Browse Items (328 total)
- Tags: Department of Integrative Medical Sciences
IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
Tags: 2020, August 2020 List, Brown JM, Carman JA, Chen Y, Dent R, Department of Integrative Medical Sciences, Dongre A, Drazba JA, Fox PL, Gao J, Hine C, journalArticle, Li X, Liu W, McDowell RE, Nature Immunology, NEOMED College of Medicine, Qian W, Schugar RC, Smith JD, Tang F, Wang H, Yang H, Yin M, Yu M, Zhao J, Zhou H
Orphan nuclear receptor oestrogen-related receptor gamma (ERRgamma) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.
Tags: 2015, Animals, bile acid, Bile Acids and Salts/metabolism, Cannabinoid, cannabinoid receptors, CB1/agonists/genetics/*metabolism, Cells, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, cholesterol 7alpha-hydroxylase (CYP7A1), Cultured, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Drug Inverse Agonism, Estrogen/genetics/*metabolism, Ethanol/pharmacology, Gene Expression, Genetic, Glycerides/pharmacology, GSK5182, HEK293 Cells, Hepatocytes/metabolism, Humans, Inbred C57BL, Jeong Won-Il, Kim Don-Kyu, Kim Seong Heon, Knockout, Lee Chul-Ho, Lee In-Kyu, Lee Ji-Min, Liver/*metabolism, Mice, NEOMED College of Medicine, oestrogen-related receptor gamma (ERRgamma), orphan nuclear receptor, Park Seung Bum, Promoter Regions, Rats, Receptor, Receptors, small heterodimer partner (SHP), Sprague-Dawley, The Biochemical journal, Transcription, Zhang Yaochen
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.
Tags: 2010, Absorption, Anderson Jody, Animals, Biological, Cell Line, Cholesterol/*metabolism, Class B/*genetics/metabolism, Coronary Disease/metabolism, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Edwards Peter A, Glucose/metabolism, Gonzalez Frank J, Hepatocyte Nuclear Factor 4/metabolism, Homeostasis, Humans, Lipoproteins/metabolism, Liver/metabolism, Ma Huiyan, Mice, Models, NEOMED College of Medicine, Receptors, Scavenger Receptors, The Journal of biological chemistry, Willson Timothy M, Yin Liya, Zhang Yanqiao
Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells.
Tags: 2000, Alitretinoin, Antineoplastic Agents/*pharmacology, Biochemical and biophysical research communications, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 4, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Hardwick J P, Humans, Hydroxylation, Leukotriene B4/metabolism, Molecular Sequence Data, NEOMED College of Medicine, Tretinoin/*pharmacology, Tumor Cells, Up-Regulation, Zhang X
Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.
Tags: *Gene Expression Regulation, *Promoter Regions, 2000, Amino Acid Sequence, Archives of biochemistry and biophysics, Base Sequence, Cell Line, Chen L, Cloning, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 4, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, DNA, DNA Footprinting, Enzymologic, Exons, Genes, Genetic, Genetic/drug effects, Hardwick J P, Humans, Introns, Leukotriene B4/metabolism, Mixed Function Oxygenases/metabolism, Models, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Peroxisome Proliferators/*metabolism, Receptors, Reporter, Retinoic Acid Receptor alpha, Retinoic Acid/metabolism, Sequence Analysis, Transcription, Transcription Factors/metabolism, Transfection, Tretinoin/*metabolism, Zhang X
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
Tags: *DNA-Binding Proteins, *Transcription, 2001, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics, Cytoplasmic and Nuclear/physiology, Department of Integrative Medical Sciences, Genetic, Genetic/physiology, Hepatocyte Nuclear Factor 4, Humans, Molecular Sequence Data, NEOMED College of Medicine, Phosphoproteins/*physiology, Promoter Regions, Receptors, Repressor Proteins/*pharmacology, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Transcription Factors/*physiology, Tumor Cells, Zhang M
Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine
Tags: *Cardiac-specific transgenic mouse, *Mitochondria, *Mitochondrial translocation, *Protein acetylation, *Protein aggregation, *SOD2, 2017, Acetylation, Animals, Cardiomegaly/*metabolism, Chen Chwen-Lih, Chen Yeong-Renn, Cytosol/*metabolism, Department of Integrative Medical Sciences, Free radical biology & medicine, Heart/*physiology, Jin Zhicheng, Kang Patrick T, Mice, Mitochondria/*metabolism, NEOMED College of Medicine, Pathological, Post-Translational, Protein Aggregation, Protein Folding, Protein Processing, Protein Transport, Reactive Oxygen Species/metabolism, Sirtuin 3/metabolism, Superoxide Dismutase/genetics/*metabolism, Transgenic, Zhang Liwen
Redox-dependent mechanisms in coronary collateral growth: the "redox window" hypothesis.
