Browse Items · NEOMED Bibliography Database

Bile acid metabolism and signaling in liver disease and therapy.

Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5).…

Tags: 2017, Bile acid metabolism, Chiang John Y L, Cholestatic liver, Department of Integrative Medical Sciences, diseases Metabolic diseases, Liver research, NEOMED College of Medicine

Bile acid metabolism and signaling.

Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling molecules and metabolic regulators that activate nuclear receptors and…

Bile Acid Metabolism in Liver Pathobiology.

Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain bile acid homeostasis, which is essential for protecting liver and other tissues and cells from cholesterol and bile acid toxicity. Bile acid…

Tags: 2018, Chiang John Y L, Department of Integrative Medical Sciences, Ferrell Jessica M, Gene Expression, NEOMED College of Medicine

BILE ACID RECEPTORS FXR AND TGR IN LIVER FIBROSIS AND INFLAMMATION: STUDY OF FXR/TGR5 DOUBLE KNOCKOUT MICE

Tags: 2019, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Ferrell Jessica M, Gilliland Tricia, Hepatology, Journal Article, NEOMED College of Medicine, November 2019 Update

Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.

Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for maintenance of whole body cholesterol homeostasis. Bile acids are physiological detergents that absorb, distribute, metabolize, and excrete nutrients, drugs,…

Tags: 2020, alcoholic and nonalcoholic fatty, American journal of physiology. Gastrointestinal and liver physiology, Bile acid metabolism, bile acid therapies, Chiang John Y L, Department of Integrative Medical Sciences, Farnesoid X receptor, Ferrell Jessica M, Liver Diseases, NEOMED College of Graduate Studies, NEOMED College of Medicine, Takeda G protein-coupled receptor 5

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

Bile acids derived from cholesterol and oxysterols derived from cholesterol and bile acid synthesis pathways are signaling molecules that regulate cholesterol homeostasis in mammals. Many nuclear receptors play pivotal roles in the regulation of bile…

Tags: 2002, Animals, Bile Acids and Salts/*physiology, Chiang John Y L, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Endocrine reviews, Gene Expression Regulation/*physiology, Humans, NEOMED College of Medicine, Receptors

Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.

Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Recent studies reveal that bile acids also are signaling molecules that activate several nuclear receptors…

Tags: 2003, American journal of physiology. Gastrointestinal and liver physiology, Animals, Bile Acids and Salts/biosynthesis/genetics/*physiology, Bile/*physiology, Cardiovascular Diseases/genetics/physiopathology, Chiang John Y L, Cholesterol/physiology, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback/physiology, Gene Expression Regulation/physiology, Humans, Liver Diseases/genetics/physiopathology, Liver/*physiology, NEOMED College of Medicine, Receptors

Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.

Bile acid synthesis is the major pathway for catabolism of cholesterol. Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway in the liver and plays an important role in regulating lipid, glucose…

Tags: 2015, Animals, Bile acid metabolism, Bile Acids and Salts/genetics/*metabolism, Biochimica et biophysica acta, Cheng Jie, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, CYP7A1, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism, Diet, farnesoid X receptor (FXR), Female, Ferrell Jessica M, Glucose/genetics/metabolism, Gonzalez Frank J, High-Fat/methods, Homeostasis, Inbred C57BL, Insulin Resistance, Intestinal Mucosa/metabolism, Jiang Changtao, Krausz Kristopher W, Li Tiangang, Lipid Metabolism/*physiology, lipidomics, Liver/metabolism, Male, Metabolome/*genetics, Metabolomics/methods, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism, Qi Yunpeng, Rats, Signal Transduction, tauro-beta-muricholic acid, Taurocholic Acid/analogs & derivatives/genetics/metabolism, Transgenic

Bile Acid signaling in liver metabolism and diseases.

Obesity, diabetes, and metabolic syndromes are increasingly recognized as health concerns worldwide. Overnutrition and insulin resistance are the major causes of diabetic hyperglycemia and hyperlipidemia in humans. Studies in the past decade provide…

Tags: 2012, Chiang John Y L, Department of Integrative Medical Sciences, Journal of lipids, Li Tiangang, NEOMED College of Medicine

Bile acid signaling in metabolic disease and drug therapy.

