Browse Items (328 total)
- Tags: Department of Integrative Medical Sciences
Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet.
Bile acid metabolism and signaling in liver disease and therapy.
Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.
Tags: 2003, American journal of physiology. Gastrointestinal and liver physiology, Animals, Bile Acids and Salts/biosynthesis/genetics/*physiology, Bile/*physiology, Cardiovascular Diseases/genetics/physiopathology, Chiang John Y L, Cholesterol/physiology, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback/physiology, Gene Expression Regulation/physiology, Humans, Liver Diseases/genetics/physiopathology, Liver/*physiology, NEOMED College of Medicine, Receptors
Bile acids: regulation of synthesis.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology
Bile acid regulation of gene expression: roles of nuclear hormone receptors.
Recent advances in understanding bile acid homeostasis.
Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Chiang John Y L, Department of Integrative Medical Sciences, Expert opinion on drug metabolism & toxicology, Gene Expression Regulation, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 4/genetics/*metabolism, Humans, Lipid Metabolism, Liver/metabolism, Mutation, NEOMED College of Medicine, Pharmaceutical Preparations/*metabolism, Signal Transduction/physiology
Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.
Tags: *Lipid Metabolism, 2005, Animals, Chiang John Y L, Chronic Disease, Current opinion in investigational drugs (London, England : 2000), Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/metabolism, Dyslipidemias/drug therapy/metabolism, Heart Diseases/*drug therapy/metabolism, Humans, Hypoglycemic Agents/therapeutic use, Hypolipidemic Agents/therapeutic use, Liver Diseases/*drug therapy/metabolism, Metabolic Diseases/*drug therapy/metabolism, NEOMED College of Medicine, Receptors
Bile Acid Metabolism in Liver Pathobiology.
Bile Acids as Metabolic Regulators and Nutrient Sensors
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.
Tags: 2020, alcoholic and nonalcoholic fatty, American journal of physiology. Gastrointestinal and liver physiology, Bile acid metabolism, bile acid therapies, Chiang John Y L, Department of Integrative Medical Sciences, Farnesoid X receptor, Ferrell Jessica M, Liver Diseases, NEOMED College of Graduate Studies, NEOMED College of Medicine, Takeda G protein-coupled receptor 5
Bile Acid Biology, Pathophysiology, and Therapeutics.
Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation.
Tags: *Signal Transduction, 2017, Animals, Bile Acids and Salts/biosynthesis/metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Digestive diseases (Basel, Switzerland), Donepudi Ajay, Ferrell Jessica, G-Protein-Coupled/*metabolism, Humans, Intestinal Mucosa/*metabolism, Liu Hailiang, Liver/metabolism, NEOMED College of Medicine, Pathak Preeti, Receptors
Coronary collateral growth–back to the future.
Tags: 2012, Chilian William M, Collateral Circulation/*physiology, Coronary Artery Disease/physiopathology/therapy, Coronary Circulation/physiology, Department of Integrative Medical Sciences, Dong Feng, Humans, Journal of molecular and cellular cardiology, Logan Suzanna, Mayorga Maritza, Myocardial Ischemia/physiopathology/therapy, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Penn Marc S, Physiologic/physiology, Pung Yuh Fen, Yin Liya
Step by Step: Advancing the Understanding of Local Vascular Control.
Tags: 2020, and vascular biology, Arterial Pressure, Arteriosclerosis, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Department of Integrative Medical Sciences, dilation, Editorials, Endothelium, hypoxia, NEOMED College of Medicine, Ohanyan Vahagn, Thrombosis, vasodilation, Yin Liya
Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress.
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function.
Tags: 2010, Chen Yeong-Renn, Chun-An Chen, Department of Integrative Medical Sciences, Druhan Lawrence J, Endothelium, Glutathione, Hemann Craig, INORGANIC compounds, Nature, NEOMED College of Medicine, NITRIC oxide, Reyes Levy A, SUPEROXIDES, Talukder M A Hassan, TETRAHYDROBIOPTERIN, Tse-Yao Wang, Varadharaj Saradhadevi, VASCULAR grafts, Zweier Jay L
Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives.
Tags: 2000, Antiviral Agents/*pharmacology, Antiviral research, Callahan M, Craigo J, Cultured, DeLucia A L, Department of Integrative Medical Sciences, Female, Gene Expression Regulation, Genetic/drug effects, HIV Long Terminal Repeat/drug effects, Huang R C, Humans, Lignans/chemistry/pharmacology, Masoprocol/*analogs & derivatives/*pharmacology, NEOMED College of Medicine, Papillomaviridae/*genetics, Promoter Regions, Simian virus 40/genetics, Tumor Cells, Viral/*drug effects
Uterine cervix adenocarcinoma with both human papillomavirus type 18 and tumor suppressor gene p53 mutation from a woman having an intact hymen.
