Browse Items (328 total)
- Tags: Department of Integrative Medical Sciences
Bile acid metabolism and signaling in liver disease and therapy.
Bile acid metabolism and signaling.
Tags: 2013, Animals, Bile Acids and Salts/*metabolism/therapeutic use, Biliary Tract Diseases/metabolism, Chiang John Y L, Cholesterol/metabolism, Comprehensive Physiology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Enterohepatic Circulation/physiology, Feedback, G-Protein-Coupled/metabolism, Homeostasis/physiology, Humans, Inflammation/metabolism, Liver/metabolism, NEOMED College of Medicine, Physiological/physiology, Receptors, Signal Transduction/*physiology
Bile Acid Metabolism in Liver Pathobiology.
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.
Tags: 2020, alcoholic and nonalcoholic fatty, American journal of physiology. Gastrointestinal and liver physiology, Bile acid metabolism, bile acid therapies, Chiang John Y L, Department of Integrative Medical Sciences, Farnesoid X receptor, Ferrell Jessica M, Liver Diseases, NEOMED College of Graduate Studies, NEOMED College of Medicine, Takeda G protein-coupled receptor 5
Bile acid regulation of gene expression: roles of nuclear hormone receptors.
Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.
Tags: 2003, American journal of physiology. Gastrointestinal and liver physiology, Animals, Bile Acids and Salts/biosynthesis/genetics/*physiology, Bile/*physiology, Cardiovascular Diseases/genetics/physiopathology, Chiang John Y L, Cholesterol/physiology, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback/physiology, Gene Expression Regulation/physiology, Humans, Liver Diseases/genetics/physiopathology, Liver/*physiology, NEOMED College of Medicine, Receptors
Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
Tags: 2015, Animals, Bile acid metabolism, Bile Acids and Salts/genetics/*metabolism, Biochimica et biophysica acta, Cheng Jie, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, CYP7A1, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism, Diet, farnesoid X receptor (FXR), Female, Ferrell Jessica M, Glucose/genetics/metabolism, Gonzalez Frank J, High-Fat/methods, Homeostasis, Inbred C57BL, Insulin Resistance, Intestinal Mucosa/metabolism, Jiang Changtao, Krausz Kristopher W, Li Tiangang, Lipid Metabolism/*physiology, lipidomics, Liver/metabolism, Male, Metabolome/*genetics, Metabolomics/methods, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism, Qi Yunpeng, Rats, Signal Transduction, tauro-beta-muricholic acid, Taurocholic Acid/analogs & derivatives/genetics/metabolism, Transgenic
Bile Acid signaling in liver metabolism and diseases.
Bile acid signaling in metabolic disease and drug therapy.
Tags: 2014, Animals, Bile Acids and Salts/biosynthesis/*metabolism/therapeutic use, Biological, Chiang John Y L, Circadian Rhythm/physiology, Department of Integrative Medical Sciences, G-Protein-Coupled/metabolism, Glucose/metabolism, Humans, Li Tiangang, Lipid Metabolism/physiology, Liver/metabolism, Metabolic Diseases/*drug therapy/*metabolism, Microbiota/physiology, MicroRNAs/metabolism, Models, NEOMED College of Medicine, Pharmacological reviews, Receptors, Signal Transduction/physiology
Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.
Tags: 2020, alcoholic liver disease (ALD), Bacterial Translocation, bile acid, binding protein, Chiang John Y L, Department of Integrative Medical Sciences, farnesoid X receptor (FXR), farnesoid-x-receptor, Fatty Liver, glucagon-like peptide-1, growth-factor 19, gut microbiota, Hepatobiliary surgery and nutrition, Journal Article, journalArticle, June 2020 Update I, Li Tiangang, Microbiota, molecular-cloning, NEOMED College of Medicine, non-alcoholic steatohepatitis (NASH), Nuclear Receptor, solute transporter-alpha
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Tags: 2009, Butadienes/pharmacology, Carcinoma, Cell Line, Chenodeoxycholic Acid/*pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cytoplasmic and Nuclear/metabolism/physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Fibroblast Growth Factor, Fibroblast Growth Factors/drug effects/*physiology, Gene Expression/drug effects, Hepatocellular/metabolism, Hepatocytes/metabolism, Hepatology (Baltimore, Md.), Humans, Isoxazoles/pharmacology, Li Tiangang, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, NEOMED College of Medicine, Nitriles/pharmacology, Owsley Erika, Receptor, Receptors, Signal Transduction/drug effects, Song Kwang-Hoon, Strom Stephen, Transcription Factors/metabolism, Tumor, Type 4/antagonists & inhibitors
Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.
