Browse Items (328 total)
- Tags: Department of Integrative Medical Sciences
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Tags: 2016, Adapala R K, Animals, Calcium Signaling/genetics, Cappelli H C, Carcinoma, Cell Line, Cell Proliferation/drug effects, Chilian W M, Cisplatin/administration & dosage, Department of Integrative Medical Sciences, Dudley A C, Endothelium, Gene Expression Regulation, Ghosh K, Humans, Ingber D E, Keshamouni V, Klagsbrun M, Leucine/administration & dosage/analogs & derivatives, Lewis Lung/drug therapy/*genetics/pathology, Meszaros J G, Mice, NEOMED College of Medicine, Neoplastic/drug effects, Neovascularization, Oncogene, Paruchuri S, Pathologic/drug therapy/*genetics/pathology, Sulfonamides/administration & dosage, Thodeti C K, Thoppil R J, TRPV Cation Channels/agonists/biosynthesis/*genetics, Tumor, Vascular Endothelial Growth Factor A/genetics, Vascular/drug effects/*pathology
TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation.
Tags: 2020, Adapala Ravi K, Basic research in cardiology, cardiac fibroblast, Cardiac fibrosis, Chilian William M, DELETION mutation, Department of Integrative Medical Sciences, Extracellular Matrix, heart, Heart failure, HEART fibrosis, Kanugula Anantha K, Mechanotransduction, myocardial infarction, NEOMED College of Medicine, NEOMED Postdoc Publications, Paruchuri Sailaja, Rho/Rho kinase, TGF-beta1, TGF-β1, Thodeti Charles K, TRPV4
PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.
Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.
Tags: *Calcium Signaling, *Cell Differentiation, *Mechanotransduction, 2013, Adapala Ravi K, Animals, Cellular, Chilian William M, Department of Integrative Medical Sciences, Extracellular Matrix/metabolism/physiology, Fibroblasts/*physiology, Gene Knockdown Techniques, Journal of molecular and cellular cardiology, Luther Daniel J, Male, Meszaros J Gary, Monoterpenes/pharmacology, Myocardium/cytology, Myofibroblasts/metabolism, NEOMED College of Medicine, Paruchuri Sailaja, Rats, RNA, Small Interfering/genetics, Sprague-Dawley, Thodeti Charles K, Thoppil Roslin J, Transforming Growth Factor beta1/physiology, TRPM Cation Channels/antagonists & inhibitors/metabolism, TRPV Cation Channels/genetics/*metabolism
Endothelial Trpv4 contributes to pressure overload-induced pathological hypertrophy via modulation of coronary angiogenesis
Tags: 2020, Adapala RK, angiogenesis, Cardiac hypertrophy, Chilian WM, Circulation research, Department of Integrative Medical Sciences, Fibrosis, Ion Channels, January 2021 List, journalArticle, Kanugula AK, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED Student Publications, Ohanyan VA, Paruchuri SM, Thodeti CK
Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice.
Tags: 2017, Akinrotimi Oludemilade, Anakk Sayeepriyadarshini, Animals, Body Weight/genetics, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Diabetes Mellitus, Fatty Liver/*genetics, Hepatology (Baltimore, Md.), Knockout, Lee Yoon-Kwang, Lipid Metabolism/genetics, Mice, NEOMED College of Medicine, Park Jung Eun, Receptors, Riessen Ryan, Schoonjans Kristina, Type 2/*genetics, VanDuyne Philip, Wong Lee-Jun, Zavacki Ann M
Transient receptor potential vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH oxidase 4.
Tags: 2020, Al-Azzam N, asthma, CAPSAICIN receptors, Chachkovskyy T, Covington K, Department of Integrative Medical Sciences, Gavilanes I, Ghebreigziabher S, growth factors, journalArticle, July 2020 List, NEOMED College of Medicine, NEOMED College of Medicine Student, NEOMED Student Publications, NICOTINAMIDE adenine dinucleotide phosphate, OXIDATION-reduction reaction, Paruchuri S, Pokhrel S, Scientific reports, Teegala LR, Thodeti CK, Thodeti S, TRP channels
Intravital Microscopy of the Beating Murine Heart to Understand Cardiac Leukocyte Dynamics.
A plant lignan, 3'-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells.