Tags: 2009, Angiotensin II/physiology, Animals, Antioxidants & redox signaling, Belmadani Souad, Carrao Ana Catarina Ribeiro, Chilian William M, Coronary Vessels/*growth & development/metabolism, Department of Integrative Medical Sciences, Humans, NEOMED College of Medicine, Ohanyan Vahagn, Oxidation-Reduction, Pung Yuh Fen, Reactive Oxygen Species/metabolism, Rocic Petra, Yun June
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
Tags: 2017, alcoholic fatty liver disease, Alcoholic/*metabolism/pathology, AMP-Activated Protein Kinases/metabolism, Animals, Current molecular pharmacology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Ethanol/chemistry/*metabolism, Fatty Liver, Humans, Inflammation, Inflammation/metabolism, Jogasuria Alvin, Lee Kwangwon, Lee Yoon-Kwang, Lipid Metabolism, Lipin-1, Liver/metabolism, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Phosphatidate Phosphatase/*metabolism, Sadana Prabodh, Signal Transduction, Sirtuin 1/metabolism, transcriptional regulators, Wu Jiashin, You Min, Zhang Yanqiao
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.
Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya
Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis.
Tags: 2011, Adenoviridae/genetics, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Cells, Cholesterol, Cholesterol/*metabolism, Cultured, Department of Integrative Medical Sciences, Edwards Peter A, Fatty Liver/metabolism/physiopathology, Ge Xuemei, HDL/metabolism, Hepatocyte Nuclear Factor 4/drug effects/genetics/*physiology, Hepatocytes/cytology/*metabolism, Homeostasis/genetics/*physiology, Inbred C57BL, Lipid Metabolism/genetics/physiology, Ma Huiyan, Mice, Models, NEOMED College of Medicine, RNA, Small Interfering/genetics/pharmacology, Triglycerides/*metabolism, VLDL/metabolism, Yin Liya, Zhang Yanqiao
On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.
Tags: *DNA-Binding Proteins, 2002, alpha-Fetoproteins/genetics/*physiology, Animals, Base Sequence, Bile Acids and Salts/*pharmacology, Biochimica et biophysica acta, Cattle, Chiang John Y L, Cytochrome P-450 Enzyme System/*genetics, Department of Integrative Medical Sciences, DNA, Eggertsen Gosta, Enzymologic/*drug effects/physiology, Gene Expression Regulation, Genetic, Genetic/*drug effects, Hepatocyte Nuclear Factor 4, Messenger/genetics, NEOMED College of Medicine, Phosphoproteins/genetics/*physiology, Promoter Regions, Rats, RNA, Sprague-Dawley, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, Transcription, Transcription Factors/genetics/*physiology, Yang Yizeng, Zhang Ming
Lipocalin‐2 Protects Against Diet‐Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes.
Tags: 2019, Chen Xiaoli, Department of Integrative Medical Sciences, Fatty Liver, Hepatology communications, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, LIPOCALIN, LIVER disease treatment, NEOMED College of Medicine, September 2019 Update, Sun Huihui, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Hepatocyte-Specific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice.
Tags: 2020, Bawa Fathima Cassim, decreases blood-lipids, deficiency, Department of Integrative Medical Sciences, dyslipidemia, hepatic steatosis, Hepatology communications, Hu Shuwei, Journal Article, journalArticle, June 2020 Update I, lipotoxicity, Liver, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Pan Xiaoli, protects, receptor-alpha, reduces atherosclerosis, transgenic expression, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis
Tags: 2019, ABCA1, ABCG1, Atherosclerosis, cholesterol efflux, Department of Integrative Medical Sciences, Fan Daping, Inflammation, Journal Article, Juguilon Cody, Li Feng, LXR, miR-34a, Molecular Therapy, NEOMED College of Graduate Studies Student, NEOMED College of Medicine, November 2019 Update, Sun Huihui, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism.