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates hepatobiliary secretion…

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.

Bile acids are synthesized from cholesterol only in hepatocytes. Bile acids circulating in the enterohepatic system act as physiological detergent molecules to help solubilize biliary cholesterol and emulsify dietary lipids and fat-soluble vitamins…

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

UNLABELLED: Mouse fibroblast growth factor 15 (FGF15) and human ortholog FGF19 have been identified as the bile acid-induced intestinal factors that mediate bile acid feedback inhibition of cholesterol 7alpha-hydroxylase gene (C YP7A1) transcription…

Tags: 2009, Butadienes/pharmacology, Carcinoma, Cell Line, Chenodeoxycholic Acid/*pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cytoplasmic and Nuclear/metabolism/physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Fibroblast Growth Factor, Fibroblast Growth Factors/drug effects/*physiology, Gene Expression/drug effects, Hepatocellular/metabolism, Hepatocytes/metabolism, Hepatology (Baltimore, Md.), Humans, Isoxazoles/pharmacology, Li Tiangang, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, NEOMED College of Medicine, Nitriles/pharmacology, Owsley Erika, Receptor, Receptors, Signal Transduction/drug effects, Song Kwang-Hoon, Strom Stephen, Transcription Factors/metabolism, Tumor, Type 4/antagonists & inhibitors

Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.

Cholesterol 7 alpha-hydroxylase (CYP7A1) of the bile acid biosynthesis pathway is suppressed by bile acids and inflammatory cytokines. Bile acids are known to induce inflammatory cytokines to activate the mitogen-activated protein kinase/c-Jun…

Bile Acids as Metabolic Regulators and Nutrient Sensors

Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabolism. The brain-gut-liver axis plays an essential role in maintaining overall glucose, bile, and immune homeostasis.…

Tags: 2019, Annual Review of Nutrition, Chiang John Y L, Department of Integrative Medical Sciences, Ferrell Jessica M, June 2019 Update, NEOMED College of Medicine

Bile acids as metabolic regulators.

PURPOSE OF REVIEW: This review focuses on the latest understanding of the molecular mechanisms underlying the complex interactions between intestine and liver bile acid signaling, gut microbiota, and their impact on whole-body lipid, glucose and…

Bile acids: regulation of synthesis.

Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear…

Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology

Bone marrow SSEA1+ cells support the myocardium in cardiac pressure overload.

RATIONALE: Stage specific embryonic antigen 1+ (SSEA1+) cells have been described as the most primitive mesenchymal progenitor cell in the bone marrow. Cardiac injury mobilizes SSEA1+ cells into the peripheral blood but their in vivo function has not…

Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.

The liver is a major organ that controls hepatic and systemic homeostasis. Dysregulation of liver metabolism may cause liver injury. Previous studies have demonstrated that carboxylesterase 1 (CES1) regulates hepatic triglyceride metabolism and…

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.

UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). So far, the underlying mechanism remains poorly understood. Here, we show that hepatic…

Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao

Cardiac mitochondria and reactive oxygen species generation.

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the…

Tags: 2014, Animals, Cardiac/*metabolism, Cardiovascular Diseases/*metabolism, Chen Yeong-Renn, Circulation research, Department of Integrative Medical Sciences, electron transport chain complex proteins, Heart/*metabolism, Humans, Membrane Potentials/physiology, Mitochondria, myocardial infarction, Myocytes, NEOMED College of Medicine, reactive oxygen species, Reactive Oxygen Species/*metabolism, Signal Transduction/physiology, Zweier Jay L

Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling.

Cardiac fibroblasts and myofibroblasts are responsible for post-MI remodeling which occurs via regulation of extracellular matrix (ECM). Accelerated post-MI remodeling leads to excessive ECM deposition and fibrosis, contributing to impaired…

Cardioprotection during ischemia by coronary collateral growth.

