toothed whales (Odontoceti, Cetacea). Furthermore, behavioral evidence suggests that gustation is very limited. In contrast, their…

Tags: 2015, Agata Kiyokazu, Antarctic minke whale genome, Archaeoceti, Cetacea, Chemoreception, Department of Anatomy & Neurobiology, Hayakawa Takashi, Imai Hiroo, Kishida Takushi, NEOMED College of Medicine, Olfactory bulb, Thewissen J G M, Zoological letters

Aquatic Habits of Cetacean Ancestors: Integrating Bone Microanatomy and Stable Isotopes.

The earliest cetaceans were interpreted as semi-aquatic based on the presence of thickened bones and stable oxygen isotopes in tooth enamel. However, the origin of aquatic behaviors in cetacean relatives (e.g., raoellids, anthracotheres) remains…

Tags: *Ecosystem, 2016, Animals, Bajpai Sunil, Bone and Bones/anatomy & histology/metabolism, Cetacea/*physiology, Clementz Mark T, Cooper Lisa Noelle, Department of Anatomy & Neurobiology, Hieronymus Tobin L, Hussain S Taseer, Integrative and comparative biology, Isotope Labeling, Isotopes/metabolism, NEOMED College of Medicine, Usip Sharon

Arboreal Primate Gait Kinematics: Do Wild Data Validate Laboratory Inferences?

Tags: 2019, 88th Annual Meeting of the American-Association-of-Physical-Anthropologists (AAPA), American journal of physical anthropology, Anthropology, Demes B, Department of Anatomy & Neurobiology, Dunham N T, Evolutionary Biology, Johnson L E, McNamara A, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Shapiro L, Young J W

Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.

Immunofluorescence staining is a widely used and powerful tool for the visualization and colocalization of two or more proteins and/or cellular organelles. For colocalization studies in fixed cells, one target protein/organelle is immunostained and…

Assessing The Determinants Of Primate Gait Kinematics In An Ecological And Phylogenetic Framework, Part I: Phylogenetic Methods For Biomechanics

Tags: 2019, 88th Annual Meeting of the American-Association-of-Physical-Anthropologists (AAPA), American journal of physical anthropology, Anthropology, Department of Anatomy & Neurobiology, Dunham N T, Evolutionary Biology, Hieronymus T L, Journal Article or Conference Abstract Publication, McNamara A, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Shapiro L J, Young J W

Assessing the determinants of primate gait kinematics in an ecological and phylogenetic framework, Part II: Platyrrhine quadrupedalism

Tags: 2019, American journal of physical anthropology, Anthropology, Department of Anatomy & Neurobiology, Dunham N T, Evolutionary Biology, Hieronymous T L, Journal Article, McNamara A, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Shapiro L J, Young J W

Asymmetrical gait kinematics of free-ranging callitrichines in response to changes in substrate diameter and orientation.

Arboreal environments present considerable biomechanical challenges for animals moving and foraging among substrates varying in diameter, orientation, and compliance. Most studies of quadrupedal gait kinematics in primates and other arboreal mammals…

Tags: 2020, Department of Anatomy & Neurobiology, Dunham Noah T, journalArticle, June 2020 Update II, Locomotion, McNamara Allison, NEOMED College of Medicine Student, NEOMED Student Publications, Phelps Taylor, Primate, Shapiro Liza J, Stability, The Journal of experimental biology, Young Jesse W

Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus.

Projections from auditory cortex (AC) affect how cells in both inferior colliculi (IC) respond to acoustic stimuli. The large projection from the AC to the ipsilateral IC is usually credited with the effects in the ipsilateral IC. The circuitry…

Tags: 2013, AC, Animals, auditory cortex, Auditory Cortex/*physiology, Auditory Pathways/cytology, Axons/metabolism/*pathology, Brain Mapping, cortical layers, Department of Anatomy & Neurobiology, Fast Blue, FB, FD, Female, FG, Fluor0Ruby, fluorescein dextran, Fluorescence, FluoroGold, FR, G-, G+, GAD, GAD-immunonegative, GAD-immunopositive, GAD-neg, gamma-Aminobutyric Acid/metabolism, GB, Glutamate Decarboxylase/metabolism, glutamic acid decarboxylase, green RetroBeads, Guinea Pigs, Hearing research, I-VI, IC, IC central nucleus, IC dorsal cortex, IC lateral cortex, IC rostral cortex, ICc, ICd, IClc, ICrc, Inferior Colliculi/pathology/*physiology, inferior colliculus, Male, Mesencephalon/pathology, Microscopy, Nakamoto Kyle T, NEOMED College of Medicine, ps, pseudosylvian sulcus, rhinal sulcus, rs, Schofield Brett R, Sowick Colleen S, white matter, wm

Auditory responses in the cochlear nucleus of awake mustached bats: precursors to spectral integration in the auditory midbrain.