Tags: 2006, Bile Acids and Salts/*metabolism, Cells, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cultured, Cytokines/*metabolism, Department of Integrative Medical Sciences, Gene Expression Regulation, Genetic, Hepatocytes/*cytology/drug effects, Hepatology (Baltimore, Md.), Humans, Immunoblotting, In Vitro Techniques, Interleukin-1/pharmacology, Jahan Asmeen, Li Tiangang, Messenger/analysis, NEOMED College of Medicine, Probability, Proto-Oncogene Proteins c-jun/*metabolism, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sensitivity and Specificity, Signal Transduction/genetics, Transcription
Bile Acids as Metabolic Regulators and Nutrient Sensors
Bile acids as metabolic regulators.
Tags: 2015, Bile Acids and Salts/*metabolism, Biological Transport, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Current opinion in gastroenterology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Energy Metabolism, Homeostasis, Humans, Inflammation/*metabolism, Intestine, Li Tiangang, Liver/*metabolism/pathology, NEOMED College of Medicine, Obesity/*metabolism, Receptors, Signal Transduction, Small/*metabolism/pathology, Type 2/*metabolism
Bile acids: regulation of synthesis.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology
Bone marrow SSEA1+ cells support the myocardium in cardiac pressure overload.
Tags: *Bone Marrow Transplantation, 2013, Animals, Bone Marrow Cells/cytology/*metabolism, Cardiac/cytology/metabolism, Cell Tracking, Department of Integrative Medical Sciences, Dong Feng, Finan Amanda, Kiedrowski Matthew, Lewis X Antigen/*metabolism, Male, Mesenchymal Stem Cells/cytology/metabolism, Mice, Myocardium/cytology/*metabolism/pathology, Myocytes, NEOMED College of Medicine, Penn Marc S, PloS one, Sopko Nikolai, Turturice Ben, Ventricular Remodeling
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.
Tags: 2016, Alcoholic/*pathology, Alcohols/*toxicity, Animals, Carboxylic Ester Hydrolases/*metabolism, Chemical and Drug Induced Liver Injury/*pathology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet/*adverse effects, Fatty Liver, Gene Expression Regulation, Genetic, Hepatocyte Nuclear Factor 4/*metabolism, Hepatocytes/metabolism, Humans, Inbred C57BL, Jadhav Kavita, Knockout, Li Yuanyuan, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Promoter Regions, Protein Binding, Scientific reports, Xu Jiesi, Xu Yang, Yin Liya, You Min, Zhang Yanqiao
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.
Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Cardiac mitochondria and reactive oxygen species generation.
Tags: 2014, Animals, Cardiac/*metabolism, Cardiovascular Diseases/*metabolism, Chen Yeong-Renn, Circulation research, Department of Integrative Medical Sciences, electron transport chain complex proteins, Heart/*metabolism, Humans, Membrane Potentials/physiology, Mitochondria, myocardial infarction, Myocytes, NEOMED College of Medicine, reactive oxygen species, Reactive Oxygen Species/*metabolism, Signal Transduction/physiology, Zweier Jay L
Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling.
Tags: 2009, Animals, Bryant Jennifer E, Cell Differentiation/*physiology, Collagen Type VI/*metabolism/physiology, Costic Donald J, Department of Integrative Medical Sciences, Doane Kathleen J, Dockry Michelle, Fibroblasts/*cytology, Immunoblotting, Integrin alpha3/*metabolism, Journal of molecular and cellular cardiology, Koshy John C, Luther Daniel J, Male, Meszaros J Gary, Mohile Monica V, Myocardial Infarction/*metabolism, Myocardium/*cytology, NEOMED College of Medicine, Olson Erik R, Protein Binding, Rats, Shamhart Patricia E
Cardioprotection during ischemia by coronary collateral growth.