Ischemic heart diseases (IHD) cause millions of deaths around the world annually. While surgical and pharmacological interventions are commonly used to treat patients with IHD, their efficacy varies from patient to patient and is limited by the…

Tags: 2019, American journal of physiology. Heart and circulatory physiology, cardioprotection, Chilian William M, Coronary Circulation, coronary collateral growth, Cumpston Devan, Department of Integrative Medical Sciences, Dong Feng, Enrick Molly, ischemia, Jamaiyar Anurag, Juguilon Cody, NEOMED College of Graduate Studies Student, NEOMED College of Medicine, Yin Liya

Cardioprotection During Ischemia by Induced Coronary Collateral Growth

Cell transplantation as an initiator of endogenous stem cell-based tissue repair.

PURPOSE OF REVIEW: The aim of this review is to summarize recent findings of endogenous cell-based tissue repair triggered by a multitude of approaches, especially stem cell therapy. RECENT FINDINGS: The emerging evidence has demonstrated that an…

Tags: *Regeneration, *Stem Cell Transplantation, *Stem cells, *Wound Healing, 2012, Caplan Arnold I, Cell Transplantation, Current opinion in organ transplantation, Department of Integrative Medical Sciences, Dong Feng, Humans, Mesenchymal Stem Cell Transplantation, NEOMED College of Medicine

Changing the Channels: Nature's Remote Controlling in Health and Disease.

Tags: *coronary artery disease, *Editorials, *hydrogen peroxide, *potassium channels, *protein kinases, *vasodilation, 2017, Circulation research, Department of Integrative Medical Sciences, NEOMED College of Medicine, Thodeti Charles K

Changing the Channels: Nature's Remote Controlling in Health and Disease.

Tags: *coronary artery disease, *Editorials, *hydrogen peroxide, *potassium channels, *protein kinases, *vasodilation, 2017, Arterioles, Circulation research, Coronary Vessels, Department of Integrative Medical Sciences, Dilatation, Humans, NEOMED College of Medicine, Thodeti Charles K

Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), one of the most lethal cancers, results in more than one million fatalities worldwide every year. In view of the limited therapeutic alternatives and poor prognosis of liver cancer, preventive control approaches,…

Tags: *Chemoprevention, 2011, Analysis of Variance, Animal, Animal Studies, Animal/drug effects, Animals, Antioxidants, Behavior, Bishayee Anupam, Blotting, Booth Tristan D, Carcinoma, Cardiotoxicity, Cardiotoxins/*toxicity, Chemoprevention, Data Analysis Software, Department of Integrative Medical Sciences, Descriptive Statistics, Disease Models, Doppler, Dose-Response Relationship, Drug, Echocardiography, Feeding Behavior/drug effects, Female, Fisher's Exact Test, Funding Source, Heart – Drug Effects, Heart/drug effects/physiopathology, Hepatocellular – Prevention and Control, Hepatocellular/*drug therapy/pathology/physiopathology, Hepatocytes/drug effects/pathology, Hodnichak Cheryl M, Humans, Investigational new drugs, Liver Neoplasms/*drug therapy/pathology/physiopathology, Liver/drug effects/pathology/physiopathology, Luther Daniel J, Meszaros J Gary, NEOMED College of Medicine, Ohanyan Vahagn, Polyphenols – Therapeutic Use, Rats, Resveratrol, Shamhart Patricia E, Sisakian Hamayak, Sprague-Dawley, Stilbenes/*therapeutic use, Systole/drug effects, Western

Chemotherapy Strategies for Young Children Newly-Diagnosed with Medulloblastoma up to the Era of Molecular Profiling - A Comparative Outcomes Analysis

Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.

Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy…

Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.

Cholesterol 7alpha-hydroxylase (CYP7A1) is the first and rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. In addition to absorption and digestion of nutrients, bile acids play a critical role in the regulation of…

Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.