In the cochlear nucleus (CN) of awake mustached bats, single- and two-tone stimuli were used to examine how responses in major CN subdivisions contribute to spectrotemporal integrative features in the inferior colliculus (IC). Across CN subdivisions,…

Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats.

Automated classification of mouse pup isolation syllables: from cluster analysis to an Excel-based "mouse pup syllable classification calculator".

Mouse pups vocalize at high rates when they are cold or isolated from the nest. The proportions of each syllable type produced carry information about disease state and are being used as behavioral markers for the internal state of animals. Manual…

Tags: 2012, Cluster Analysis, College of Anatomy & Neurobiology, communication call, Department of Anatomy & Neurobiology, Frontiers in behavioral neuroscience, Gadziola Marie A, Grimsley Jasmine M S, isolation calls, mouse pup calls, mouse song, NEOMED College of Medicine, Vocalization, Wenstrup Jeffrey J

Autophagy activation by sucrose exhibits chondroprotective effect in human OA chondrocytes.

Tags: 2016, Ansari M Y, Department of Anatomy & Neurobiology, Haqqi T M, Khan MN, NEOMED College of Medicine, Osteoarthritis & Cartilage

Autophagy plays an essential role in bone homeostasis.

Autophagy is very critical for multiple cellular processes. Autophagy plays a critical role in bone cell differentiation and function.

Tags: 2019, Al-Adlaan Asaad A, Ansari Mohammad Y, autophagosome, Autophagy, Department of Anatomy & Neurobiology, Hussein Nazar J, Jaber Fatima A, Journal of cellular physiology, Khan Nazir M, NEOMED College of Medicine, OSTEOBLAST, osteoclast, osteocytes, Safadi Fayez F

Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.

Bcl-2 is an anti-apoptotic protein that has recently been shown to regulate other cellular functions. We previously reported that Bcl-2 regulates chondrocyte matrix gene expression, independent of its anti-apoptotic function. Here, we further…

Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko

Behavioral implications of ontogenetic changes in intrinsic hand and foot proportions in olive baboons (Papio Anubis).

OBJECTIVES: Relatively long digits are considered to enhance grasping performance in primates. We tested whether growth-related changes in intrinsic hand and foot proportions may have behavioral implications for growing animals, by examining whether…

Benefits of Stimulus Exposure: Developmental Learning Independent of Task Performance.

Perceptual learning (training-induced performance improvement) can be elicited by task-irrelevant stimulus exposure in humans. In contrast, task-irrelevant stimulus exposure in animals typically disrupts perception in juveniles while causing little…

Tags: 2016, Adolescent, Adult, Auditory Perception, Department of Anatomy & Neurobiology, development, experience, Frontiers in neuroscience, gap detection, Green David B, Learning, NEOMED College of Medicine, Ohlemacher Jocelyn, prepulse inhibition, Rosen Merri J

Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.

The processes of lipid deposition and utilization, via the gene leptin (Lep), are poorly understood in taxa with varying degrees of adipose storage. This study examines how these systems may have adapted in marine aquatic environments inhabited by…

Biased synaptopathy as a central mechanism of age-related hearing loss.

Tags: 2021, Age-related hearing loss, bushy cell, Department of Anatomy & Neurobiology, February 2021 List, innervation, journalArticle, Lu Y, NEOMED College of Medicine, The Journal of physiology

Bilateral projections to the thalamus from individual neurons in the inferior colliculus.

The medial geniculate body (MG) receives a large input from the ipsilateral inferior colliculus (IC) and a smaller but substantial input from the contralateral IC. Both crossed and uncrossed inputs comprise a large percentage of glutamatergic cells…

Tags: 2019, Beebe Nichole L, collateral, Department of Anatomy & Neurobiology, GABA, inferior colliculus, medial geniculate body, Mellott Jeffrey G, NEOMED College of Medicine, RRID:AB2278725, RRID:AB260754, Schofield Brett R, synchronization, The Journal of comparative neurology

Bilateral projections to the thalamus from individual neurons in the inferior colliculus.

The medial geniculate body (MG) receives a large input from the ipsilateral inferior colliculus (IC) and a smaller but substantial input from the contralateral IC. Both crossed and uncrossed inputs comprise a large percentage of glutamatergic cells…

Tags: 2019, Beebe Nichole L, collateral, Department of Anatomy & Neurobiology, GABA, inferior colliculus, medial geniculate body, Mellott Jeffrey G, NEOMED College of Medicine, RRID:AB2278725, RRID:AB260754, Schofield Brett R, synchronization, The Journal of comparative neurology

Body size and the small branch niche: using marsupial ontogeny to model primate locomotor evolution.