Tags: 2019, American journal of physiology. Heart and circulatory physiology, cardioprotection, Chilian William M, Coronary Circulation, coronary collateral growth, Cumpston Devan, Department of Integrative Medical Sciences, Dong Feng, Enrick Molly, ischemia, Jamaiyar Anurag, Juguilon Cody, NEOMED College of Graduate Studies Student, NEOMED College of Medicine, Yin Liya
Cardioprotection During Ischemia by Induced Coronary Collateral Growth
Tags: 2019, Chilian William, Chinchilla Sofia, Circulation research, Cumpston Devan, Department of Integrative Medical Sciences, Enrick Molly, Gadd James, Jamaiyar Anurag, Juguilon Cody, McCabe Caige, NEOMED College of Graduate Studies Student, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED College of Medicine Student, NEOMED Postdoc Publications, NEOMED Student Publications, Pu Autumn Y, Wang Tao, Weiguo Wan, Yin Liya, Zhiyuan Wang
Cell transplantation as an initiator of endogenous stem cell-based tissue repair.
Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.
Tags: *Chemoprevention, 2011, Analysis of Variance, Animal, Animal Studies, Animal/drug effects, Animals, Antioxidants, Behavior, Bishayee Anupam, Blotting, Booth Tristan D, Carcinoma, Cardiotoxicity, Cardiotoxins/*toxicity, Chemoprevention, Data Analysis Software, Department of Integrative Medical Sciences, Descriptive Statistics, Disease Models, Doppler, Dose-Response Relationship, Drug, Echocardiography, Feeding Behavior/drug effects, Female, Fisher's Exact Test, Funding Source, Heart – Drug Effects, Heart/drug effects/physiopathology, Hepatocellular – Prevention and Control, Hepatocellular/*drug therapy/pathology/physiopathology, Hepatocytes/drug effects/pathology, Hodnichak Cheryl M, Humans, Investigational new drugs, Liver Neoplasms/*drug therapy/pathology/physiopathology, Liver/drug effects/pathology/physiopathology, Luther Daniel J, Meszaros J Gary, NEOMED College of Medicine, Ohanyan Vahagn, Polyphenols – Therapeutic Use, Rats, Resveratrol, Shamhart Patricia E, Sisakian Hamayak, Sprague-Dawley, Stilbenes/*therapeutic use, Systole/drug effects, Western
Chemotherapy Strategies for Young Children Newly-Diagnosed with Medulloblastoma up to the Era of Molecular Profiling - A Comparative Outcomes Analysis
Tags: 2019, Akron Children's Hospital, Ashley D, Cohen B H, Department of Integrative Medical Sciences, Department of Pediatrics, Dhall G, Finlay J, Gajjar A, Gerber N, Geyer J R, Journal Article, Lafay-Cousin L, Leary S, Mazewski C M, Mynarek M, NEOMED College of Medicine, November 2019 Update, Pediatric blood & cancer, Rutkowski S, Tait D, von Bueren A O
Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Tags: *bile acid, *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, *Farnesoid X receptor, *Homeostasis, *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control, *Liver/enzymology/pathology, *nuclear receptor, *Takeda G protein-coupled receptor 5, 2016, Animals, Boehme Shannon, Chiang John Y L, Cholesterol/genetics/*metabolism, Department of Integrative Medical Sciences, G-Protein-Coupled/genetics/metabolism, Hep G2 Cells, Humans, Journal of lipid research, Knockout, Liu Hailiang, Mice, NEOMED College of Medicine, NF-kappa B/genetics/metabolism, Oxidative Stress, Pathak Preeti, Receptors, Tumor Necrosis Factor-alpha/genetics/metabolism
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Tags: *estrogen, *estrogen receptor alpha, *lipid and lipoprotein metabolism, *small heterodimer partner, *triglycerides, *very low density lipoprotein, 2016, Animals, Cholesterol Ester Transfer Proteins/*physiology, Department of Integrative Medical Sciences, Estrogen Receptor alpha/metabolism, Estrogens/physiology, Female, Inbred C57BL, Journal of lipid research, Le Thao D, Lee Yoon-Kwang, Lipid Metabolism, Liver/*metabolism, Metabolic Networks and Pathways, Mice, NEOMED College of Medicine, Oxidation-Reduction, Palmisano Brian T, Stafford John M, Transgenic, Triglycerides/biosynthesis/*blood, Zhu Lin
Chronic reperfusion mediates restoring the integrity of c-type cytochrome, limiting superoxide overproduction, and conferring reconditioning mitochondrial function in the postischemic heart
Circadian rhythms in liver metabolism and disease.