Elevated plasma TGs increase risk of cardiovascular disease in women. Estrogen treatment raises plasma TGs in women, but molecular mechanisms remain poorly understood. Here we explore the role of cholesteryl ester transfer protein (CETP) in the…

Chronic reperfusion mediates restoring the integrity of c-type cytochrome, limiting superoxide overproduction, and conferring reconditioning mitochondrial function in the postischemic heart

Background A serious consequence of acute myocardial ischemia‐reperfusion injury (acute I/R) is oxidative damage which causes mitochondrial dysfunction. Such I/R‐induced mitochondrial dysfunction is observed as impaired state‐3 respiration and…

Tags: 2020, Chen C, Chen Y, Department of Integrative Medical Sciences, Faseb Journal, journalArticle, NEOMED College of Medicine, September 2020 List

Chronic-plus-binge alcohol exposure impairs hematopoietic precursor cell activation during the granulopoietic response to bacteremia.

Tags: 2017, Alcohol, Department of Integrative Medical Sciences, Lin Yuan-Ping, NEOMED College of Medicine, Shi Xin, Zhang Ping

Circadian rhythms in liver metabolism and disease.

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result…

Tags: 2015, Acta pharmaceutica Sinica. B, ARC, arcuate nucleus, BMAL1, brain and muscle ARNT-like 1, CAR, Chiang John Y L, cholesterol 7alpha-hydroxylase, circadian locomotor output cycles kaput, Circadian Rhythm, CLOCK, constitutive androstane receptor, CRY, cryptochrome, CYP7A1, CYPs, cytochrome P450 enzymes, D-site binding protein, DBP, Department of Integrative Medical Sciences, E-box, emergency medical technician, EMT, enhance box, FAA, familial advanced sleep-phase syndrome, farnesoid-X receptor, FASPS, FEO, Ferrell Jessica M, food anticipatory activity, food entrainable oscillator, forkhead box O3, FOXO3, FXR, G protein-coupled bile acid receptor, glucose transporter 2, GLUT2, HDAC3, hepatic leukemia factor, Hip, histone deacetylase 3, HLF, hypoxia inducing protein, LDL, Liver, liver receptor homolog 1, Low-density lipoprotein, LRH1, Metabolic syndrome, NAD+, NEOMED College of Medicine, nicotinamide adenine dinucleotide, PER, period, retinohypothalamic tract, retinoid-related orphan receptor alpha, RHT, ROR-response element, RORalpha, RORE, SCN, SHP, SIRT1, sirtuin 1, small heterodimer partner, suprachiasmatic nucleus, TEF, TGR5, thyrotroph embryonic factor, transcriptional translational feedback loop, TTFL, Type 2 diabetes

Circadian variation in cell-adhesion molecule expression by normal human leukocytes.

Adhesion molecules located on the surface of blood-borne leukocytes permit adherence of leukocytes to the microvascular endothelium, diapedesis of leukocytes across vessel walls, formation of intimate multicell interactions, and enhanced…

Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.

A cholesterol 7 alpha-hydroxylase gene containing 8 kb of the 5'-flanking region and 5 kb of the transcription region which covers exons 1 to 5 was isolated from a rat genomic library. The 2015 bp nucleotide sequence 5'-upstream from the start codon…

Tags: *Promoter Regions, 1992, Amino Acid Sequence, Animals, Base Sequence, Biochimica et biophysica acta, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Department of Integrative Medical Sciences, DNA, Genetic, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Rats, Restriction Mapping, Wang D P, Yang T P

Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s.

We have studied the immunochemical properties of two major 3-methylcholanthrene inducible hamster liver cytochrome P450 isozymes, P450 MC1 and P450 MC4. Immunoblots using specific antibodies against P450 MC1 and P450 MC4 demonstrated that these two…

Comparing cardioprotetion by DiOHF intervention and ischemic preconditioning.

Tags: *Cardioprotecton, *Flavonol, *Ischemia/reperfusion injury, *Ischemic preconditioning, *Reperfusion Injury, 2018, Chen Yeong-Renn, Department of Integrative Medical Sciences, Humans, International journal of cardiology, NEOMED College of Medicine

Connecting the dots–establishing causality between chronic stress, depression, and cardiovascular disease.

Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis

The purpose of this review is to briefly summarize the roles of alcohol (ethanol) and related compounds in promoting cancer and inflammatory injury in many tissues. Long-term chronic heavy alcohol exposure is known to increase the chances of…

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