Recently proposed ancestral locomotor and morphological 'stages' leading to the evolution of primates have emphasized small body size, and a transition from a clawed non-grasping stage, to a clawed, grasping stage with clawless opposable hallux, to a…

Bone mineral density in adolescent urinary stone formers: is sex important?

Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This…

Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.

In childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal processing. However, early therapeutic interventions targeting temporal processing may improve later speech-related outcomes. Gap detection is a…

Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.

BACKGROUND/AIMS: Butein (2',3,4,4'-Tetrahydroxychalcone), a polyphenol produced by several plants including Butea monoserpma, has been reported to exert potent anti-inflammatory activity but the mechanism remains unknown. In the present work we…

Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1

Callitrichid responses to dead and dying infants: the effects of paternal bonding and cause of death.

Many primates show responses to dead infants, yet testing explanations for these behaviors has been difficult. Callitrichids present a unique opportunity to delineate between hypotheses, since unlike most species, male caretakers form closer social…

Canertinib induces ototoxicity in three preclinical models.

Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing…

Capsaicin improves swallow safety during infant feeding

Tags: 2021, Adjerid K, Bond LE, Department of Anatomy & Neurobiology, Edmonds CE, German RZ, Gould FDH, Integrative and comparative biology, journalArticle, July 2021 List, Mayerl CJ, NEOMED College of Medicine, NEOMED Postdoc Publications, Steer KE

Carpal morphology and function in the earliest cetaceans

During the land-to-water transition in the Eocene epoch, the cetacean skeleton underwent modifications to accommodate life in the seas. These changes are well-documented in the fossil record. The forelimb transformed from a weight-bearing limb with…

Tags: 2021, ARTICLES, Cooper LN, Department of Anatomy & Neurobiology, Fish FE, Gavazzi LM, Hussain ST, January 2021 List, Journal of Vertebrate Paleontology, journalArticle, NEOMED College of Medicine, NEOMED Student Publications, Thewissen JGM

Cells in auditory cortex that project to the cochlear nucleus in guinea pigs.

Fluorescent retrograde tracers were used to identify the cells in auditory cortex that project directly to the cochlear nucleus (CN). Following injection of a tracer into the CN, cells were labeled bilaterally in primary auditory cortex and the…

Tags: 2006, Animals, Auditory Cortex/*cytology, Cochlear Nucleus/*cytology, Coomes Diana L, Department of Anatomy & Neurobiology, Fluorescent Dyes, Guinea Pigs, Journal of the Association for Research in Otolaryngology : JARO, NEOMED College of Medicine, Pyramidal Cells/*cytology, Schofield Brett R, Schofield Ryan M

Central nervous system integration of sensorimotor signals in oral and pharyngeal structures: oropharyngeal kinematics response to recurrent laryngeal nerve lesion.

Safe, efficient liquid feeding in infant mammals requires the central coordination of oropharyngeal structures innervated by multiple cranial and spinal nerves. The importance of laryngeal sensation and central sensorimotor integration in this system…

Changes in Skeletal Loading as a Mediator of Morphological Change across Evolutionary Transitions in Habitat

Presented at the 12th International Congress of Vertebrate Morphology, held July 21 – 25, 2019 in Prague, Czech Republic.

Tags: 2019, Anatomy & Morphology, Blob R W, Department of Anatomy & Neurobiology, Diamond K M, Journal of morphology, June 2019 Update, Kawano S M, Mayerl C J, Munteanu V D, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Young V K H

Changes in the coordination between respiration and swallowing from suckling through weaning.

All mammals undergo weaning from milk to solid food. This process requires substantial changes to mammalian oropharyngeal function. The coordination of swallowing and respiration is a crucial component of maintaining airway function throughout…

Chapter 10 - Postcranial skeleton and musculature

The postcranial skeleton of bowhead whales was described in detail more than 100 years ago. The musculature of bowheads has not been studied in detail but matches that of other mysticetes in general features. In this chapter, we focus on some aspects…

Chapter 13 - Female and male reproduction

An understanding of the functional morphology of the bowhead whale continues to have significance for population management. This chapter first examines the anatomical features of the bowhead whale reproductive system, with an emphasis on the female.…

Chapter 18 - Sensory systems

The sensory biology of bowhead whales reflects features both related to their origin from land mammals and adaptations to their current environment, polar seas. There is anatomical and genomic evidence that bowheads have a sense of smell. Their sense…

Tags: 2021, audition, Balaena mysticetus, Balance, bowhead whale, Department of Anatomy & Neurobiology, George JC, gustation, January 2021 List, journalArticle, magnetosense, mechanosense, NEOMED College of Medicine, olfaction, Sformo TL, Suydam RS, The Bowhead Whale, Thewissen JGM, Vision

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