Tags: 2007, Allen Kristi L, Apoptosis Regulatory Proteins/metabolism, Apoptosis/*drug effects, Awad Keytam S, bcl-2-Associated X Protein/metabolism, Caspase 3/metabolism, Caspase 9/metabolism, Cultured/drug effects, DeLucia Angelo L, Department of Integrative Medical Sciences, Enzyme Activation/drug effects, Female, Genetic, Humans, Luciferases, Lynch William P, Masoprocol/*analogs & derivatives/therapeutic use, Molecular carcinogenesis, NEOMED College of Medicine, Oncogene Proteins, Plants/chemistry, Proto-Oncogene Proteins/metabolism, Repressor Proteins/*metabolism, Transcription, Tschantz Deidra R, Tumor Cells, Tumor Suppressor Protein p53/genetics/*metabolism, Uterine Cervical Neoplasms/*drug therapy/metabolism/pathology, Viral/*metabolism
Mice with Bile acid‐CoA: amino acid N‐acyltransferase deletion are protected from obesity
Mitochondrial diseases in North America: An analysis of the NAMDC Registry.
Tags: 2020, Akron Children's Hospital, Barca Emanuele, Bedoyan Jirair K, Buchsbaum Richard, Camp Kathryn, Cohen Bruce H, Cooley Victoria, criteria, DeBrosse Susanne D, Department of Integrative Medical Sciences, Department of Pediatrics, DiMauro Salvatore, DNA, Emmanuele Valentina, Engelstad Kristin, Enns Gregory M, Falk Marni J, Ganesh Jaya, Gavrilova Ralitza H, Goldstein Amy C, Grier Johnston, Gropman Andrea, Haas Richard, Hirano Michio, Journal Article, journalArticle, June 2020 Update I, Karaa Amel, Kriger Joshua, Krotoski Danuta, Larson Austin, Long Yuelin, melas, merrf, natural-history, NEOMED College of Medicine, Neurology. Genetics, nuclear, Parikh Sumit, Prevalence, Rosales Xiomara Q, Saneto Russell P, Scaglia Fernando, Schoenaker Robert, Stacpoole Peter W, Tarnopolsky Mark, Thompson John L P, Van Hove Johan L K, Vladutiu Georgirene D, Zolkipli-Cunningham Zarazuela
Retinoic acid receptor α signaling protects against diet‐induced hepatosteatosis and obesity in mice
Utility of specific amino acid ratios in screening for pyruvate dehydrogenase complex deficiencies and other mitochondrial disorders associated with congenital lactic acidosis and newborn screening prospects.
Tags: 2020, alanine, Bartholomew D, Bedoyan JK, Cohen B, DeBrosse S, December 2020 List, Department of Integrative Medical Sciences, Department of Pediatrics, Ducich N, Ferren E, Hage R, Jimd Reports, journalArticle, Kerr D, ketogenic amino acids, Ketogenic diet, lactic acidosis, Lehman A, Linard S, Manickam K, mitochondrial disorder, Mori Mari, NEOMED College of Medicine, newborn screening, Parikh S, proline, pyruvate dehydrogenase complex deficiency, Schillaci L, Shin HK, Wilson K
Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling.
Tags: 2017, Adenosine Triphosphate – Metabolism, Adenosine Triphosphate/*metabolism, Ammi Azzdine Y, Animal Studies, Animals, Belcik J Todd, Chilian William M, Chon Chae Ryung, Circulation, contrast echocardiography, Davidson Brian P, Department of Integrative Medical Sciences, Equipment and Supplies, Field Joshua, Harmann Leanne, Hemodynamics, Humans, Inbred C57BL, Liang Sherry, Linden Joel, Lindner Jonathan R, Male, Mice, Microbubbles, Microcirculation, Muscle, NEOMED College of Medicine, Neurotransmitter Agents – Metabolism, Perfusion, Purinergic Agents/*metabolism, Qi Yue, Signal Transduction, Skeletal – Blood Supply, Skeletal/*blood supply, Ultrasonography – Methods, Ultrasonography/*methods, Wu Melinda D, Xie Aris, Yadava Mrinal
A Novel Exercise Testing Algorithm to Diagnose Mitochondrial Myopathy.
Tags: 2021, Bhatia Rajeev, Cardiopulmonary exercise testing, Cohen BH, Department of Integrative Medical Sciences, Department of Pediatrics, February 2021 List, journalArticle, McNinch N, Mitochondrial myopathy, Muscle & nerve, NEOMED College of Medicine, O2 /Work slope, O2), Oxygen uptake (V&c.dotab, Oxygen Uptake Efficiency Slope (OUES), V&c.dotab
Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling.