Tags: 2015, Animals, Apolipoproteins E/genetics, Atherosclerosis/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Experimental/genetics/metabolism, Hep G2 Cells, Hepatocyte Nuclear Factor 4/*genetics/metabolism, Humans, Knockout, LDL/genetics, Li Yuanyuan, Lipid Metabolism/*genetics, Lipoproteins/metabolism, Liver/metabolism, Mice, MicroRNAs/*genetics/metabolism, Middle Aged, Nature communications, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease/*genetics/metabolism, Physiological/*genetics, Receptors, Stress, Triglycerides/*metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice.
Tags: *Intestinal Absorption, 2016, Adorini Luciano, Animals, Bile Acids and Salts/*chemistry, Biological Transport, Cholesterol/*metabolism, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Gonzalez Frank J, Hepatology (Baltimore, Md.), Inbred C57BL, Lee Yoon-Kwang, Li Fei, Mice, NEOMED College of Medicine, Receptors, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Hepatocyte nuclear factor 4α prevents the steatosis-to-NASH progression by regulating p53 and bile acid signaling.
Tags: 2020, Apoptosis, Bawa FC, bile acid, Chen S, Department of Integrative Medical Sciences, Gopoju R, Hepatology, HNF4α, Hu S, journalArticle, Lipolysis, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, October 2020 List, p53, Pan X, steatohepatitis, Stroup D, Xu Y, Yin Liya, Zhang Y, Zhu Y
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice.
Tags: 2021, American Journal Of Physiology: Gastrointestinal & Liver Physiology, Bawa FC, CES2, Department of Integrative Medical Sciences, Fatty acid oxidation, Fatty Liver, insulin sensitivity, journalArticle, LABORATORY mice, Li Y, Lipolysis, lipotoxicity, March 2021 List, NEOMED College of Medicine, NEOMED Postdoc Publications, Pan X, Shuwei H, steatohepatitis, STEROL regulatory element-binding proteins, Xu Y, Yin L, Zhang Y, Zhu Y
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism.
Tags: 2021, Atherosclerosis, Chen L, Chen S, Department of Integrative Medical Sciences, February 2021 List, Hu S, Jadhav K, journalArticle, Li Y, Nature Metabolism, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Pan X, Tang Y, Wang DQ-H, Wang HH, Xu Y, Yang L, Yin L, Zhang Y, Zhu Y
Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease.
Tags: 2021, Bawa FC, BILE acids, Department of Integrative Medical Sciences, Hu S, journalArticle, lipid absorption, Lipogenesis, May 2021 List, miR-34a, Molecular metabolism, NAFLD, NEOMED College of Medicine, NEOMED Postdoc Publications, NEOMED Student Publications, Pan X, Wang DQ, Wang HH, Xu Y, Yin L, Zhang Y, Zhu Y
Hepatocyte-specific expression of human carboxylesterase 2 attenuates non-alcoholic steatohepatitis in mice.
Tags: 2020, American Journal of Physiology-Gastrointestinal and Liver Physiology, Cassim BF, CES2, Department of Integrative Medical Sciences, Fatty acid oxidation, Hu S, January 2021 List, journalArticle, Li Y, Lipolysis, lipotoxicity, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Pan X, steatohepatitis, Xu Y, Yin L, Zhang Y, Zhu Y
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.
Tags: *Postprandial Period, 2014, Acetylation/drug effects, Animals, ATP Citrate (pro-S)-Lyase/metabolism, Blood Glucose/*metabolism, Carboxylic Ester Hydrolases/*metabolism, Cheng Gang, Chromatin/metabolism, Department of Integrative Medical Sciences, Enzymologic/drug effects, Gene Expression Regulation, Glucose/*pharmacology, Histones/metabolism, Homeostasis, Inbred C57BL, Li Yuanyuan, Liver/*enzymology, Male, Mice, NEOMED College of Medicine, Nutritional Status, PloS one, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr (-/-) mice.
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.