Tags: 2015, Acta pharmaceutica Sinica. B, ARC, arcuate nucleus, BMAL1, brain and muscle ARNT-like 1, CAR, Chiang John Y L, cholesterol 7alpha-hydroxylase, circadian locomotor output cycles kaput, Circadian Rhythm, CLOCK, constitutive androstane receptor, CRY, cryptochrome, CYP7A1, CYPs, cytochrome P450 enzymes, D-site binding protein, DBP, Department of Integrative Medical Sciences, E-box, emergency medical technician, EMT, enhance box, FAA, familial advanced sleep-phase syndrome, farnesoid-X receptor, FASPS, FEO, Ferrell Jessica M, food anticipatory activity, food entrainable oscillator, forkhead box O3, FOXO3, FXR, G protein-coupled bile acid receptor, glucose transporter 2, GLUT2, HDAC3, hepatic leukemia factor, Hip, histone deacetylase 3, HLF, hypoxia inducing protein, LDL, Liver, liver receptor homolog 1, Low-density lipoprotein, LRH1, Metabolic syndrome, NAD+, NEOMED College of Medicine, nicotinamide adenine dinucleotide, PER, period, retinohypothalamic tract, retinoid-related orphan receptor alpha, RHT, ROR-response element, RORalpha, RORE, SCN, SHP, SIRT1, sirtuin 1, small heterodimer partner, suprachiasmatic nucleus, TEF, TGR5, thyrotroph embryonic factor, transcriptional translational feedback loop, TTFL, Type 2 diabetes
Circadian variation in cell-adhesion molecule expression by normal human leukocytes.
Tags: *Circadian Rhythm, 2002, Adult, Canadian journal of physiology and pharmacology, CD11a Antigen/metabolism, CD11b Antigen/metabolism, Cell Adhesion Molecules/*metabolism, Department of Integrative Medical Sciences, Department of Internal Medicine, Ervin Elyce, Fagan Diana L, Female, Flow Cytometry, Humans, Integrin alpha Chains/metabolism, Intercellular Adhesion Molecule-1/metabolism, Khanna Kamal, L-Selectin/metabolism, Leukocytes/*metabolism, Lymphocytes/metabolism, Male, Middle Aged, Monocytes/metabolism, NEOMED College of Medicine, Neutrophils/metabolism, Niehaus Gary D, Patel Amit, Vanek Vincent W
Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.
Tags: *Promoter Regions, 1992, Amino Acid Sequence, Animals, Base Sequence, Biochimica et biophysica acta, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Department of Integrative Medical Sciences, DNA, Genetic, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Rats, Restriction Mapping, Wang D P, Yang T P
Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s.
Tags: 1990, Amino Acid Sequence, Animals, Archives of biochemistry and biophysics, Base Sequence, Chiang J Y, Cloning, Cricetinae, Cytochrome P-450 Enzyme System/biosynthesis/*genetics, Department of Integrative Medical Sciences, Enzyme Induction, Female, Humans, Immunoblotting, Inbred Strains, Lai T S, Liver/drug effects/*enzymology, Liver/enzymology, Male, Mesocricetus, Methylcholanthrene/*pharmacology, Microsomes, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Nucleic Acid, Nucleic Acid Hybridization, Phenobarbital/pharmacology, Rats, Reference Values, Restriction Mapping, Sequence Homology
Connecting the dots–establishing causality between chronic stress, depression, and cardiovascular disease.
Tags: 2014, Animal/*physiology, Animals, Behavior, Chilian William M, Department of Family & Community Medicine, Department of Integrative Medical Sciences, Depression/*physiopathology, Di Vincenzo Lola, Endothelium, Female, Journal of applied physiology (Bethesda, Md. : 1985), Male, NEOMED College of Medicine, Perera Vidushani, Psychological/*physiopathology, Reber Megan, Stress, Vascular Diseases/*physiopathology, Vascular/*physiopathology
Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis
Tags: 2019, acetaldehyde, Alcohol, Biomedical and Life Sciences, Byoung-Joon Song, Cancer, Cancer Research, Cell Biology, CYP2E1, Department of Integrative Medical Sciences, DNA mutation, Human Cell Transformation : Advances In Cell Models For The Study Of Cancer And Aging, Inflammation, James P Hardwick, Johng S Rhim, Journal Article, Life sciences, Min-Kyung Song, Mohamed A Abdelmegeed, Mohammed Akbar, NEOMED College of Medicine, November 2019 Update, oncology, Oxidative Stress, Young-Eun Cho