Tags: 2009, Animals, Bryant Jennifer E, Cell Differentiation/*physiology, Collagen Type VI/*metabolism/physiology, Costic Donald J, Department of Integrative Medical Sciences, Doane Kathleen J, Dockry Michelle, Fibroblasts/*cytology, Immunoblotting, Integrin alpha3/*metabolism, Journal of molecular and cellular cardiology, Koshy John C, Luther Daniel J, Male, Meszaros J Gary, Mohile Monica V, Myocardial Infarction/*metabolism, Myocardium/*cytology, NEOMED College of Medicine, Olson Erik R, Protein Binding, Rats, Shamhart Patricia E
Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis
Tags: 2019, acetaldehyde, Alcohol, Biomedical and Life Sciences, Byoung-Joon Song, Cancer, Cancer Research, Cell Biology, CYP2E1, Department of Integrative Medical Sciences, DNA mutation, Human Cell Transformation : Advances In Cell Models For The Study Of Cancer And Aging, Inflammation, James P Hardwick, Johng S Rhim, Journal Article, Life sciences, Min-Kyung Song, Mohamed A Abdelmegeed, Mohammed Akbar, NEOMED College of Medicine, November 2019 Update, oncology, Oxidative Stress, Young-Eun Cho
Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.
Tags: 2020, Adapala R K, Cappelli HC, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, ECM stiffness, Guarino BD, human retinal endothelial cells, Journal of cellular physiology, journalArticle, Kanugula AK, Mechanotransduction, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED College of Medicine Student, NEOMED College of Pharmacy, NEOMED Postdoc Publications, NEOMED Student Publications, Neovascularization, October 2020 List, Paruchuri S, Perera V, Smith MA, Thodeti CK, TRPV4
Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis.
Tags: 2019, Adapala Ravi K, Amin Vibhatsu, angiogenesis, Cancer letters, Cappelli Holly C, Department of Integrative Medical Sciences, Kanugula Anantha K, Mechanotransduction, Midha Priya, NEOMED College of Medicine, Paruchuri Sailaja, Sharma Priya, Stiffness, Thodeti Charles K, TRPV4, Vascular integrity, VE-cadherin
Astrocyte Infection Is Required for Retrovirus-Induced Spongiform Neurodegeneration Despite Suppressed Viral Protein Expression
Tags: 2019, Astrocytes, Cardona Sandra M, Das Alvin S, Department of Integrative Medical Sciences, Dunphy Jaclyn M, Frontiers in neuroscience, glia, Journal Article, Lynch Connor R, Lynch William P, NEOMED College of Medicine, neural progenitor cells, Neural stem cells, neurotropism, November 2019 Update, retrovirus, spongiform neurodegeneration, virus suppression
Molecular basis of takotsubo syndrome
Why Is a Child Not a Miniadult for Infections?
Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
Tags: 2012, Adapala Ravi K, American journal of physiology. Cell physiology, Animals, Cell Movement/physiology, Cells, Chavez Ronaldo J, Cuadra Rene H, Cultured, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/physiology, Haney Rebecca M, Humans, Inbred C57BL, Janus Kinase 2/*biosynthesis, Knockout, Leptin/*physiology, Male, MAP Kinase Signaling System/*physiology, Mice, Muscle, Myocytes, NEOMED College of Medicine, Raman Priya, Smooth, Smooth Muscle/enzymology/metabolism, Thodeti Charles K, Thrombospondin 1/*biosynthesis, Up-Regulation/*physiology, Vascular/enzymology/*metabolism
Reperfusion mediates heme impairment with increased protein cysteine sulfonation of mitochondrial complex III in the post-ischemic heart.
Tags: 2021, August 2021 List, Chen C, Chen Y-R, Chilian WM, Complex III, Cysteine sulfonation, Department of Integrative Medical Sciences, Heme damage, Journal of molecular and cellular cardiology, journalArticle, Kang PT, Myocardial ischemia and reperfusion, NEOMED College of Medicine, Oxidative Stress, Protein Structure, Xiao K, Zhang L, Zweier JL
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.
Tags: 1993, 2-Acetylaminofluorene, Aflatoxin B1, Amino Acid, Amino Acid Sequence, Animals, Antisense Elements (Genetics), Archives of biochemistry and biophysics, Base Sequence, Blotting, Chen L, Clofibrate, Cytochrome P-450 Enzyme System/analysis/*genetics, Department of Integrative Medical Sciences, Hardwick J P, Humans, Liver Neoplasms/chemically induced/*enzymology/genetics, Male, Microsomes/enzymology, Molecular Sequence Data, Multigene Family, NEOMED College of Medicine, Northern, Rats, Sequence Homology, Western
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells
Chronic reperfusion mediates restoring the integrity of c-type cytochrome, limiting superoxide overproduction, and conferring reconditioning mitochondrial function in the postischemic heart
Cardiac mitochondria and reactive oxygen species generation.