Tags: 2016, Alcoholic/*pathology, Alcohols/*toxicity, Animals, Carboxylic Ester Hydrolases/*metabolism, Chemical and Drug Induced Liver Injury/*pathology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet/*adverse effects, Fatty Liver, Gene Expression Regulation, Genetic, Hepatocyte Nuclear Factor 4/*metabolism, Hepatocytes/metabolism, Humans, Inbred C57BL, Jadhav Kavita, Knockout, Li Yuanyuan, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Promoter Regions, Protein Binding, Scientific reports, Xu Jiesi, Xu Yang, Yin Liya, You Min, Zhang Yanqiao
Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.
Tags: *Homeostasis, *Lipid Metabolism, 2014, Adorini Luciano, Animals, Carboxylic Ester Hydrolases/*physiology, Chen Wei-Dong, Cholesterol/blood, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Fatty Acids/metabolism, Ge Xuemei, Hepatology (Baltimore, Md.), Inbred C57BL, Jadhav Kavita, Li Yuanyuan, Lipogenesis, Liver/*enzymology, Mice, NEOMED College of Medicine, Receptors, Sterol Regulatory Element Binding Protein 1/physiology, Triglycerides/metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zhang Yanqiao
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.
Tags: 1999, Animals, Base Sequence, Blotting, Cell Line, Chiang J Y, Chromosome Mapping, Cloning, Codon, Complementary/biosynthesis/*isolation & purification, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA, Genetic, Genetic/genetics, Humans, Hydroxycholesterols/metabolism, Initiator, Javitt N B, Journal of lipid research, Luciferases/genetics, Martin K O, Mice, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Northern, Nucleic Acid, Promoter Regions, Regulatory Sequences, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Wu Z
Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1.
Tags: 2001, Base Sequence, Binding, Binding Sites/genetics, Cell Line, Chiang J Y, Competitive, CpG Islands/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA/genetics, Enzymologic, gene, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics/metabolism, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid/genetics, Protein Binding, Recombinant Fusion Proteins/genetics/metabolism, Regulatory Sequences, Sequence Deletion, Site-Directed, Sp1 Transcription Factor/metabolism/*physiology, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Tumor Cells, Wu Z
Lipophilic Ga Complex with Broad-Spectrum Antimicrobial Activity and the Ability to Overcome Gallium Resistance in both Pseudomonas aeruginosa and Staphylococcus aureus.
Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a
Tags: 2017, 4EBP-1, ACAT, acyl-CoA:cholesterol acyltransferase, CE, Cellular and molecular gastroenterology and hepatology, Chavan Hemantkumar, Chiang John Y L, chloroquine, Cholesterol, cholesterol 7alpha-hydroxylase, cholesterol ester, Cholestyramine, ChTM, CQ, CYP7A1, Department of Integrative Medical Sciences, diet-induced obesity, Ding Wen-Xing, Ding Yifeng, DIO, endoplasmic reticulum, ER, eukaryotic translation initiation factor 4E-binding protein 1, Fatty Liver, FC, free cholesterol, glycogen synthase kinase 3beta, GSK3beta, HMG-CoA reductase, HMGCR, Krishnamurthy Partha, LC3, LDLR, Li Jibiao, Li Tiangang, LMP, low-density lipoprotein receptor, lysosome membrane permeabilization, Matye David, messenger RNA, microtubule-associated protein 1A/1B-light chain 3, mRNA, mTOR, NEOMED College of Medicine, Ni Hong-Min, Nuclear Receptor, phosphatidylinositol, PI, plasma membrane, PM, S6, SREBP, sterol response element binding protein, the nutrient sensing mechanistic target of rapamycin, tibosomal protein S6, Wang Yifeng
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.
Tags: *Promoter Regions, *Transcription, *Transcription Factors, 1996, Base Sequence, Binding Sites, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Consensus Sequence, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Repression, Enzymologic/*drug effects, Galli G, Gene Expression Regulation, Genes, Genetic, Glucocorticoid/genetics/metabolism, Glucocorticoids/pharmacology, Hepatocyte Nuclear Factor 3-alpha, Humans, Insulin/pharmacology, Journal of lipid research, Marrapodi M, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/genetics/metabolism, Phorbol Esters/pharmacology, Receptors, Recombinant Fusion Proteins/biosynthesis, Reporter, Stroup D, Thyroid Hormones/pharmacology, Transfection, Wang D P
Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7).