Tags: *Genes, *Hymen, *Mutation, 1995, Adenocarcinoma/*genetics, Adult, Craigo J, DeLucia A, Department of Integrative Medical Sciences, DNA, Female, Gene Deletion, Genome, Gynecologic oncology, Hopkins M, Humans, NEOMED College of Medicine, Neoplasm/genetics, p53, Papillomaviridae/classification/*genetics, Polymerase Chain Reaction, Polymorphism, Sexually Transmitted Diseases, Single-Stranded Conformational, Uterine Cervical Neoplasms/*genetics, Viral/genetics
Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: 1993, Amino Acid, Amino Acid Sequence, Animals, Archives of biochemistry and biophysics, Base Sequence, Blotting, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cricetinae, Department of Integrative Medical Sciences, DNA/genetics/isolation & purification, Galli G, Genomic Library, Humans, Liver/enzymology, Mesocricetus/*genetics, Messenger/biosynthesis/metabolism, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Northern, Poly A/biosynthesis/metabolism, Rats, Restriction Mapping, RNA, Sequence Homology, Southern
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.
Tags: 1994, Animals, Bile Acids and Salts/*pharmacology, Biochemical and biophysical research communications, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Crestani M, Cultured, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Genetic, Genetic/genetics, Humans, Karam W G, Luciferases/biosynthesis/genetics, Messenger/*biosynthesis, NEOMED College of Medicine, Promoter Regions, Rats, Recombinant Fusion Proteins/biosynthesis, RNA, Steroids/*pharmacology, Thyroid Hormones/*pharmacology, Transcription, Transfection
The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Promoter Regions, 1996, Animals, Base Sequence, Biochemical and biophysical research communications, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Crestani M, Department of Integrative Medical Sciences, DNA Primers, Galli G, Genetic, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Rats, Sadeghpour A, Signal Transduction, Stroup D, Tetradecanoylphorbol Acetate/*pharmacology, Tretinoin/*pharmacology
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells
Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.
Tags: *Coronary Circulation, *Microcirculation, 2016, Animals, Basic research in cardiology, Bratz Ian N, Capsaicin, Chen Yeong-Renn, Connell Patrick J, Coronary blood flow, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetic Angiopathies/*metabolism, Dick Gregory M, Fahmy Joseph N, Fancher Ibra S, HEK293 Cells, Humans, Hydrogen peroxide, Hydrogen Peroxide/*metabolism, Inbred C57BL, Kang Patrick T, Klarich Brittany, Knockout, Male, Mice, NEOMED College of Medicine, reactive oxygen species, Thodeti Charles K, TRPV Cation Channels/*metabolism, TRPV1
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
Connecting the dots–establishing causality between chronic stress, depression, and cardiovascular disease.
Tags: 2014, Animal/*physiology, Animals, Behavior, Chilian William M, Department of Family & Community Medicine, Department of Integrative Medical Sciences, Depression/*physiopathology, Di Vincenzo Lola, Endothelium, Female, Journal of applied physiology (Bethesda, Md. : 1985), Male, NEOMED College of Medicine, Perera Vidushani, Psychological/*physiopathology, Reber Megan, Stress, Vascular Diseases/*physiopathology, Vascular/*physiopathology
Resveratrol inhibition of herpes simplex virus replication.
Tags: 1999, Animals, Antiviral Agents/*pharmacology/toxicity, Antiviral research, Cell Cycle/drug effects, Cell Line, Cercopithecus aethiops, DeLucia A L, Department of Integrative Medical Sciences, Docherty J J, Fu M M, Herpesvirus 1, Herpesvirus 2, Human/*drug effects/physiology, Humans, Immediate-Early Proteins/antagonists & inhibitors/biosynthesis, Limperos R J, Mice, NEOMED College of Medicine, Pokabla C M, Resveratrol, Stiffler B S, Stilbenes/*pharmacology/toxicity, Vero Cells, Virus Latency/drug effects/physiology, Virus Replication/*drug effects/physiology
Genomic structure and regulation of the rat hepatic CYP4F1 gene by peroxisome proliferators.
Tags: 2008, Animals, Archives of biochemistry and biophysics, Cell Line, Chen Liping, Chromosome Mapping, Cytochrome P-450 Enzyme System/*genetics, Department of Integrative Medical Sciences, Donelson Ellen, Gene Expression Regulation/drug effects/*genetics, Genetic/*genetics, Goswami Puja, Hardwick James P, Hepatocytes/drug effects/*physiology, Liver/drug effects/*physiology, NEOMED College of Medicine, Peroxisome Proliferator-Activated Receptors/*genetics, Peroxisome Proliferators/*pharmacology, Promoter Regions, Rats, Song Byoung J, Zhang Xiaolan
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction
Deficiency of cholesterol 7alpha-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice.
Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction.
Tags: 2012, Agarwal U, Animal Studies, Apoptosis – Physiology, Cardiovascular System Physiology, Cell Movement – Physiology, Cell Physiology, Cell Surface, Cell Surface – Metabolism, Cells, Circulation, Coronary Circulation – Physiology, Cytokines – Metabolism, Department of Integrative Medical Sciences, Dong F, Finan A, Gene Expression – Physiology, Harvey J, Mice, myocardial infarction, Myocardial Infarction – Pathology, Myocardial Infarction – Therapy, Myocardium, NEOMED College of Medicine, Penn M S, Proteins, Receptors, Stem Cells – Metabolism, Stem Cells – Transplantation, Weber K