Tags: 2014, Animals, Cardiac/*metabolism, Cardiovascular Diseases/*metabolism, Chen Yeong-Renn, Circulation research, Department of Integrative Medical Sciences, electron transport chain complex proteins, Heart/*metabolism, Humans, Membrane Potentials/physiology, Mitochondria, myocardial infarction, Myocytes, NEOMED College of Medicine, reactive oxygen species, Reactive Oxygen Species/*metabolism, Signal Transduction/physiology, Zweier Jay L
Regulation of bile acid synthesis.
Tags: 1998, Animals, Bile Acids and Salts/*biosynthesis, Chiang J Y, Cholestanetriol 26-Monooxygenase, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cholesterol/metabolism, Cytochrome P-450 Enzyme System/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, Frontiers in bioscience : a journal and virtual library, Gene Expression Regulation, Humans, Liver/metabolism, NEOMED College of Medicine, Steroid 12-alpha-Hydroxylase/metabolism, Steroid Hydroxylases/metabolism
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Tags: 2001, Animals, Binding Sites, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/drug effects/*genetics/metabolism, Cricetinae, Cultured, Department of Integrative Medical Sciences, gene, Gene Expression Regulation/drug effects, Genetic, Humans, Hydroxycholesterols, Kimmel R, Liver/physiology, Lovastatin/pharmacology, Luciferases/genetics/metabolism, Mevalonic Acid/metabolism/pharmacology, NEOMED College of Medicine, Nicotinic Acids/pharmacology, Organ Specificity, Polyisoprenyl Phosphates/pharmacology, Rats, Receptors, Response Elements, Retinoic Acid/genetics/metabolism, Retinoid X Receptors, Species Specificity, Steroid/genetics/*metabolism, Stroup D, Tetrahydronaphthalenes/pharmacology, Transcription, Transcription Factors/genetics/metabolism, Transfection
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *Transcription, 2000, Animals, Bile Acids and Salts/*pharmacology, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, DNA-Binding Proteins/*physiology, Genetic, Humans, Kimmel R, NEOMED College of Medicine, Promoter Regions, Receptors, Repressor Proteins/*physiology, Response Elements, Retinoic Acid/genetics, Retinoid X Receptors, Stroup D, The Journal of biological chemistry, Transcription Factors/genetics/*physiology, Tumor Cells, Weinberger C
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.
Tags: *Circadian Rhythm, 1990, Animals, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/isolation & purification/metabolism, Cholestyramine Resin/*pharmacology, Chromatography, Department of Integrative Medical Sciences, Durapatite, Enzyme Induction, Hydroxyapatites, Inbred Strains, Ion Exchange, Isoenzymes/*biosynthesis/isolation & purification, Kinetics, Lin G M, Liver/drug effects/*enzymology, Microsomes, Miller W F, NEOMED College of Medicine, Obesity/enzymology, Organ Specificity, Polyethylene Glycols, Rats, Steroid Hydroxylases/*biosynthesis, The Journal of biological chemistry, Zucker
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
Tags: *Promoter Regions, 1994, Animals, Antigens, Base Sequence, Bile Acids and Salts/*metabolism, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cloning, Deoxyribonuclease I, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/metabolism, Oligodeoxyribonucleotides, Polyomavirus Transforming/genetics, Rats, Recombinant Fusion Proteins/genetics/metabolism, Sprague-Dawley, Stroup D, The Journal of biological chemistry, Thyroid Hormones/genetics
Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.
Tags: *Promoter Regions, 1992, Amino Acid Sequence, Animals, Base Sequence, Biochimica et biophysica acta, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Department of Integrative Medical Sciences, DNA, Genetic, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Rats, Restriction Mapping, Wang D P, Yang T P
Bile acid metabolism and signaling.
Tags: 2013, Animals, Bile Acids and Salts/*metabolism/therapeutic use, Biliary Tract Diseases/metabolism, Chiang John Y L, Cholesterol/metabolism, Comprehensive Physiology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Enterohepatic Circulation/physiology, Feedback, G-Protein-Coupled/metabolism, Homeostasis/physiology, Humans, Inflammation/metabolism, Liver/metabolism, NEOMED College of Medicine, Physiological/physiology, Receptors, Signal Transduction/*physiology