On the mechanisms of biliary flux.
The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice.
Tags: 2015, Animals, Bile Acids and Salts/metabolism, Cytoplasmic and Nuclear/biosynthesis/*genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/*drug therapy/genetics/metabolism, Gene Expression Regulation/drug effects, Glucose/metabolism, Hepatocytes/drug effects, Humans, Insulin Resistance/genetics, Insulin/*metabolism, Journal of biomedical science, Lee Yoon-Kwang, Leptin/deficiency/genetics, Lipid Metabolism/drug effects, Messenger/genetics, Mice, Moore David D, NEOMED College of Medicine, Obese, Park Young Joo, PPAR gamma/*biosynthesis/genetics, Receptors, RNA, Thiazolidinediones/*administration & dosage, Tseng Hsiu-Ting
α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.
Tags: 2021, Akhtar MW, Bodhinathan K, Department of Integrative Medical Sciences, Eisele YS, February 2021 List, Ghatak S, journalArticle, Kelly JW, Lipton SA, Lynch WP, NEOMED College of Medicine, neuron loss, Piña-Crespo JC, Sanz-Blasco S, synapse loss, Talantova M, The Journal of Neuroscience, Trudler D
Reexamination of amphotropic murine leukemia virus neurovirulence: neural stem cell-mediated microglial infection fails to induce acute neurodegeneration.
Tags: *Leukemia Virus, *Reassortant Viruses/pathogenicity, 2002, Animals, Cell Line, Central Nervous System Diseases/*pathology/virology, Department of Integrative Medical Sciences, Experimental/*pathology, Friend murine leukemia virus/genetics/pathogenicity, Leukemia, Lynch William P, Mice, Microglia/pathology/virology, Murine/isolation & purification/pathogenicity, NEOMED College of Medicine, Newborn, Retroviridae Infections/*pathology, Traister Russell S, Tumor Virus Infections/*pathology, Viral Envelope Proteins/genetics/isolation & purification, Viremia, Virology, Virulence
TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.
Tags: 2016, Adapala Ravi K, Animals, Cappelli Holly C, Carcinoma, Cell Movement/physiology, Department of Integrative Medical Sciences, endothelial cell, Endothelial Cells/metabolism/pathology, Inbred C57BL, Kanugula Anantha K, Knockout, Lewis Lung/metabolism/*pathology, Mechanotransduction, Mice, NEOMED College of Medicine, Neovascularization, Oncotarget, Paruchuri Sailaja, Pathologic/*metabolism/pathology, rho-Associated Kinases/*metabolism, Rho/Rho kinase, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/*metabolism, TRPV4, tumor angiogenesis
TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation.
Tags: 2015, Adapala Ravi K, Animals, Antineoplastic Agents/pharmacology, Cappelli Holly C, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Dudley Andrew C, Endothelial Cells/drug effects/metabolism, Kondeti Vinay, Leucine/analogs & derivatives/pharmacology, MAP Kinase Signaling System, Meszaros J Gary, Mice, NEOMED College of Medicine, Neoplasms/drug therapy/*metabolism/pathology, Neovascularization, Paruchuri Sailaja, Pathologic/drug therapy, Scientific reports, Sulfonamides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/drug effects/genetics/*metabolism, Up-Regulation
A TRP to cardiac fibroblast differentiation.
Tags: *Calcium Signaling, *Cell Differentiation, *Cell Transdifferentiation, *Mechanotransduction, *Wound Healing, 2013, Animals, Atrial Fibrillation/*metabolism, cardiac fibroblast, Cellular, Channels (Austin, Tex.), Department of Integrative Medical Sciences, differentiation, ECM stiffness, Female, Fibroblasts/*metabolism/*physiology, Humans, integrin, Male, mechanical signaling, Meszaros J Gary, myofibroblast, Myofibroblasts/*cytology/*metabolism, NEOMED College of Medicine, Paruchuri Sailaja, Rho/ROCK, Thodeti Charles K, TRPC Cation Channels/*metabolism, TRPM Cation Channels/*metabolism, TRPV Cation Channels/*metabolism, TRPV4